The impacts of pesticide exposure on fish conspecific behavioural interactions: a systematic review and meta-analysis

Load packages and data

Load packages

rm(list = ls())

pacman::p_load(tidyverse, here, kableExtra, magrittr, patchwork, metafor, metagear,
    ape, rotl, orchaRd, clubSandwich, MuMIn, ggsankey)

Load Data

data <- read_csv(here("data", "fish_conspecific_behaviour_ma_data.csv"), skip = 0)

# Format ID variables as characters
data <- mutate_at(data, vars(study_id, exp_id, exp2_id, assay_id, assay2_id), as.character)
# Table of the dataset
kable(data, "html") %>%
    kable_styling("bordered", position = "left") %>%
    scroll_box(width = "250%", height = "800px")

comment_checker	comment_extractor	initials_checker	initials_extractor	title	doi	url	journal	study_id	exp_id	exp2_id	assay_id	assay2_id	species_english	species_latin	source	source2	sex	pesticide	pesticide_grade	cas_id	cas_id_comment	pesticide_chemical_class	dosage	dosage_unit	duration	duration_unit	control_solvent	solvent2	temperature	temperature_unit	behaviour_measured	behaviour_measured_standardised	behaviour_assay	behavioural_assay_standardised	behavioural_assay_standardised2	effect_direction	data_source	data_file	control_effective_n	control_shoal_n	control_fish_n	control_n	control_mean	control_sd	control_shoal_sd	control_fish_sd	control_se	statistics_comment_control	sample_size_comment_control	treatment_effective_n	treatment_shoal_n	treatment_fish_n	treatment_n	treatment_mean	treatment_sd	treatment_shoal_sd	treatment_fish_sd	treatment_se	statistics_comment_treatment	sample_size_comment_treatment	contact_author	contacted_date	contact_response	contact_comments
NA	NA	NA	KM	From dysbiosis to neuropathologies: Toxic effects of glyphosate in zebrafish	10.1016/j.ecoenv.2023.115888	https://www.sciencedirect.com/science/article/pii/S0147651323013921	Ecotoxicology and Environmental Safety	bellot_2024	bellot_2024_exp_001	bellot_2024_exp2_001	bellot_2024_exp_001_assay_001	bellot_2024_exp2_001_assay2_002	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	glyphosate	analytical	1071<96>83-6	in paper	organophosphate	0.3	ug/L	2	weeks	not reported	NA	28.5	celsius	social interaction	sociality	time spent in conspecific zone	time spent in social zone	zone	NA	fig4	bellot_2024_fig4	NA	NA	NA	15	61.0344828	19.7736111	NA	NA	5.105524437	calculated from scatter plot	counted from the scatter plot	NA	NA	NA	16	45.6896552	11.2390246	NA	NA	2.809756146	calculated from scatter plot	counted from the scatter plot	NA	NA	NA	NA
NA	NA	NA	KM	From dysbiosis to neuropathologies: Toxic effects of glyphosate in zebrafish	10.1016/j.ecoenv.2023.115888	https://www.sciencedirect.com/science/article/pii/S0147651323013921	Ecotoxicology and Environmental Safety	bellot_2024	bellot_2024_exp_002	bellot_2024_exp2_002	bellot_2024_exp_002_assay_001	bellot_2024_exp2_002_assay2_002	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	glyphosate	analytical	1071<96>83-6	in paper	organophosphate	3	ug/L	2	weeks	not reported	NA	28.5	celsius	social interaction	sociality	time spent in conspecific zone	time spent in social zone	zone	NA	fig4	bellot_2024_fig4	NA	NA	NA	15	61.0344828	19.7736111	NA	NA	5.105524437	calculated from scatter plot	counted from the scatter plot	NA	NA	NA	16	45.2945402	15.0522332	NA	NA	3.763058307	calculated from scatter plot	counted from the scatter plot	NA	NA	NA	NA
NA	NA	SN	KM	Diuron metabolites act as endocrine disruptors and alter aggressive behavior in Nile tilapia (Oreochromis niloticus)	10.1016/j.chemosphere.2017.10.009	https://www.sciencedirect.com/science/article/pii/S0045653517315801?via%3Dihub	Chemosphere	boscolo_2018	boscolo_2018_exp_001	boscolo_2018_exp2_001	boscolo_2018_exp_001_assay_001	boscolo_2018_exp2_001_assay2_001	Nile tilapia	Oreochromis niloticus	laboratory stock from not specified source	not_wild	male	diuron	not reported	330-54-1	https://commonchemistry.cas.org/detail?cas_rn=330-54-1&search=diuron	urea	100	ng/L	10	days	acetone	solvent_used	27	celsius	aggression	aggression	total frequency of aggressive interactions	frequency of aggressive behaviour	count	NA	fig2	boscolo_2019_fig2	NA	NA	NA	12	41.8874519	35.5260736	NA	NA	10.25549408	study reports mean and se	exact sample size provided	NA	NA	NA	12	44.3101781	35.3497491	NA	NA	10.20459358	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	SN	KM	Diuron metabolites act as endocrine disruptors and alter aggressive behavior in Nile tilapia (Oreochromis niloticus)	10.1016/j.chemosphere.2017.10.009	https://www.sciencedirect.com/science/article/pii/S0045653517315801?via%3Dihub	Chemosphere	boscolo_2018	boscolo_2018_exp_002	boscolo_2018_exp2_002	boscolo_2018_exp_002_assay_001	boscolo_2018_exp2_002_assay2_001	Nile tilapia	Oreochromis niloticus	laboratory stock from not specified source	not_wild	male	DCPMU	not reported	3567-62-2	https://commonchemistry.cas.org/detail?cas_rn=3567-62-2&search=DCPMU	urea	100	ng/L	10	days	acetone	solvent_used	27	celsius	aggression	aggression	total frequency of aggressive interactions	frequency of aggressive behaviour	count	NA	fig2	boscolo_2019_fig2	NA	NA	NA	12	41.8874519	35.5260736	NA	NA	10.25549408	study reports mean and se	exact sample size provided	NA	NA	NA	12	20.7776130	13.7057934	NA	NA	3.956521739	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	SN	KM	Diuron metabolites act as endocrine disruptors and alter aggressive behavior in Nile tilapia (Oreochromis niloticus)	10.1016/j.chemosphere.2017.10.009	https://www.sciencedirect.com/science/article/pii/S0045653517315801?via%3Dihub	Chemosphere	boscolo_2018	boscolo_2018_exp_003	boscolo_2018_exp2_003	boscolo_2018_exp_003_assay_001	boscolo_2018_exp2_003_assay2_001	Nile tilapia	Oreochromis niloticus	laboratory stock from not specified source	not_wild	male	DCA	not reported	NA	NA	urea	100	ng/L	10	days	acetone	solvent_used	27	celsius	aggression	aggression	total frequency of aggressive interactions	frequency of aggressive behaviour	count	NA	fig2	boscolo_2019_fig2	NA	NA	NA	12	41.8874519	35.5260736	NA	NA	10.25549408	study reports mean and se	exact sample size provided	NA	NA	NA	12	13.5725886	8.9533703	NA	NA	2.584615385	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Glyphosate and Roundup<ae><a0>alter morphology and behavior in zebrafish	10.1016/j.tox.2017.10.007	https://www.sciencedirect.com/science/article/pii/S0300483X17303128?via%3Dihub	Toxicology	bridi_2017	bridi_2017_exp_001	bridi_2017_exp2_001	bridi_2017_exp_001_assay_001	bridi_2017_exp2_001_assay2_001	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	glyphosate	not reported	1071-83-6	https://commonchemistry.cas.org/detail?cas_rn=1071-83-6&search=GLYPHOSATE	organophosphate	0.01	mg/L	96	hours	none	none	26	celsius	aggression	aggression	time spent close to stimulus	time spent in aggression zone	zone	NA	fig6a	bridi_2017_fig6a	NA	NA	NA	26	122.2071971	28.8770683	NA	NA	5.663259022	study reports mean and se	exact sample size provided	NA	NA	NA	26	91.1310966	29.3484305	NA	NA	5.755700754	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Glyphosate and Roundup<ae><a0>alter morphology and behavior in zebrafish	10.1016/j.tox.2017.10.007	https://www.sciencedirect.com/science/article/pii/S0300483X17303128?via%3Dihub	Toxicology	bridi_2017	bridi_2017_exp_002	bridi_2017_exp2_002	bridi_2017_exp_002_assay_001	bridi_2017_exp2_002_assay2_001	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	glyphosate	not reported	1071-83-6	https://commonchemistry.cas.org/detail?cas_rn=1071-83-6&search=GLYPHOSATE	organophosphate	0.065	mg/L	96	hours	none	none	26	celsius	aggression	aggression	time spent close to stimulus	time spent in aggression zone	zone	NA	fig6a	bridi_2017_fig6a	NA	NA	NA	26	122.2071971	28.8770683	NA	NA	5.663259022	study reports mean and se	exact sample size provided	NA	NA	NA	26	93.3694247	35.0550697	NA	NA	6.874864789	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Glyphosate and Roundup<ae><a0>alter morphology and behavior in zebrafish	10.1016/j.tox.2017.10.007	https://www.sciencedirect.com/science/article/pii/S0300483X17303128?via%3Dihub	Toxicology	bridi_2017	bridi_2017_exp_003	bridi_2017_exp2_003	bridi_2017_exp_003_assay_001	bridi_2017_exp2_003_assay2_001	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	glyphosate	not reported	1071-83-6	https://commonchemistry.cas.org/detail?cas_rn=1071-83-6&search=GLYPHOSATE	organophosphate	0.5	mg/L	96	hours	none	none	26	celsius	aggression	aggression	time spent close to stimulus	time spent in aggression zone	zone	NA	fig6a	bridi_2017_fig6a	NA	NA	NA	26	122.2071971	28.8770683	NA	NA	5.663259022	study reports mean and se	exact sample size provided	NA	NA	NA	26	93.5293053	39.9464748	NA	NA	7.834148248	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Glyphosate and Roundup<ae><a0>alter morphology and behavior in zebrafish	10.1016/j.tox.2017.10.007	https://www.sciencedirect.com/science/article/pii/S0300483X17303128?via%3Dihub	Toxicology	bridi_2017	bridi_2017_exp_004	bridi_2017_exp2_004	bridi_2017_exp_004_assay_001	bridi_2017_exp2_004_assay2_001	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	roundup	commercial	38641-94-0	https://commonchemistry.cas.org/detail?cas_rn=38641-94-0&search=ROUNDUP	organophosphate	0.01	mg/L	96	hours	none	none	26	celsius	aggression	aggression	time spent close to stimulus	time spent in aggression zone	zone	NA	fig6a	bridi_2017_fig6a	NA	NA	NA	26	122.2071971	28.8770683	NA	NA	5.663259022	study reports mean and se	exact sample size provided	NA	NA	NA	26	85.8550376	17.9351520	NA	NA	3.517372683	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Glyphosate and Roundup<ae><a0>alter morphology and behavior in zebrafish	10.1016/j.tox.2017.10.007	https://www.sciencedirect.com/science/article/pii/S0300483X17303128?via%3Dihub	Toxicology	bridi_2017	bridi_2017_exp_005	bridi_2017_exp2_005	bridi_2017_exp_005_assay_001	bridi_2017_exp2_005_assay2_001	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	roundup	commercial	38641-94-0	https://commonchemistry.cas.org/detail?cas_rn=38641-94-0&search=ROUNDUP	organophosphate	0.065	mg/L	96	hours	none	none	26	celsius	aggression	aggression	time spent close to stimulus	time spent in aggression zone	zone	NA	fig6a	bridi_2017_fig6a	NA	NA	NA	26	122.2071971	28.8770683	NA	NA	5.663259022	study reports mean and se	exact sample size provided	NA	NA	NA	26	86.3346793	37.5007722	NA	NA	7.354506518	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Glyphosate and Roundup<ae><a0>alter morphology and behavior in zebrafish	10.1016/j.tox.2017.10.007	https://www.sciencedirect.com/science/article/pii/S0300483X17303128?via%3Dihub	Toxicology	bridi_2017	bridi_2017_exp_006	bridi_2017_exp2_006	bridi_2017_exp_006_assay_001	bridi_2017_exp2_006_assay2_001	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	roundup	commercial	38641-94-0	https://commonchemistry.cas.org/detail?cas_rn=38641-94-0&search=ROUNDUP	organophosphate	0.5	mg/L	96	hours	none	none	26	celsius	aggression	aggression	time spent close to stimulus	time spent in aggression zone	zone	NA	fig6a	bridi_2017_fig6a	NA	NA	NA	26	122.2071971	28.8770683	NA	NA	5.663259022	study reports mean and se	exact sample size provided	NA	NA	NA	26	94.6484693	16.3046836	NA	NA	3.19761153	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Glyphosate and Roundup<ae><a0>alter morphology and behavior in zebrafish	10.1016/j.tox.2017.10.007	https://www.sciencedirect.com/science/article/pii/S0300483X17303128?via%3Dihub	Toxicology	bridi_2017	bridi_2017_exp_001	bridi_2017_exp2_001	bridi_2017_exp_001_assay_002	bridi_2017_exp2_001_assay2_002	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	glyphosate	not reported	1071-83-6	https://commonchemistry.cas.org/detail?cas_rn=1071-83-6&search=GLYPHOSATE	organophosphate	0.01	mg/L	96	hours	none	none	26	celsius	aggression	aggression	number of enteries	frequency of entries into aggression zone	entry	NA	fig6b	bridi_2017_fig6b	NA	NA	NA	26	39.4858436	18.8042738	NA	NA	3.687821494	study reports mean and se	exact sample size provided	NA	NA	NA	26	27.7557133	10.6687460	NA	NA	2.092313231	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Glyphosate and Roundup<ae><a0>alter morphology and behavior in zebrafish	10.1016/j.tox.2017.10.007	https://www.sciencedirect.com/science/article/pii/S0300483X17303128?via%3Dihub	Toxicology	bridi_2017	bridi_2017_exp_002	bridi_2017_exp2_002	bridi_2017_exp_002_assay_002	bridi_2017_exp2_002_assay2_002	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	glyphosate	not reported	1071-83-6	https://commonchemistry.cas.org/detail?cas_rn=1071-83-6&search=GLYPHOSATE	organophosphate	0.065	mg/L	96	hours	none	none	26	celsius	aggression	aggression	number of enteries	frequency of entries into aggression zone	entry	NA	fig6b	bridi_2017_fig6b	NA	NA	NA	26	39.4858436	18.8042738	NA	NA	3.687821494	study reports mean and se	exact sample size provided	NA	NA	NA	26	24.8235417	12.7349286	NA	NA	2.497524975	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Glyphosate and Roundup<ae><a0>alter morphology and behavior in zebrafish	10.1016/j.tox.2017.10.007	https://www.sciencedirect.com/science/article/pii/S0300483X17303128?via%3Dihub	Toxicology	bridi_2017	bridi_2017_exp_003	bridi_2017_exp2_003	bridi_2017_exp_003_assay_002	bridi_2017_exp2_003_assay2_002	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	glyphosate	not reported	1071-83-6	https://commonchemistry.cas.org/detail?cas_rn=1071-83-6&search=GLYPHOSATE	organophosphate	0.5	mg/L	96	hours	none	none	26	celsius	aggression	aggression	number of enteries	frequency of entries into aggression zone	entry	NA	fig6b	bridi_2017_fig6b	NA	NA	NA	26	39.4858436	18.8042738	NA	NA	3.687821494	study reports mean and se	exact sample size provided	NA	NA	NA	26	21.9990956	6.1678357	NA	NA	1.209612096	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Glyphosate and Roundup<ae><a0>alter morphology and behavior in zebrafish	10.1016/j.tox.2017.10.007	https://www.sciencedirect.com/science/article/pii/S0300483X17303128?via%3Dihub	Toxicology	bridi_2017	bridi_2017_exp_004	bridi_2017_exp2_004	bridi_2017_exp_004_assay_002	bridi_2017_exp2_004_assay2_002	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	roundup	commercial	38641-94-0	https://commonchemistry.cas.org/detail?cas_rn=38641-94-0&search=ROUNDUP	organophosphate	0.01	mg/L	96	hours	none	none	26	celsius	aggression	aggression	number of enteries	frequency of entries into aggression zone	entry	NA	fig6b	bridi_2017_fig6b	NA	NA	NA	26	39.4858436	18.8042738	NA	NA	3.687821494	study reports mean and se	exact sample size provided	NA	NA	NA	26	24.8335687	9.4773286	NA	NA	1.858657048	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Glyphosate and Roundup<ae><a0>alter morphology and behavior in zebrafish	10.1016/j.tox.2017.10.007	https://www.sciencedirect.com/science/article/pii/S0300483X17303128?via%3Dihub	Toxicology	bridi_2017	bridi_2017_exp_005	bridi_2017_exp2_005	bridi_2017_exp_005_assay_002	bridi_2017_exp2_005_assay2_002	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	roundup	commercial	38641-94-0	https://commonchemistry.cas.org/detail?cas_rn=38641-94-0&search=ROUNDUP	organophosphate	0.065	mg/L	96	hours	none	none	26	celsius	aggression	aggression	number of enteries	frequency of entries into aggression zone	entry	NA	fig6b	bridi_2017_fig6b	NA	NA	NA	26	39.4858436	18.8042738	NA	NA	3.687821494	study reports mean and se	exact sample size provided	NA	NA	NA	26	23.4381956	6.6910003	NA	NA	1.312213122	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Glyphosate and Roundup<ae><a0>alter morphology and behavior in zebrafish	10.1016/j.tox.2017.10.007	https://www.sciencedirect.com/science/article/pii/S0300483X17303128?via%3Dihub	Toxicology	bridi_2017	bridi_2017_exp_006	bridi_2017_exp2_006	bridi_2017_exp_006_assay_002	bridi_2017_exp2_006_assay2_002	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	roundup	commercial	38641-94-0	https://commonchemistry.cas.org/detail?cas_rn=38641-94-0&search=ROUNDUP	organophosphate	0.5	mg/L	96	hours	none	none	26	celsius	aggression	aggression	number of enteries	frequency of entries into aggression zone	entry	NA	fig6b	bridi_2017_fig6b	NA	NA	NA	26	39.4858436	18.8042738	NA	NA	3.687821494	study reports mean and se	exact sample size provided	NA	NA	NA	26	24.7084876	5.8935449	NA	NA	1.155819251	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Exposure to difenoconazole induces reproductive toxicity in zebrafish by interfering with gamete maturation and reproductive behavior	10.1016/j.scitotenv.2022.155610	https://www.sciencedirect.com/science/article/pii/S0048969722027061?via%3Dihub	Science of The Total Environment	chen_2022	chen_2022_exp_001	chen_2022_exp2_001	chen_2022_exp_001_assay_001	chen_2022_exp2_001_assay2_001	zebrafish	Danio rerio	not reported	NA	mixed	difenoconazole	analytical	119446-68-3	in paper	dioxolanes	0.1	ug/L	120	days	acetone	solvent_used	not reported	not reported	reproductive behaviour	courtship	contact time	time spent near potential mate	NA	NA	fig4a	chen_2022_fig4a	NA	NA	NA	8	180.9746781	23.4351145	NA	NA	8.285564192	study reports mean and sd	states four male and four female per tank (section 2.6. Analysis of reproductive behaviour)	NA	NA	NA	8	126.7255128	19.8473282	NA	NA	7.017090195	study reports mean and sd	states four male and four female per tank (section 2.6. Analysis of reproductive behaviour)	NA	NA	NA	NA
NA	NA	NA	KM	Exposure to difenoconazole induces reproductive toxicity in zebrafish by interfering with gamete maturation and reproductive behavior	10.1016/j.scitotenv.2022.155610	https://www.sciencedirect.com/science/article/pii/S0048969722027061?via%3Dihub	Science of The Total Environment	chen_2022	chen_2022_exp_002	chen_2022_exp2_002	chen_2022_exp_002_assay_001	chen_2022_exp2_002_assay2_001	zebrafish	Danio rerio	not reported	NA	mixed	difenoconazole	analytical	119446-68-3	in paper	dioxolanes	1	ug/L	120	days	acetone	solvent_used	not reported	not reported	reproductive behaviour	courtship	contact time	time spent near potential mate	NA	NA	fig4a	chen_2022_fig4a	NA	NA	NA	8	180.9746781	23.4351145	NA	NA	8.285564192	study reports mean and sd	states four male and four female per tank (section 2.6. Analysis of reproductive behaviour)	NA	NA	NA	8	189.5675534	61.7124682	NA	NA	21.81865237	study reports mean and sd	states four male and four female per tank (section 2.6. Analysis of reproductive behaviour)	NA	NA	NA	NA
NA	NA	NA	KM	Exposure to difenoconazole induces reproductive toxicity in zebrafish by interfering with gamete maturation and reproductive behavior	10.1016/j.scitotenv.2022.155610	https://www.sciencedirect.com/science/article/pii/S0048969722027061?via%3Dihub	Science of The Total Environment	chen_2022	chen_2022_exp_003	chen_2022_exp2_003	chen_2022_exp_003_assay_001	chen_2022_exp2_003_assay2_001	zebrafish	Danio rerio	not reported	NA	mixed	difenoconazole	analytical	119446-68-3	in paper	dioxolanes	10	ug/L	120	days	acetone	solvent_used	not reported	not reported	reproductive behaviour	courtship	contact time	time spent near potential mate	NA	NA	fig4a	chen_2022_fig4a	NA	NA	NA	8	180.9746781	23.4351145	NA	NA	8.285564192	study reports mean and sd	states four male and four female per tank (section 2.6. Analysis of reproductive behaviour)	NA	NA	NA	8	68.4861285	27.3409669	NA	NA	9.666491557	study reports mean and sd	states four male and four female per tank (section 2.6. Analysis of reproductive behaviour)	NA	NA	NA	NA
NA	NA	NA	KM	Exposure to difenoconazole induces reproductive toxicity in zebrafish by interfering with gamete maturation and reproductive behavior	10.1016/j.scitotenv.2022.155610	https://www.sciencedirect.com/science/article/pii/S0048969722027061?via%3Dihub	Science of The Total Environment	chen_2022	chen_2022_exp_001	chen_2022_exp2_001	chen_2022_exp_001_assay_002	chen_2022_exp2_001_assay2_002	zebrafish	Danio rerio	not reported	NA	mixed	difenoconazole	analytical	119446-68-3	in paper	dioxolanes	0.1	ug/L	120	days	acetone	solvent_used	not reported	not reported	reproductive behaviour	courtship	contact time	time spent near potential mate	NA	NA	fig4b	chen_2022_fig4b	NA	NA	NA	8	199.3015298	29.6565579	NA	NA	10.4851766	study reports mean and sd	states four male and four female per tank (section 2.6. Analysis of reproductive behaviour)	NA	NA	NA	8	195.5944600	41.4517798	NA	NA	14.6554173	study reports mean and sd	states four male and four female per tank (section 2.6. Analysis of reproductive behaviour)	NA	NA	NA	NA
NA	NA	NA	KM	Exposure to difenoconazole induces reproductive toxicity in zebrafish by interfering with gamete maturation and reproductive behavior	10.1016/j.scitotenv.2022.155610	https://www.sciencedirect.com/science/article/pii/S0048969722027061?via%3Dihub	Science of The Total Environment	chen_2022	chen_2022_exp_002	chen_2022_exp2_002	chen_2022_exp_002_assay_002	chen_2022_exp2_002_assay2_002	zebrafish	Danio rerio	not reported	NA	mixed	difenoconazole	analytical	119446-68-3	in paper	dioxolanes	1	ug/L	120	days	acetone	solvent_used	not reported	not reported	reproductive behaviour	courtship	contact time	time spent near potential mate	NA	NA	fig4b	chen_2022_fig4b	NA	NA	NA	8	199.3015298	29.6565579	NA	NA	10.4851766	study reports mean and sd	states four male and four female per tank (section 2.6. Analysis of reproductive behaviour)	NA	NA	NA	8	194.2464347	23.2534374	NA	NA	8.221331654	study reports mean and sd	states four male and four female per tank (section 2.6. Analysis of reproductive behaviour)	NA	NA	NA	NA
NA	NA	NA	KM	Exposure to difenoconazole induces reproductive toxicity in zebrafish by interfering with gamete maturation and reproductive behavior	10.1016/j.scitotenv.2022.155610	https://www.sciencedirect.com/science/article/pii/S0048969722027061?via%3Dihub	Science of The Total Environment	chen_2022	chen_2022_exp_003	chen_2022_exp2_003	chen_2022_exp_003_assay_002	chen_2022_exp2_003_assay2_002	zebrafish	Danio rerio	not reported	NA	mixed	difenoconazole	analytical	119446-68-3	in paper	dioxolanes	10	ug/L	120	days	acetone	solvent_used	not reported	not reported	reproductive behaviour	courtship	contact time	time spent near potential mate	NA	NA	fig4b	chen_2022_fig4b	NA	NA	NA	8	199.3015298	29.6565579	NA	NA	10.4851766	study reports mean and sd	states four male and four female per tank (section 2.6. Analysis of reproductive behaviour)	NA	NA	NA	8	222.5549672	34.3746467	NA	NA	12.15327288	study reports mean and sd	states four male and four female per tank (section 2.6. Analysis of reproductive behaviour)	NA	NA	NA	NA
NA	NA	NA	KM	Exposure to difenoconazole induces reproductive toxicity in zebrafish by interfering with gamete maturation and reproductive behavior	10.1016/j.scitotenv.2022.155610	https://www.sciencedirect.com/science/article/pii/S0048969722027061?via%3Dihub	Science of The Total Environment	chen_2022	chen_2022_exp_001	chen_2022_exp2_001	chen_2022_exp_001_assay_003	chen_2022_exp2_001_assay2_003	zebrafish	Danio rerio	not reported	NA	mixed	difenoconazole	analytical	119446-68-3	in paper	dioxolanes	0.1	ug/L	120	days	acetone	solvent_used	not reported	not reported	reproductive behaviour	courtship	contact time	time spent near potential mate	NA	NA	fig4c	chen_2022_fig4c	NA	NA	NA	8	145.9508599	5.3249169	NA	NA	1.882642423	study reports mean and sd	states four male and four female per tank (section 2.6. Analysis of reproductive behaviour)	NA	NA	NA	8	122.1935383	25.8053665	NA	NA	9.123574818	study reports mean and sd	states four male and four female per tank (section 2.6. Analysis of reproductive behaviour)	NA	NA	NA	NA
NA	NA	NA	KM	Exposure to difenoconazole induces reproductive toxicity in zebrafish by interfering with gamete maturation and reproductive behavior	10.1016/j.scitotenv.2022.155610	https://www.sciencedirect.com/science/article/pii/S0048969722027061?via%3Dihub	Science of The Total Environment	chen_2022	chen_2022_exp_002	chen_2022_exp2_002	chen_2022_exp_002_assay_003	chen_2022_exp2_002_assay2_003	zebrafish	Danio rerio	not reported	NA	mixed	difenoconazole	analytical	119446-68-3	in paper	dioxolanes	1	ug/L	120	days	acetone	solvent_used	not reported	not reported	reproductive behaviour	courtship	contact time	time spent near potential mate	NA	NA	fig4c	chen_2022_fig4c	NA	NA	NA	8	145.9508599	5.3249169	NA	NA	1.882642423	study reports mean and sd	states four male and four female per tank (section 2.6. Analysis of reproductive behaviour)	NA	NA	NA	8	137.5538755	11.6738563	NA	NA	4.127331465	study reports mean and sd	states four male and four female per tank (section 2.6. Analysis of reproductive behaviour)	NA	NA	NA	NA
NA	NA	NA	KM	Exposure to difenoconazole induces reproductive toxicity in zebrafish by interfering with gamete maturation and reproductive behavior	10.1016/j.scitotenv.2022.155610	https://www.sciencedirect.com/science/article/pii/S0048969722027061?via%3Dihub	Science of The Total Environment	chen_2022	chen_2022_exp_003	chen_2022_exp2_003	chen_2022_exp_003_assay_003	chen_2022_exp2_003_assay2_003	zebrafish	Danio rerio	not reported	NA	mixed	difenoconazole	analytical	119446-68-3	in paper	dioxolanes	10	ug/L	120	days	acetone	solvent_used	not reported	not reported	reproductive behaviour	courtship	contact time	time spent near potential mate	NA	NA	fig4c	chen_2022_fig4c	NA	NA	NA	8	145.9508599	5.3249169	NA	NA	1.882642423	study reports mean and sd	states four male and four female per tank (section 2.6. Analysis of reproductive behaviour)	NA	NA	NA	8	108.0620281	4.7105034	NA	NA	1.665414451	study reports mean and sd	states four male and four female per tank (section 2.6. Analysis of reproductive behaviour)	NA	NA	NA	NA
NA	NA	NA	KM	Neonicotinoid Imidacloprid Affects the Social Behavior of Adult Zebrafish by Damaging Telencephalon Neurons through Oxidation Stress, Inflammation, and Apoptosis	10.3390/life13061418<a0>	https://www.mdpi.com/2075-1729/13/6/1418#:~:text=Our%20behavioral%20and%20histological%20experiments,zebrafish%20through%20oxidative%20stress%2C%20inflammation	Life	chung_2023	chung_2023_exp_001	chung_2023_exp2_001	chung_2023_exp_001_assay_001	chung_2023_exp2_001_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	imidacloprid	analytical	138261-41-3	in paper	neonicotinoid	0.1	ppm	5	days	none	none	25	celsius	heterosexual attraction	courtship	distance between male and female	distance between potential mates	NA	change	fig5c	chung_2023_fig5c	NA	NA	NA	10	4.4371410	1.8613055	NA	NA	0.588596491	study reports mean and se	exact sample size provided	NA	NA	NA	10	10.2614352	4.7267729	NA	NA	1.494736842	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Neonicotinoid Imidacloprid Affects the Social Behavior of Adult Zebrafish by Damaging Telencephalon Neurons through Oxidation Stress, Inflammation, and Apoptosis	10.3390/life13061418<a0>	https://www.mdpi.com/2075-1729/13/6/1418#:~:text=Our%20behavioral%20and%20histological%20experiments,zebrafish%20through%20oxidative%20stress%2C%20inflammation	Life	chung_2023	chung_2023_exp_002	chung_2023_exp2_002	chung_2023_exp_002_assay_001	chung_2023_exp2_002_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	imidacloprid	analytical	138261-41-3	in paper	neonicotinoid	0.5	ppm	5	days	none	none	25	celsius	heterosexual attraction	courtship	distance between male and female	distance between potential mates	NA	change	fig5c	chung_2023_fig5c	NA	NA	NA	10	4.4371410	1.8613055	NA	NA	0.588596491	study reports mean and se	exact sample size provided	NA	NA	NA	10	11.4526297	4.9691449	NA	NA	1.571381579	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Neonicotinoid Imidacloprid Affects the Social Behavior of Adult Zebrafish by Damaging Telencephalon Neurons through Oxidation Stress, Inflammation, and Apoptosis	10.3390/life13061418<a0>	https://www.mdpi.com/2075-1729/13/6/1418#:~:text=Our%20behavioral%20and%20histological%20experiments,zebrafish%20through%20oxidative%20stress%2C%20inflammation	Life	chung_2023	chung_2023_exp_003	chung_2023_exp2_003	chung_2023_exp_003_assay_001	chung_2023_exp2_003_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	imidacloprid	analytical	138261-41-3	in paper	neonicotinoid	1	ppm	5	days	none	none	25	celsius	heterosexual attraction	courtship	distance between male and female	distance between potential mates	NA	change	fig5c	chung_2023_fig5c	NA	NA	NA	10	4.4371410	1.8613055	NA	NA	0.588596491	study reports mean and se	exact sample size provided	NA	NA	NA	10	14.6312253	4.9212946	NA	NA	1.55625	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Neonicotinoid Imidacloprid Affects the Social Behavior of Adult Zebrafish by Damaging Telencephalon Neurons through Oxidation Stress, Inflammation, and Apoptosis	10.3390/life13061418<a0>	https://www.mdpi.com/2075-1729/13/6/1418#:~:text=Our%20behavioral%20and%20histological%20experiments,zebrafish%20through%20oxidative%20stress%2C%20inflammation	Life	chung_2023	chung_2023_exp_001	chung_2023_exp2_004	chung_2023_exp_001_assay_002	chung_2023_exp2_004_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	male	imidacloprid	analytical	138261-41-3	in paper	neonicotinoid	0.1	ppm	5	days	none	none	25	celsius	defensive alert behaviour	aggression	male confrontation distance	confrontation distance	NA	change	fig6c	chung_2023_fig6c	NA	NA	NA	10	16.5992051	4.9695724	NA	NA	1.571516773	study reports mean and se	exact sample size provided	NA	NA	NA	10	13.4650111	4.9152299	NA	NA	1.554332167	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Neonicotinoid Imidacloprid Affects the Social Behavior of Adult Zebrafish by Damaging Telencephalon Neurons through Oxidation Stress, Inflammation, and Apoptosis	10.3390/life13061418<a0>	https://www.mdpi.com/2075-1729/13/6/1418#:~:text=Our%20behavioral%20and%20histological%20experiments,zebrafish%20through%20oxidative%20stress%2C%20inflammation	Life	chung_2023	chung_2023_exp_002	chung_2023_exp2_005	chung_2023_exp_002_assay_002	chung_2023_exp2_005_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	male	imidacloprid	analytical	138261-41-3	in paper	neonicotinoid	0.5	ppm	5	days	none	none	25	celsius	defensive alert behaviour	aggression	male confrontation distance	confrontation distance	NA	change	fig6c	chung_2023_fig6c	NA	NA	NA	10	16.5992051	4.9695724	NA	NA	1.571516773	study reports mean and se	exact sample size provided	NA	NA	NA	10	12.3161622	4.6034927	NA	NA	1.455752212	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Neonicotinoid Imidacloprid Affects the Social Behavior of Adult Zebrafish by Damaging Telencephalon Neurons through Oxidation Stress, Inflammation, and Apoptosis	10.3390/life13061418<a0>	https://www.mdpi.com/2075-1729/13/6/1418#:~:text=Our%20behavioral%20and%20histological%20experiments,zebrafish%20through%20oxidative%20stress%2C%20inflammation	Life	chung_2023	chung_2023_exp_003	chung_2023_exp2_006	chung_2023_exp_003_assay_002	chung_2023_exp2_006_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	male	imidacloprid	analytical	138261-41-3	in paper	neonicotinoid	1	ppm	5	days	none	none	25	celsius	defensive alert behaviour	aggression	male confrontation distance	confrontation distance	NA	change	fig6c	chung_2023_fig6c	NA	NA	NA	10	16.5992051	4.9695724	NA	NA	1.571516773	study reports mean and se	exact sample size provided	NA	NA	NA	10	12.3789323	4.8273708	NA	NA	1.526548673	study reports mean and se	exact sample size provided	NA	NA	NA	NA
used species median of shoal	NA	NA	KM	Glyphosate targets fish monoaminergic systems leading to oxidative stress and anxiety	10.1016/j.envint.2020.106253	https://www.sciencedirect.com/science/article/pii/S0278584618306961?via%3Dihub	Progress in Neuro-Psychopharmacology and Biological Psychiatry	faria_2021	faria_2021_exp_001	faria_2021_exp2_001	faria_2021_exp_001_assay_001	faria_2021_exp_001_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	glyphosate	analytical	1071-83-6	in paper	organophosphate	0.3	ug/L	2	weeks	not reported	NA	28	celsius	shoaling	collective behaviour	average interfish distance	group arrangment	NA	change	fig1ca	faria_2021_fig1ca	9.500000	6.333333	19	19	6.3473684	1.9851920	1.1461511	1.9851920	0.455434271	calculated from scatter plot	counted from the scatter plot	10.500000	7.000000	21	21	4.5980952	1.7724774	1.0233403	1.7724774	0.386786282	calculated from scatter plot	counted from the scatter plot	NA	NA	NA	NA
used species median of shoal	NA	NA	KM	Glyphosate targets fish monoaminergic systems leading to oxidative stress and anxiety	10.1016/j.envint.2020.106253	https://www.sciencedirect.com/science/article/pii/S0278584618306961?via%3Dihub	Progress in Neuro-Psychopharmacology and Biological Psychiatry	faria_2021	faria_2021_exp_002	faria_2021_exp2_002	faria_2021_exp_002_assay_001	faria_2021_exp_002_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	glyphosate	analytical	1071-83-6	in paper	organophosphate	3	ug/L	2	weeks	not reported	NA	28	celsius	shoaling	collective behaviour	average interfish distance	group arrangment	NA	change	fig1ca	faria_2021_fig1ca	9.500000	6.333333	19	19	6.3473684	1.9851920	1.1461511	1.9851920	0.455434271	calculated from scatter plot	counted from the scatter plot	9.500000	6.333333	19	19	4.1852632	1.1541007	0.6663204	1.1541007	0.26476887	calculated from scatter plot	counted from the scatter plot	NA	NA	NA	NA
used species median of shoal	NA	NA	KM	Glyphosate targets fish monoaminergic systems leading to oxidative stress and anxiety	10.1016/j.envint.2020.106253	https://www.sciencedirect.com/science/article/pii/S0278584618306961?via%3Dihub	Progress in Neuro-Psychopharmacology and Biological Psychiatry	faria_2021	faria_2021_exp_001	faria_2021_exp2_001	faria_2021_exp_001_assay_002	faria_2021_exp_001_assay2_002	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	glyphosate	analytical	1071-83-6	in paper	organophosphate	0.3	ug/L	2	weeks	not reported	NA	28	celsius	shoaling	collective behaviour	farthest distance	group arrangment	NA	change	fig1cb	faria_2021_fig1cb	10.000000	6.666667	20	20	8.9156627	3.0988088	1.7890981	3.0988088	0.69291471	calculated from scatter plot	counted from the scatter plot	10.000000	6.666667	20	20	7.5108434	2.4946464	1.4402848	2.4946464	0.557819889	calculated from scatter plot	counted from the scatter plot	NA	NA	NA	NA
used species median of shoal	NA	NA	KM	Glyphosate targets fish monoaminergic systems leading to oxidative stress and anxiety	10.1016/j.envint.2020.106253	https://www.sciencedirect.com/science/article/pii/S0278584618306961?via%3Dihub	Progress in Neuro-Psychopharmacology and Biological Psychiatry	faria_2021	faria_2021_exp_002	faria_2021_exp2_002	faria_2021_exp_002_assay_002	faria_2021_exp_002_assay2_002	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	glyphosate	analytical	1071-83-6	in paper	organophosphate	3	ug/L	2	weeks	not reported	NA	28	celsius	shoaling	collective behaviour	farthest distance	group arrangment	NA	change	fig1cb	faria_2021_fig1cb	10.000000	6.666667	20	20	8.9156627	3.0988088	1.7890981	3.0988088	0.69291471	calculated from scatter plot	counted from the scatter plot	9.500000	6.333333	19	19	6.3817375	1.7880691	1.0323422	1.7880691	0.410211192	calculated from scatter plot	counted from the scatter plot	NA	NA	NA	NA
NA	NA	SN	KM	The kisspeptin-GnIH signaling pathway in the role of zebrafish courtship and aggressive behavior induced by azoxystrobin	10.1016/j.envpol.2023.121461	https://www.sciencedirect.com/science/article/pii/S0269749123004633?via%3Dihub	Environmental Pollution	guo_2023	guo_2023_exp_001	guo_2023_exp2_001	guo_2023_exp_001_assay_001	guo_2023_exp2_001_assay2_001	zebrafish	Danio rerio	commercial supplier	not_wild	male	azoxystrobin	analytical	131860-33-8	in paper	B-methoxyacrylates	0.2	ug/L	42	days	DMSO	solvent_used	27	celsius	courting	courtship	distance in region of attraction	distance in attraction zone	NA	NA	fig1a	guo_2023_fig1a	NA	NA	NA	18	1373.4542280	409.2070780	NA	NA	96.45103324	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	18	1270.4882060	381.0371636	NA	NA	89.81132075	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	NA
NA	NA	SN	KM	The kisspeptin-GnIH signaling pathway in the role of zebrafish courtship and aggressive behavior induced by azoxystrobin	10.1016/j.envpol.2023.121461	https://www.sciencedirect.com/science/article/pii/S0269749123004633?via%3Dihub	Environmental Pollution	guo_2023	guo_2023_exp_002	guo_2023_exp2_002	guo_2023_exp_002_assay_001	guo_2023_exp2_002_assay2_001	zebrafish	Danio rerio	commercial supplier	not_wild	male	azoxystrobin	analytical	131860-33-8	in paper	B-methoxyacrylates	20	ug/L	42	days	DMSO	solvent_used	27	celsius	courting	courtship	distance in region of attraction	distance in attraction zone	NA	NA	fig1a	guo_2023_fig1a	NA	NA	NA	18	1373.4542280	409.2070780	NA	NA	96.45103324	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	18	1158.6011610	290.3140294	NA	NA	68.42767296	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	NA
NA	NA	SN	KM	The kisspeptin-GnIH signaling pathway in the role of zebrafish courtship and aggressive behavior induced by azoxystrobin	10.1016/j.envpol.2023.121461	https://www.sciencedirect.com/science/article/pii/S0269749123004633?via%3Dihub	Environmental Pollution	guo_2023	guo_2023_exp_003	guo_2023_exp2_003	guo_2023_exp_003_assay_001	guo_2023_exp2_003_assay2_001	zebrafish	Danio rerio	commercial supplier	not_wild	male	azoxystrobin	analytical	131860-33-8	in paper	B-methoxyacrylates	200	ug/L	42	days	DMSO	solvent_used	27	celsius	courting	courtship	distance in region of attraction	distance in attraction zone	NA	NA	fig1a	guo_2023_fig1a	NA	NA	NA	18	1373.4542280	409.2070780	NA	NA	96.45103324	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	18	949.9591025	206.1473570	NA	NA	48.58939802	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	NA
NA	NA	SN	KM	The kisspeptin-GnIH signaling pathway in the role of zebrafish courtship and aggressive behavior induced by azoxystrobin	10.1016/j.envpol.2023.121461	https://www.sciencedirect.com/science/article/pii/S0269749123004633?via%3Dihub	Environmental Pollution	guo_2023	guo_2023_exp_001	guo_2023_exp2_001	guo_2023_exp_001_assay_002	guo_2023_exp2_001_assay2_002	zebrafish	Danio rerio	commercial supplier	not_wild	male	azoxystrobin	analytical	131860-33-8	in paper	B-methoxyacrylates	0.2	ug/L	42	days	DMSO	solvent_used	27	celsius	courting	courtship	frequency in region of attraction	frequency of entries into attraction zone	entry	NA	fig1b	guo_2023_fig1b	NA	NA	NA	18	309.5539912	45.7650012	NA	NA	10.78691424	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	18	297.0195325	55.0080310	NA	NA	12.96551724	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	NA
NA	NA	SN	KM	The kisspeptin-GnIH signaling pathway in the role of zebrafish courtship and aggressive behavior induced by azoxystrobin	10.1016/j.envpol.2023.121461	https://www.sciencedirect.com/science/article/pii/S0269749123004633?via%3Dihub	Environmental Pollution	guo_2023	guo_2023_exp_002	guo_2023_exp2_002	guo_2023_exp_002_assay_002	guo_2023_exp2_002_assay2_002	zebrafish	Danio rerio	commercial supplier	not_wild	male	azoxystrobin	analytical	131860-33-8	in paper	B-methoxyacrylates	20	ug/L	42	days	DMSO	solvent_used	27	celsius	courting	courtship	frequency in region of attraction	frequency of entries into attraction zone	entry	NA	fig1b	guo_2023_fig1b	NA	NA	NA	18	309.5539912	45.7650012	NA	NA	10.78691424	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	18	261.8035239	61.7302344	NA	NA	14.54995579	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	NA
NA	NA	SN	KM	The kisspeptin-GnIH signaling pathway in the role of zebrafish courtship and aggressive behavior induced by azoxystrobin	10.1016/j.envpol.2023.121461	https://www.sciencedirect.com/science/article/pii/S0269749123004633?via%3Dihub	Environmental Pollution	guo_2023	guo_2023_exp_003	guo_2023_exp2_003	guo_2023_exp_003_assay_002	guo_2023_exp2_003_assay2_002	zebrafish	Danio rerio	commercial supplier	not_wild	male	azoxystrobin	analytical	131860-33-8	in paper	B-methoxyacrylates	200	ug/L	42	days	DMSO	solvent_used	27	celsius	courting	courtship	frequency in region of attraction	frequency of entries into attraction zone	entry	NA	fig1b	guo_2023_fig1b	NA	NA	NA	18	309.5539912	45.7650012	NA	NA	10.78691424	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	18	229.1189647	28.2242516	NA	NA	6.652519894	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	NA
NA	NA	SN	KM	The kisspeptin-GnIH signaling pathway in the role of zebrafish courtship and aggressive behavior induced by azoxystrobin	10.1016/j.envpol.2023.121461	https://www.sciencedirect.com/science/article/pii/S0269749123004633?via%3Dihub	Environmental Pollution	guo_2023	guo_2023_exp_001	guo_2023_exp2_004	guo_2023_exp_001_assay_003	guo_2023_exp2_004_assay2_001	zebrafish	Danio rerio	commercial supplier	not_wild	female	azoxystrobin	analytical	131860-33-8	in paper	B-methoxyacrylates	0.2	ug/L	42	days	DMSO	solvent_used	27	celsius	courting	courtship	distance in region of attraction	distance in attraction zone	NA	NA	fig1c	guo_2023_fig1c	NA	NA	NA	18	1884.3730430	237.0771902	NA	NA	55.87962963	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	18	1847.5386150	344.1253002	NA	NA	81.11111111	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	NA
NA	NA	SN	KM	The kisspeptin-GnIH signaling pathway in the role of zebrafish courtship and aggressive behavior induced by azoxystrobin	10.1016/j.envpol.2023.121461	https://www.sciencedirect.com/science/article/pii/S0269749123004633?via%3Dihub	Environmental Pollution	guo_2023	guo_2023_exp_002	guo_2023_exp2_005	guo_2023_exp_002_assay_003	guo_2023_exp2_005_assay2_001	zebrafish	Danio rerio	commercial supplier	not_wild	female	azoxystrobin	analytical	131860-33-8	in paper	B-methoxyacrylates	20	ug/L	42	days	DMSO	solvent_used	27	celsius	courting	courtship	distance in region of attraction	distance in attraction zone	NA	NA	fig1c	guo_2023_fig1c	NA	NA	NA	18	1884.3730430	237.0771902	NA	NA	55.87962963	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	18	1630.6968560	267.0180022	NA	NA	62.93674669	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	NA
NA	NA	SN	KM	The kisspeptin-GnIH signaling pathway in the role of zebrafish courtship and aggressive behavior induced by azoxystrobin	10.1016/j.envpol.2023.121461	https://www.sciencedirect.com/science/article/pii/S0269749123004633?via%3Dihub	Environmental Pollution	guo_2023	guo_2023_exp_003	guo_2023_exp2_006	guo_2023_exp_003_assay_003	guo_2023_exp2_006_assay2_001	zebrafish	Danio rerio	commercial supplier	not_wild	female	azoxystrobin	analytical	131860-33-8	in paper	B-methoxyacrylates	200	ug/L	42	days	DMSO	solvent_used	27	celsius	courting	courtship	distance in region of attraction	distance in attraction zone	NA	NA	fig1c	guo_2023_fig1c	NA	NA	NA	18	1884.3730430	237.0771902	NA	NA	55.87962963	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	18	1551.1200200	246.3088621	NA	NA	58.05555556	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	NA
NA	NA	SN	KM	The kisspeptin-GnIH signaling pathway in the role of zebrafish courtship and aggressive behavior induced by azoxystrobin	10.1016/j.envpol.2023.121461	https://www.sciencedirect.com/science/article/pii/S0269749123004633?via%3Dihub	Environmental Pollution	guo_2023	guo_2023_exp_001	guo_2023_exp2_004	guo_2023_exp_001_assay_004	guo_2023_exp2_004_assay2_002	zebrafish	Danio rerio	commercial supplier	not_wild	female	azoxystrobin	analytical	131860-33-8	in paper	B-methoxyacrylates	0.2	ug/L	42	days	DMSO	solvent_used	27	celsius	courting	courtship	frequency in region of attraction	frequency of entries into attraction zone	NA	NA	fig1d	guo_2023_fig1d	NA	NA	NA	18	409.4204690	94.9970023	NA	NA	22.39100817	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	18	350.5993116	108.2921041	NA	NA	25.52469371	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	NA
NA	NA	SN	KM	The kisspeptin-GnIH signaling pathway in the role of zebrafish courtship and aggressive behavior induced by azoxystrobin	10.1016/j.envpol.2023.121461	https://www.sciencedirect.com/science/article/pii/S0269749123004633?via%3Dihub	Environmental Pollution	guo_2023	guo_2023_exp_002	guo_2023_exp2_005	guo_2023_exp_002_assay_004	guo_2023_exp2_005_assay2_002	zebrafish	Danio rerio	commercial supplier	not_wild	female	azoxystrobin	analytical	131860-33-8	in paper	B-methoxyacrylates	20	ug/L	42	days	DMSO	solvent_used	27	celsius	courting	courtship	frequency in region of attraction	frequency of entries into attraction zone	NA	NA	fig1d	guo_2023_fig1d	NA	NA	NA	18	409.4204690	94.9970023	NA	NA	22.39100817	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	18	318.4471427	45.7307342	NA	NA	10.77883742	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	NA
NA	NA	SN	KM	The kisspeptin-GnIH signaling pathway in the role of zebrafish courtship and aggressive behavior induced by azoxystrobin	10.1016/j.envpol.2023.121461	https://www.sciencedirect.com/science/article/pii/S0269749123004633?via%3Dihub	Environmental Pollution	guo_2023	guo_2023_exp_003	guo_2023_exp2_006	guo_2023_exp_003_assay_004	guo_2023_exp2_006_assay2_002	zebrafish	Danio rerio	commercial supplier	not_wild	female	azoxystrobin	analytical	131860-33-8	in paper	B-methoxyacrylates	200	ug/L	42	days	DMSO	solvent_used	27	celsius	courting	courtship	frequency in region of attraction	frequency of entries into attraction zone	NA	NA	fig1d	guo_2023_fig1d	NA	NA	NA	18	409.4204690	94.9970023	NA	NA	22.39100817	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	18	247.1051863	37.7633368	NA	NA	8.900903843	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	NA
NA	NA	SN	KM	The kisspeptin-GnIH signaling pathway in the role of zebrafish courtship and aggressive behavior induced by azoxystrobin	10.1016/j.envpol.2023.121461	https://www.sciencedirect.com/science/article/pii/S0269749123004633?via%3Dihub	Environmental Pollution	guo_2023	guo_2023_exp_001	guo_2023_exp2_007	guo_2023_exp_001_assay_005	guo_2023_exp2_007_assay2_001	zebrafish	Danio rerio	commercial supplier	not_wild	male	azoxystrobin	analytical	131860-33-8	in paper	B-methoxyacrylates	0.2	ug/L	42	days	DMSO	solvent_used	27	celsius	courting	courtship	time near female	time spent near potential mate	NA	NA	fig3a	guo_2023_fig3a	NA	NA	NA	18	268.9578769	75.3692640	NA	NA	17.76470588	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	18	235.1859327	23.4864342	NA	NA	5.535805627	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	NA
NA	NA	SN	KM	The kisspeptin-GnIH signaling pathway in the role of zebrafish courtship and aggressive behavior induced by azoxystrobin	10.1016/j.envpol.2023.121461	https://www.sciencedirect.com/science/article/pii/S0269749123004633?via%3Dihub	Environmental Pollution	guo_2023	guo_2023_exp_002	guo_2023_exp2_008	guo_2023_exp_002_assay_005	guo_2023_exp2_008_assay2_001	zebrafish	Danio rerio	commercial supplier	not_wild	male	azoxystrobin	analytical	131860-33-8	in paper	B-methoxyacrylates	20	ug/L	42	days	DMSO	solvent_used	27	celsius	courting	courtship	time near female	time spent near potential mate	NA	NA	fig3a	guo_2023_fig3a	NA	NA	NA	18	268.9578769	75.3692640	NA	NA	17.76470588	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	18	219.6814749	10.9266987	NA	NA	2.57544757	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	NA
NA	NA	SN	KM	The kisspeptin-GnIH signaling pathway in the role of zebrafish courtship and aggressive behavior induced by azoxystrobin	10.1016/j.envpol.2023.121461	https://www.sciencedirect.com/science/article/pii/S0269749123004633?via%3Dihub	Environmental Pollution	guo_2023	guo_2023_exp_003	guo_2023_exp2_009	guo_2023_exp_003_assay_005	guo_2023_exp2_009_assay2_001	zebrafish	Danio rerio	commercial supplier	not_wild	male	azoxystrobin	analytical	131860-33-8	in paper	B-methoxyacrylates	200	ug/L	42	days	DMSO	solvent_used	27	celsius	courting	courtship	time near female	time spent near potential mate	NA	NA	fig3a	guo_2023_fig3a	NA	NA	NA	18	268.9578769	75.3692640	NA	NA	17.76470588	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	18	185.9934066	29.5411490	NA	NA	6.962915601	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	NA
NA	NA	SN	KM	The kisspeptin-GnIH signaling pathway in the role of zebrafish courtship and aggressive behavior induced by azoxystrobin	10.1016/j.envpol.2023.121461	https://www.sciencedirect.com/science/article/pii/S0269749123004633?via%3Dihub	Environmental Pollution	guo_2023	guo_2023_exp_001	guo_2023_exp2_010	guo_2023_exp_001_assay_006	guo_2023_exp2_010_assay2_001	zebrafish	Danio rerio	commercial supplier	not_wild	female	azoxystrobin	analytical	131860-33-8	in paper	B-methoxyacrylates	0.2	ug/L	42	days	DMSO	solvent_used	27	celsius	courting	courtship	time near male	time spent near potential mate	NA	NA	fig3b	guo_2023_fig3b	NA	NA	NA	18	375.9013678	57.8482422	NA	NA	13.63496144	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	18	351.1144493	10.3830178	NA	NA	2.447300771	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	NA
NA	NA	SN	KM	The kisspeptin-GnIH signaling pathway in the role of zebrafish courtship and aggressive behavior induced by azoxystrobin	10.1016/j.envpol.2023.121461	https://www.sciencedirect.com/science/article/pii/S0269749123004633?via%3Dihub	Environmental Pollution	guo_2023	guo_2023_exp_002	guo_2023_exp2_011	guo_2023_exp_002_assay_006	guo_2023_exp2_011_assay2_001	zebrafish	Danio rerio	commercial supplier	not_wild	female	azoxystrobin	analytical	131860-33-8	in paper	B-methoxyacrylates	20	ug/L	42	days	DMSO	solvent_used	27	celsius	courting	courtship	time near male	time spent near potential mate	NA	NA	fig3b	guo_2023_fig3b	NA	NA	NA	18	375.9013678	57.8482422	NA	NA	13.63496144	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	18	299.3022884	25.0850221	NA	NA	5.912596401	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	NA
NA	NA	SN	KM	The kisspeptin-GnIH signaling pathway in the role of zebrafish courtship and aggressive behavior induced by azoxystrobin	10.1016/j.envpol.2023.121461	https://www.sciencedirect.com/science/article/pii/S0269749123004633?via%3Dihub	Environmental Pollution	guo_2023	guo_2023_exp_003	guo_2023_exp2_012	guo_2023_exp_003_assay_006	guo_2023_exp2_012_assay2_001	zebrafish	Danio rerio	commercial supplier	not_wild	female	azoxystrobin	analytical	131860-33-8	in paper	B-methoxyacrylates	200	ug/L	42	days	DMSO	solvent_used	27	celsius	courting	courtship	time near male	time spent near potential mate	NA	NA	fig3b	guo_2023_fig3b	NA	NA	NA	18	375.9013678	57.8482422	NA	NA	13.63496144	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	18	288.2150279	37.1258326	NA	NA	8.750642674	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	NA
NA	NA	SN	KM	The kisspeptin-GnIH signaling pathway in the role of zebrafish courtship and aggressive behavior induced by azoxystrobin	10.1016/j.envpol.2023.121461	https://www.sciencedirect.com/science/article/pii/S0269749123004633?via%3Dihub	Environmental Pollution	guo_2023	guo_2023_exp_001	guo_2023_exp2_013	guo_2023_exp_001_assay_007	guo_2023_exp2_013_assay2_001	zebrafish	Danio rerio	commercial supplier	not_wild	female	azoxystrobin	analytical	131860-33-8	in paper	B-methoxyacrylates	0.2	ug/L	42	days	DMSO	solvent_used	27	celsius	aggression	aggression	distance in region of contact	distance travelled in aggressive zone	NA	NA	fig4a	guo_2023_fig4a	NA	NA	NA	18	791.2936092	22.3047106	NA	NA	5.257270694	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	18	822.1038557	43.8501118	NA	NA	10.33557047	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	NA
NA	NA	SN	KM	The kisspeptin-GnIH signaling pathway in the role of zebrafish courtship and aggressive behavior induced by azoxystrobin	10.1016/j.envpol.2023.121461	https://www.sciencedirect.com/science/article/pii/S0269749123004633?via%3Dihub	Environmental Pollution	guo_2023	guo_2023_exp_002	guo_2023_exp2_014	guo_2023_exp_002_assay_007	guo_2023_exp2_014_assay2_001	zebrafish	Danio rerio	commercial supplier	not_wild	female	azoxystrobin	analytical	131860-33-8	in paper	B-methoxyacrylates	20	ug/L	42	days	DMSO	solvent_used	27	celsius	aggression	aggression	distance in region of contact	distance travelled in aggressive zone	NA	NA	fig4a	guo_2023_fig4a	NA	NA	NA	18	791.2936092	22.3047106	NA	NA	5.257270694	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	18	835.5618474	65.1867030	NA	NA	15.36465324	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	NA
NA	NA	SN	KM	The kisspeptin-GnIH signaling pathway in the role of zebrafish courtship and aggressive behavior induced by azoxystrobin	10.1016/j.envpol.2023.121461	https://www.sciencedirect.com/science/article/pii/S0269749123004633?via%3Dihub	Environmental Pollution	guo_2023	guo_2023_exp_003	guo_2023_exp2_015	guo_2023_exp_003_assay_007	guo_2023_exp2_015_assay2_001	zebrafish	Danio rerio	commercial supplier	not_wild	female	azoxystrobin	analytical	131860-33-8	in paper	B-methoxyacrylates	200	ug/L	42	days	DMSO	solvent_used	27	celsius	aggression	aggression	distance in region of contact	distance travelled in aggressive zone	NA	NA	fig4a	guo_2023_fig4a	NA	NA	NA	18	791.2936092	22.3047106	NA	NA	5.257270694	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	18	883.1714357	53.8160463	NA	NA	12.68456376	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	NA
NA	NA	SN	KM	The kisspeptin-GnIH signaling pathway in the role of zebrafish courtship and aggressive behavior induced by azoxystrobin	10.1016/j.envpol.2023.121461	https://www.sciencedirect.com/science/article/pii/S0269749123004633?via%3Dihub	Environmental Pollution	guo_2023	guo_2023_exp_001	guo_2023_exp2_013	guo_2023_exp_001_assay_008	guo_2023_exp2_013_assay2_002	zebrafish	Danio rerio	commercial supplier	not_wild	male	azoxystrobin	analytical	131860-33-8	in paper	B-methoxyacrylates	0.2	ug/L	42	days	DMSO	solvent_used	27	celsius	aggression	aggression	distance in region of contact	distance travelled in aggressive zone	NA	NA	fig4c	guo_2023_fig4c	NA	NA	NA	18	718.7022832	88.9227981	NA	NA	20.95930452	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	18	811.1211318	259.4663803	NA	NA	61.15681234	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	NA
NA	NA	SN	KM	The kisspeptin-GnIH signaling pathway in the role of zebrafish courtship and aggressive behavior induced by azoxystrobin	10.1016/j.envpol.2023.121461	https://www.sciencedirect.com/science/article/pii/S0269749123004633?via%3Dihub	Environmental Pollution	guo_2023	guo_2023_exp_002	guo_2023_exp2_014	guo_2023_exp_002_assay_008	guo_2023_exp2_014_assay2_002	zebrafish	Danio rerio	commercial supplier	not_wild	male	azoxystrobin	analytical	131860-33-8	in paper	B-methoxyacrylates	20	ug/L	42	days	DMSO	solvent_used	27	celsius	aggression	aggression	distance in region of contact	distance travelled in aggressive zone	NA	NA	fig4c	guo_2023_fig4c	NA	NA	NA	18	718.7022832	88.9227981	NA	NA	20.95930452	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	18	970.9377468	367.0593119	NA	NA	86.51670951	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	NA
NA	NA	SN	KM	The kisspeptin-GnIH signaling pathway in the role of zebrafish courtship and aggressive behavior induced by azoxystrobin	10.1016/j.envpol.2023.121461	https://www.sciencedirect.com/science/article/pii/S0269749123004633?via%3Dihub	Environmental Pollution	guo_2023	guo_2023_exp_003	guo_2023_exp2_015	guo_2023_exp_003_assay_008	guo_2023_exp2_015_assay2_002	zebrafish	Danio rerio	commercial supplier	not_wild	male	azoxystrobin	analytical	131860-33-8	in paper	B-methoxyacrylates	200	ug/L	42	days	DMSO	solvent_used	27	celsius	aggression	aggression	distance in region of contact	distance travelled in aggressive zone	NA	NA	fig4c	guo_2023_fig4c	NA	NA	NA	18	718.7022832	88.9227981	NA	NA	20.95930452	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	18	1072.1142850	379.6290892	NA	NA	89.47943445	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	NA
NA	NA	SN	KM	The kisspeptin-GnIH signaling pathway in the role of zebrafish courtship and aggressive behavior induced by azoxystrobin	10.1016/j.envpol.2023.121461	https://www.sciencedirect.com/science/article/pii/S0269749123004633?via%3Dihub	Environmental Pollution	guo_2023	guo_2023_exp_001	guo_2023_exp2_016	guo_2023_exp_001_assay_009	guo_2023_exp2_016_assay2_001	zebrafish	Danio rerio	commercial supplier	not_wild	female	azoxystrobin	analytical	131860-33-8	in paper	B-methoxyacrylates	0.2	ug/L	42	days	DMSO	solvent_used	27	celsius	aggression	aggression	frequency in region of contact	frequency of entries into aggression zone	entry	NA	fig4b	guo_2023_fig4b	NA	NA	NA	18	295.2174154	51.7694062	NA	NA	12.20216606	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	18	301.5914375	52.1369996	NA	NA	12.28880866	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	NA
NA	NA	SN	KM	The kisspeptin-GnIH signaling pathway in the role of zebrafish courtship and aggressive behavior induced by azoxystrobin	10.1016/j.envpol.2023.121461	https://www.sciencedirect.com/science/article/pii/S0269749123004633?via%3Dihub	Environmental Pollution	guo_2023	guo_2023_exp_002	guo_2023_exp2_017	guo_2023_exp_002_assay_009	guo_2023_exp2_017_assay2_001	zebrafish	Danio rerio	commercial supplier	not_wild	female	azoxystrobin	analytical	131860-33-8	in paper	B-methoxyacrylates	20	ug/L	42	days	DMSO	solvent_used	27	celsius	aggression	aggression	frequency in region of contact	frequency of entries into aggression zone	entry	NA	fig4b	guo_2023_fig4b	NA	NA	NA	18	295.2174154	51.7694062	NA	NA	12.20216606	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	18	330.3398204	32.9302436	NA	NA	7.761732852	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	NA
NA	NA	SN	KM	The kisspeptin-GnIH signaling pathway in the role of zebrafish courtship and aggressive behavior induced by azoxystrobin	10.1016/j.envpol.2023.121461	https://www.sciencedirect.com/science/article/pii/S0269749123004633?via%3Dihub	Environmental Pollution	guo_2023	guo_2023_exp_003	guo_2023_exp2_018	guo_2023_exp_003_assay_009	guo_2023_exp2_018_assay2_001	zebrafish	Danio rerio	commercial supplier	not_wild	female	azoxystrobin	analytical	131860-33-8	in paper	B-methoxyacrylates	200	ug/L	42	days	DMSO	solvent_used	27	celsius	aggression	aggression	frequency in region of contact	frequency of entries into aggression zone	entry	NA	fig4b	guo_2023_fig4b	NA	NA	NA	18	295.2174154	51.7694062	NA	NA	12.20216606	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	18	373.8358539	35.7280077	NA	NA	8.421172178	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	NA
NA	NA	SN	KM	The kisspeptin-GnIH signaling pathway in the role of zebrafish courtship and aggressive behavior induced by azoxystrobin	10.1016/j.envpol.2023.121461	https://www.sciencedirect.com/science/article/pii/S0269749123004633?via%3Dihub	Environmental Pollution	guo_2023	guo_2023_exp_001	guo_2023_exp2_016	guo_2023_exp_001_assay_010	guo_2023_exp2_016_assay2_002	zebrafish	Danio rerio	commercial supplier	not_wild	male	azoxystrobin	analytical	131860-33-8	in paper	B-methoxyacrylates	0.2	ug/L	42	days	DMSO	solvent_used	27	celsius	aggression	aggression	frequency in region of contact	frequency of entries into aggression zone	entry	NA	fig4d	guo_2023_fig4d	NA	NA	NA	18	401.5002235	46.0038347	NA	NA	10.84320782	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	18	404.2687021	27.4065398	NA	NA	6.459783385	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	NA
NA	NA	SN	KM	The kisspeptin-GnIH signaling pathway in the role of zebrafish courtship and aggressive behavior induced by azoxystrobin	10.1016/j.envpol.2023.121461	https://www.sciencedirect.com/science/article/pii/S0269749123004633?via%3Dihub	Environmental Pollution	guo_2023	guo_2023_exp_002	guo_2023_exp2_017	guo_2023_exp_002_assay_010	guo_2023_exp2_017_assay2_002	zebrafish	Danio rerio	commercial supplier	not_wild	male	azoxystrobin	analytical	131860-33-8	in paper	B-methoxyacrylates	20	ug/L	42	days	DMSO	solvent_used	27	celsius	aggression	aggression	frequency in region of contact	frequency of entries into aggression zone	entry	NA	fig4d	guo_2023_fig4d	NA	NA	NA	18	401.5002235	46.0038347	NA	NA	10.84320782	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	18	454.2716458	116.7980733	NA	NA	27.52956989	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	NA
NA	NA	SN	KM	The kisspeptin-GnIH signaling pathway in the role of zebrafish courtship and aggressive behavior induced by azoxystrobin	10.1016/j.envpol.2023.121461	https://www.sciencedirect.com/science/article/pii/S0269749123004633?via%3Dihub	Environmental Pollution	guo_2023	guo_2023_exp_003	guo_2023_exp2_018	guo_2023_exp_003_assay_010	guo_2023_exp2_018_assay2_002	zebrafish	Danio rerio	commercial supplier	not_wild	male	azoxystrobin	analytical	131860-33-8	in paper	B-methoxyacrylates	200	ug/L	42	days	DMSO	solvent_used	27	celsius	aggression	aggression	frequency in region of contact	frequency of entries into aggression zone	entry	NA	fig4d	guo_2023_fig4d	NA	NA	NA	18	401.5002235	46.0038347	NA	NA	10.84320782	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	18	506.6776000	68.1248300	NA	NA	15.87722473	study reports mean and se	states N=3, 18 per treatment - I assume this is 18 for each concentration	NA	NA	NA	NA
NA	NA	YY	KM	Pyriproxyfen Exposure Impairs Cognitive Parameters and Alters Cortisol Levels in Zebrafish	10.3389/fnbeh.2020.00103	https://www.frontiersin.org/articles/10.3389/fnbeh.2020.00103/full	Frontiers in Behavioral Neuroscience	gusso_2020	gusso_2020_exp_001	gusso_2020_exp2_001	gusso_2020_exp_001_assay_001	gusso_2020_exp2_001_assay2_001	zebrafish	Danio rerio	not reported	NA	mixed	pyriproxyfen	not reported	95737- 68-1	in paper	phenoxy	0.125	mg/L	96	hours	none	none	28	celsius	aggression	aggression	total aggressive behaviours towards mirror	frequency of aggressive behaviour	count	NA	fig3a	gusso_2020_fig3a	NA	NA	NA	14	111.4008331	61.6942041	NA	NA	16.4884696	study reports mean and se	sample size provided as a range so selected the lowest value	NA	NA	NA	14	97.3645968	67.1674566	NA	NA	17.95125786	study reports mean and se	sample size provided as a range so selected the lowest value	NA	NA	NA	NA
NA	NA	YY	KM	Pyriproxyfen Exposure Impairs Cognitive Parameters and Alters Cortisol Levels in Zebrafish	10.3389/fnbeh.2020.00103	https://www.frontiersin.org/articles/10.3389/fnbeh.2020.00103/full	Frontiers in Behavioral Neuroscience	gusso_2020	gusso_2020_exp_002	gusso_2020_exp2_002	gusso_2020_exp_002_assay_001	gusso_2020_exp2_002_assay2_001	zebrafish	Danio rerio	not reported	NA	mixed	pyriproxyfen	not reported	95737- 68-1	in paper	phenoxy	0.675	mg/L	96	hours	none	none	28	celsius	aggression	aggression	total aggressive behaviours towards mirror	frequency of aggressive behaviour	count	NA	fig3a	gusso_2020_fig3a	NA	NA	NA	14	111.4008331	61.6942041	NA	NA	16.4884696	study reports mean and se	sample size provided as a range so selected the lowest value	NA	NA	NA	14	115.4811997	55.9483675	NA	NA	14.95283019	study reports mean and se	sample size provided as a range so selected the lowest value	NA	NA	NA	NA
NA	NA	YY	KM	Pyriproxyfen Exposure Impairs Cognitive Parameters and Alters Cortisol Levels in Zebrafish	10.3389/fnbeh.2020.00103	https://www.frontiersin.org/articles/10.3389/fnbeh.2020.00103/full	Frontiers in Behavioral Neuroscience	gusso_2020	gusso_2020_exp_003	gusso_2020_exp2_003	gusso_2020_exp_003_assay_001	gusso_2020_exp2_003_assay2_001	zebrafish	Danio rerio	not reported	NA	mixed	pyriproxyfen	not reported	95737- 68-1	in paper	phenoxy	1.75	mg/L	96	hours	none	none	28	celsius	aggression	aggression	total aggressive behaviours towards mirror	frequency of aggressive behaviour	count	NA	fig3a	gusso_2020_fig3a	NA	NA	NA	14	111.4008331	61.6942041	NA	NA	16.4884696	study reports mean and se	sample size provided as a range so selected the lowest value	NA	NA	NA	14	89.6508764	68.6872598	NA	NA	18.35744235	study reports mean and se	sample size provided as a range so selected the lowest value	NA	NA	NA	NA
NA	NA	YY	KM	Pyriproxyfen Exposure Impairs Cognitive Parameters and Alters Cortisol Levels in Zebrafish	10.3389/fnbeh.2020.00103	https://www.frontiersin.org/articles/10.3389/fnbeh.2020.00103/full	Frontiers in Behavioral Neuroscience	gusso_2020	gusso_2020_exp_001	gusso_2020_exp2_001	gusso_2020_exp_001_assay_002	gusso_2020_exp2_001_assay2_002	zebrafish	Danio rerio	not reported	NA	mixed	pyriproxyfen	not reported	95737- 68-1	in paper	phenoxy	0.125	mg/L	96	hours	DMSO	solvent_used	28	celsius	aggression	aggression	total aggressive behaviours towards mirror	frequency of aggressive behaviour	count	NA	fig3a	gusso_2020_fig3a	NA	NA	NA	14	85.2610740	53.8304483	NA	NA	14.38679245	study reports mean and se	sample size provided as a range so selected the lowest value	NA	NA	NA	14	97.3645968	67.1674566	NA	NA	17.95125786	study reports mean and se	sample size provided as a range so selected the lowest value	NA	NA	NA	NA
NA	NA	YY	KM	Pyriproxyfen Exposure Impairs Cognitive Parameters and Alters Cortisol Levels in Zebrafish	10.3389/fnbeh.2020.00103	https://www.frontiersin.org/articles/10.3389/fnbeh.2020.00103/full	Frontiers in Behavioral Neuroscience	gusso_2020	gusso_2020_exp_002	gusso_2020_exp2_002	gusso_2020_exp_002_assay_002	gusso_2020_exp2_002_assay2_002	zebrafish	Danio rerio	not reported	NA	mixed	pyriproxyfen	not reported	95737- 68-1	in paper	phenoxy	0.675	mg/L	96	hours	DMSO	solvent_used	28	celsius	aggression	aggression	total aggressive behaviours towards mirror	frequency of aggressive behaviour	count	NA	fig3a	gusso_2020_fig3a	NA	NA	NA	14	85.2610740	53.8304483	NA	NA	14.38679245	study reports mean and se	sample size provided as a range so selected the lowest value	NA	NA	NA	14	115.4811997	55.9483675	NA	NA	14.95283019	study reports mean and se	sample size provided as a range so selected the lowest value	NA	NA	NA	NA
NA	NA	YY	KM	Pyriproxyfen Exposure Impairs Cognitive Parameters and Alters Cortisol Levels in Zebrafish	10.3389/fnbeh.2020.00103	https://www.frontiersin.org/articles/10.3389/fnbeh.2020.00103/full	Frontiers in Behavioral Neuroscience	gusso_2020	gusso_2020_exp_003	gusso_2020_exp2_003	gusso_2020_exp_003_assay_002	gusso_2020_exp2_003_assay2_002	zebrafish	Danio rerio	not reported	NA	mixed	pyriproxyfen	not reported	95737- 68-1	in paper	phenoxy	1.75	mg/L	96	hours	DMSO	solvent_used	28	celsius	aggression	aggression	total aggressive behaviours towards mirror	frequency of aggressive behaviour	count	NA	fig3a	gusso_2020_fig3a	NA	NA	NA	14	85.2610740	53.8304483	NA	NA	14.38679245	study reports mean and se	sample size provided as a range so selected the lowest value	NA	NA	NA	14	89.6508764	68.6872598	NA	NA	18.35744235	study reports mean and se	sample size provided as a range so selected the lowest value	NA	NA	NA	NA
NA	NA	YY	KM	Pyriproxyfen Exposure Impairs Cognitive Parameters and Alters Cortisol Levels in Zebrafish	10.3389/fnbeh.2020.00103	https://www.frontiersin.org/articles/10.3389/fnbeh.2020.00103/full	Frontiers in Behavioral Neuroscience	gusso_2020	gusso_2020_exp_001	gusso_2020_exp2_004	gusso_2020_exp_001_assay_003	gusso_2020_exp2_004_assay2_001	zebrafish	Danio rerio	not reported	NA	mixed	pyriproxyfen	not reported	95737- 68-1	in paper	phenoxy	0.125	mg/L	96	hours	none	none	28	celsius	social interaction	sociality	time spent in the area closest to the stimulus aquarium	time spent in social zone	zone	NA	fig3b	gusso_2020_fig3b	NA	NA	NA	13	221.2292884	59.9173979	NA	NA	16.61809619	study reports mean and se	sample size provided as a range so selected the lowest value	NA	NA	NA	13	217.1531516	83.6582537	NA	NA	23.20262487	study reports mean and se	sample size provided as a range so selected the lowest value	NA	NA	NA	NA
NA	NA	YY	KM	Pyriproxyfen Exposure Impairs Cognitive Parameters and Alters Cortisol Levels in Zebrafish	10.3389/fnbeh.2020.00103	https://www.frontiersin.org/articles/10.3389/fnbeh.2020.00103/full	Frontiers in Behavioral Neuroscience	gusso_2020	gusso_2020_exp_002	gusso_2020_exp2_005	gusso_2020_exp_002_assay_003	gusso_2020_exp2_005_assay2_001	zebrafish	Danio rerio	not reported	NA	mixed	pyriproxyfen	not reported	95737- 68-1	in paper	phenoxy	0.675	mg/L	96	hours	none	none	28	celsius	social interaction	sociality	time spent in the area closest to the stimulus aquarium	time spent in social zone	zone	NA	fig3b	gusso_2020_fig3b	NA	NA	NA	13	221.2292884	59.9173979	NA	NA	16.61809619	study reports mean and se	sample size provided as a range so selected the lowest value	NA	NA	NA	13	202.4163493	73.4836012	NA	NA	20.38068401	study reports mean and se	sample size provided as a range so selected the lowest value	NA	NA	NA	NA
NA	NA	YY	KM	Pyriproxyfen Exposure Impairs Cognitive Parameters and Alters Cortisol Levels in Zebrafish	10.3389/fnbeh.2020.00103	https://www.frontiersin.org/articles/10.3389/fnbeh.2020.00103/full	Frontiers in Behavioral Neuroscience	gusso_2020	gusso_2020_exp_003	gusso_2020_exp2_006	gusso_2020_exp_003_assay_003	gusso_2020_exp2_006_assay2_001	zebrafish	Danio rerio	not reported	NA	mixed	pyriproxyfen	not reported	95737- 68-1	in paper	phenoxy	1.75	mg/L	96	hours	none	none	28	celsius	social interaction	sociality	time spent in the area closest to the stimulus aquarium	time spent in social zone	zone	NA	fig3b	gusso_2020_fig3b	NA	NA	NA	13	221.2292884	59.9173979	NA	NA	16.61809619	study reports mean and se	sample size provided as a range so selected the lowest value	NA	NA	NA	13	233.7712478	46.3511946	NA	NA	12.85550837	study reports mean and se	sample size provided as a range so selected the lowest value	NA	NA	NA	NA
NA	NA	YY	KM	Pyriproxyfen Exposure Impairs Cognitive Parameters and Alters Cortisol Levels in Zebrafish	10.3389/fnbeh.2020.00103	https://www.frontiersin.org/articles/10.3389/fnbeh.2020.00103/full	Frontiers in Behavioral Neuroscience	gusso_2020	gusso_2020_exp_001	gusso_2020_exp2_004	gusso_2020_exp_001_assay_004	gusso_2020_exp2_004_assay2_002	zebrafish	Danio rerio	not reported	NA	mixed	pyriproxyfen	not reported	95737- 68-1	in paper	phenoxy	0.125	mg/L	96	hours	DMSO	solvent_used	28	celsius	social interaction	sociality	time spent in the area closest to the stimulus aquarium	time spent in social zone	zone	NA	fig3b	gusso_2020_fig3b	NA	NA	NA	13	221.2292884	59.9173979	NA	NA	16.61809619	study reports mean and se	sample size provided as a range so selected the lowest value	NA	NA	NA	13	217.1531516	83.6582537	NA	NA	23.20262487	study reports mean and se	sample size provided as a range so selected the lowest value	NA	NA	NA	NA
NA	NA	YY	KM	Pyriproxyfen Exposure Impairs Cognitive Parameters and Alters Cortisol Levels in Zebrafish	10.3389/fnbeh.2020.00103	https://www.frontiersin.org/articles/10.3389/fnbeh.2020.00103/full	Frontiers in Behavioral Neuroscience	gusso_2020	gusso_2020_exp_002	gusso_2020_exp2_005	gusso_2020_exp_002_assay_004	gusso_2020_exp2_005_assay2_002	zebrafish	Danio rerio	not reported	NA	mixed	pyriproxyfen	not reported	95737- 68-1	in paper	phenoxy	0.675	mg/L	96	hours	DMSO	solvent_used	28	celsius	social interaction	sociality	time spent in the area closest to the stimulus aquarium	time spent in social zone	zone	NA	fig3b	gusso_2020_fig3b	NA	NA	NA	13	221.2292884	59.9173979	NA	NA	16.61809619	study reports mean and se	sample size provided as a range so selected the lowest value	NA	NA	NA	13	202.4163493	73.4836012	NA	NA	20.38068401	study reports mean and se	sample size provided as a range so selected the lowest value	NA	NA	NA	NA
NA	NA	YY	KM	Pyriproxyfen Exposure Impairs Cognitive Parameters and Alters Cortisol Levels in Zebrafish	10.3389/fnbeh.2020.00103	https://www.frontiersin.org/articles/10.3389/fnbeh.2020.00103/full	Frontiers in Behavioral Neuroscience	gusso_2020	gusso_2020_exp_003	gusso_2020_exp2_006	gusso_2020_exp_003_assay_004	gusso_2020_exp2_006_assay2_002	zebrafish	Danio rerio	not reported	NA	mixed	pyriproxyfen	not reported	95737- 68-1	in paper	phenoxy	1.75	mg/L	96	hours	DMSO	solvent_used	28	celsius	social interaction	sociality	time spent in the area closest to the stimulus aquarium	time spent in social zone	zone	NA	fig3b	gusso_2020_fig3b	NA	NA	NA	13	221.2292884	59.9173979	NA	NA	16.61809619	study reports mean and se	sample size provided as a range so selected the lowest value	NA	NA	NA	13	233.7712478	46.3511946	NA	NA	12.85550837	study reports mean and se	sample size provided as a range so selected the lowest value	NA	NA	NA	NA
used species median of shoal	NA	YY	KM	Adult exposure to insecticides causes persistent behavioral and neurochemical alterations in zebrafish	10.1016/j.ntt.2019.106853	https://www.sciencedirect.com/science/article/pii/S0892036219301539?via%3Dihub	Neurotoxicology and Teratology	hawkey_2020	hawkey_2020_exp_001	hawkey_2020_exp2_001	hawkey_2020_exp_001_assay_001	hawkey_2020_exp2_001_assay2_001	zebrafish	Danio rerio	labratory stock from wild population	not_wild	mixed	DDT	not reported	50-29-3	https://commonchemistry.cas.org/detail?cas_rn=50-29-3&search=DDT	organochlorine	10	nm	5	weeks	DMSO	solvent_used	28	celsius	shoaling	collective behaviour	total distance moved	group movement	NA	NA	fig3b	hawkey_2020_fig3b	18.000000	12.000000	36	36	2013.6537020	535.6481481	309.2566025	535.6481482	89.27469136	study reports mean and se	exact sample size provided	17.500000	11.666667	35	35	1494.9636350	687.3399572	89.2746914	116.1816578	116.1816578	study reports mean and se	exact sample size provided	NA	NA	NA	NA
used species median of shoal	NA	YY	KM	Adult exposure to insecticides causes persistent behavioral and neurochemical alterations in zebrafish	10.1016/j.ntt.2019.106853	https://www.sciencedirect.com/science/article/pii/S0892036219301539?via%3Dihub	Neurotoxicology and Teratology	hawkey_2020	hawkey_2020_exp_002	hawkey_2020_exp2_002	hawkey_2020_exp_002_assay_001	hawkey_2020_exp2_002_assay2_001	zebrafish	Danio rerio	labratory stock from wild population	not_wild	mixed	DDT	not reported	50-29-3	https://commonchemistry.cas.org/detail?cas_rn=50-29-3&search=DDT	organochlorine	30	nm	5	weeks	DMSO	solvent_used	28	celsius	shoaling	collective behaviour	total distance moved	group movement	NA	NA	fig3b	hawkey_2020_fig3b	18.000000	12.000000	36	36	2013.6537020	535.6481481	309.2566025	535.6481482	89.27469136	study reports mean and se	exact sample size provided	17.500000	11.666667	35	35	1741.4132600	571.8485849	89.2746914	96.6600529	96.66005291	study reports mean and se	exact sample size provided	NA	NA	NA	NA
used species median of shoal	NA	YY	KM	Adult exposure to insecticides causes persistent behavioral and neurochemical alterations in zebrafish	10.1016/j.ntt.2019.106853	https://www.sciencedirect.com/science/article/pii/S0892036219301539?via%3Dihub	Neurotoxicology and Teratology	hawkey_2020	hawkey_2020_exp_003	hawkey_2020_exp2_003	hawkey_2020_exp_003_assay_001	hawkey_2020_exp2_003_assay2_001	zebrafish	Danio rerio	labratory stock from wild population	not_wild	mixed	chlorpyrifos	not reported	2921-88-2	https://commonchemistry.cas.org/detail?cas_rn=2921-88-2&search=chlorpyrifos	organophosphate	0.3	um	2	weeks	DMSO	solvent_used	28	celsius	shoaling	collective behaviour	change in position	group movement	NA	NA	fig5b	hawkey_2020_fig5b	11.000000	7.333333	22	22	1.6812550	4.6226932	2.6689132	4.6226932	0.985561497	study reports mean and se	exact sample size provided	9.000000	6.000000	18	18	3.4988493	3.8752855	0.9855615	0.9134135	0.913413547	study reports mean and se	exact sample size provided	NA	NA	NA	NA
used species median of shoal	NA	YY	KM	Adult exposure to insecticides causes persistent behavioral and neurochemical alterations in zebrafish	10.1016/j.ntt.2019.106853	https://www.sciencedirect.com/science/article/pii/S0892036219301539?via%3Dihub	Neurotoxicology and Teratology	hawkey_2020	hawkey_2020_exp_004	hawkey_2020_exp2_004	hawkey_2020_exp_004_assay_001	hawkey_2020_exp2_004_assay2_001	zebrafish	Danio rerio	labratory stock from wild population	not_wild	mixed	chlorpyrifos	not reported	2921-88-2	https://commonchemistry.cas.org/detail?cas_rn=2921-88-2&search=chlorpyrifos	organophosphate	1	um	2	weeks	DMSO	solvent_used	28	celsius	shoaling	collective behaviour	change in position	group movement	NA	NA	fig5b	hawkey_2020_fig5b	11.000000	7.333333	22	22	1.6812550	4.6226932	2.6689132	4.6226932	0.985561497	study reports mean and se	exact sample size provided	11.000000	7.333333	22	22	5.1874444	4.5148387	0.9855615	0.9625668	0.962566845	study reports mean and se	exact sample size provided	NA	NA	NA	NA
used species median of shoal	NA	YY	KM	Adult exposure to insecticides causes persistent behavioral and neurochemical alterations in zebrafish	10.1016/j.ntt.2019.106853	https://www.sciencedirect.com/science/article/pii/S0892036219301539?via%3Dihub	Neurotoxicology and Teratology	hawkey_2020	hawkey_2020_exp_005	hawkey_2020_exp2_005	hawkey_2020_exp_005_assay_001	hawkey_2020_exp2_005_assay2_001	zebrafish	Danio rerio	labratory stock from wild population	not_wild	mixed	chlorpyrifos	not reported	2921-88-2	https://commonchemistry.cas.org/detail?cas_rn=2921-88-2&search=chlorpyrifos	organophosphate	3	um	2	weeks	DMSO	solvent_used	28	celsius	shoaling	collective behaviour	change in position	group movement	NA	NA	fig5b	hawkey_2020_fig5b	11.000000	7.333333	22	22	1.6812550	4.6226932	2.6689132	4.6226932	0.985561497	study reports mean and se	exact sample size provided	10.000000	6.666667	20	20	7.2280091	6.2089749	0.9855615	1.3883690	1.388368984	study reports mean and se	exact sample size provided	NA	NA	NA	NA
used species median of shoal	NA	NA	KM	Neurobehavioral anomalies in zebrafish after sequential exposures to DDT and chlorpyrifos in adulthood: Do multiple exposures interact?	10.1016/j.ntt.2021.106985	https://www.sciencedirect.com/science/article/pii/S0892036221000398	Neurotoxicology and Teratology	hawkey_2021	hawkey_2021_exp_001	hawkey_2021_exp2_001	hawkey_2021_exp_001_assay_001	hawkey_2021_exp2_001_assay2_001	zebrafish	Danio rerio	labratory stock from wild population	not_wild	mixed	chlorpyrifos	not reported	2921-88-2	https://commonchemistry.cas.org/detail?cas_rn=2921-88-2&search=chlorpyrifos	organophosphate	NA	NA	5	weeks	DMSO	solvent_used	28	celsius	shoaling	collective behaviour	distance	group movement	NA	NA	fig3a	hawkey_2021_fig3a	23.000000	15.333333	46	46	184.4213398	76.0345316	48.9472505	84.7791248	12.5	study reports mean and se	exact sample size provided	23.500000	15.666667	47	47	167.6488638	61.7590761	41.3195012	71.5674754	10.43918919	study reports mean and se	exact sample size provided	NA	NA	NA	NA
used species median of shoal	NA	NA	KM	Neurobehavioral anomalies in zebrafish after sequential exposures to DDT and chlorpyrifos in adulthood: Do multiple exposures interact?	10.1016/j.ntt.2021.106985	https://www.sciencedirect.com/science/article/pii/S0892036221000398	Neurotoxicology and Teratology	hawkey_2021	hawkey_2021_exp_002	hawkey_2021_exp2_002	hawkey_2021_exp_002_assay_001	hawkey_2021_exp2_002_assay2_001	zebrafish	Danio rerio	labratory stock from wild population	not_wild	mixed	DDT	not reported	50-29-3	https://commonchemistry.cas.org/detail?cas_rn=50-29-3&search=DDT; https://commonchemistry.cas.org/detail?cas_rn=2921-88-2&search=chlorpyrifos	organochlorine	NA	NA	5	weeks	DMSO	solvent_used	28	celsius	shoaling	collective behaviour	distance	group movement	NA	NA	fig3a	hawkey_2021_fig3a	23.000000	15.333333	46	46	184.4213398	76.0345316	48.9472505	84.7791248	12.5	study reports mean and se	exact sample size provided	21.000000	14.000000	42	42	191.4803442	87.2189923	52.2567961	90.5114259	13.96621622	study reports mean and se	exact sample size provided	NA	NA	NA	NA
used species median of shoal	NA	NA	KM	Neurobehavioral anomalies in zebrafish after sequential exposures to DDT and chlorpyrifos in adulthood: Do multiple exposures interact?	10.1016/j.ntt.2021.106985	https://www.sciencedirect.com/science/article/pii/S0892036221000398	Neurotoxicology and Teratology	hawkey_2021	hawkey_2021_exp_003	hawkey_2021_exp2_003	hawkey_2021_exp_003_assay_001	hawkey_2021_exp2_003_assay2_001	zebrafish	Danio rerio	labratory stock from wild population	not_wild	mixed	chlorpyrifos ; DDT	not reported	2921-88-2 ; 50-29-3	https://commonchemistry.cas.org/detail?cas_rn=2921-88-2&search=chlorpyrifos	organophosphate and organochlorine	NA	NA	5	weeks	DMSO	solvent_used	28	celsius	shoaling	collective behaviour	distance	group movement	NA	NA	fig3a	hawkey_2021_fig3a	23.000000	15.333333	46	46	184.4213398	76.0345316	48.9472505	84.7791248	12.5	study reports mean and se	exact sample size provided	16.000000	10.666667	32	32	226.6114671	68.5836312	46.7058112	80.8968380	14.30067568	study reports mean and se	exact sample size provided	NA	NA	NA	NA
used species median of shoal	NA	NA	KM	Neurobehavioral anomalies in zebrafish after sequential exposures to DDT and chlorpyrifos in adulthood: Do multiple exposures interact?	10.1016/j.ntt.2021.106985	https://www.sciencedirect.com/science/article/pii/S0892036221000398	Neurotoxicology and Teratology	hawkey_2021	hawkey_2021_exp_001	hawkey_2021_exp2_004	hawkey_2021_exp_001_assay_002	hawkey_2021_exp2_004_assay2_001	zebrafish	Danio rerio	labratory stock from wild population	not_wild	mixed	chlorpyrifos	not reported	2921-88-2	https://commonchemistry.cas.org/detail?cas_rn=2921-88-2&search=chlorpyrifos	organophosphate	NA	NA	5	weeks	DMSO	solvent_used	28	celsius	shoaling	collective behaviour	change in position	group movement	NA	NA	fig3b	hawkey_2021_fig3b	23.000000	15.333333	46	46	4.1697558	6.3808160	3.6839659	6.3808160	0.9408	study reports mean and se	exact sample size provided	23.500000	15.666667	47	47	6.4433558	7.7551165	4.4774186	7.7551165	1.1312	study reports mean and se	exact sample size provided	NA	NA	NA	NA
used species median of shoal	NA	NA	KM	Neurobehavioral anomalies in zebrafish after sequential exposures to DDT and chlorpyrifos in adulthood: Do multiple exposures interact?	10.1016/j.ntt.2021.106985	https://www.sciencedirect.com/science/article/pii/S0892036221000398	Neurotoxicology and Teratology	hawkey_2021	hawkey_2021_exp_002	hawkey_2021_exp2_005	hawkey_2021_exp_002_assay_002	hawkey_2021_exp2_005_assay2_001	zebrafish	Danio rerio	labratory stock from wild population	not_wild	mixed	DDT	not reported	50-29-3	https://commonchemistry.cas.org/detail?cas_rn=50-29-3&search=DDT	organochlorine	NA	NA	5	weeks	DMSO	solvent_used	28	celsius	shoaling	collective behaviour	change in position	group movement	NA	NA	fig3b	hawkey_2021_fig3b	23.000000	15.333333	46	46	4.1697558	6.3808160	3.6839659	6.3808160	0.9408	study reports mean and se	exact sample size provided	21.000000	14.000000	42	42	6.7793558	8.0568568	4.6516285	8.0568568	1.2432	study reports mean and se	exact sample size provided	NA	NA	NA	NA
used species median of shoal	NA	NA	KM	Neurobehavioral anomalies in zebrafish after sequential exposures to DDT and chlorpyrifos in adulthood: Do multiple exposures interact?	10.1016/j.ntt.2021.106985	https://www.sciencedirect.com/science/article/pii/S0892036221000398	Neurotoxicology and Teratology	hawkey_2021	hawkey_2021_exp_003	hawkey_2021_exp2_006	hawkey_2021_exp_003_assay_002	hawkey_2021_exp2_006_assay2_001	zebrafish	Danio rerio	labratory stock from wild population	not_wild	mixed	chlorpyrifos ; DDT	not reported	2921-88-2 ; 50-29-3	https://commonchemistry.cas.org/detail?cas_rn=50-29-3&search=DDT; https://commonchemistry.cas.org/detail?cas_rn=2921-88-2&search=chlorpyrifos	organophosphate and organochlorine	NA	NA	5	weeks	DMSO	solvent_used	28	celsius	shoaling	collective behaviour	change in position	group movement	NA	NA	fig3b	hawkey_2021_fig3b	23.000000	15.333333	46	46	4.1697558	6.3808160	3.6839659	6.3808160	0.9408	study reports mean and se	exact sample size provided	16.000000	10.666667	32	32	2.3441558	9.1233745	5.2673827	9.1233745	1.6128	study reports mean and se	exact sample size provided	NA	NA	NA	NA
used species median of shoal	NA	NA	KM	Neurobehavioral anomalies in zebrafish after sequential exposures to DDT and chlorpyrifos in adulthood: Do multiple exposures interact?	10.1016/j.ntt.2021.106985	https://www.sciencedirect.com/science/article/pii/S0892036221000398	Neurotoxicology and Teratology	hawkey_2021	hawkey_2021_exp_004	hawkey_2021_exp2_007	hawkey_2021_exp_004_assay_001	hawkey_2021_exp2_007_assay2_001	zebrafish	Danio rerio	labratory stock from wild population	not_wild	mixed	chlorpyrifos	not reported	2921-88-2	https://commonchemistry.cas.org/detail?cas_rn=2921-88-2&search=chlorpyrifos	organophosphate	NA	NA	5	weeks	DMSO	solvent_used	28	celsius	shoaling	collective behaviour	change in position	group movement	NA	NA	fig3b	hawkey_2021_fig3b	18.500000	12.333333	37	37	5.1429639	8.2206508	4.7461950	8.2206508	1.351466667	study reports mean and se	exact sample size provided	17.500000	11.666667	35	35	7.3793195	7.7098352	4.4512754	7.7098352	1.3032	study reports mean and se	exact sample size provided	NA	NA	NA	NA
used species median of shoal	NA	NA	KM	Neurobehavioral anomalies in zebrafish after sequential exposures to DDT and chlorpyrifos in adulthood: Do multiple exposures interact?	10.1016/j.ntt.2021.106985	https://www.sciencedirect.com/science/article/pii/S0892036221000398	Neurotoxicology and Teratology	hawkey_2021	hawkey_2021_exp_005	hawkey_2021_exp2_008	hawkey_2021_exp_005_assay_001	hawkey_2021_exp2_008_assay2_001	zebrafish	Danio rerio	labratory stock from wild population	not_wild	mixed	DDT	not reported	50-29-3	https://commonchemistry.cas.org/detail?cas_rn=50-29-3&search=DDT	organochlorine	NA	NA	5	weeks	DMSO	solvent_used	28	celsius	shoaling	collective behaviour	change in position	group movement	NA	NA	fig3b	hawkey_2021_fig3b	18.500000	12.333333	37	37	5.1429639	8.2206508	4.7461950	8.2206508	1.351466667	study reports mean and se	exact sample size provided	19.500000	13.000000	39	39	0.9437639	10.5498833	6.0909780	10.5498833	1.689333333	study reports mean and se	exact sample size provided	NA	NA	NA	NA
used species median of shoal	NA	NA	KM	Neurobehavioral anomalies in zebrafish after sequential exposures to DDT and chlorpyrifos in adulthood: Do multiple exposures interact?	10.1016/j.ntt.2021.106985	https://www.sciencedirect.com/science/article/pii/S0892036221000398	Neurotoxicology and Teratology	hawkey_2021	hawkey_2021_exp_006	hawkey_2021_exp2_009	hawkey_2021_exp_006_assay_001	hawkey_2021_exp2_009_assay2_001	zebrafish	Danio rerio	labratory stock from wild population	not_wild	mixed	chlorpyrifos ; DDT	not reported	2921-88-2 ; 50-29-3	https://commonchemistry.cas.org/detail?cas_rn=50-29-3&search=DDT; https://commonchemistry.cas.org/detail?cas_rn=2921-88-2&search=chlorpyrifos	organophosphate and organochlorine	NA	NA	5	weeks	DMSO	solvent_used	28	celsius	shoaling	collective behaviour	change in position	group movement	NA	NA	fig3b	hawkey_2021_fig3b	18.500000	12.333333	37	37	5.1429639	8.2206508	4.7461950	8.2206508	1.351466667	study reports mean and se	exact sample size provided	11.500000	7.666667	23	23	2.1986972	6.1727680	3.5638493	6.1727680	1.287111111	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	SN	KM	Exposure to a commercial glyphosate formulation (Roundup<ae>) alters normal gill and liver histology and affects male sexual activity of Jenynsia multidentata (Anablepidae, Cyprinodontiformes).	10.1007/s00244-011-9686-7	https://link.springer.com/article/10.1007/s00244-011-9686-7#article-info	Archives of Environmental Contamination and Toxicology	hued_2011	hued_2011_exp_001	hued_2011_exp2_001	hued_2011_exp_001_assay_001	hued_2011_exp2_001_assay_001	killifish	Jenynsia multidentata	wild collected	wild	male	roundup	commercial	38641-94-0	https://commonchemistry.cas.org/detail?cas_rn=38641-94-0&search=ROUNDUP	organophosphate	0.5	mg/L	7	days	not reported	NA	21	celsius	sexual activity	courtship	number of persecutions	frequency of courting events	count	NA	table2	hued_2011_table2	NA	NA	NA	9	74.0000000	40.0000000	NA	NA	not reported	study does not seem to report sample size	sample size is not provided	NA	NA	NA	9	52.4000000	28.9000000	NA	NA	not reported	study does not seem to report sample size	exact sample size provided	NA	NA	NA	NA
NA	NA	SN	KM	Exposure to a commercial glyphosate formulation (Roundup<ae>) alters normal gill and liver histology and affects male sexual activity of Jenynsia multidentata (Anablepidae, Cyprinodontiformes).	10.1007/s00244-011-9686-7	https://link.springer.com/article/10.1007/s00244-011-9686-7#article-info	Archives of Environmental Contamination and Toxicology	hued_2011	hued_2011_exp_001	hued_2011_exp2_002	hued_2011_exp_001_assay_002	hued_2011_exp2_002_assay_001	killifish	Jenynsia multidentata	wild collected	wild	male	roundup	commercial	38641-94-0	https://commonchemistry.cas.org/detail?cas_rn=38641-94-0&search=ROUNDUP	organophosphate	0.5	mg/L	28	days	not reported	NA	21	celsius	sexual activity	courtship	number of persecutions	frequency of courting events	count	NA	table2	hued_2011_table2	NA	NA	NA	9	74.0000000	40.0000000	NA	NA	not reported	study does not seem to report sample size	sample size is not provided	NA	NA	NA	9	56.1600000	29.8000000	NA	NA	not reported	study does not seem to report sample size	sample size is not provided	NA	NA	NA	NA
NA	NA	SN	KM	Exposure to a commercial glyphosate formulation (Roundup<ae>) alters normal gill and liver histology and affects male sexual activity of Jenynsia multidentata (Anablepidae, Cyprinodontiformes).	10.1007/s00244-011-9686-7	https://link.springer.com/article/10.1007/s00244-011-9686-7#article-info	Archives of Environmental Contamination and Toxicology	hued_2011	hued_2011_exp_001	hued_2011_exp2_001	hued_2011_exp_001_assay_003	hued_2011_exp2_001_assay_002	killifish	Jenynsia multidentata	wild collected	wild	male	roundup	commercial	38641-94-0	https://commonchemistry.cas.org/detail?cas_rn=38641-94-0&search=ROUNDUP	organophosphate	0.5	mg/L	7	days	not reported	NA	21	celsius	sexual activity	courtship	number of copulation attempts	frequency of courting events	count	NA	table2	hued_2011_table2	NA	NA	NA	9	30.0000000	28.0000000	NA	NA	not reported	study does not seem to report sample size	sample size is not provided	NA	NA	NA	9	16.0000000	10.0000000	NA	NA	not reported	study does not seem to report sample size	sample size is not provided	NA	NA	NA	NA
NA	NA	SN	KM	Exposure to a commercial glyphosate formulation (Roundup<ae>) alters normal gill and liver histology and affects male sexual activity of Jenynsia multidentata (Anablepidae, Cyprinodontiformes).	10.1007/s00244-011-9686-7	https://link.springer.com/article/10.1007/s00244-011-9686-7#article-info	Archives of Environmental Contamination and Toxicology	hued_2011	hued_2011_exp_001	hued_2011_exp2_002	hued_2011_exp_001_assay_004	hued_2011_exp2_002_assay_002	killifish	Jenynsia multidentata	wild collected	wild	male	roundup	commercial	38641-94-0	https://commonchemistry.cas.org/detail?cas_rn=38641-94-0&search=ROUNDUP	organophosphate	0.5	mg/L	28	days	not reported	NA	21	celsius	sexual activity	courtship	number of copulation attempts	frequency of courting events	count	NA	table2	hued_2011_table2	NA	NA	NA	9	30.0000000	28.0000000	NA	NA	not reported	study does not seem to report sample size	sample size is not provided	NA	NA	NA	9	19.0000000	9.8000000	NA	NA	not reported	study does not seem to report sample size	sample size is not provided	NA	NA	NA	NA
NA	NA	SN	KM	Exposure to a commercial glyphosate formulation (Roundup<ae>) alters normal gill and liver histology and affects male sexual activity of Jenynsia multidentata (Anablepidae, Cyprinodontiformes).	10.1007/s00244-011-9686-7	https://link.springer.com/article/10.1007/s00244-011-9686-7#article-info	Archives of Environmental Contamination and Toxicology	hued_2011	hued_2011_exp_001	hued_2011_exp2_001	hued_2011_exp_001_assay_005	hued_2011_exp2_001_assay_003	killifish	Jenynsia multidentata	wild collected	wild	male	roundup	commercial	38641-94-0	https://commonchemistry.cas.org/detail?cas_rn=38641-94-0&search=ROUNDUP	organophosphate	0.5	mg/L	7	days	not reported	NA	21	celsius	sexual activity	courtship	number of copulations	frequency of courting events	count	NA	table2	hued_2011_table2	NA	NA	NA	9	3.3100000	1.5000000	NA	NA	not reported	study does not seem to report sample size	sample size is not provided	NA	NA	NA	9	1.4000000	0.8900000	NA	NA	not reported	study does not seem to report sample size	sample size is not provided	NA	NA	NA	NA
NA	NA	SN	KM	Exposure to a commercial glyphosate formulation (Roundup<ae>) alters normal gill and liver histology and affects male sexual activity of Jenynsia multidentata (Anablepidae, Cyprinodontiformes).	10.1007/s00244-011-9686-7	https://link.springer.com/article/10.1007/s00244-011-9686-7#article-info	Archives of Environmental Contamination and Toxicology	hued_2011	hued_2011_exp_001	hued_2011_exp2_002	hued_2011_exp_001_assay_006	hued_2011_exp2_002_assay_003	killifish	Jenynsia multidentata	wild collected	wild	male	roundup	commercial	38641-94-0	https://commonchemistry.cas.org/detail?cas_rn=38641-94-0&search=ROUNDUP	organophosphate	0.5	mg/L	28	days	not reported	NA	21	celsius	sexual activity	courtship	number of copulations	frequency of courting events	count	NA	table2	hued_2011_table2	NA	NA	NA	9	3.3100000	1.5000000	NA	NA	not reported	study does not seem to report sample size	sample size is not provided	NA	NA	NA	9	1.3000000	0.8100000	NA	NA	not reported	study does not seem to report sample size	sample size is not provided	NA	NA	NA	NA
NA	NA	SN	KM	Exposure to a commercial glyphosate formulation (Roundup<ae>) alters normal gill and liver histology and affects male sexual activity of Jenynsia multidentata (Anablepidae, Cyprinodontiformes).	10.1007/s00244-011-9686-7	https://link.springer.com/article/10.1007/s00244-011-9686-7#article-info	Archives of Environmental Contamination and Toxicology	hued_2011	hued_2011_exp_001	hued_2011_exp2_001	hued_2011_exp_001_assay_007	hued_2011_exp2_001_assay_004	killifish	Jenynsia multidentata	wild collected	wild	male	roundup	commercial	38641-94-0	https://commonchemistry.cas.org/detail?cas_rn=38641-94-0&search=ROUNDUP	organophosphate	0.5	mg/L	7	days	not reported	NA	21	celsius	sexual activity	courtship	mating success	frequency of courting success	count	NA	table2	hued_2011_table2	NA	NA	NA	9	0.1700000	0.0300000	NA	NA	not reported	study does not seem to report sample size	sample size is not provided	NA	NA	NA	9	0.1300000	0.0700000	NA	NA	not reported	study does not seem to report sample size	sample size is not provided	NA	NA	NA	NA
NA	NA	SN	KM	Exposure to a commercial glyphosate formulation (Roundup<ae>) alters normal gill and liver histology and affects male sexual activity of Jenynsia multidentata (Anablepidae, Cyprinodontiformes).	10.1007/s00244-011-9686-7	https://link.springer.com/article/10.1007/s00244-011-9686-7#article-info	Archives of Environmental Contamination and Toxicology	hued_2011	hued_2011_exp_001	hued_2011_exp2_002	hued_2011_exp_001_assay_008	hued_2011_exp2_002_assay_004	killifish	Jenynsia multidentata	wild collected	wild	male	roundup	commercial	38641-94-0	https://commonchemistry.cas.org/detail?cas_rn=38641-94-0&search=ROUNDUP	organophosphate	0.5	mg/L	28	days	not reported	NA	21	celsius	sexual activity	courtship	mating success	frequency of courting success	count	NA	table2	hued_2011_table2	NA	NA	NA	9	0.1700000	0.0300000	NA	NA	not reported	study does not seem to report sample size	sample size is not provided	NA	NA	NA	9	0.1100000	0.0700000	NA	NA	not reported	study does not seem to report sample size	sample size is not provided	NA	NA	NA	NA
NA	NA	NA	KM	Waterborne Exposure of Paclobutrazol at Environmental Relevant Concentration Induce Locomotion Hyperactivity in Larvae and Anxiolytic Exploratory Behavior in Adult Zebrafish	10.3390/ijerph17134632<a0>	https://www.mdpi.com/1660-4601/17/13/4632	Environmental Research and Public Health	hussian_2020	hussian_2020_exp_001	hussian_2020_exp2_001	hussian_2020_exp_001_assay_001	hussian_2020_exp2_001_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	paclobutrazol	not reported	76738-62-0	https://commonchemistry.cas.org/detail?cas_rn=76738-62-0&search=paclobutrazol	triazole	100	ug/L	14	days	not reported	NA	26.5	celsius	aggression	aggression	mirror biting time	frequency of aggressive behaviour	count	NA	fig6a	hussian_2020_fig6a	NA	NA	NA	30	35.9972400	92.5622300	NA	NA	16.89947	study reports mean and se	exact sample size provided	NA	NA	NA	NA	18.1328600	196.3489900	NA	NA	35.84826	study reports mean and se	sample size is not provided	NA	NA	NA	NA
NA	NA	NA	KM	Waterborne Exposure of Paclobutrazol at Environmental Relevant Concentration Induce Locomotion Hyperactivity in Larvae and Anxiolytic Exploratory Behavior in Adult Zebrafish	10.3390/ijerph17134632<a0>	https://www.mdpi.com/1660-4601/17/13/4633	Environmental Research and Public Health	hussian_2020	hussian_2020_exp_002	hussian_2020_exp2_002	hussian_2020_exp_002_assay_001	hussian_2020_exp2_002_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	paclobutrazol	not reported	76738-62-0	https://commonchemistry.cas.org/detail?cas_rn=76738-62-0&search=paclobutrazol	triazole	1000	ug/L	14	days	not reported	NA	26.5	celsius	aggression	aggression	mirror biting time	frequency of aggressive behaviour	count	NA	fig6a	hussian_2020_fig6a	NA	NA	NA	30	35.9972400	92.5622300	NA	NA	16.89947	study reports mean and se	exact sample size provided	NA	NA	NA	NA	16.0956800	96.7800100	NA	NA	17.66953	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Waterborne Exposure of Paclobutrazol at Environmental Relevant Concentration Induce Locomotion Hyperactivity in Larvae and Anxiolytic Exploratory Behavior in Adult Zebrafish	10.3390/ijerph17134632<a0>	https://www.mdpi.com/1660-4601/17/13/4634	Environmental Research and Public Health	hussian_2020	hussian_2020_exp_001	hussian_2020_exp2_001	hussian_2020_exp_001_assay_002	hussian_2020_exp2_001_assay2_002	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	paclobutrazol	not reported	76738-62-0	https://commonchemistry.cas.org/detail?cas_rn=76738-62-0&search=paclobutrazol	triazole	100	ug/L	14	days	not reported	NA	26.5	celsius	aggression	aggression	duration of stay on mirror side	time spent in aggression zone	zone	NA	fig6f	hussian_2020_fig6f	NA	NA	NA	30	7.6879031	54.6897674	NA	NA	9.984939759	study reports mean and se	exact sample size provided	NA	NA	NA	NA	1.4853408	64.7258484	NA	NA	11.81726908	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Waterborne Exposure of Paclobutrazol at Environmental Relevant Concentration Induce Locomotion Hyperactivity in Larvae and Anxiolytic Exploratory Behavior in Adult Zebrafish	10.3390/ijerph17134632<a0>	https://www.mdpi.com/1660-4601/17/13/4635	Environmental Research and Public Health	hussian_2020	hussian_2020_exp_002	hussian_2020_exp2_002	hussian_2020_exp_002_assay_002	hussian_2020_exp2_002_assay2_002	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	paclobutrazol	not reported	76738-62-0	https://commonchemistry.cas.org/detail?cas_rn=76738-62-0&search=paclobutrazol	triazole	1000	ug/L	14	days	not reported	NA	26.5	celsius	aggression	aggression	duration of stay on mirror side	time spent in aggression zone	zone	NA	fig6f	hussian_2020_fig6f	NA	NA	NA	30	7.6879031	54.6897674	NA	NA	9.984939759	study reports mean and se	exact sample size provided	NA	NA	NA	NA	1.4488098	28.3897360	NA	NA	5.183232932	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Waterborne Exposure of Paclobutrazol at Environmental Relevant Concentration Induce Locomotion Hyperactivity in Larvae and Anxiolytic Exploratory Behavior in Adult Zebrafish	10.3390/ijerph17134632<a0>	https://www.mdpi.com/1660-4601/17/13/4635	Environmental Research and Public Health	hussian_2020	hussian_2020_exp_001	hussian_2020_exp2_003	hussian_2020_exp_001_assay_003	hussian_2020_exp2_003_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	paclobutrazol	not reported	76738-62-0	https://commonchemistry.cas.org/detail?cas_rn=76738-62-0&search=paclobutrazol	triazole	100	ug/L	14	days	not reported	NA	26.5	celsius	social interaction	sociality	interaction time percentage	time spent in social zone	zone	NA	fig8a	hussian_2020_fig8a	NA	NA	NA	30	81.5410522	61.7080349	NA	NA	11.26629423	study reports mean and se	exact sample size provided	NA	NA	NA	30	69.9260687	90.4902433	NA	NA	16.5211825	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Waterborne Exposure of Paclobutrazol at Environmental Relevant Concentration Induce Locomotion Hyperactivity in Larvae and Anxiolytic Exploratory Behavior in Adult Zebrafish	10.3390/ijerph17134632<a0>	https://www.mdpi.com/1660-4601/17/13/4635	Environmental Research and Public Health	hussian_2020	hussian_2020_exp_002	hussian_2020_exp2_004	hussian_2020_exp_002_assay_003	hussian_2020_exp2_004_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	paclobutrazol	not reported	76738-62-0	https://commonchemistry.cas.org/detail?cas_rn=76738-62-0&search=paclobutrazol	triazole	1000	ug/L	14	days	not reported	NA	26.5	celsius	social interaction	sociality	interaction time percentage	time spent in social zone	zone	NA	fig8a	hussian_2020_fig8a	NA	NA	NA	30	81.5410522	61.7080349	NA	NA	11.26629423	study reports mean and se	exact sample size provided	NA	NA	NA	30	60.9047814	188.3561267	NA	NA	34.38896648	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Waterborne Exposure of Paclobutrazol at Environmental Relevant Concentration Induce Locomotion Hyperactivity in Larvae and Anxiolytic Exploratory Behavior in Adult Zebrafish	10.3390/ijerph17134632<a0>	https://www.mdpi.com/1660-4601/17/13/4635	Environmental Research and Public Health	hussian_2020	hussian_2020_exp_001	hussian_2020_exp2_003	hussian_2020_exp_001_assay_004	hussian_2020_exp2_003_assay2_002	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	paclobutrazol	not reported	76738-62-0	https://commonchemistry.cas.org/detail?cas_rn=76738-62-0&search=paclobutrazol	triazole	100	ug/L	14	days	not reported	NA	26.5	celsius	social interaction	sociality	longest duration of stay in seperator side	time spent in social zone	zone	NA	fig8b	hussian_2020_fig8b	NA	NA	NA	30	13.1883201	100.5626276	NA	NA	18.36013986	study reports mean and se	exact sample size provided	NA	NA	NA	30	12.2685210	103.4161472	NA	NA	18.88111888	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Waterborne Exposure of Paclobutrazol at Environmental Relevant Concentration Induce Locomotion Hyperactivity in Larvae and Anxiolytic Exploratory Behavior in Adult Zebrafish	10.3390/ijerph17134632<a0>	https://www.mdpi.com/1660-4601/17/13/4635	Environmental Research and Public Health	hussian_2020	hussian_2020_exp_002	hussian_2020_exp2_004	hussian_2020_exp_002_assay_004	hussian_2020_exp2_004_assay2_002	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	paclobutrazol	not reported	76738-62-0	https://commonchemistry.cas.org/detail?cas_rn=76738-62-0&search=paclobutrazol	triazole	1000	ug/L	14	days	not reported	NA	26.5	celsius	social interaction	sociality	longest duration of stay in seperator side	time spent in social zone	zone	NA	fig8b	hussian_2020_fig8b	NA	NA	NA	30	13.1883201	100.5626276	NA	NA	18.36013986	study reports mean and se	exact sample size provided	NA	NA	NA	30	8.9571015	69.3526558	NA	NA	12.66200466	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Waterborne Exposure of Paclobutrazol at Environmental Relevant Concentration Induce Locomotion Hyperactivity in Larvae and Anxiolytic Exploratory Behavior in Adult Zebrafish	10.3390/ijerph17134632<a0>	https://www.mdpi.com/1660-4601/17/13/4635	Environmental Research and Public Health	hussian_2020	hussian_2020_exp_001	hussian_2020_exp2_003	hussian_2020_exp_001_assay_006	hussian_2020_exp2_003_assay2_003	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	paclobutrazol	not reported	76738-62-0	https://commonchemistry.cas.org/detail?cas_rn=76738-62-0&search=paclobutrazol	triazole	100	ug/L	14	days	not reported	NA	26.5	celsius	social interaction	sociality	average distance to seperator	distance from social zone	zone	change	fig8c	hussian_2020_fig8c	NA	NA	NA	30	2.2370159	8.1965795	NA	NA	1.496483826	study reports mean and se	exact sample size provided	NA	NA	NA	30	3.2841125	8.7789680	NA	NA	1.60281294	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Waterborne Exposure of Paclobutrazol at Environmental Relevant Concentration Induce Locomotion Hyperactivity in Larvae and Anxiolytic Exploratory Behavior in Adult Zebrafish	10.3390/ijerph17134632<a0>	https://www.mdpi.com/1660-4601/17/13/4635	Environmental Research and Public Health	hussian_2020	hussian_2020_exp_002	hussian_2020_exp2_004	hussian_2020_exp_002_assay_006	hussian_2020_exp2_004_assay2_003	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	paclobutrazol	not reported	76738-62-0	https://commonchemistry.cas.org/detail?cas_rn=76738-62-0&search=paclobutrazol	triazole	1000	ug/L	14	days	not reported	NA	26.5	celsius	social interaction	sociality	average distance to seperator	distance from social zone	zone	change	fig8c	hussian_2020_fig8c	NA	NA	NA	30	2.2370159	8.1965795	NA	NA	1.496483826	study reports mean and se	exact sample size provided	NA	NA	NA	30	3.6411234	5.5326911	NA	NA	1.010126582	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Waterborne Exposure of Paclobutrazol at Environmental Relevant Concentration Induce Locomotion Hyperactivity in Larvae and Anxiolytic Exploratory Behavior in Adult Zebrafish	10.3390/ijerph17134632<a0>	https://www.mdpi.com/1660-4601/17/13/4635	Environmental Research and Public Health	hussian_2020	hussian_2020_exp_001	hussian_2020_exp2_003	hussian_2020_exp_001_assay_007	hussian_2020_exp2_003_assay2_004	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	paclobutrazol	not reported	76738-62-0	https://commonchemistry.cas.org/detail?cas_rn=76738-62-0&search=paclobutrazol	triazole	100	ug/L	14	days	not reported	NA	26.5	celsius	shoaling	collective behaviour	average speed	group movement	NA	NA	fig9a	hussian_2020_fig9a	15.000000	10.000000	30	30	4.2971430	5.1144954	2.9528553	5.1144954	0.933774834	study reports mean and se	exact sample size provided	15.000000	10.000000	30	30	2.7982062	4.6908266	2.7082500	4.6908266	0.856423841	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Waterborne Exposure of Paclobutrazol at Environmental Relevant Concentration Induce Locomotion Hyperactivity in Larvae and Anxiolytic Exploratory Behavior in Adult Zebrafish	10.3390/ijerph17134632<a0>	https://www.mdpi.com/1660-4601/17/13/4635	Environmental Research and Public Health	hussian_2020	hussian_2020_exp_002	hussian_2020_exp2_004	hussian_2020_exp_002_assay_007	hussian_2020_exp2_004_assay2_004	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	paclobutrazol	not reported	76738-62-0	https://commonchemistry.cas.org/detail?cas_rn=76738-62-0&search=paclobutrazol	triazole	1000	ug/L	14	days	not reported	NA	26.5	celsius	shoaling	collective behaviour	average speed	group movement	NA	NA	fig9a	hussian_2020_fig9a	15.000000	10.000000	30	30	4.2971430	5.1144954	2.9528553	5.1144954	0.933774834	study reports mean and se	exact sample size provided	15.000000	10.000000	30	30	2.8712296	2.4908681	1.4381034	2.4908681	0.454768212	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Waterborne Exposure of Paclobutrazol at Environmental Relevant Concentration Induce Locomotion Hyperactivity in Larvae and Anxiolytic Exploratory Behavior in Adult Zebrafish	10.3390/ijerph17134632<a0>	https://www.mdpi.com/1660-4601/17/13/4635	Environmental Research and Public Health	hussian_2020	hussian_2020_exp_001	hussian_2020_exp2_005	hussian_2020_exp_001_assay_008	hussian_2020_exp2_005_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	paclobutrazol	not reported	76738-62-0	https://commonchemistry.cas.org/detail?cas_rn=76738-62-0&search=paclobutrazol	triazole	100	ug/L	14	days	not reported	NA	26.5	celsius	shoaling	collective behaviour	time in top	group movement	NA	NA	fig9b	hussian_2020_fig9b	15.000000	10.000000	30	30	33.5594914	62.1723871	35.8952444	62.1723871	11.35107296	study reports mean and se	exact sample size provided	15.000000	10.000000	30	30	7.0652319	93.0282081	53.7098610	93.0282081	16.98454936	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Waterborne Exposure of Paclobutrazol at Environmental Relevant Concentration Induce Locomotion Hyperactivity in Larvae and Anxiolytic Exploratory Behavior in Adult Zebrafish	10.3390/ijerph17134632<a0>	https://www.mdpi.com/1660-4601/17/13/4635	Environmental Research and Public Health	hussian_2020	hussian_2020_exp_002	hussian_2020_exp2_006	hussian_2020_exp_002_assay_008	hussian_2020_exp2_006_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	paclobutrazol	not reported	76738-62-0	https://commonchemistry.cas.org/detail?cas_rn=76738-62-0&search=paclobutrazol	triazole	1000	ug/L	14	days	not reported	NA	26.5	celsius	shoaling	collective behaviour	time in top	group movement	NA	NA	fig9b	hussian_2020_fig9b	15.000000	10.000000	30	30	33.5594914	62.1723871	35.8952444	62.1723871	11.35107296	study reports mean and se	exact sample size provided	15.000000	10.000000	30	30	26.2600044	91.1711231	52.6376724	91.1711231	16.64549356	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Waterborne Exposure of Paclobutrazol at Environmental Relevant Concentration Induce Locomotion Hyperactivity in Larvae and Anxiolytic Exploratory Behavior in Adult Zebrafish	10.3390/ijerph17134632<a0>	https://www.mdpi.com/1660-4601/17/13/4635	Environmental Research and Public Health	hussian_2020	hussian_2020_exp_001	hussian_2020_exp2_005	hussian_2020_exp_001_assay_009	hussian_2020_exp2_005_assay2_002	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	paclobutrazol	not reported	76738-62-0	https://commonchemistry.cas.org/detail?cas_rn=76738-62-0&search=paclobutrazol	triazole	100	ug/L	14	days	not reported	NA	26.5	celsius	shoaling	collective behaviour	distance between individuals	group arrangment	NA	change	fig9c	hussian_2020_fig9c	15.000000	10.000000	30	30	4.8245342	4.5187111	2.6088791	4.5187111	0.825	study reports mean and se	exact sample size provided	15.000000	10.000000	30	30	4.9235806	3.5976724	2.0771171	3.5976724	0.656842105	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Waterborne Exposure of Paclobutrazol at Environmental Relevant Concentration Induce Locomotion Hyperactivity in Larvae and Anxiolytic Exploratory Behavior in Adult Zebrafish	10.3390/ijerph17134632<a0>	https://www.mdpi.com/1660-4601/17/13/4635	Environmental Research and Public Health	hussian_2020	hussian_2020_exp_002	hussian_2020_exp2_006	hussian_2020_exp_002_assay_009	hussian_2020_exp2_006_assay2_002	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	paclobutrazol	not reported	76738-62-0	https://commonchemistry.cas.org/detail?cas_rn=76738-62-0&search=paclobutrazol	triazole	1000	ug/L	14	days	not reported	NA	26.5	celsius	shoaling	collective behaviour	distance between individuals	group arrangment	NA	change	fig9c	hussian_2020_fig9c	15.000000	10.000000	30	30	4.8245342	4.5187111	2.6088791	4.5187111	0.825	study reports mean and se	exact sample size provided	15.000000	10.000000	30	30	4.6594483	5.1745368	2.9875202	5.1745368	0.944736842	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Waterborne Exposure of Paclobutrazol at Environmental Relevant Concentration Induce Locomotion Hyperactivity in Larvae and Anxiolytic Exploratory Behavior in Adult Zebrafish	10.3390/ijerph17134632<a0>	https://www.mdpi.com/1660-4601/17/13/4635	Environmental Research and Public Health	hussian_2020	hussian_2020_exp_001	hussian_2020_exp2_005	hussian_2020_exp_001_assay_010	hussian_2020_exp2_005_assay2_003	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	paclobutrazol	not reported	76738-62-0	https://commonchemistry.cas.org/detail?cas_rn=76738-62-0&search=paclobutrazol	triazole	100	ug/L	14	days	not reported	NA	26.5	celsius	shoaling	collective behaviour	average shoal area	group arrangment	NA	change	fig9d	hussian_2020_fig9d	15.000000	10.000000	30	30	4.1354624	4.5613382	2.6334898	4.5613382	0.832782609	study reports mean and se	exact sample size provided	15.000000	10.000000	30	30	4.5206079	1.1537895	0.6661407	1.1537895	0.210652174	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Waterborne Exposure of Paclobutrazol at Environmental Relevant Concentration Induce Locomotion Hyperactivity in Larvae and Anxiolytic Exploratory Behavior in Adult Zebrafish	10.3390/ijerph17134632<a0>	https://www.mdpi.com/1660-4601/17/13/4635	Environmental Research and Public Health	hussian_2020	hussian_2020_exp_002	hussian_2020_exp2_006	hussian_2020_exp_002_assay_010	hussian_2020_exp2_006_assay2_003	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	paclobutrazol	not reported	76738-62-0	https://commonchemistry.cas.org/detail?cas_rn=76738-62-0&search=paclobutrazol	triazole	1000	ug/L	14	days	not reported	NA	26.5	celsius	shoaling	collective behaviour	average shoal area	group arrangment	NA	change	fig9d	hussian_2020_fig9d	15.000000	10.000000	30	30	4.1354624	4.5613382	2.6334898	4.5613382	0.832782609	study reports mean and se	exact sample size provided	15.000000	10.000000	30	30	4.6947100	1.7086562	0.9864931	1.7086562	0.311956522	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Waterborne Exposure of Paclobutrazol at Environmental Relevant Concentration Induce Locomotion Hyperactivity in Larvae and Anxiolytic Exploratory Behavior in Adult Zebrafish	10.3390/ijerph17134632<a0>	https://www.mdpi.com/1660-4601/17/13/4635	Environmental Research and Public Health	hussian_2020	hussian_2020_exp_001	hussian_2020_exp2_005	hussian_2020_exp_001_assay_011	hussian_2020_exp2_005_assay2_004	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	paclobutrazol	not reported	76738-62-0	https://commonchemistry.cas.org/detail?cas_rn=76738-62-0&search=paclobutrazol	triazole	100	ug/L	14	days	not reported	NA	26.5	celsius	shoaling	collective behaviour	average nearest neighbor distance	group arrangment	NA	change	fig9e	hussian_2020_fig9e	15.000000	10.000000	30	30	3.0067802	4.0631055	2.3458351	4.0631055	0.741818182	study reports mean and se	exact sample size provided	15.000000	10.000000	30	30	3.2103035	2.7722823	1.6005779	2.7722823	0.506147186	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Waterborne Exposure of Paclobutrazol at Environmental Relevant Concentration Induce Locomotion Hyperactivity in Larvae and Anxiolytic Exploratory Behavior in Adult Zebrafish	10.3390/ijerph17134632<a0>	https://www.mdpi.com/1660-4601/17/13/4635	Environmental Research and Public Health	hussian_2020	hussian_2020_exp_002	hussian_2020_exp2_006	hussian_2020_exp_002_assay_011	hussian_2020_exp2_006_assay2_004	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	paclobutrazol	not reported	76738-62-0	https://commonchemistry.cas.org/detail?cas_rn=76738-62-0&search=paclobutrazol	triazole	1000	ug/L	14	days	not reported	NA	26.5	celsius	shoaling	collective behaviour	average nearest neighbor distance	group arrangment	NA	change	fig9e	hussian_2020_fig9e	15.000000	10.000000	30	30	3.0067802	4.0631055	2.3458351	4.0631055	0.741818182	study reports mean and se	exact sample size provided	15.000000	10.000000	30	30	3.0050537	4.0687961	2.3491205	4.0687961	0.742857143	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Waterborne Exposure of Paclobutrazol at Environmental Relevant Concentration Induce Locomotion Hyperactivity in Larvae and Anxiolytic Exploratory Behavior in Adult Zebrafish	10.3390/ijerph17134632<a0>	https://www.mdpi.com/1660-4601/17/13/4635	Environmental Research and Public Health	hussian_2020	hussian_2020_exp_001	hussian_2020_exp2_005	hussian_2020_exp_001_assay_012	hussian_2020_exp2_005_assay2_005	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	paclobutrazol	not reported	76738-62-0	https://commonchemistry.cas.org/detail?cas_rn=76738-62-0&search=paclobutrazol	triazole	100	ug/L	14	days	not reported	NA	26.5	celsius	shoaling	collective behaviour	average farthest neighbor distance	group arrangment	NA	change	fig9f	hussian_2020_fig9f	15.000000	10.000000	30	30	5.0477878	6.2732733	3.6218760	6.2732733	1.145337763	study reports mean and se	exact sample size provided	15.000000	10.000000	30	30	3.8698030	3.1553187	1.8217241	3.1553187	0.576079734	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Waterborne Exposure of Paclobutrazol at Environmental Relevant Concentration Induce Locomotion Hyperactivity in Larvae and Anxiolytic Exploratory Behavior in Adult Zebrafish	10.3390/ijerph17134632<a0>	https://www.mdpi.com/1660-4601/17/13/4635	Environmental Research and Public Health	hussian_2020	hussian_2020_exp_002	hussian_2020_exp2_006	hussian_2020_exp_002_assay_012	hussian_2020_exp2_006_assay2_005	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	paclobutrazol	not reported	76738-62-0	https://commonchemistry.cas.org/detail?cas_rn=76738-62-0&search=paclobutrazol	triazole	1000	ug/L	14	days	not reported	NA	26.5	celsius	shoaling	collective behaviour	average farthest neighbor distance	group arrangment	NA	change	fig9f	hussian_2020_fig9f	15.000000	10.000000	30	30	5.0477878	6.2732733	3.6218760	6.2732733	1.145337763	study reports mean and se	exact sample size provided	15.000000	10.000000	30	30	4.6385098	6.0769909	3.5085523	6.0769909	1.109501661	study reports mean and se	exact sample size provided	NA	NA	NA	NA
does not report error type, so used a conservative estimate using SE	NA	NA	KM	Acute mancozeb-fungicide exposure induces neuro-ethology disruption, health disorders, and immune-oxidative dysfunction in Nile tilapia (Oreochromis niloticus)	10.1016/j.aquatox.2023.106630	https://www.sciencedirect.com/science/article/pii/S0166445X23002333?via%3Dihub	Acute mancozeb-fungicide exposure induces neuro-ethology disruption, health disorders, and immune-oxidative dysfunction in Nile tilapia (Oreochromis niloticus)	ibrahim_2023	ibrahim_2023_exp_001	ibrahim_2023_exp2_001	ibrahim_2023_exp_001_assay_001	ibrahim_2023_exp2_001_assay2_001	Nile tilapia	Oreochromis niloticus	commercial supplier	not_wild	not reported	mancozeb	analytical	NA	NA	dithiocarbamate	4	mg/L	96	hours	not reported	NA	23	celsius	aggression	aggression	number of chases	frequency of aggressive behaviour	count	NA	table1	ibrahim_2023_table1	NA	NA	NA	10	-0.2000000	0.0316228	NA	NA	0.01	study does not state error type used, so we assumed to be SE	exact sample size provided	NA	NA	NA	10	1.2000000	0.4110961	NA	NA	0.13	study does not state error type used, so we assumed to be SE	exact sample size provided	NA	NA	NA	NA
does not report error type, so used a conservative estimate using SE	NA	NA	KM	Acute mancozeb-fungicide exposure induces neuro-ethology disruption, health disorders, and immune-oxidative dysfunction in Nile tilapia (Oreochromis niloticus)	10.1016/j.aquatox.2023.106630	https://www.sciencedirect.com/science/article/pii/S0166445X23002333?via%3Dihub	Acute mancozeb-fungicide exposure induces neuro-ethology disruption, health disorders, and immune-oxidative dysfunction in Nile tilapia (Oreochromis niloticus)	ibrahim_2023	ibrahim_2023_exp_002	ibrahim_2023_exp2_002	ibrahim_2023_exp_001_assay_002	ibrahim_2023_exp2_002_assay2_001	Nile tilapia	Oreochromis niloticus	commercial supplier	not_wild	not reported	mancozeb	analytical	NA	NA	dithiocarbamate	8	mg/L	96	hours	not reported	NA	23	celsius	aggression	aggression	number of chases	frequency of aggressive behaviour	count	NA	table1	ibrahim_2023_table1	NA	NA	NA	10	-0.2000000	0.0316228	NA	NA	0.01	study does not state error type used, so we assumed to be SE	exact sample size provided	NA	NA	NA	10	1.6000000	0.2846050	NA	NA	0.09	study does not state error type used, so we assumed to be SE	exact sample size provided	NA	NA	NA	NA
does not report error type, so used a conservative estimate using SE	NA	NA	KM	Acute mancozeb-fungicide exposure induces neuro-ethology disruption, health disorders, and immune-oxidative dysfunction in Nile tilapia (Oreochromis niloticus)	10.1016/j.aquatox.2023.106630	https://www.sciencedirect.com/science/article/pii/S0166445X23002333?via%3Dihub	Acute mancozeb-fungicide exposure induces neuro-ethology disruption, health disorders, and immune-oxidative dysfunction in Nile tilapia (Oreochromis niloticus)	ibrahim_2023	ibrahim_2023_exp_003	ibrahim_2023_exp2_003	ibrahim_2023_exp_001_assay_003	ibrahim_2023_exp2_003_assay2_001	Nile tilapia	Oreochromis niloticus	commercial supplier	not_wild	not reported	mancozeb	analytical	NA	NA	dithiocarbamate	12	mg/L	96	hours	not reported	NA	23	celsius	aggression	aggression	number of chases	frequency of aggressive behaviour	count	NA	table1	ibrahim_2023_table1	NA	NA	NA	10	-0.2000000	0.0316228	NA	NA	0.01	study does not state error type used, so we assumed to be SE	exact sample size provided	NA	NA	NA	10	1.9000000	0.2213594	NA	NA	0.07	study does not state error type used, so we assumed to be SE	exact sample size provided	NA	NA	NA	NA
does not report error type, so used a conservative estimate using SE	NA	NA	KM	Acute mancozeb-fungicide exposure induces neuro-ethology disruption, health disorders, and immune-oxidative dysfunction in Nile tilapia (Oreochromis niloticus)	10.1016/j.aquatox.2023.106630	https://www.sciencedirect.com/science/article/pii/S0166445X23002333?via%3Dihub	Acute mancozeb-fungicide exposure induces neuro-ethology disruption, health disorders, and immune-oxidative dysfunction in Nile tilapia (Oreochromis niloticus)	ibrahim_2023	ibrahim_2023_exp_004	ibrahim_2023_exp2_004	ibrahim_2023_exp_001_assay_004	ibrahim_2023_exp2_004_assay2_001	Nile tilapia	Oreochromis niloticus	commercial supplier	not_wild	not reported	mancozeb	analytical	NA	NA	dithiocarbamate	16	mg/L	96	hours	not reported	NA	23	celsius	aggression	aggression	number of chases	frequency of aggressive behaviour	count	NA	table1	ibrahim_2023_table1	NA	NA	NA	10	-0.2000000	0.0316228	NA	NA	0.01	study does not state error type used, so we assumed to be SE	exact sample size provided	NA	NA	NA	10	1.9600000	0.3478505	NA	NA	0.11	study does not state error type used, so we assumed to be SE	exact sample size provided	NA	NA	NA	NA
does not report error type, so used a conservative estimate using SE	NA	NA	KM	Acute mancozeb-fungicide exposure induces neuro-ethology disruption, health disorders, and immune-oxidative dysfunction in Nile tilapia (Oreochromis niloticus)	10.1016/j.aquatox.2023.106630	https://www.sciencedirect.com/science/article/pii/S0166445X23002333?via%3Dihub	Acute mancozeb-fungicide exposure induces neuro-ethology disruption, health disorders, and immune-oxidative dysfunction in Nile tilapia (Oreochromis niloticus)	ibrahim_2023	ibrahim_2023_exp_005	ibrahim_2023_exp2_005	ibrahim_2023_exp_001_assay_005	ibrahim_2023_exp2_005_assay2_001	Nile tilapia	Oreochromis niloticus	commercial supplier	not_wild	not reported	mancozeb	analytical	NA	NA	dithiocarbamate	20	mg/L	96	hours	not reported	NA	23	celsius	aggression	aggression	number of chases	frequency of aggressive behaviour	count	NA	table1	ibrahim_2023_table1	NA	NA	NA	10	-0.2000000	0.0316228	NA	NA	0.01	study does not state error type used, so we assumed to be SE	exact sample size provided	NA	NA	NA	10	2.1100000	0.4743416	NA	NA	0.15	study does not state error type used, so we assumed to be SE	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	The Possible Role of<a0>Bifidobacterium longum<a0>BB536 and<a0>Lactobacillus rhamnosus<a0>HN001 on Locomotor Activity and Oxidative Stress in a Rotenone-Induced Zebrafish Model of Parkinson’s Disease	10.1155/2021/9629102	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531778/	Oxidative Medicine and Cellular Longevity	ilie_2021	ilie_2021_exp_001	ilie_2021_exp2_001	ilie_2021_exp_001_assay_001	ilie_2021_exp2_001_assay2_001	zebrafish	Danio rerio	commercial supplier	not_wild	not reported	rotenone	commercial	83-79-4	https://commonchemistry.cas.org/detail?cas_rn=83-79-4&search=rotenone	rotenones	2	ug/L	1	days	none	none	26	celsius	social interaction	sociality	time spent in the left arm	time spent in social zone	zone	NA	fig5	ilie_2021_fig5	NA	NA	NA	15	140.5891426	112.8291361	NA	NA	29.13235767	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	15	102.8164520	66.1634655	NA	NA	17.08333333	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	NA
NA	NA	NA	KM	The Possible Role of<a0>Bifidobacterium longum<a0>BB536 and<a0>Lactobacillus rhamnosus<a0>HN001 on Locomotor Activity and Oxidative Stress in a Rotenone-Induced Zebrafish Model of Parkinson’s Disease	10.1155/2021/9629102	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531778/	Oxidative Medicine and Cellular Longevity	ilie_2021	ilie_2021_exp_001	ilie_2021_exp2_001	ilie_2021_exp_001_assay_002	ilie_2021_exp2_001_assay2_002	zebrafish	Danio rerio	commercial supplier	not_wild	not reported	rotenone	commercial	83-79-4	https://commonchemistry.cas.org/detail?cas_rn=83-79-4&search=rotenone	rotenones	2	ug/L	2	days	none	none	26	celsius	social interaction	sociality	time spent in the left arm	time spent in social zone	zone	NA	fig5	ilie_2021_fig5	NA	NA	NA	15	127.9395662	132.1288567	NA	NA	34.11552412	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	15	145.3694823	85.4110191	NA	NA	22.0530303	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	NA
NA	NA	NA	KM	The Possible Role of<a0>Bifidobacterium longum<a0>BB536 and<a0>Lactobacillus rhamnosus<a0>HN001 on Locomotor Activity and Oxidative Stress in a Rotenone-Induced Zebrafish Model of Parkinson’s Disease	10.1155/2021/9629102	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531778/	Oxidative Medicine and Cellular Longevity	ilie_2021	ilie_2021_exp_001	ilie_2021_exp2_001	ilie_2021_exp_001_assay_003	ilie_2021_exp2_001_assay2_003	zebrafish	Danio rerio	commercial supplier	not_wild	not reported	rotenone	commercial	83-79-4	https://commonchemistry.cas.org/detail?cas_rn=83-79-4&search=rotenone	rotenones	2	ug/L	3	days	none	none	26	celsius	social interaction	sociality	time spent in the left arm	time spent in social zone	zone	NA	fig5	ilie_2021_fig5	NA	NA	NA	15	128.7062072	102.4369788	NA	NA	26.4491142	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	15	133.2558459	97.4407401	NA	NA	25.15909091	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	NA
NA	NA	NA	KM	The Possible Role of<a0>Bifidobacterium longum<a0>BB536 and<a0>Lactobacillus rhamnosus<a0>HN001 on Locomotor Activity and Oxidative Stress in a Rotenone-Induced Zebrafish Model of Parkinson’s Disease	10.1155/2021/9629102	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531778/	Oxidative Medicine and Cellular Longevity	ilie_2021	ilie_2021_exp_001	ilie_2021_exp2_001	ilie_2021_exp_001_assay_004	ilie_2021_exp2_001_assay2_004	zebrafish	Danio rerio	commercial supplier	not_wild	not reported	rotenone	commercial	83-79-4	https://commonchemistry.cas.org/detail?cas_rn=83-79-4&search=rotenone	rotenones	2	ug/L	4	days	none	none	26	celsius	social interaction	sociality	time spent in the left arm	time spent in social zone	zone	NA	fig5	ilie_2021_fig5	NA	NA	NA	15	98.4238880	59.3837558	NA	NA	15.33281983	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	15	167.7331186	34.8861909	NA	NA	9.007575758	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	NA
NA	NA	NA	KM	The Possible Role of<a0>Bifidobacterium longum<a0>BB536 and<a0>Lactobacillus rhamnosus<a0>HN001 on Locomotor Activity and Oxidative Stress in a Rotenone-Induced Zebrafish Model of Parkinson’s Disease	10.1155/2021/9629103	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531778/	Oxidative Medicine and Cellular Longevity	ilie_2021	ilie_2021_exp_001	ilie_2021_exp2_001	ilie_2021_exp_001_assay_005	ilie_2021_exp2_001_assay2_005	zebrafish	Danio rerio	commercial supplier	not_wild	not reported	rotenone	commercial	83-79-4	https://commonchemistry.cas.org/detail?cas_rn=83-79-4&search=rotenone	rotenones	2	ug/L	5	days	none	none	26	celsius	social interaction	sociality	time spent in the left arm	time spent in social zone	zone	NA	fig5	ilie_2021_fig5	NA	NA	NA	15	154.7720009	65.3221314	NA	NA	16.86610181	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	15	136.0513004	39.6980793	NA	NA	10.25	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	NA
NA	NA	NA	KM	The Possible Role of<a0>Bifidobacterium longum<a0>BB536 and<a0>Lactobacillus rhamnosus<a0>HN001 on Locomotor Activity and Oxidative Stress in a Rotenone-Induced Zebrafish Model of Parkinson’s Disease	10.1155/2021/9629102	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531778/	Oxidative Medicine and Cellular Longevity	ilie_2021	ilie_2021_exp_001	ilie_2021_exp2_001	ilie_2021_exp_001_assay_006	ilie_2021_exp2_001_assay2_006	zebrafish	Danio rerio	commercial supplier	not_wild	not reported	rotenone	commercial	83-79-4	https://commonchemistry.cas.org/detail?cas_rn=83-79-4&search=rotenone	rotenones	2	ug/L	6	days	none	none	26	celsius	social interaction	sociality	time spent in the left arm	time spent in social zone	zone	NA	fig5	ilie_2021_fig5	NA	NA	NA	15	150.5554755	65.3221314	NA	NA	16.86610181	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	15	72.0664520	117.8912658	NA	NA	30.43939394	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	NA
NA	NA	NA	KM	The Possible Role of<a0>Bifidobacterium longum<a0>BB536 and<a0>Lactobacillus rhamnosus<a0>HN001 on Locomotor Activity and Oxidative Stress in a Rotenone-Induced Zebrafish Model of Parkinson’s Disease	10.1155/2021/9629102	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531778/	Oxidative Medicine and Cellular Longevity	ilie_2021	ilie_2021_exp_001	ilie_2021_exp2_001	ilie_2021_exp_001_assay_007	ilie_2021_exp2_001_assay2_007	zebrafish	Danio rerio	commercial supplier	not_wild	not reported	rotenone	commercial	83-79-4	https://commonchemistry.cas.org/detail?cas_rn=83-79-4&search=rotenone	rotenones	2	ug/L	7	days	none	none	26	celsius	social interaction	sociality	time spent in the left arm	time spent in social zone	zone	NA	fig5	ilie_2021_fig5	NA	NA	NA	15	153.2387189	56.4145680	NA	NA	14.56617884	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	15	153.4452398	80.5991307	NA	NA	20.81060606	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	NA
NA	NA	NA	KM	The Possible Role of<a0>Bifidobacterium longum<a0>BB536 and<a0>Lactobacillus rhamnosus<a0>HN001 on Locomotor Activity and Oxidative Stress in a Rotenone-Induced Zebrafish Model of Parkinson’s Disease	10.1155/2021/9629102	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531778/	Oxidative Medicine and Cellular Longevity	ilie_2021	ilie_2021_exp_001	ilie_2021_exp2_001	ilie_2021_exp_001_assay_008	ilie_2021_exp2_001_assay2_008	zebrafish	Danio rerio	commercial supplier	not_wild	not reported	rotenone	commercial	83-79-4	https://commonchemistry.cas.org/detail?cas_rn=83-79-4&search=rotenone	rotenones	2	ug/L	8	days	none	none	26	celsius	social interaction	sociality	time spent in the left arm	time spent in social zone	zone	NA	fig5	ilie_2021_fig5	NA	NA	NA	15	141.9599901	67.4764101	NA	NA	17.42233417	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	15	92.8770580	61.3515771	NA	NA	15.84090909	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	NA
NA	NA	NA	KM	The Possible Role of<a0>Bifidobacterium longum<a0>BB536 and<a0>Lactobacillus rhamnosus<a0>HN001 on Locomotor Activity and Oxidative Stress in a Rotenone-Induced Zebrafish Model of Parkinson’s Disease	10.1155/2021/9629102	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531778/	Oxidative Medicine and Cellular Longevity	ilie_2021	ilie_2021_exp_001	ilie_2021_exp2_001	ilie_2021_exp_001_assay_009	ilie_2021_exp2_001_assay2_009	zebrafish	Danio rerio	commercial supplier	not_wild	not reported	rotenone	commercial	83-79-4	https://commonchemistry.cas.org/detail?cas_rn=83-79-4&search=rotenone	rotenones	2	ug/L	9	days	none	none	26	celsius	social interaction	sociality	time spent in the left arm	time spent in social zone	zone	NA	fig5	ilie_2021_fig5	NA	NA	NA	15	126.2798894	79.6221639	NA	NA	20.55835432	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	15	151.8922095	141.9507078	NA	NA	36.65151515	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	NA
NA	NA	NA	KM	The Possible Role of<a0>Bifidobacterium longum<a0>BB536 and<a0>Lactobacillus rhamnosus<a0>HN001 on Locomotor Activity and Oxidative Stress in a Rotenone-Induced Zebrafish Model of Parkinson’s Disease	10.1155/2021/9629102	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531778/	Oxidative Medicine and Cellular Longevity	ilie_2021	ilie_2021_exp_001	ilie_2021_exp2_001	ilie_2021_exp_001_assay_010	ilie_2021_exp2_001_assay2_010	zebrafish	Danio rerio	commercial supplier	not_wild	not reported	rotenone	commercial	83-79-4	https://commonchemistry.cas.org/detail?cas_rn=83-79-4&search=rotenone	rotenones	2	ug/L	10	days	none	none	26	celsius	social interaction	sociality	time spent in the left arm	time spent in social zone	zone	NA	fig5	ilie_2021_fig5	NA	NA	NA	15	121.7500825	101.2146152	NA	NA	26.13350126	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	15	90.0816035	93.8318238	NA	NA	24.22727273	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	NA
NA	NA	NA	KM	The Possible Role of<a0>Bifidobacterium longum<a0>BB536 and<a0>Lactobacillus rhamnosus<a0>HN001 on Locomotor Activity and Oxidative Stress in a Rotenone-Induced Zebrafish Model of Parkinson’s Disease	10.1155/2021/9629102	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531778/	Oxidative Medicine and Cellular Longevity	ilie_2021	ilie_2021_exp_001	ilie_2021_exp2_001	ilie_2021_exp_001_assay_011	ilie_2021_exp2_001_assay2_011	zebrafish	Danio rerio	commercial supplier	not_wild	not reported	rotenone	commercial	83-79-4	https://commonchemistry.cas.org/detail?cas_rn=83-79-4&search=rotenone	rotenones	2	ug/L	11	days	none	none	26	celsius	social interaction	sociality	time spent in the left arm	time spent in social zone	zone	NA	fig5	ilie_2021_fig5	NA	NA	NA	15	157.2916442	26.9905640	NA	NA	6.968933669	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	15	135.4300883	111.8764053	NA	NA	28.88636364	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	NA
NA	NA	NA	KM	The Possible Role of<a0>Bifidobacterium longum<a0>BB536 and<a0>Lactobacillus rhamnosus<a0>HN001 on Locomotor Activity and Oxidative Stress in a Rotenone-Induced Zebrafish Model of Parkinson’s Disease	10.1155/2021/9629102	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531778/	Oxidative Medicine and Cellular Longevity	ilie_2021	ilie_2021_exp_001	ilie_2021_exp2_001	ilie_2021_exp_001_assay_012	ilie_2021_exp2_001_assay2_012	zebrafish	Danio rerio	commercial supplier	not_wild	not reported	rotenone	commercial	83-79-4	https://commonchemistry.cas.org/detail?cas_rn=83-79-4&search=rotenone	rotenones	2	ug/L	12	days	none	none	26	celsius	social interaction	sociality	time spent in the left arm	time spent in social zone	zone	NA	fig5	ilie_2021_fig5	NA	NA	NA	15	143.0053302	94.4669742	NA	NA	24.39126784	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	15	142.2634217	42.1040235	NA	NA	10.87121212	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	NA
NA	NA	NA	KM	The Possible Role of<a0>Bifidobacterium longum<a0>BB536 and<a0>Lactobacillus rhamnosus<a0>HN001 on Locomotor Activity and Oxidative Stress in a Rotenone-Induced Zebrafish Model of Parkinson’s Disease	10.1155/2021/9629102	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531778/	Oxidative Medicine and Cellular Longevity	ilie_2021	ilie_2021_exp_001	ilie_2021_exp2_001	ilie_2021_exp_001_assay_013	ilie_2021_exp2_001_assay2_013	zebrafish	Danio rerio	commercial supplier	not_wild	not reported	rotenone	commercial	83-79-4	https://commonchemistry.cas.org/detail?cas_rn=83-79-4&search=rotenone	rotenones	2	ug/L	13	days	none	none	26	celsius	social interaction	sociality	time spent in the left arm	time spent in social zone	zone	NA	fig5	ilie_2021_fig5	NA	NA	NA	15	101.8886215	66.1268819	NA	NA	17.07388749	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	15	76.4149368	111.8764053	NA	NA	28.88636364	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	NA
NA	NA	NA	KM	The Possible Role of<a0>Bifidobacterium longum<a0>BB536 and<a0>Lactobacillus rhamnosus<a0>HN001 on Locomotor Activity and Oxidative Stress in a Rotenone-Induced Zebrafish Model of Parkinson’s Disease	10.1155/2021/9629102	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531778/	Oxidative Medicine and Cellular Longevity	ilie_2021	ilie_2021_exp_001	ilie_2021_exp2_001	ilie_2021_exp_001_assay_014	ilie_2021_exp2_001_assay2_014	zebrafish	Danio rerio	commercial supplier	not_wild	not reported	rotenone	commercial	83-79-4	https://commonchemistry.cas.org/detail?cas_rn=83-79-4&search=rotenone	rotenones	2	ug/L	14	days	none	none	26	celsius	social interaction	sociality	time spent in the left arm	time spent in social zone	zone	NA	fig5	ilie_2021_fig5	NA	NA	NA	15	133.2488231	47.2334871	NA	NA	12.19563392	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	15	96.2937247	98.6437122	NA	NA	25.46969697	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	NA
NA	NA	NA	KM	The Possible Role of<a0>Bifidobacterium longum<a0>BB536 and<a0>Lactobacillus rhamnosus<a0>HN001 on Locomotor Activity and Oxidative Stress in a Rotenone-Induced Zebrafish Model of Parkinson’s Disease	10.1155/2021/9629102	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531778/	Oxidative Medicine and Cellular Longevity	ilie_2021	ilie_2021_exp_001	ilie_2021_exp2_001	ilie_2021_exp_001_assay_015	ilie_2021_exp2_001_assay2_015	zebrafish	Danio rerio	commercial supplier	not_wild	not reported	rotenone	commercial	83-79-4	https://commonchemistry.cas.org/detail?cas_rn=83-79-4&search=rotenone	rotenones	2	ug/L	15	days	none	none	26	celsius	social interaction	sociality	time spent in the left arm	time spent in social zone	zone	NA	fig5	ilie_2021_fig5	NA	NA	NA	15	103.2688888	28.7128377	NA	NA	7.413622827	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	15	133.8770580	73.3812981	NA	NA	18.9469697	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	NA
NA	NA	NA	KM	The Possible Role of<a0>Bifidobacterium longum<a0>BB536 and<a0>Lactobacillus rhamnosus<a0>HN001 on Locomotor Activity and Oxidative Stress in a Rotenone-Induced Zebrafish Model of Parkinson’s Disease	10.1155/2021/9629102	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531778/	Oxidative Medicine and Cellular Longevity	ilie_2021	ilie_2021_exp_001	ilie_2021_exp2_001	ilie_2021_exp_001_assay_016	ilie_2021_exp2_001_assay2_016	zebrafish	Danio rerio	commercial supplier	not_wild	not reported	rotenone	commercial	83-79-4	https://commonchemistry.cas.org/detail?cas_rn=83-79-4&search=rotenone	rotenones	2	ug/L	16	days	none	none	26	celsius	social interaction	sociality	time spent in the left arm	time spent in social zone	zone	NA	fig5	ilie_2021_fig5	NA	NA	NA	15	116.0367948	73.3772520	NA	NA	18.945925	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	15	86.6649368	131.1239589	NA	NA	33.85606061	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	NA
NA	NA	NA	KM	The Possible Role of<a0>Bifidobacterium longum<a0>BB536 and<a0>Lactobacillus rhamnosus<a0>HN001 on Locomotor Activity and Oxidative Stress in a Rotenone-Induced Zebrafish Model of Parkinson’s Disease	10.1155/2021/9629102	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531778/	Oxidative Medicine and Cellular Longevity	ilie_2021	ilie_2021_exp_001	ilie_2021_exp2_001	ilie_2021_exp_001_assay_017	ilie_2021_exp2_001_assay2_017	zebrafish	Danio rerio	commercial supplier	not_wild	not reported	rotenone	commercial	83-79-4	https://commonchemistry.cas.org/detail?cas_rn=83-79-4&search=rotenone	rotenones	2	ug/L	17	days	none	none	26	celsius	social interaction	sociality	time spent in the left arm	time spent in social zone	zone	NA	fig5	ilie_2021_fig5	NA	NA	NA	15	147.7506257	84.5433556	NA	NA	21.82900054	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	15	132.3240277	90.2229075	NA	NA	23.29545455	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	NA
NA	NA	NA	KM	The Possible Role of<a0>Bifidobacterium longum<a0>BB536 and<a0>Lactobacillus rhamnosus<a0>HN001 on Locomotor Activity and Oxidative Stress in a Rotenone-Induced Zebrafish Model of Parkinson’s Disease	10.1155/2021/9629102	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531778/	Oxidative Medicine and Cellular Longevity	ilie_2021	ilie_2021_exp_001	ilie_2021_exp2_001	ilie_2021_exp_001_assay_018	ilie_2021_exp2_001_assay2_018	zebrafish	Danio rerio	commercial supplier	not_wild	not reported	rotenone	commercial	83-79-4	https://commonchemistry.cas.org/detail?cas_rn=83-79-4&search=rotenone	rotenones	2	ug/L	18	days	none	none	26	celsius	social interaction	sociality	time spent in the left arm	time spent in social zone	zone	NA	fig5	ilie_2021_fig5	NA	NA	NA	15	117.2723986	79.7578826	NA	NA	20.59339674	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	15	146.3013004	90.2229075	NA	NA	23.29545455	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	NA
NA	NA	NA	KM	The Possible Role of<a0>Bifidobacterium longum<a0>BB536 and<a0>Lactobacillus rhamnosus<a0>HN001 on Locomotor Activity and Oxidative Stress in a Rotenone-Induced Zebrafish Model of Parkinson’s Disease	10.1155/2021/9629102	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531778/	Oxidative Medicine and Cellular Longevity	ilie_2021	ilie_2021_exp_001	ilie_2021_exp2_001	ilie_2021_exp_001_assay_019	ilie_2021_exp2_001_assay2_019	zebrafish	Danio rerio	commercial supplier	not_wild	not reported	rotenone	commercial	83-79-4	https://commonchemistry.cas.org/detail?cas_rn=83-79-4&search=rotenone	rotenones	2	ug/L	19	days	none	none	26	celsius	social interaction	sociality	time spent in the left arm	time spent in social zone	zone	NA	fig5	ilie_2021_fig5	NA	NA	NA	15	107.3875681	124.4222969	NA	NA	32.12569891	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	15	133.5664520	105.8615448	NA	NA	27.33333333	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	NA
NA	NA	NA	KM	The Possible Role of<a0>Bifidobacterium longum<a0>BB536 and<a0>Lactobacillus rhamnosus<a0>HN001 on Locomotor Activity and Oxidative Stress in a Rotenone-Induced Zebrafish Model of Parkinson’s Disease	10.1155/2021/9629102	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531778/	Oxidative Medicine and Cellular Longevity	ilie_2021	ilie_2021_exp_001	ilie_2021_exp2_001	ilie_2021_exp_001_assay_020	ilie_2021_exp2_001_assay2_020	zebrafish	Danio rerio	commercial supplier	not_wild	not reported	rotenone	commercial	83-79-4	https://commonchemistry.cas.org/detail?cas_rn=83-79-4&search=rotenone	rotenones	2	ug/L	20	days	none	none	26	celsius	social interaction	sociality	time spent in the left arm	time spent in social zone	zone	NA	fig5	ilie_2021_fig5	NA	NA	NA	15	100.7976812	76.5675673	NA	NA	19.76966087	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	15	171.1497853	99.8466843	NA	NA	25.78030303	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	NA
NA	NA	NA	KM	The Possible Role of<a0>Bifidobacterium longum<a0>BB536 and<a0>Lactobacillus rhamnosus<a0>HN001 on Locomotor Activity and Oxidative Stress in a Rotenone-Induced Zebrafish Model of Parkinson’s Disease	10.1155/2021/9629102	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531778/	Oxidative Medicine and Cellular Longevity	ilie_2021	ilie_2021_exp_001	ilie_2021_exp2_001	ilie_2021_exp_001_assay_021	ilie_2021_exp2_001_assay2_021	zebrafish	Danio rerio	commercial supplier	not_wild	not reported	rotenone	commercial	83-79-4	https://commonchemistry.cas.org/detail?cas_rn=83-79-4&search=rotenone	rotenones	2	ug/L	21	days	none	none	26	celsius	social interaction	sociality	time spent in the left arm	time spent in social zone	zone	NA	fig5	ilie_2021_fig5	NA	NA	NA	15	118.0961344	55.8305178	NA	NA	14.41537772	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	15	169.5967550	86.6139912	NA	NA	22.36363636	study reports mean and se	exact sample size provided (section 2.4. Design Protocol)	NA	NA	NA	NA
NA	NA	NA	KM	Assessing Anti-Social and Aggressive Behavior in a Zebrafish (Danio rerio) Model of Parkinson<92>s Disease Chronically Exposed to Rotenone	10.3390/brainsci12070898	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313068/	Brain Sciences	ilie_2022	ilie_2022_exp_001	ilie_2022_exp2_001	ilie_2022_exp_001_assay_001	ilie_2022_exp2_001_assay2_001	zebrafish	Danio rerio	commercial supplier	not_wild	not reported	rotenone	commercial	83-79-4	https://commonchemistry.cas.org/detail?cas_rn=83-79-4&search=rotenone	rotenones	2.5	ug/L	1	days	none	none	26	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig4e treatment; fig4a control	ilie_2022_fig4e_treatment; fig4a_control	NA	NA	NA	5	24.1711521	6.1675584	NA	NA	2.758215962	study reports mean and se	exact sample size provided	NA	NA	NA	5	54.3138300	18.2243696	NA	NA	8.150185874	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Assessing Anti-Social and Aggressive Behavior in a Zebrafish (Danio rerio) Model of Parkinson<92>s Disease Chronically Exposed to Rotenone	10.3390/brainsci12070898	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313068/	Brain Sciences	ilie_2022	ilie_2022_exp_001	ilie_2022_exp2_001	ilie_2022_exp_001_assay_002	ilie_2022_exp2_001_assay2_002	zebrafish	Danio rerio	commercial supplier	not_wild	not reported	rotenone	commercial	83-79-4	https://commonchemistry.cas.org/detail?cas_rn=83-79-4&search=rotenone	rotenones	2.5	ug/L	4	days	none	none	26	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig4e treatment; fig4a control	ilie_2022_fig4e_treatment; fig4a_control	NA	NA	NA	5	14.5725605	13.0752238	NA	NA	5.84741784	study reports mean and se	exact sample size provided	NA	NA	NA	5	37.1078821	47.2483657	NA	NA	21.13011152	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Assessing Anti-Social and Aggressive Behavior in a Zebrafish (Danio rerio) Model of Parkinson<92>s Disease Chronically Exposed to Rotenone	10.3390/brainsci12070898	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313068/	Brain Sciences	ilie_2022	ilie_2022_exp_001	ilie_2022_exp2_001	ilie_2022_exp_001_assay_003	ilie_2022_exp2_001_assay2_003	zebrafish	Danio rerio	commercial supplier	not_wild	not reported	rotenone	commercial	83-79-4	https://commonchemistry.cas.org/detail?cas_rn=83-79-4&search=rotenone	rotenones	2.5	ug/L	8	days	none	none	26	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig4e treatment; fig4a control	ilie_2022_fig4e_treatment; fig4a_control	NA	NA	NA	5	10.3800723	5.1807490	NA	NA	2.316901408	study reports mean and se	exact sample size provided	NA	NA	NA	5	25.9391089	11.4746031	NA	NA	5.131598513	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Assessing Anti-Social and Aggressive Behavior in a Zebrafish (Danio rerio) Model of Parkinson<92>s Disease Chronically Exposed to Rotenone	10.3390/brainsci12070898	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313068/	Brain Sciences	ilie_2022	ilie_2022_exp_001	ilie_2022_exp2_001	ilie_2022_exp_001_assay_004	ilie_2022_exp2_001_assay2_004	zebrafish	Danio rerio	commercial supplier	not_wild	not reported	rotenone	commercial	83-79-4	https://commonchemistry.cas.org/detail?cas_rn=83-79-4&search=rotenone	rotenones	2.5	ug/L	12	days	none	none	26	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig4e treatment; fig4a control	ilie_2022_fig4e_treatment; fig4a_control	NA	NA	NA	5	20.7509643	15.7889495	NA	NA	7.061032864	study reports mean and se	exact sample size provided	NA	NA	NA	5	8.1294434	11.8120914	NA	NA	5.282527881	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Assessing Anti-Social and Aggressive Behavior in a Zebrafish (Danio rerio) Model of Parkinson<92>s Disease Chronically Exposed to Rotenone	10.3390/brainsci12070898	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313068/	Brain Sciences	ilie_2022	ilie_2022_exp_001	ilie_2022_exp2_001	ilie_2022_exp_001_assay_005	ilie_2022_exp2_001_assay2_005	zebrafish	Danio rerio	commercial supplier	not_wild	not reported	rotenone	commercial	83-79-4	https://commonchemistry.cas.org/detail?cas_rn=83-79-4&search=rotenone	rotenones	2.5	ug/L	16	days	none	none	26	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig4e treatment; fig4a control	ilie_2022_fig4e_treatment; fig4a_control	NA	NA	NA	5	10.1594150	11.8417121	NA	NA	5.295774648	study reports mean and se	exact sample size provided	NA	NA	NA	5	12.5063951	13.8370214	NA	NA	6.188104089	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Assessing Anti-Social and Aggressive Behavior in a Zebrafish (Danio rerio) Model of Parkinson<92>s Disease Chronically Exposed to Rotenone	10.3390/brainsci12070898	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313068/	Brain Sciences	ilie_2022	ilie_2022_exp_001	ilie_2022_exp2_001	ilie_2022_exp_001_assay_006	ilie_2022_exp2_001_assay2_006	zebrafish	Danio rerio	commercial supplier	not_wild	not reported	rotenone	commercial	83-79-4	https://commonchemistry.cas.org/detail?cas_rn=83-79-4&search=rotenone	rotenones	2.5	ug/L	20	days	none	none	26	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig4e treatment; fig4a control	ilie_2022_fig4e_treatment; fig4a_control	NA	NA	NA	5	14.9035465	6.6609631	NA	NA	2.978873239	study reports mean and se	exact sample size provided	NA	NA	NA	5	11.4498895	14.8494864	NA	NA	6.640892193	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Assessing Anti-Social and Aggressive Behavior in a Zebrafish (Danio rerio) Model of Parkinson<92>s Disease Chronically Exposed to Rotenone	10.3390/brainsci12070898	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313068/	Brain Sciences	ilie_2022	ilie_2022_exp_001	ilie_2022_exp2_001	ilie_2022_exp_001_assay_007	ilie_2022_exp2_001_assay2_007	zebrafish	Danio rerio	commercial supplier	not_wild	not reported	rotenone	commercial	83-79-4	https://commonchemistry.cas.org/detail?cas_rn=83-79-4&search=rotenone	rotenones	2.5	ug/L	24	days	none	none	26	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig4e treatment; fig4a control	ilie_2022_fig4e_treatment; fig4a_control	NA	NA	NA	5	17.2204479	8.3878794	NA	NA	3.751173709	study reports mean and se	exact sample size provided	NA	NA	NA	5	9.7896665	8.7746965	NA	NA	3.924163569	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Assessing Anti-Social and Aggressive Behavior in a Zebrafish (Danio rerio) Model of Parkinson<92>s Disease Chronically Exposed to Rotenone	10.3390/brainsci12070898	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313068/	Brain Sciences	ilie_2022	ilie_2022_exp_001	ilie_2022_exp2_001	ilie_2022_exp_001_assay_008	ilie_2022_exp2_001_assay2_008	zebrafish	Danio rerio	commercial supplier	not_wild	not reported	rotenone	commercial	83-79-4	https://commonchemistry.cas.org/detail?cas_rn=83-79-4&search=rotenone	rotenones	2.5	ug/L	28	days	none	none	26	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig4e treatment; fig4a control	ilie_2022_fig4e_treatment; fig4a_control	NA	NA	NA	5	18.4340629	14.0620331	NA	NA	6.288732394	study reports mean and se	exact sample size provided	NA	NA	NA	5	3.7524918	3.7123716	NA	NA	1.660223048	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Assessing Anti-Social and Aggressive Behavior in a Zebrafish (Danio rerio) Model of Parkinson<92>s Disease Chronically Exposed to Rotenone	10.3390/brainsci12070898	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313068/	Brain Sciences	ilie_2022	ilie_2022_exp_001	ilie_2022_exp2_001	ilie_2022_exp_001_assay_009	ilie_2022_exp2_001_assay2_009	zebrafish	Danio rerio	commercial supplier	not_wild	not reported	rotenone	commercial	83-79-4	https://commonchemistry.cas.org/detail?cas_rn=83-79-4&search=rotenone	rotenones	2.5	ug/L	32	days	none	none	26	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig4e treatment; fig4a control	ilie_2022_fig4e_treatment; fig4a_control	NA	NA	NA	5	14.0209173	12.8285214	NA	NA	5.737089202	study reports mean and se	exact sample size provided	NA	NA	NA	5	3.6015624	3.0373949	NA	NA	1.358364312	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Effects of a pyrethroid pesticide on endocrine responses to female odours and reproductive behaviour in male parr of brown trout (Salmo trutta L.)	10.1016/j.aquatox.2006.10.011	https://www.sciencedirect.com/science/article/pii/S0166445X06003870?via%3Dihub	Aquatic Toxicology	jaensson_2007	jaensson_2007_exp_001	jaensson_2007_exp2_001	jaensson_2007_exp_001_assay_001	jaensson_2007_exp2_001_assay2_001	brown trout	Salmo trutta	wild collected	wild	male	cypermethrin	not reported	52315-07-8	https://commonchemistry.cas.org/detail?cas_rn=52315-07-8&search=cypermethrin	pyrethroid	0.1	ug/L	4	days	not reported	NA	6	celsius	courting	courtship	number of courting events per six minutes	frequency of courting events	count	NA	fig2a	jaensson_2007_fig2a	NA	NA	NA	24	5.4455962	8.3404826	NA	NA	1.702493876	study reports mean and sd	exact sample size provided	NA	NA	NA	12	8.6996395	11.9034852	NA	NA	3.436240208	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Effects of a pyrethroid pesticide on endocrine responses to female odours and reproductive behaviour in male parr of brown trout (Salmo trutta L.)	10.1016/j.aquatox.2006.10.011	https://www.sciencedirect.com/science/article/pii/S0166445X06003870?via%3Dihub	Aquatic Toxicology	jaensson_2007	jaensson_2007_exp_002	jaensson_2007_exp2_002	jaensson_2007_exp_002_assay_001	jaensson_2007_exp2_002_assay2_001	brown trout	Salmo trutta	wild collected	wild	male	cypermethrin	not reported	52315-07-8	https://commonchemistry.cas.org/detail?cas_rn=52315-07-8&search=cypermethrin	pyrethroid	0.1	ug/L	4	days	not reported	NA	6	celsius	courting	courtship	time near female	time spent near potential mate	NA	NA	fig2b	jaensson_2007_fig2b	NA	NA	NA	15	360.3483120	426.5316456	NA	NA	110.1299973	study reports mean and sd	exact sample size provided	NA	NA	NA	7	671.4445668	512.6708861	NA	NA	193.7713813	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Effects of a pyrethroid pesticide on endocrine responses to female odours and reproductive behaviour in male parr of brown trout (Salmo trutta L.)	10.1016/j.aquatox.2006.10.011	https://www.sciencedirect.com/science/article/pii/S0166445X06003870?via%3Dihub	Aquatic Toxicology	jaensson_2007	jaensson_2007_exp_003	jaensson_2007_exp2_003	jaensson_2007_exp_002_assay_002	jaensson_2007_exp2_003_assay2_001	brown trout	Salmo trutta	wild collected	wild	male	cypermethrin	not reported	52315-07-8	https://commonchemistry.cas.org/detail?cas_rn=52315-07-8&search=cypermethrin	pyrethroid	1	ug/L	4	days	not reported	NA	6	celsius	courting	courtship	time near female	time spent near potential mate	NA	NA	fig2b	jaensson_2007_fig2b	NA	NA	NA	15	360.3483120	426.5316456	NA	NA	110.1299973	study reports mean and sd	exact sample size provided	NA	NA	NA	5	76.9169366	66.0509931	NA	NA	29.5389021	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
unclear on number of shoals but seems to be one	NA	NA	KM	Alterations in social behavior of Japanese medaka (Oryzias latipes) in response to sublethal chlorpyrifos exposure	10.1016/j.chemosphere.2013.02.042	https://www.sciencedirect.com/science/article/pii/S0045653513003500?via%3Dihub	Chemosphere	khalil_2013	khalil_2013_exp_001	khalil_2013_exp2_001	khalil_2013_exp_001_assay_001	khalil_2013_exp2_001_assay2_001	Japanese medaka	Oryzias latipes	laboratory stock from not specified source	not_wild	not reported	chlorpyrifos	analytical	2921-88-2	https://commonchemistry.cas.org/detail?cas_rn=2921-88-2&search=chlorpyrifos	organophosphate	0.012	mg/L	4	days	DTNB	solvent_used	25	celsius	schooling	collective behaviour	swimming speed	group movement	NA	NA	fig3a	khalil_2013_fig3a	1.714286	1.000000	6	6	1.3847356	0.6346154	0.2590806	0.6346154	0.259080646	study reports mean and sd	states six fish were placed in recording glass aquarium for social behaviour (section 2.4. Subacute testing)	1.714286	1.000000	6	6	1.2924279	0.4846154	0.1978434	0.4846154	0.197843402	study reports mean and sd	states six fish were placed in recording glass aquarium for social behaviour (section 2.4. Subacute testing)	NA	NA	NA	NA
NA	NA	NA	KM	Alterations in social behavior of Japanese medaka (Oryzias latipes) in response to sublethal chlorpyrifos exposure	10.1016/j.chemosphere.2013.02.042	https://www.sciencedirect.com/science/article/pii/S0045653513003500?via%3Dihub	Chemosphere	khalil_2013	khalil_2013_exp_001	khalil_2013_exp2_002	khalil_2013_exp_001_assay_002	khalil_2013_exp2_002_assay2_001	Japanese medaka	Oryzias latipes	laboratory stock from not specified source	not_wild	not reported	chlorpyrifos	analytical	2921-88-2	https://commonchemistry.cas.org/detail?cas_rn=2921-88-2&search=chlorpyrifos	organophosphate	0.012	mg/L	8	days	DTNB	solvent_used	25	celsius	schooling	collective behaviour	swimming speed	group movement	NA	NA	fig3a	khalil_2013_fig3a	1.714286	1.000000	6	6	0.7270433	0.1384615	0.0565267	0.1384615	0.056526686	study reports mean and sd	states six fish were placed in recording glass aquarium for social behaviour (section 2.4. Subacute testing)	1.714286	1.000000	6	6	1.4424279	0.4961538	0.2025540	0.4961538	0.202553959	study reports mean and sd	states six fish were placed in recording glass aquarium for social behaviour (section 2.4. Subacute testing)	NA	NA	NA	NA
NA	NA	NA	KM	Alterations in social behavior of Japanese medaka (Oryzias latipes) in response to sublethal chlorpyrifos exposure	10.1016/j.chemosphere.2013.02.042	https://www.sciencedirect.com/science/article/pii/S0045653513003500?via%3Dihub	Chemosphere	khalil_2013	khalil_2013_exp_001	khalil_2013_exp2_001	khalil_2013_exp_001_assay_003	khalil_2013_exp2_001_assay2_002	Japanese medaka	Oryzias latipes	laboratory stock from not specified source	not_wild	not reported	chlorpyrifos	analytical	2921-88-2	https://commonchemistry.cas.org/detail?cas_rn=2921-88-2&search=chlorpyrifos	organophosphate	0.012	mg/L	4	days	DTNB	solvent_used	25	celsius	schooling	collective behaviour	duration	duration of group behaviour	NA	NA	fig3c	khalil_2013_fig3c	1.714286	1.000000	6	6	8.5929786	4.7407407	1.9353993	4.7407407	1.935399303	study reports mean and sd	states six fish were placed in recording glass aquarium for social behaviour (section 2.4. Subacute testing)	1.714286	1.000000	6	6	6.8522378	2.5925926	1.0584215	2.5925926	1.058421494	study reports mean and sd	states six fish were placed in recording glass aquarium for social behaviour (section 2.4. Subacute testing)	NA	NA	NA	NA
NA	NA	NA	KM	Alterations in social behavior of Japanese medaka (Oryzias latipes) in response to sublethal chlorpyrifos exposure	10.1016/j.chemosphere.2013.02.042	https://www.sciencedirect.com/science/article/pii/S0045653513003500?via%3Dihub	Chemosphere	khalil_2013	khalil_2013_exp_001	khalil_2013_exp2_002	khalil_2013_exp_001_assay_004	khalil_2013_exp2_002_assay2_002	Japanese medaka	Oryzias latipes	laboratory stock from not specified source	not_wild	not reported	chlorpyrifos	analytical	2921-88-2	https://commonchemistry.cas.org/detail?cas_rn=2921-88-2&search=chlorpyrifos	organophosphate	0.012	mg/L	8	days	DTNB	solvent_used	25	celsius	schooling	collective behaviour	duration	duration of group behaviour	NA	NA	fig3c	khalil_2013_fig3c	1.714286	1.000000	6	6	5.2966823	3.9259259	1.6027525	3.9259259	1.602752548	study reports mean and sd	states six fish were placed in recording glass aquarium for social behaviour (section 2.4. Subacute testing)	1.714286	1.000000	6	6	2.7040897	1.1481481	0.4687295	1.1481481	0.468729519	study reports mean and sd	states six fish were placed in recording glass aquarium for social behaviour (section 2.4. Subacute testing)	NA	NA	NA	NA
NA	NA	NA	KM	Alterations in social behavior of Japanese medaka (Oryzias latipes) in response to sublethal chlorpyrifos exposure	10.1016/j.chemosphere.2013.02.042	https://www.sciencedirect.com/science/article/pii/S0045653513003500?via%3Dihub	Chemosphere	khalil_2013	khalil_2013_exp_001	khalil_2013_exp2_001	khalil_2013_exp_001_assay_005	khalil_2013_exp2_001_assay2_003	Japanese medaka	Oryzias latipes	laboratory stock from not specified source	not_wild	not reported	chlorpyrifos	analytical	2921-88-2	https://commonchemistry.cas.org/detail?cas_rn=2921-88-2&search=chlorpyrifos	organophosphate	0.012	mg/L	4	days	DTNB	solvent_used	25	celsius	schooling	collective behaviour	frequency	frequency of group behaviour	NA	NA	fig3d	khalil_2013_fig3d	1.714286	1.000000	6	6	42.3950804	57.9710145	23.6665676	57.9710145	23.66656756	study reports mean and sd	states six fish were placed in recording glass aquarium for social behaviour (section 2.4. Subacute testing)	1.714286	1.000000	6	6	81.5255151	43.4782609	17.7499257	43.4782609	17.74992567	study reports mean and sd	states six fish were placed in recording glass aquarium for social behaviour (section 2.4. Subacute testing)	NA	NA	NA	NA
NA	NA	NA	KM	Alterations in social behavior of Japanese medaka (Oryzias latipes) in response to sublethal chlorpyrifos exposure	10.1016/j.chemosphere.2013.02.042	https://www.sciencedirect.com/science/article/pii/S0045653513003500?via%3Dihub	Chemosphere	khalil_2013	khalil_2013_exp_001	khalil_2013_exp2_002	khalil_2013_exp_001_assay_006	khalil_2013_exp2_002_assay2_003	Japanese medaka	Oryzias latipes	laboratory stock from not specified source	not_wild	not reported	chlorpyrifos	analytical	2921-88-2	https://commonchemistry.cas.org/detail?cas_rn=2921-88-2&search=chlorpyrifos	organophosphate	0.012	mg/L	8	days	DTNB	solvent_used	25	celsius	schooling	collective behaviour	frequency	frequency of group behaviour	NA	NA	fig3d	khalil_2013_fig3d	1.714286	1.000000	6	6	31.1631963	8.3333333	3.4020691	8.3333333	3.402069087	study reports mean and sd	states six fish were placed in recording glass aquarium for social behaviour (section 2.4. Subacute testing)	1.714286	1.000000	6	6	43.1197180	14.1304348	5.7687258	14.1304348	5.768725844	study reports mean and sd	states six fish were placed in recording glass aquarium for social behaviour (section 2.4. Subacute testing)	NA	NA	NA	NA
NA	NA	NA	KM	Alterations in social behavior of Japanese medaka (Oryzias latipes) in response to sublethal chlorpyrifos exposure	10.1016/j.chemosphere.2013.02.042	https://www.sciencedirect.com/science/article/pii/S0045653513003500?via%3Dihub	Chemosphere	khalil_2013	khalil_2013_exp_001	khalil_2013_exp2_001	khalil_2013_exp_001_assay_007	khalil_2013_exp2_001_assay2_004	Japanese medaka	Oryzias latipes	laboratory stock from not specified source	not_wild	not reported	chlorpyrifos	analytical	2921-88-2	https://commonchemistry.cas.org/detail?cas_rn=2921-88-2&search=chlorpyrifos	organophosphate	0.012	mg/L	4	days	DTNB	solvent_used	25	celsius	shoaling	collective behaviour	duration	duration of group behaviour	NA	NA	fig3g	khalil_2013_fig3g	1.714286	1.000000	6	6	4.2084367	4.1089109	1.6774558	4.1089109	1.677455847	study reports mean and sd	states six fish were placed in recording glass aquarium for social behaviour (section 2.4. Subacute testing)	1.714286	1.000000	6	6	7.1292288	0.8910891	0.3637856	0.8910891	0.363785605	study reports mean and sd	states six fish were placed in recording glass aquarium for social behaviour (section 2.4. Subacute testing)	NA	NA	NA	NA
NA	NA	NA	KM	Alterations in social behavior of Japanese medaka (Oryzias latipes) in response to sublethal chlorpyrifos exposure	10.1016/j.chemosphere.2013.02.042	https://www.sciencedirect.com/science/article/pii/S0045653513003500?via%3Dihub	Chemosphere	khalil_2013	khalil_2013_exp_001	khalil_2013_exp2_002	khalil_2013_exp_001_assay_008	khalil_2013_exp2_002_assay2_004	Japanese medaka	Oryzias latipes	laboratory stock from not specified source	not_wild	not reported	chlorpyrifos	analytical	2921-88-2	https://commonchemistry.cas.org/detail?cas_rn=2921-88-2&search=chlorpyrifos	organophosphate	0.012	mg/L	8	days	DTNB	solvent_used	25	celsius	shoaling	collective behaviour	duration	duration of group behaviour	NA	NA	fig3g	khalil_2013_fig3g	1.714286	1.000000	6	6	9.2084367	2.2772277	0.9296743	2.2772277	0.929674325	study reports mean and sd	states six fish were placed in recording glass aquarium for social behaviour (section 2.4. Subacute testing)	1.714286	1.000000	6	6	10.1490308	0.8415842	0.3435753	0.8415842	0.343575294	study reports mean and sd	states six fish were placed in recording glass aquarium for social behaviour (section 2.4. Subacute testing)	NA	NA	NA	NA
NA	NA	NA	KM	Alterations in social behavior of Japanese medaka (Oryzias latipes) in response to sublethal chlorpyrifos exposure	10.1016/j.chemosphere.2013.02.042	https://www.sciencedirect.com/science/article/pii/S0045653513003500?via%3Dihub	Chemosphere	khalil_2013	khalil_2013_exp_001	khalil_2013_exp2_001	khalil_2013_exp_001_assay_009	khalil_2013_exp2_001_assay2_005	Japanese medaka	Oryzias latipes	laboratory stock from not specified source	not_wild	not reported	chlorpyrifos	analytical	2921-88-2	https://commonchemistry.cas.org/detail?cas_rn=2921-88-2&search=chlorpyrifos	organophosphate	0.012	mg/L	4	days	DTNB	solvent_used	25	celsius	shoaling	collective behaviour	frequency	frequency of group behaviour	count	NA	fig3h	khalil_2013_fig3h	1.714286	1.000000	6	6	54.5151962	44.7368421	18.2637393	44.7368421	18.26373931	study reports mean and sd	states six fish were placed in recording glass aquarium for social behaviour (section 2.4. Subacute testing)	1.714286	1.000000	6	6	68.0490307	20.6766917	8.4412241	20.6766917	8.441224051	study reports mean and sd	states six fish were placed in recording glass aquarium for social behaviour (section 2.4. Subacute testing)	NA	NA	NA	NA
NA	NA	NA	KM	Alterations in social behavior of Japanese medaka (Oryzias latipes) in response to sublethal chlorpyrifos exposure	10.1016/j.chemosphere.2013.02.042	https://www.sciencedirect.com/science/article/pii/S0045653513003500?via%3Dihub	Chemosphere	khalil_2013	khalil_2013_exp_001	khalil_2013_exp2_002	khalil_2013_exp_001_assay_010	khalil_2013_exp2_002_assay2_005	Japanese medaka	Oryzias latipes	laboratory stock from not specified source	not_wild	not reported	chlorpyrifos	analytical	2921-88-2	https://commonchemistry.cas.org/detail?cas_rn=2921-88-2&search=chlorpyrifos	organophosphate	0.012	mg/L	8	days	DTNB	solvent_used	25	celsius	shoaling	collective behaviour	frequency	frequency of group behaviour	count	NA	fig3h	khalil_2013_fig3h	1.714286	1.000000	6	6	56.3948954	19.1729323	7.8273168	19.1729323	7.827316847	study reports mean and sd	states six fish were placed in recording glass aquarium for social behaviour (section 2.4. Subacute testing)	1.714286	1.000000	6	6	57.8986548	7.1428571	2.9160592	7.1428571	2.916059218	study reports mean and sd	states six fish were placed in recording glass aquarium for social behaviour (section 2.4. Subacute testing)	NA	NA	NA	NA
NA	NA	NA	KM	Comparison of social behavior responses of Japanese medaka (Oryzias latipes) to lethal and sublethal chlorpyrifos concentrations at different exposure times	10.1016/j.ecoenv.2017.07.007	https://www.sciencedirect.com/science/article/pii/S0147651317304219?via%3Dihub	Ecotoxicology and Environmental Safety	khalil_2017	khalil_2017_exp_001	khalil_2017_exp2_001	khalil_2017_exp_001_assay_001	khalil_2017_exp2_001_assay2_001	Japanese medaka	Oryzias latipes	laboratory stock from not specified source	not_wild	not reported	chlorpyrifos	analytical	2921-88-2	https://commonchemistry.cas.org/detail?cas_rn=2921-88-2&search=chlorpyrifos	organophosphate	0.012	mg/L	4	days	ethanol	solvent_used	25	celsius	schooling	collective behaviour	frequency	frequency of group behaviour	count	NA	fig1a	khalil_2017_fig1a	1.600000	1.000000	4	4	25.1622508	6.5437788	3.2718894	6.5437788	3.271889401	study reports mean and sd	exact sample size provided	1.600000	1.000000	4	4	21.6227979	5.9523810	5.9523810	11.9047619	5.952380952	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Comparison of social behavior responses of Japanese medaka (Oryzias latipes) to lethal and sublethal chlorpyrifos concentrations at different exposure times	10.1016/j.ecoenv.2017.07.007	https://www.sciencedirect.com/science/article/pii/S0147651317304219?via%3Dihub	Ecotoxicology and Environmental Safety	khalil_2017	khalil_2017_exp_001	khalil_2017_exp2_001	khalil_2017_exp_001_assay_002	khalil_2017_exp2_001_assay2_002	Japanese medaka	Oryzias latipes	laboratory stock from not specified source	not_wild	not reported	chlorpyrifos	analytical	2921-88-2	https://commonchemistry.cas.org/detail?cas_rn=2921-88-2&search=chlorpyrifos	organophosphate	0.012	mg/L	8	days	ethanol	solvent_used	25	celsius	schooling	collective behaviour	frequency	frequency of group behaviour	count	NA	fig1a	khalil_2017_fig1a	1.600000	1.000000	4	4	13.7336794	1.6589862	0.8294931	1.6589862	0.829493088	study reports mean and sd	exact sample size provided	1.600000	1.000000	4	4	18.7974491	4.8387097	4.8387097	9.6774194	4.838709677	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Comparison of social behavior responses of Japanese medaka (Oryzias latipes) to lethal and sublethal chlorpyrifos concentrations at different exposure times	10.1016/j.ecoenv.2017.07.007	https://www.sciencedirect.com/science/article/pii/S0147651317304219?via%3Dihub	Ecotoxicology and Environmental Safety	khalil_2017	khalil_2017_exp_001	khalil_2017_exp2_001	khalil_2017_exp_001_assay_003	khalil_2017_exp2_001_assay2_003	Japanese medaka	Oryzias latipes	laboratory stock from not specified source	not_wild	not reported	chlorpyrifos	analytical	2921-88-2	https://commonchemistry.cas.org/detail?cas_rn=2921-88-2&search=chlorpyrifos	organophosphate	0.012	mg/L	12	days	ethanol	solvent_used	25	celsius	schooling	collective behaviour	frequency	frequency of group behaviour	count	NA	fig1a	khalil_2017_fig1a	1.600000	1.000000	4	4	12.8742828	3.1585253	1.5792627	3.1585253	1.579262673	study reports mean and sd	exact sample size provided	1.600000	1.000000	4	4	4.4249237	0.3686636	0.3686636	0.7373272	0.368663594	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Comparison of social behavior responses of Japanese medaka (Oryzias latipes) to lethal and sublethal chlorpyrifos concentrations at different exposure times	10.1016/j.ecoenv.2017.07.007	https://www.sciencedirect.com/science/article/pii/S0147651317304219?via%3Dihub	Ecotoxicology and Environmental Safety	khalil_2017	khalil_2017_exp_002	khalil_2017_exp2_002	khalil_2017_exp_002_assay_001	khalil_2017_exp2_002_assay2_001	Japanese medaka	Oryzias latipes	laboratory stock from not specified source	not_wild	not reported	chlorpyrifos	analytical	2921-88-2	https://commonchemistry.cas.org/detail?cas_rn=2921-88-2&search=chlorpyrifos	organophosphate	0.12	mg/L	4	days	ethanol	solvent_used	25	celsius	schooling	collective behaviour	frequency	frequency of group behaviour	count	NA	fig1a	khalil_2017_fig1a	1.600000	1.000000	4	4	25.1622508	6.5437788	3.2718894	6.5437788	3.271889401	study reports mean and sd	exact sample size provided	1.600000	1.000000	4	4	7.6507301	2.1198157	2.1198157	4.2396313	2.119815668	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Comparison of social behavior responses of Japanese medaka (Oryzias latipes) to lethal and sublethal chlorpyrifos concentrations at different exposure times	10.1016/j.ecoenv.2017.07.007	https://www.sciencedirect.com/science/article/pii/S0147651317304219?via%3Dihub	Ecotoxicology and Environmental Safety	khalil_2017	khalil_2017_exp_001	khalil_2017_exp2_001	khalil_2017_exp_001_assay_004	khalil_2017_exp2_001_assay2_004	Japanese medaka	Oryzias latipes	laboratory stock from not specified source	not_wild	not reported	chlorpyrifos	analytical	2921-88-2	https://commonchemistry.cas.org/detail?cas_rn=2921-88-2&search=chlorpyrifos	organophosphate	0.012	mg/L	4	days	ethanol	solvent_used	25	celsius	schooling	collective behaviour	duration	duration of group behaviour	NA	NA	fig1b	khalil_2017_fig1b	1.600000	1.000000	4	4	2.6283093	0.9241877	0.4620939	0.9241877	0.462093863	study reports mean and sd	exact sample size provided	1.600000	1.000000	4	4	2.6283093	0.9241877	0.4275572	0.8551143	0.42755716	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Comparison of social behavior responses of Japanese medaka (Oryzias latipes) to lethal and sublethal chlorpyrifos concentrations at different exposure times	10.1016/j.ecoenv.2017.07.007	https://www.sciencedirect.com/science/article/pii/S0147651317304219?via%3Dihub	Ecotoxicology and Environmental Safety	khalil_2017	khalil_2017_exp_001	khalil_2017_exp2_001	khalil_2017_exp_001_assay_005	khalil_2017_exp2_001_assay2_005	Japanese medaka	Oryzias latipes	laboratory stock from not specified source	not_wild	not reported	chlorpyrifos	analytical	2921-88-2	https://commonchemistry.cas.org/detail?cas_rn=2921-88-2&search=chlorpyrifos	organophosphate	0.012	mg/L	8	days	ethanol	solvent_used	25	celsius	schooling	collective behaviour	duration	duration of group behaviour	NA	NA	fig1b	khalil_2017_fig1b	1.600000	1.000000	4	4	1.7179245	0.4049697	0.2024849	0.4049697	0.202484858	study reports mean and sd	exact sample size provided	1.600000	1.000000	4	4	1.7179245	0.4049697	1.0384116	2.0768231	1.038411552	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Comparison of social behavior responses of Japanese medaka (Oryzias latipes) to lethal and sublethal chlorpyrifos concentrations at different exposure times	10.1016/j.ecoenv.2017.07.007	https://www.sciencedirect.com/science/article/pii/S0147651317304219?via%3Dihub	Ecotoxicology and Environmental Safety	khalil_2017	khalil_2017_exp_001	khalil_2017_exp2_001	khalil_2017_exp_001_assay_006	khalil_2017_exp2_001_assay2_006	Japanese medaka	Oryzias latipes	laboratory stock from not specified source	not_wild	not reported	chlorpyrifos	analytical	2921-88-2	https://commonchemistry.cas.org/detail?cas_rn=2921-88-2&search=chlorpyrifos	organophosphate	0.012	mg/L	12	days	ethanol	solvent_used	25	celsius	schooling	collective behaviour	duration	duration of group behaviour	NA	NA	fig1b	khalil_2017_fig1b	1.600000	1.000000	4	4	1.8170988	0.4161252	0.2080626	0.4161252	0.208062575	study reports mean and sd	exact sample size provided	1.600000	1.000000	4	4	1.8170988	0.4161252	0.0361011	0.0722022	0.036101083	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Comparison of social behavior responses of Japanese medaka (Oryzias latipes) to lethal and sublethal chlorpyrifos concentrations at different exposure times	10.1016/j.ecoenv.2017.07.007	https://www.sciencedirect.com/science/article/pii/S0147651317304219?via%3Dihub	Ecotoxicology and Environmental Safety	khalil_2017	khalil_2017_exp_002	khalil_2017_exp2_002	khalil_2017_exp_002_assay_002	khalil_2017_exp2_002_assay2_002	Japanese medaka	Oryzias latipes	laboratory stock from not specified source	not_wild	not reported	chlorpyrifos	analytical	2921-88-2	https://commonchemistry.cas.org/detail?cas_rn=2921-88-2&search=chlorpyrifos	organophosphate	0.12	mg/L	4	days	ethanol	solvent_used	25	celsius	schooling	collective behaviour	duration	duration of group behaviour	NA	NA	fig1b	khalil_2017_fig1b	1.600000	1.000000	4	4	2.6283093	0.9241877	0.4620939	0.9241877	0.462093863	study reports mean and sd	exact sample size provided	1.600000	1.000000	4	4	2.6283093	0.9241877	0.0476534	0.0953069	0.04765343	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Comparison of social behavior responses of Japanese medaka (Oryzias latipes) to lethal and sublethal chlorpyrifos concentrations at different exposure times	10.1016/j.ecoenv.2017.07.007	https://www.sciencedirect.com/science/article/pii/S0147651317304219?via%3Dihub	Ecotoxicology and Environmental Safety	khalil_2017	khalil_2017_exp_001	khalil_2017_exp2_001	khalil_2017_exp_001_assay_007	khalil_2017_exp2_001_assay2_007	Japanese medaka	Oryzias latipes	laboratory stock from not specified source	not_wild	not reported	chlorpyrifos	analytical	2921-88-2	https://commonchemistry.cas.org/detail?cas_rn=2921-88-2&search=chlorpyrifos	organophosphate	0.012	mg/L	4	days	ethanol	solvent_used	25	celsius	shoaling	collective behaviour	frequency	frequency of group behaviour	count	NA	fig1c	khalil_2017_fig1c	1.600000	1.000000	4	4	32.7539254	5.2864608	2.6432304	5.2864608	2.643230404	study reports mean and sd	exact sample size provided	1.600000	1.000000	4	4	28.2736546	6.6555819	3.3277910	6.6555819	3.327790974	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Comparison of social behavior responses of Japanese medaka (Oryzias latipes) to lethal and sublethal chlorpyrifos concentrations at different exposure times	10.1016/j.ecoenv.2017.07.007	https://www.sciencedirect.com/science/article/pii/S0147651317304219?via%3Dihub	Ecotoxicology and Environmental Safety	khalil_2017	khalil_2017_exp_001	khalil_2017_exp2_001	khalil_2017_exp_001_assay_008	khalil_2017_exp2_001_assay2_008	Japanese medaka	Oryzias latipes	laboratory stock from not specified source	not_wild	not reported	chlorpyrifos	analytical	2921-88-2	https://commonchemistry.cas.org/detail?cas_rn=2921-88-2&search=chlorpyrifos	organophosphate	0.012	mg/L	8	days	ethanol	solvent_used	25	celsius	shoaling	collective behaviour	frequency	frequency of group behaviour	count	NA	fig1c	khalil_2017_fig1c	1.600000	1.000000	4	4	20.1702236	2.2992874	1.1496437	2.2992874	1.149643705	study reports mean and sd	exact sample size provided	1.600000	1.000000	4	4	20.8205371	6.1325416	3.0662708	6.1325416	3.066270784	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Comparison of social behavior responses of Japanese medaka (Oryzias latipes) to lethal and sublethal chlorpyrifos concentrations at different exposure times	10.1016/j.ecoenv.2017.07.007	https://www.sciencedirect.com/science/article/pii/S0147651317304219?via%3Dihub	Ecotoxicology and Environmental Safety	khalil_2017	khalil_2017_exp_001	khalil_2017_exp2_001	khalil_2017_exp_001_assay_009	khalil_2017_exp2_001_assay2_009	Japanese medaka	Oryzias latipes	laboratory stock from not specified source	not_wild	not reported	chlorpyrifos	analytical	2921-88-2	https://commonchemistry.cas.org/detail?cas_rn=2921-88-2&search=chlorpyrifos	organophosphate	0.012	mg/L	12	days	ethanol	solvent_used	25	celsius	shoaling	collective behaviour	frequency	frequency of group behaviour	count	NA	fig1c	khalil_2017_fig1c	1.600000	1.000000	4	4	15.1612349	3.3583531	1.6791766	3.3583531	1.679176564	study reports mean and sd	exact sample size provided	1.600000	1.000000	4	4	14.1766689	2.9878068	1.4939034	2.9878068	1.493903405	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Comparison of social behavior responses of Japanese medaka (Oryzias latipes) to lethal and sublethal chlorpyrifos concentrations at different exposure times	10.1016/j.ecoenv.2017.07.007	https://www.sciencedirect.com/science/article/pii/S0147651317304219?via%3Dihub	Ecotoxicology and Environmental Safety	khalil_2017	khalil_2017_exp_002	khalil_2017_exp2_002	khalil_2017_exp_002_assay_003	khalil_2017_exp2_002_assay2_003	Japanese medaka	Oryzias latipes	laboratory stock from not specified source	not_wild	not reported	chlorpyrifos	analytical	2921-88-2	https://commonchemistry.cas.org/detail?cas_rn=2921-88-2&search=chlorpyrifos	organophosphate	0.12	mg/L	4	days	ethanol	solvent_used	25	celsius	shoaling	collective behaviour	frequency	frequency of group behaviour	count	NA	fig1c	khalil_2017_fig1c	1.600000	1.000000	4	4	32.7539254	5.2864608	2.6432304	5.2864608	2.643230404	study reports mean and sd	exact sample size provided	1.600000	1.000000	4	4	13.0943802	4.5160728	2.2580364	4.5160728	2.258036421	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Comparison of social behavior responses of Japanese medaka (Oryzias latipes) to lethal and sublethal chlorpyrifos concentrations at different exposure times	10.1016/j.ecoenv.2017.07.007	https://www.sciencedirect.com/science/article/pii/S0147651317304219?via%3Dihub	Ecotoxicology and Environmental Safety	khalil_2017	khalil_2017_exp_001	khalil_2017_exp2_001	khalil_2017_exp_001_assay_010	khalil_2017_exp2_001_assay2_010	Japanese medaka	Oryzias latipes	laboratory stock from not specified source	not_wild	not reported	chlorpyrifos	analytical	2921-88-2	https://commonchemistry.cas.org/detail?cas_rn=2921-88-2&search=chlorpyrifos	organophosphate	0.012	mg/L	4	days	ethanol	solvent_used	25	celsius	shoaling	collective behaviour	duration	duration of group behaviour	NA	NA	fig1d	khalil_2017_fig1d	1.600000	1.000000	4	4	32.7539254	5.2864608	2.6432304	5.2864608	2.643230404	study reports mean and sd	exact sample size provided	1.600000	1.000000	4	4	28.2736546	6.6555819	3.3277910	6.6555819	3.327790974	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Comparison of social behavior responses of Japanese medaka (Oryzias latipes) to lethal and sublethal chlorpyrifos concentrations at different exposure times	10.1016/j.ecoenv.2017.07.007	https://www.sciencedirect.com/science/article/pii/S0147651317304219?via%3Dihub	Ecotoxicology and Environmental Safety	khalil_2017	khalil_2017_exp_001	khalil_2017_exp2_001	khalil_2017_exp_001_assay_011	khalil_2017_exp2_001_assay2_011	Japanese medaka	Oryzias latipes	laboratory stock from not specified source	not_wild	not reported	chlorpyrifos	analytical	2921-88-2	https://commonchemistry.cas.org/detail?cas_rn=2921-88-2&search=chlorpyrifos	organophosphate	0.012	mg/L	8	days	ethanol	solvent_used	25	celsius	shoaling	collective behaviour	duration	duration of group behaviour	NA	NA	fig1d	khalil_2017_fig1d	1.600000	1.000000	4	4	20.1702236	2.2992874	1.1496437	2.2992874	1.149643705	study reports mean and sd	exact sample size provided	1.600000	1.000000	4	4	20.8205371	6.1325416	3.0662708	6.1325416	3.066270784	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Comparison of social behavior responses of Japanese medaka (Oryzias latipes) to lethal and sublethal chlorpyrifos concentrations at different exposure times	10.1016/j.ecoenv.2017.07.007	https://www.sciencedirect.com/science/article/pii/S0147651317304219?via%3Dihub	Ecotoxicology and Environmental Safety	khalil_2017	khalil_2017_exp_001	khalil_2017_exp2_001	khalil_2017_exp_001_assay_012	khalil_2017_exp2_001_assay2_012	Japanese medaka	Oryzias latipes	laboratory stock from not specified source	not_wild	not reported	chlorpyrifos	analytical	2921-88-2	https://commonchemistry.cas.org/detail?cas_rn=2921-88-2&search=chlorpyrifos	organophosphate	0.012	mg/L	12	days	ethanol	solvent_used	25	celsius	shoaling	collective behaviour	duration	duration of group behaviour	NA	NA	fig1d	khalil_2017_fig1d	1.600000	1.000000	4	4	15.1612349	3.3583531	1.6791766	3.3583531	1.679176564	study reports mean and sd	exact sample size provided	1.600000	1.000000	4	4	14.1766689	2.9878068	1.4939034	2.9878068	1.493903405	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Comparison of social behavior responses of Japanese medaka (Oryzias latipes) to lethal and sublethal chlorpyrifos concentrations at different exposure times	10.1016/j.ecoenv.2017.07.007	https://www.sciencedirect.com/science/article/pii/S0147651317304219?via%3Dihub	Ecotoxicology and Environmental Safety	khalil_2017	khalil_2017_exp_002	khalil_2017_exp2_002	khalil_2017_exp_002_assay_004	khalil_2017_exp2_002_assay2_004	Japanese medaka	Oryzias latipes	laboratory stock from not specified source	not_wild	not reported	chlorpyrifos	analytical	2921-88-2	https://commonchemistry.cas.org/detail?cas_rn=2921-88-2&search=chlorpyrifos	organophosphate	0.12	mg/L	4	days	ethanol	solvent_used	25	celsius	shoaling	collective behaviour	duration	duration of group behaviour	NA	NA	fig1d	khalil_2017_fig1d	1.600000	1.000000	4	4	32.7539254	5.2864608	2.6432304	5.2864608	2.643230404	study reports mean and sd	exact sample size provided	1.600000	1.000000	4	4	13.0943802	4.5160728	2.2580364	4.5160728	2.258036421	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	YY	KM	New evidence for neurobehavioral toxicity of deltamethrin at environmentally relevant levels in zebrafish	10.1016/j.scitotenv.2022.153623	https://www.sciencedirect.com/science/article/pii/S004896972200715X#:~:text=Taken%20together%2C%20deltamethrin%20exposure%20increased,social%20behaviors%20in%20adult%20zebrafish.	Science of The Total Environment	lei_2022	lei_2022_exp_001	lei_2022_exp2_001	lei_2022_exp_001_assay_001	lei_2022_exp2_001_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	female	deltamethrin	analytical	52918-63-5	in paper	pyrethroid	30	ng/L	21	days	DMSO	solvent_used	28	celsius	social preference	sociality	proportion of time in near zone	time spent in social zone	zone	NA	fig1a	lei_2022_fig1a	NA	NA	NA	16	67.7652167	5.6063447	NA	NA	1.401586177	study reports boxplot	exact sample size provided	NA	NA	NA	16	71.5867192	4.3421273	NA	NA	1.085531837	study reports boxplot	exact sample size provided	NA	NA	NA	NA
NA	NA	YY	KM	New evidence for neurobehavioral toxicity of deltamethrin at environmentally relevant levels in zebrafish	10.1016/j.scitotenv.2022.153623	https://www.sciencedirect.com/science/article/pii/S004896972200715X#:~:text=Taken%20together%2C%20deltamethrin%20exposure%20increased,social%20behaviors%20in%20adult%20zebrafish.	Science of The Total Environment	lei_2022	lei_2022_exp_002	lei_2022_exp2_002	lei_2022_exp_002_assay_001	lei_2022_exp2_002_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	female	deltamethrin	analytical	52918-63-5	in paper	pyrethroid	100	ng/L	21	days	DMSO	solvent_used	28	celsius	social preference	sociality	proportion of time in near zone	time spent in social zone	zone	NA	fig1a	lei_2022_fig1a	NA	NA	NA	16	67.7652167	5.6063447	NA	NA	1.401586177	study reports boxplot	exact sample size provided	NA	NA	NA	16	71.7727601	4.0249352	NA	NA	1.006233793	study reports boxplot	exact sample size provided	NA	NA	NA	NA
NA	NA	YY	KM	New evidence for neurobehavioral toxicity of deltamethrin at environmentally relevant levels in zebrafish	10.1016/j.scitotenv.2022.153623	https://www.sciencedirect.com/science/article/pii/S004896972200715X#:~:text=Taken%20together%2C%20deltamethrin%20exposure%20increased,social%20behaviors%20in%20adult%20zebrafish.	Science of The Total Environment	lei_2022	lei_2022_exp_003	lei_2022_exp2_003	lei_2022_exp_003_assay_001	lei_2022_exp2_003_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	female	deltamethrin	analytical	52918-63-5	in paper	pyrethroid	333	ng/L	21	days	DMSO	solvent_used	28	celsius	social preference	sociality	proportion of time in near zone	time spent in social zone	zone	NA	fig1a	lei_2022_fig1a	NA	NA	NA	16	67.7652167	5.6063447	NA	NA	1.401586177	study reports boxplot	exact sample size provided	NA	NA	NA	16	70.8589712	4.6576603	NA	NA	1.164415072	study reports boxplot	exact sample size provided	NA	NA	NA	NA
NA	NA	YY	KM	New evidence for neurobehavioral toxicity of deltamethrin at environmentally relevant levels in zebrafish	10.1016/j.scitotenv.2022.153623	https://www.sciencedirect.com/science/article/pii/S004896972200715X#:~:text=Taken%20together%2C%20deltamethrin%20exposure%20increased,social%20behaviors%20in%20adult%20zebrafish.	Science of The Total Environment	lei_2022	lei_2022_exp_001	lei_2022_exp2_004	lei_2022_exp_001_assay_002	lei_2022_exp2_004_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	female	deltamethrin	analytical	52918-63-6	in paper	pyrethroid	30	ng/L	21	days	DMSO	solvent_used	28	celsius	shoaling	collective behaviour	nearest neighbour distance	group arrangment	NA	change	fig2b	lei_2022_fig2b	5.333330	3.000000	24	24	0.2164954	0.0320216	0.0359223	0.1016036	0.02073975	study reports boxplot	calculated effective sample size from Rutkowska et al., 2014 (ICC assumed at 0.5)	4.500000	3.000000	24	24	0.2413325	0.0395154	0.0432253	0.1222597	0.024956164	study reports boxplot	calculated effective sample size from Rutkowska et al., 2014 (ICC assumed at 0.5)	NA	NA	NA	NA
NA	NA	YY	KM	New evidence for neurobehavioral toxicity of deltamethrin at environmentally relevant levels in zebrafish	10.1016/j.scitotenv.2022.153623	https://www.sciencedirect.com/science/article/pii/S004896972200715X#:~:text=Taken%20together%2C%20deltamethrin%20exposure%20increased,social%20behaviors%20in%20adult%20zebrafish.	Science of The Total Environment	lei_2022	lei_2022_exp_002	lei_2022_exp2_005	lei_2022_exp_002_assay_002	lei_2022_exp2_005_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	female	deltamethrin	analytical	52918-63-7	in paper	pyrethroid	100	ng/L	21	days	DMSO	solvent_used	28	celsius	shoaling	collective behaviour	nearest neighbour distance	group arrangment	NA	change	fig2b	lei_2022_fig2b	5.333330	3.000000	24	24	0.2164954	0.0320216	0.0359223	0.1016036	0.02073975	study reports boxplot	calculated effective sample size from Rutkowska et al., 2014 (ICC assumed at 0.5)	4.500000	3.000000	24	24	0.2036391	0.0185236	0.0198888	0.0562540	0.0114828	study reports boxplot	calculated effective sample size from Rutkowska et al., 2014 (ICC assumed at 0.5)	NA	NA	NA	NA
NA	NA	YY	KM	New evidence for neurobehavioral toxicity of deltamethrin at environmentally relevant levels in zebrafish	10.1016/j.scitotenv.2022.153623	https://www.sciencedirect.com/science/article/pii/S004896972200715X#:~:text=Taken%20together%2C%20deltamethrin%20exposure%20increased,social%20behaviors%20in%20adult%20zebrafish.	Science of The Total Environment	lei_2022	lei_2022_exp_003	lei_2022_exp2_006	lei_2022_exp_003_assay_002	lei_2022_exp2_006_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	female	deltamethrin	analytical	52918-63-8	in paper	pyrethroid	333	ng/L	21	days	DMSO	solvent_used	28	celsius	shoaling	collective behaviour	nearest neighbour distance	group arrangment	NA	change	fig2b	lei_2022_fig2b	5.333330	3.000000	24	24	0.2164954	0.0320216	0.0359223	0.1016036	0.02073975	study reports boxplot	calculated effective sample size from Rutkowska et al., 2014 (ICC assumed at 0.5)	4.500000	3.000000	24	24	0.2257956	0.0230866	0.0241803	0.0683923	0.01396052	study reports boxplot	calculated effective sample size from Rutkowska et al., 2014 (ICC assumed at 0.5)	NA	NA	NA	NA
NA	NA	YY	KM	New evidence for neurobehavioral toxicity of deltamethrin at environmentally relevant levels in zebrafish	10.1016/j.scitotenv.2022.153623	https://www.sciencedirect.com/science/article/pii/S004896972200715X#:~:text=Taken%20together%2C%20deltamethrin%20exposure%20increased,social%20behaviors%20in%20adult%20zebrafish.	Science of The Total Environment	lei_2022	lei_2022_exp_001	lei_2022_exp2_004	lei_2022_exp_001_assay_003	lei_2022_exp2_004_assay2_002	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	female	deltamethrin	analytical	52918-63-9	in paper	pyrethroid	30	ng/L	21	days	DMSO	solvent_used	28	celsius	shoaling	collective behaviour	inter individual difference	group arrangment	NA	change	fig2c	lei_2022_fig2c	5.333330	3.000000	24	24	0.1117781	0.0228166	0.1275315	0.3607136	0.073630358	study reports boxplot	calculated effective sample size from Rutkowska et al., 2014 (ICC assumed at 0.5)	4.500000	3.000000	24	24	0.1594948	0.0325567	0.1675055	0.4737772	0.096709364	study reports boxplot	calculated effective sample size from Rutkowska et al., 2014 (ICC assumed at 0.5)	NA	NA	NA	NA
NA	NA	YY	KM	New evidence for neurobehavioral toxicity of deltamethrin at environmentally relevant levels in zebrafish	10.1016/j.scitotenv.2022.153623	https://www.sciencedirect.com/science/article/pii/S004896972200715X#:~:text=Taken%20together%2C%20deltamethrin%20exposure%20increased,social%20behaviors%20in%20adult%20zebrafish.	Science of The Total Environment	lei_2022	lei_2022_exp_002	lei_2022_exp2_005	lei_2022_exp_002_assay_003	lei_2022_exp2_005_assay2_002	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	female	deltamethrin	analytical	52918-63-10	in paper	pyrethroid	100	ng/L	21	days	DMSO	solvent_used	28	celsius	shoaling	collective behaviour	inter individual difference	group arrangment	NA	change	fig2c	lei_2022_fig2c	5.333330	3.000000	24	24	0.1117781	0.0228166	0.1275315	0.3607136	0.073630358	study reports boxplot	calculated effective sample size from Rutkowska et al., 2014 (ICC assumed at 0.5)	4.500000	3.000000	24	24	0.1511267	0.0308486	0.1643491	0.4648494	0.094886987	study reports boxplot	calculated effective sample size from Rutkowska et al., 2014 (ICC assumed at 0.5)	NA	NA	NA	NA
NA	NA	YY	KM	New evidence for neurobehavioral toxicity of deltamethrin at environmentally relevant levels in zebrafish	10.1016/j.scitotenv.2022.153623	https://www.sciencedirect.com/science/article/pii/S004896972200715X#:~:text=Taken%20together%2C%20deltamethrin%20exposure%20increased,social%20behaviors%20in%20adult%20zebrafish.	Science of The Total Environment	lei_2022	lei_2022_exp_003	lei_2022_exp2_006	lei_2022_exp_003_assay_003	lei_2022_exp2_006_assay2_002	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	female	deltamethrin	analytical	52918-63-11	in paper	pyrethroid	333	ng/L	21	days	DMSO	solvent_used	28	celsius	shoaling	collective behaviour	inter individual difference	group arrangment	NA	change	fig2c	lei_2022_fig2c	5.333330	3.000000	24	24	0.1117781	0.0228166	0.1275315	0.3607136	0.073630358	study reports boxplot	calculated effective sample size from Rutkowska et al., 2014 (ICC assumed at 0.5)	4.500000	3.000000	24	24	0.1182762	0.0241430	0.1329097	0.3759255	0.076735472	study reports boxplot	calculated effective sample size from Rutkowska et al., 2014 (ICC assumed at 0.5)	NA	NA	NA	NA
NA	NA	NA	KM	Swimming under Pressure: The Sub-Lethal Effects of a Pesticide on the Behaviour of Native and Non-Native Cypriniformes Fish	10.3390/fishes8090462<a0>	https://www.mdpi.com/2410-3888/8/9/462	Fishes	leite_2023	leite_2023_exp_001	leite_2023_exp2_001	leite_2023_exp_001_assay_001	leite_2023_exp2_001_assay2_001	Iberian barbel	Luciobarbus bocagei	wild collected	wild	not reported	esfenvalerate	commercial	66230-04-4	https://commonchemistry.cas.org/detail?cas_rn=66230-04-4&search=esfenvalerate	pyrethroid	1.2	ug/L	2	hours	not reported	NA	not reported	not reported	shoaling	collective behaviour	cohesion	group arrangment	NA	change	in_text	leite_2023_in_text	4.800000	3.000000	12	12	0.8130000	0.4535143	0.3585345	0.7170690	0.207	study does not state error type used, so we assumed to be SE	calculated effective sample size from Rutkowska et al., 2014 (ICC assumed at 0.5)	4.800000	3.000000	12	12	0.7050000	0.4666596	0.3689268	0.7378536	0.213	study does not state error type used, so we assumed to be SE	calculated effective sample size from Rutkowska et al., 2014 (ICC assumed at 0.5)	NA	NA	NA	NA
NA	NA	NA	KM	Swimming under Pressure: The Sub-Lethal Effects of a Pesticide on the Behaviour of Native and Non-Native Cypriniformes Fish	10.3390/fishes8090462<a0>	https://www.mdpi.com/2410-3888/8/9/462	Fishes	leite_2023	leite_2023_exp_002	leite_2023_exp2_002	leite_2023_exp_002_assay_001	leite_2023_exp2_002_assay2_001	Iberian barbel	Luciobarbus bocagei	wild collected	wild	not reported	esfenvalerate	commercial	66230-04-4	https://commonchemistry.cas.org/detail?cas_rn=66230-04-4&search=esfenvalerate	pyrethroid	2	ug/L	2	hours	not reported	NA	not reported	not reported	shoaling	collective behaviour	cohesion	group arrangment	NA	change	in_text	leite_2023_in_text	4.800000	3.000000	12	12	0.8130000	0.4535143	0.3585345	0.7170690	0.207	study does not state error type used, so we assumed to be SE	calculated effective sample size from Rutkowska et al., 2014 (ICC assumed at 0.5)	4.800000	3.000000	12	12	0.7110000	0.4622778	0.3654627	0.7309254	0.211	study does not state error type used, so we assumed to be SE	calculated effective sample size from Rutkowska et al., 2014 (ICC assumed at 0.5)	NA	NA	NA	NA
NA	NA	NA	KM	Swimming under Pressure: The Sub-Lethal Effects of a Pesticide on the Behaviour of Native and Non-Native Cypriniformes Fish	10.3390/fishes8090462<a0>	https://www.mdpi.com/2410-3888/8/9/462	Fishes	leite_2023	leite_2023_exp_003	leite_2023_exp2_003	leite_2023_exp_003_assay_001	leite_2023_exp2_003_assay2_001	Bleak	Alburnus alburnus	wild collected	wild	not reported	esfenvalerate	commercial	66230-04-4	https://commonchemistry.cas.org/detail?cas_rn=66230-04-4&search=esfenvalerate	pyrethroid	1.2	ug/L	2	hours	not reported	NA	not reported	not reported	shoaling	collective behaviour	cohesion	group arrangment	NA	change	in_text	leite_2023_in_text	4.800000	3.000000	12	12	0.3111064	0.2840000	0.2459512	0.4919024	0.142	study does not state error type used, so we assumed to be SE	calculated effective sample size from Rutkowska et al., 2014 (ICC assumed at 0.5)	4.800000	3.000000	12	12	0.9580000	0.3111064	0.2459512	0.4919024	0.142	study does not state error type used, so we assumed to be SE	calculated effective sample size from Rutkowska et al., 2014 (ICC assumed at 0.5)	NA	NA	NA	NA
NA	NA	NA	KM	Swimming under Pressure: The Sub-Lethal Effects of a Pesticide on the Behaviour of Native and Non-Native Cypriniformes Fish	10.3390/fishes8090462<a0>	https://www.mdpi.com/2410-3888/8/9/462	Fishes	leite_2023	leite_2023_exp_004	leite_2023_exp2_004	leite_2023_exp_004_assay_001	leite_2023_exp2_004_assay2_001	Bleak	Alburnus alburnus	wild collected	wild	not reported	esfenvalerate	commercial	66230-04-4	https://commonchemistry.cas.org/detail?cas_rn=66230-04-4&search=esfenvalerate	pyrethroid	2	ug/L	2	hours	not reported	NA	not reported	not reported	shoaling	collective behaviour	cohesion	group arrangment	NA	change	in_text	leite_2023_in_text	4.800000	3.000000	12	12	0.3111064	0.2840000	0.2459512	0.4919024	0.142	study does not state error type used, so we assumed to be SE	calculated effective sample size from Rutkowska et al., 2014 (ICC assumed at 0.5)	4.800000	3.000000	12	12	0.8960000	0.4031238	0.3186973	0.6373947	0.184	study does not state error type used, so we assumed to be SE	calculated effective sample size from Rutkowska et al., 2014 (ICC assumed at 0.5)	NA	NA	NA	NA
states inter-fish distance as social and I would classify this as shoaling	NA	NA	KM	DDT and titanium dioxide nanoparticle coexposure induced neurobehavioral deficits in zebrafish	10.1016/j.ntt.2024.107323	https://www.sciencedirect.com/science/article/pii/S0892036224000059?via%3Dihub	NA	lin_2024	lin_2024_exp_001	lin_2024_exp2_001	lin_2024_exp_001_assay_001	lin_2024_exp2_001_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	female	DDT	analytical	P-029NB-250	in paper	organochlorine	5	nm	40	days	DMSO	solvent_used	28	celsius	social interaction	collective behaviour	inter-individual distance	group arrangment	NA	change	fig3d	lin_2024_fig3d	3.200000	2.000000	8	2	26.8768721	0.6609307	0.6609307	1.3218615	0.467348605	study reports mean and sd	calculated effective sample size from Rutkowska et al., 2014 (ICC assumed at 0.5)	2.500000	2.000000	8	2	22.7407249	0.6822511	0.6822511	1.3645022	0.482424367	study reports mean and sd	calculated effective sample size from Rutkowska et al., 2014 (ICC assumed at 0.5)	NA	NA	NA	NA
NA	NA	NA	KM	DDT and titanium dioxide nanoparticle coexposure induced neurobehavioral deficits in zebrafish	10.1016/j.ntt.2024.107323	https://www.sciencedirect.com/science/article/pii/S0892036224000059?via%3Dihub	NA	lin_2024	lin_2024_exp_002	lin_2024_exp2_002	lin_2024_exp_002_assay_001	lin_2024_exp2_002_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	male	DDT	analytical	P-029NB-250	in paper	organochlorine	5	nm	40	days	DMSO	solvent_used	28	celsius	social interaction	collective behaviour	inter-individual distance	group arrangment	NA	change	fig3d	lin_2024_fig3d	3.200000	2.000000	8	2	24.5276826	0.5636322	0.5636322	1.1272645	0.39854817	study reports mean and sd	calculated effective sample size from Rutkowska et al., 2014 (ICC assumed at 0.5)	2.500000	2.000000	8	2	24.0457362	0.6616552	0.6616552	1.3233104	0.467860896	study reports mean and sd	calculated effective sample size from Rutkowska et al., 2014 (ICC assumed at 0.5)	NA	NA	NA	NA
NA	NA	NA	KM	DDT and titanium dioxide nanoparticle coexposure induced neurobehavioral deficits in zebrafish	10.1016/j.ntt.2024.107323	https://www.sciencedirect.com/science/article/pii/S0892036224000059?via%3Dihub	NA	lin_2024	lin_2024_exp_001	lin_2024_exp2_003	lin_2024_exp_001_assay_002	lin_2024_exp2_003_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	female	DDT	analytical	P-029NB-250	in paper	organochlorine	5	nm	40	days	DMSO	solvent_used	28	celsius	social interaction	sociality	time in contact percentage	time spent with live fish	NA	NA	fig3c	lin_2024_fig3c	NA	NA	NA	8	11.9623969	0.2969048	NA	NA	0.104971685	study reports mean and sd	calculated effective sample size from Rutkowska et al., 2014 (ICC assumed at 0.5)	NA	NA	NA	8	11.7371588	0.2610714	NA	NA	0.092302689	study reports mean and sd	calculated effective sample size from Rutkowska et al., 2014 (ICC assumed at 0.5)	NA	NA	NA	NA
NA	NA	NA	KM	DDT and titanium dioxide nanoparticle coexposure induced neurobehavioral deficits in zebrafish	10.1016/j.ntt.2024.107323	https://www.sciencedirect.com/science/article/pii/S0892036224000059?via%3Dihub	NA	lin_2024	lin_2024_exp_002	lin_2024_exp2_004	lin_2024_exp_002_assay_002	lin_2024_exp2_004_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	male	DDT	analytical	P-029NB-250	in paper	organochlorine	5	nm	40	days	DMSO	solvent_used	28	celsius	social interaction	sociality	time in contact percentage	time spent with live fish	NA	NA	fig3c	lin_2024_fig3c	NA	NA	NA	8	12.7914032	0.2208333	NA	NA	0.078076374	study reports mean and sd	calculated effective sample size from Rutkowska et al., 2014 (ICC assumed at 0.5)	NA	NA	NA	8	11.6809270	0.3470238	NA	NA	0.122691444	study reports mean and sd	calculated effective sample size from Rutkowska et al., 2014 (ICC assumed at 0.5)	NA	NA	NA	NA
stated mirror bites as social and I would classify as aggression	NA	NA	KM	DDT and titanium dioxide nanoparticle coexposure induced neurobehavioral deficits in zebrafish	10.1016/j.ntt.2024.107323	https://www.sciencedirect.com/science/article/pii/S0892036224000059?via%3Dihub	NA	lin_2024	lin_2024_exp_001	lin_2024_exp2_005	lin_2024_exp_001_assay_003	lin_2024_exp2_005_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	female	DDT	analytical	P-029NB-250	in paper	organochlorine	5	nm	40	days	DMSO	solvent_used	28	celsius	social interaction	aggression	mirror attack per minute	frequency of aggressive behaviour	count	NA	fig3e	lin_2024_fig3e	NA	NA	NA	12	23.9643904	2.7620853	NA	NA	0.797345348	study reports mean and sd	exact sample size provided	NA	NA	NA	12	35.7255278	4.0985782	NA	NA	1.183157613	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	DDT and titanium dioxide nanoparticle coexposure induced neurobehavioral deficits in zebrafish	10.1016/j.ntt.2024.107323	https://www.sciencedirect.com/science/article/pii/S0892036224000059?via%3Dihub	NA	lin_2024	lin_2024_exp_002	lin_2024_exp2_006	lin_2024_exp_002_assay_003	lin_2024_exp2_006_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	male	DDT	analytical	P-029NB-250	in paper	organochlorine	5	nm	40	days	DMSO	solvent_used	28	celsius	social interaction	aggression	mirror attack per minute	frequency of aggressive behaviour	count	NA	fig3e	lin_2024_fig3e	NA	NA	NA	12	39.2094239	5.2042654	NA	NA	1.502342016	study reports mean and sd	exact sample size provided	NA	NA	NA	12	30.4108457	3.9687204	NA	NA	1.14567089	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Fenpropathrin causes alterations in locomotion and social behaviors in zebrafish (Danio rerio)	10.1016/j.aquatox.2023.106756	https://www.sciencedirect.com/science/article/pii/S0166445X23003582?via%3Dihub	Aquatic Toxicology	liu_2023	liu_2023_exp_001	liu_2023_exp2_001	liu_2023_exp_001_assay_001	liu_2023_exp2_001_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	fenpropathrin	not reported	39,515<96>41<96>8	in paper	pyrethroid	500	ppb	72	hours	DMSO	solvent_used	28	celsius	social preference	sociality	time in conspecific segment	time spent in social zone	zone	NA	fig3e	liu_2023_fig3e	NA	NA	NA	10	408.9260085	418.2034951	NA	NA	132.247557	study reports mean and se	exact sample size provided	NA	NA	NA	10	542.6038649	580.1835287	NA	NA	183.4701412	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Fenpropathrin causes alterations in locomotion and social behaviors in zebrafish (Danio rerio)	10.1016/j.aquatox.2023.106756	https://www.sciencedirect.com/science/article/pii/S0166445X23003582?via%3Dihub	Aquatic Toxicology	liu_2023	liu_2023_exp_001	liu_2023_exp2_002	liu_2023_exp_001_assay_002	liu_2023_exp2_002_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	fenpropathrin	not reported	39,515<96>41<96>8	in paper	pyrethroid	500	ppb	72	hours	DMSO	solvent_used	28	celsius	fighting	aggression	duration of fight control vs fenpropathrin	duration of aggressive behaviour	NA	NA	fig5c	liu_2023_fig5c	NA	NA	NA	13	388.1335352	204.6781894	NA	NA	56.76751592	study reports mean and se	exact sample size provided	NA	NA	NA	10	212.9291478	180.9413651	NA	NA	57.21868365	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Fenpropathrin causes alterations in locomotion and social behaviors in zebrafish (Danio rerio)	10.1016/j.aquatox.2023.106756	https://www.sciencedirect.com/science/article/pii/S0166445X23003582?via%3Dihub	Aquatic Toxicology	liu_2023	liu_2023_exp_001	liu_2023_exp2_002	liu_2023_exp_001_assay_003	liu_2023_exp2_002_assay2_002	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	fenpropathrin	not reported	39,515<96>41<96>8	in paper	pyrethroid	500	ppb	72	hours	DMSO	solvent_used	28	celsius	fighting	aggression	biting numbers	frequency of aggressive behaviour	count	NA	fig5f	liu_2023_fig5f	NA	NA	NA	8	277.9932098	86.5616551	NA	NA	30.60416667	study reports mean and se	exact sample size provided	NA	NA	NA	10	219.9341103	80.6710207	NA	NA	25.51041667	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Integrate transcriptomic and metabolomic analysis reveals the underlying mechanisms of behavioral disorders in zebrafish (Danio rerio) induced by imidacloprid	10.1016/j.scitotenv.2023.161541	https://www.sciencedirect.com/science/article/pii/S0048969723001560?via%3Dihub	NA	liu_2023a	liu_2023a_exp_001	liu_2023a_exp2_001	liu_2023a_exp_001_assay_001	liu_2023a_exp2_001_assay2_001	zebrafish	Danio rerio	commercial supplier	wild	not reported	imidacloprid	analytical	138261-41-3	https://commonchemistry.cas.org/detail?cas_rn=138261-41-3&search=imidacloprid	neonicotinoid	1	ug/L	21	days	not reported	NA	26	celsius	social interaction	sociality	time spent in conspecific zone	time spent in social zone	zone	NA	fig3e	liu_2023a_3e	NA	NA	NA	14	258.3014343	31.0746713	NA	NA	8.305055233	caluclated difference in zone 2 and 1	states range of sample sizes so selected lowest	NA	NA	NA	14	263.8601587	33.8996414	NA	NA	9.060060255	caluclated difference in zone 2 and 1	states range of sample sizes so selected lowest	NA	NA	NA	NA
NA	NA	NA	KM	Integrate transcriptomic and metabolomic analysis reveals the underlying mechanisms of behavioral disorders in zebrafish (Danio rerio) induced by imidacloprid	10.1016/j.scitotenv.2023.161541	https://www.sciencedirect.com/science/article/pii/S0048969723001560?via%3Dihub	NA	liu_2023a	liu_2023a_exp_002	liu_2023a_exp2_002	liu_2023a_exp_002_assay_001	liu_2023a_exp2_002_assay2_001	zebrafish	Danio rerio	commercial supplier	wild	not reported	imidacloprid	analytical	138261-41-3	https://commonchemistry.cas.org/detail?cas_rn=138261-41-3&search=imidacloprid	neonicotinoid	10	ug/L	21	days	not reported	NA	26	celsius	social interaction	sociality	time spent in conspecific zone	time spent in social zone	zone	NA	fig3e	liu_2023a_3e	NA	NA	NA	14	258.3014343	31.0746713	NA	NA	8.305055233	caluclated difference in zone 2 and 1	states range of sample sizes so selected lowest	NA	NA	NA	14	271.1182344	40.9620667	NA	NA	10.94757281	caluclated difference in zone 2 and 1	states range of sample sizes so selected lowest	NA	NA	NA	NA
NA	NA	NA	KM	Integrate transcriptomic and metabolomic analysis reveals the underlying mechanisms of behavioral disorders in zebrafish (Danio rerio) induced by imidacloprid	10.1016/j.scitotenv.2023.161541	https://www.sciencedirect.com/science/article/pii/S0048969723001560?via%3Dihub	NA	liu_2023a	liu_2023a_exp_003	liu_2023a_exp2_003	liu_2023a_exp_003_assay_001	liu_2023a_exp2_003_assay2_001	zebrafish	Danio rerio	commercial supplier	wild	not reported	imidacloprid	analytical	138261-41-3	https://commonchemistry.cas.org/detail?cas_rn=138261-41-3&search=imidacloprid	neonicotinoid	100	ug/L	21	days	not reported	NA	26	celsius	social interaction	sociality	time spent in conspecific zone	time spent in social zone	zone	NA	fig3e	liu_2023a_3e	NA	NA	NA	14	258.3014343	31.0746713	NA	NA	8.305055233	caluclated difference in zone 2 and 1	states range of sample sizes so selected lowest	NA	NA	NA	14	290.2281193	18.3623058	NA	NA	4.907532638	caluclated difference in zone 2 and 1	states range of sample sizes so selected lowest	NA	NA	NA	NA
NA	NA	NA	KM	Environmentally Realistic Waterborne Atrazine Exposure Affects Behavior in Poecilia latipinna	10.3390/w15020306	https://www.mdpi.com/2073-4441/15/2/306	Water	maclaren_2023	maclaren_2023_exp_001	maclaren_2023_exp2_001	maclaren_2023_exp_001_assay_001	maclaren_2023_exp2_001_assay2_001	sailfin mollie	Poecilia latipinna	labratory stock from wild population	not_wild	female	atrazine	not reported	1912-24-9	in paper	triazine	1	ppb	12	weeks	DMSO	solvent_used	25	celsius	courting	courtship	time in preference zone of female	time spent in courtship zone	zone	NA	fig3a	maclaren_2023_fig3a	NA	NA	NA	20	362.0208435	NA	NA	NA	NA	study does not report error	exact sample size provided	NA	NA	NA	20	370.0208435	NA	NA	NA	NA	study does not report error	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Environmentally Realistic Waterborne Atrazine Exposure Affects Behavior in Poecilia latipinna	10.3390/w15020307	https://www.mdpi.com/2073-4441/15/2/307	Water	maclaren_2023	maclaren_2023_exp_002	maclaren_2023_exp2_002	maclaren_2023_exp_002_assay_001	maclaren_2023_exp2_002_assay2_001	sailfin mollie	Poecilia latipinna	labratory stock from wild population	not_wild	female	atrazine	not reported	1912-24-9	in paper	triazine	15	ppb	12	weeks	DMSO	solvent_used	25	celsius	courting	courtship	time in preference zone of female	time spent in courtship zone	zone	NA	fig3a	maclaren_2023_fig3a	NA	NA	NA	20	362.0208435	NA	NA	NA	NA	study does not report error	exact sample size provided	NA	NA	NA	20	344.0208435	NA	NA	NA	NA	study does not report error	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Environmentally Realistic Waterborne Atrazine Exposure Affects Behavior in Poecilia latipinna	10.3390/w15020308	https://www.mdpi.com/2073-4441/15/2/308	Water	maclaren_2023	maclaren_2023_exp_001	maclaren_2023_exp2_003	maclaren_2023_exp_001_assay_002	maclaren_2023_exp2_003_assay2_001	sailfin mollie	Poecilia latipinna	labratory stock from wild population	not_wild	female	atrazine	not reported	1912-24-9	in paper	triazine	1	ppb	12	weeks	DMSO	solvent_used	25	celsius	courting	courtship	time in preference zone of male	time spent in courtship zone	zone	NA	fig3a	maclaren_2023_fig3a	NA	NA	NA	20	480.0208435	NA	NA	NA	NA	study does not report error	exact sample size provided	NA	NA	NA	20	276.0208435	NA	NA	NA	NA	study does not report error	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Environmentally Realistic Waterborne Atrazine Exposure Affects Behavior in Poecilia latipinna	10.3390/w15020309	https://www.mdpi.com/2073-4441/15/2/309	Water	maclaren_2023	maclaren_2023_exp_002	maclaren_2023_exp2_004	maclaren_2023_exp_002_assay_002	maclaren_2023_exp2_004_assay2_001	sailfin mollie	Poecilia latipinna	labratory stock from wild population	not_wild	female	atrazine	not reported	1912-24-9	in paper	triazine	15	ppb	12	weeks	DMSO	solvent_used	25	celsius	courting	courtship	time in preference zone of male	time spent in courtship zone	zone	NA	fig3a	maclaren_2023_fig3a	NA	NA	NA	20	480.0208435	NA	NA	NA	NA	study does not report error	exact sample size provided	NA	NA	NA	20	356.0208435	NA	NA	NA	NA	study does not report error	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Environmentally Realistic Waterborne Atrazine Exposure Affects Behavior in Poecilia latipinna	10.3390/w15020306	https://www.mdpi.com/2073-4441/15/2/306	Water	maclaren_2023	maclaren_2023_exp_003	maclaren_2023_exp2_005	maclaren_2023_exp_003_assay_001	maclaren_2023_exp2_005_assay2_001	sailfin mollie	Poecilia latipinna	labratory stock from wild population	not_wild	male	atrazine	not reported	1912-24-9	in paper	triazine	1	ppb	12	weeks	DMSO	solvent_used	25	celsius	courting	courtship	time in preference zone of female	time spent in courtship zone	zone	NA	fig3b	maclaren_2023_fig3b	NA	NA	NA	20	437.5210116	NA	NA	NA	NA	study does not report error	exact sample size provided	NA	NA	NA	20	298.4081084	NA	NA	NA	NA	study does not report error	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Environmentally Realistic Waterborne Atrazine Exposure Affects Behavior in Poecilia latipinna	10.3390/w15020307	https://www.mdpi.com/2073-4441/15/2/307	Water	maclaren_2023	maclaren_2023_exp_004	maclaren_2023_exp2_006	maclaren_2023_exp_004_assay_001	maclaren_2023_exp2_006_assay2_001	sailfin mollie	Poecilia latipinna	labratory stock from wild population	not_wild	male	atrazine	not reported	1912-24-9	in paper	triazine	15	ppb	12	weeks	DMSO	solvent_used	25	celsius	courting	courtship	time in preference zone of female	time spent in courtship zone	zone	NA	fig3b	maclaren_2023_fig3b	NA	NA	NA	20	437.5210116	NA	NA	NA	NA	study does not report error	exact sample size provided	NA	NA	NA	20	304.4564955	NA	NA	NA	NA	study does not report error	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Environmentally Realistic Waterborne Atrazine Exposure Affects Behavior in Poecilia latipinna	10.3390/w15020308	https://www.mdpi.com/2073-4441/15/2/308	Water	maclaren_2023	maclaren_2023_exp_003	maclaren_2023_exp2_007	maclaren_2023_exp_003_assay_002	maclaren_2023_exp2_007_assay2_001	sailfin mollie	Poecilia latipinna	labratory stock from wild population	not_wild	male	atrazine	not reported	1912-24-9	in paper	triazine	1	ppb	12	weeks	DMSO	solvent_used	25	celsius	courting	courtship	time in preference zone of male	time spent in courtship zone	zone	NA	fig3b	maclaren_2023_fig3b	NA	NA	NA	20	401.2306890	NA	NA	NA	NA	study does not report error	exact sample size provided	NA	NA	NA	20	276.2306890	NA	NA	NA	NA	study does not report error	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Environmentally Realistic Waterborne Atrazine Exposure Affects Behavior in Poecilia latipinna	10.3390/w15020309	https://www.mdpi.com/2073-4441/15/2/309	Water	maclaren_2023	maclaren_2023_exp_004	maclaren_2023_exp2_008	maclaren_2023_exp_004_assay_002	maclaren_2023_exp2_008_assay2_001	sailfin mollie	Poecilia latipinna	labratory stock from wild population	not_wild	male	atrazine	not reported	1912-24-9	in paper	triazine	15	ppb	12	weeks	DMSO	solvent_used	25	celsius	courting	courtship	time in preference zone of male	time spent in courtship zone	zone	NA	fig3b	maclaren_2023_fig3b	NA	NA	NA	20	401.2306890	NA	NA	NA	NA	study does not report error	exact sample size provided	NA	NA	NA	20	296.3919793	NA	NA	NA	NA	study does not report error	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Environmentally Realistic Waterborne Atrazine Exposure Affects Behavior in Poecilia latipinna	10.3390/w15020309	https://www.mdpi.com/2073-4441/15/2/309	Water	maclaren_2023	maclaren_2023_exp_003	maclaren_2023_exp2_009	maclaren_2023_exp_003_assay_003	maclaren_2023_exp2_009_assay2_001	sailfin mollie	Poecilia latipinna	labratory stock from wild population	not_wild	male	atrazine	not reported	1912-24-9	in paper	triazine	1	ppb	12	weeks	DMSO	solvent_used	25	celsius	courting	courtship	mean total time with dummy	time spent with simulated fish	NA	NA	fig4a	maclaren_2023_fig4a	NA	NA	NA	20	842.5219795	NA	NA	NA	NA	study does not report error	exact sample size provided	NA	NA	NA	20	644.1194236	NA	NA	NA	NA	study does not report error	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Environmentally Realistic Waterborne Atrazine Exposure Affects Behavior in Poecilia latipinna	10.3390/w15020309	https://www.mdpi.com/2073-4441/15/2/309	Water	maclaren_2023	maclaren_2023_exp_004	maclaren_2023_exp2_010	maclaren_2023_exp_004_assay_003	maclaren_2023_exp2_010_assay2_001	sailfin mollie	Poecilia latipinna	labratory stock from wild population	not_wild	male	atrazine	not reported	1912-24-9	in paper	triazine	15	ppb	12	weeks	DMSO	solvent_used	25	celsius	courting	courtship	mean total time with dummy	time spent with simulated fish	NA	NA	fig4a	maclaren_2023_fig4a	NA	NA	NA	20	842.5219795	NA	NA	NA	NA	study does not report error	exact sample size provided	NA	NA	NA	20	698.7520114	NA	NA	NA	NA	study does not report error	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Environmentally Realistic Waterborne Atrazine Exposure Affects Behavior in Poecilia latipinna	10.3390/w15020309	https://www.mdpi.com/2073-4441/15/2/309	Water	maclaren_2023	maclaren_2023_exp_003	maclaren_2023_exp2_011	maclaren_2023_exp_003_assay_004	maclaren_2023_exp2_011_assay2_001	sailfin mollie	Poecilia latipinna	labratory stock from wild population	not_wild	male	atrazine	not reported	1912-24-9	in paper	triazine	1	ppb	12	weeks	DMSO	solvent_used	25	celsius	courting	courtship	mean total time with dummy	time spent with simulated fish	NA	NA	fig4b	maclaren_2023_fig4b	NA	NA	NA	20	733.5729629	NA	NA	NA	NA	study does not report error	exact sample size provided	NA	NA	NA	20	503.5410141	NA	NA	NA	NA	study does not report error	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Environmentally Realistic Waterborne Atrazine Exposure Affects Behavior in Poecilia latipinna	10.3390/w15020309	https://www.mdpi.com/2073-4441/15/2/309	Water	maclaren_2023	maclaren_2023_exp_004	maclaren_2023_exp2_012	maclaren_2023_exp_004_assay_004	maclaren_2023_exp2_012_assay2_001	sailfin mollie	Poecilia latipinna	labratory stock from wild population	not_wild	male	atrazine	not reported	1912-24-9	in paper	triazine	15	ppb	12	weeks	DMSO	solvent_used	25	celsius	courting	courtship	mean total time with dummy	time spent with simulated fish	NA	NA	fig4b	maclaren_2023_fig4b	NA	NA	NA	20	733.5729629	NA	NA	NA	NA	study does not report error	exact sample size provided	NA	NA	NA	20	523.9882984	NA	NA	NA	NA	study does not report error	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Environmentally Realistic Waterborne Atrazine Exposure Affects Behavior in Poecilia latipinna	10.3390/w15020309	https://www.mdpi.com/2073-4441/15/2/309	Water	maclaren_2023	maclaren_2023_exp_001	maclaren_2023_exp2_013	maclaren_2023_exp_001_assay_003	maclaren_2023_exp2_013_assay2_001	sailfin mollie	Poecilia latipinna	labratory stock from wild population	not_wild	female	atrazine	not reported	1912-24-9	in paper	triazine	1	ppb	12	weeks	DMSO	solvent_used	25	celsius	courting	courtship	time with smaller male (small and intermediate male present)	time spent near potential mate	NA	NA	table1	maclaren_2023_table1	NA	NA	NA	20	144.6900000	67.4398102	NA	NA	15.08	study does not state error type used, so we assumed to be SE	exact sample size provided	NA	NA	NA	20	187.0600000	155.8986594	NA	NA	34.86	study does not state error type used, so we assumed to be SE	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Environmentally Realistic Waterborne Atrazine Exposure Affects Behavior in Poecilia latipinna	10.3390/w15020309	https://www.mdpi.com/2073-4441/15/2/309	Water	maclaren_2023	maclaren_2023_exp_002	maclaren_2023_exp2_014	maclaren_2023_exp_002_assay_003	maclaren_2023_exp2_014_assay2_001	sailfin mollie	Poecilia latipinna	labratory stock from wild population	not_wild	female	atrazine	not reported	1912-24-9	in paper	triazine	15	ppb	12	weeks	DMSO	solvent_used	25	celsius	courting	courtship	time with smaller male (small and intermediate male present)	time spent near potential mate	NA	NA	table1	maclaren_2023_table1	NA	NA	NA	20	144.6900000	67.4398102	NA	NA	15.08	study does not state error type used, so we assumed to be SE	exact sample size provided	NA	NA	NA	20	193.8000000	141.5878243	NA	NA	31.66	study does not state error type used, so we assumed to be SE	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Environmentally Realistic Waterborne Atrazine Exposure Affects Behavior in Poecilia latipinna	10.3390/w15020309	https://www.mdpi.com/2073-4441/15/2/309	Water	maclaren_2023	maclaren_2023_exp_001	maclaren_2023_exp2_015	maclaren_2023_exp_001_assay_004	maclaren_2023_exp2_015_assay2_001	sailfin mollie	Poecilia latipinna	labratory stock from wild population	not_wild	female	atrazine	not reported	1912-24-9	in paper	triazine	1	ppb	12	weeks	DMSO	solvent_used	25	celsius	courting	courtship	time with larger male (small and intermediate male present)	time spent near potential mate	NA	NA	table1	maclaren_2023_table1	NA	NA	NA	20	246.3800000	80.0512336	NA	NA	17.9	study does not state error type used, so we assumed to be SE	exact sample size provided	NA	NA	NA	20	206.7200000	158.9397118	NA	NA	35.54	study does not state error type used, so we assumed to be SE	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Environmentally Realistic Waterborne Atrazine Exposure Affects Behavior in Poecilia latipinna	10.3390/w15020309	https://www.mdpi.com/2073-4441/15/2/309	Water	maclaren_2023	maclaren_2023_exp_002	maclaren_2023_exp2_016	maclaren_2023_exp_002_assay_004	maclaren_2023_exp2_016_assay2_001	sailfin mollie	Poecilia latipinna	labratory stock from wild population	not_wild	female	atrazine	not reported	1912-24-9	in paper	triazine	15	ppb	12	weeks	DMSO	solvent_used	25	celsius	courting	courtship	time with larger male (small and intermediate male present)	time spent near potential mate	NA	NA	table1	maclaren_2023_table1	NA	NA	NA	20	246.3800000	80.0512336	NA	NA	17.9	study does not state error type used, so we assumed to be SE	exact sample size provided	NA	NA	NA	20	249.1000000	148.2960283	NA	NA	33.16	study does not state error type used, so we assumed to be SE	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Environmentally Realistic Waterborne Atrazine Exposure Affects Behavior in Poecilia latipinna	10.3390/w15020309	https://www.mdpi.com/2073-4441/15/2/309	Water	maclaren_2023	maclaren_2023_exp_001	maclaren_2023_exp2_017	maclaren_2023_exp_001_assay_005	maclaren_2023_exp2_017_assay2_001	sailfin mollie	Poecilia latipinna	labratory stock from wild population	not_wild	female	atrazine	not reported	1912-24-9	in paper	triazine	1	ppb	12	weeks	DMSO	solvent_used	25	celsius	courting	courtship	time with smaller male (small and large male present)	time spent near potential mate	NA	NA	table1	maclaren_2023_table1	NA	NA	NA	20	132.2300000	43.4244401	NA	NA	9.71	study does not state error type used, so we assumed to be SE	exact sample size provided	NA	NA	NA	20	140.2800000	158.8502691	NA	NA	35.52	study does not state error type used, so we assumed to be SE	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Environmentally Realistic Waterborne Atrazine Exposure Affects Behavior in Poecilia latipinna	10.3390/w15020309	https://www.mdpi.com/2073-4441/15/2/309	Water	maclaren_2023	maclaren_2023_exp_002	maclaren_2023_exp2_018	maclaren_2023_exp_002_assay_005	maclaren_2023_exp2_018_assay2_001	sailfin mollie	Poecilia latipinna	labratory stock from wild population	not_wild	female	atrazine	not reported	1912-24-9	in paper	triazine	15	ppb	12	weeks	DMSO	solvent_used	25	celsius	courting	courtship	time with smaller male (small and large male present)	time spent near potential mate	NA	NA	table1	maclaren_2023_table1	NA	NA	NA	20	132.2300000	43.4244401	NA	NA	9.71	study does not state error type used, so we assumed to be SE	exact sample size provided	NA	NA	NA	20	132.2500000	80.7667754	NA	NA	18.06	study does not state error type used, so we assumed to be SE	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Environmentally Realistic Waterborne Atrazine Exposure Affects Behavior in Poecilia latipinna	10.3390/w15020309	https://www.mdpi.com/2073-4441/15/2/309	Water	maclaren_2023	maclaren_2023_exp_001	maclaren_2023_exp2_019	maclaren_2023_exp_001_assay_006	maclaren_2023_exp2_019_assay2_001	sailfin mollie	Poecilia latipinna	labratory stock from wild population	not_wild	female	atrazine	not reported	1912-24-9	in paper	triazine	1	ppb	12	weeks	DMSO	solvent_used	25	celsius	courting	courtship	time with larger male (small and large male present)	time spent near potential mate	NA	NA	table1	maclaren_2023_table1	NA	NA	NA	20	230.4600000	52.3239907	NA	NA	11.7	study does not state error type used, so we assumed to be SE	exact sample size provided	NA	NA	NA	20	183.9400000	155.2278390	NA	NA	34.71	study does not state error type used, so we assumed to be SE	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Environmentally Realistic Waterborne Atrazine Exposure Affects Behavior in Poecilia latipinna	10.3390/w15020309	https://www.mdpi.com/2073-4441/15/2/309	Water	maclaren_2023	maclaren_2023_exp_002	maclaren_2023_exp2_020	maclaren_2023_exp_002_assay_006	maclaren_2023_exp2_020_assay2_001	sailfin mollie	Poecilia latipinna	labratory stock from wild population	not_wild	female	atrazine	not reported	1912-24-9	in paper	triazine	15	ppb	12	weeks	DMSO	solvent_used	25	celsius	courting	courtship	time with larger male (small and large male present)	time spent near potential mate	NA	NA	table1	maclaren_2023_table1	NA	NA	NA	20	230.4600000	52.3239907	NA	NA	11.7	study does not state error type used, so we assumed to be SE	exact sample size provided	NA	NA	NA	20	183.9400000	155.2278390	NA	NA	34.71	study does not state error type used, so we assumed to be SE	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Environmentally Realistic Waterborne Atrazine Exposure Affects Behavior in Poecilia latipinna	10.3390/w15020309	https://www.mdpi.com/2073-4441/15/2/309	Water	maclaren_2023	maclaren_2023_exp_001	maclaren_2023_exp2_021	maclaren_2023_exp_001_assay_007	maclaren_2023_exp2_021_assay2_001	sailfin mollie	Poecilia latipinna	labratory stock from wild population	not_wild	female	atrazine	not reported	1912-24-9	in paper	triazine	1	ppb	12	weeks	DMSO	solvent_used	25	celsius	courting	courtship	time with smaller male (intermediate and large male present)	time spent near potential mate	NA	NA	table1	maclaren_2023_table1	NA	NA	NA	20	143.0000000	53.7997955	NA	NA	12.03	study does not state error type used, so we assumed to be SE	exact sample size provided	NA	NA	NA	20	143.3300000	125.8906271	NA	NA	28.15	study does not state error type used, so we assumed to be SE	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Environmentally Realistic Waterborne Atrazine Exposure Affects Behavior in Poecilia latipinna	10.3390/w15020309	https://www.mdpi.com/2073-4441/15/2/309	Water	maclaren_2023	maclaren_2023_exp_002	maclaren_2023_exp2_022	maclaren_2023_exp_002_assay_007	maclaren_2023_exp2_022_assay2_001	sailfin mollie	Poecilia latipinna	labratory stock from wild population	not_wild	female	atrazine	not reported	1912-24-9	in paper	triazine	15	ppb	12	weeks	DMSO	solvent_used	25	celsius	courting	courtship	time with smaller male (intermediate and large male present)	time spent near potential mate	NA	NA	table1	maclaren_2023_table1	NA	NA	NA	20	143.0000000	53.7997955	NA	NA	12.03	study does not state error type used, so we assumed to be SE	exact sample size provided	NA	NA	NA	20	178.0000000	126.5614475	NA	NA	28.3	study does not state error type used, so we assumed to be SE	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Environmentally Realistic Waterborne Atrazine Exposure Affects Behavior in Poecilia latipinna	10.3390/w15020309	https://www.mdpi.com/2073-4441/15/2/309	Water	maclaren_2023	maclaren_2023_exp_001	maclaren_2023_exp2_023	maclaren_2023_exp_001_assay_008	maclaren_2023_exp2_023_assay2_001	sailfin mollie	Poecilia latipinna	labratory stock from wild population	not_wild	female	atrazine	not reported	1912-24-9	in paper	triazine	1	ppb	12	weeks	DMSO	solvent_used	25	celsius	courting	courtship	time with larger male (intermediate and large male present)	time spent near potential mate	NA	NA	table1	maclaren_2023_table1	NA	NA	NA	20	240.9200000	65.6956772	NA	NA	14.69	study does not state error type used, so we assumed to be SE	exact sample size provided	NA	NA	NA	20	143.3300000	125.8906271	NA	NA	28.15	study does not state error type used, so we assumed to be SE	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Environmentally Realistic Waterborne Atrazine Exposure Affects Behavior in Poecilia latipinna	10.3390/w15020309	https://www.mdpi.com/2073-4441/15/2/309	Water	maclaren_2023	maclaren_2023_exp_002	maclaren_2023_exp2_024	maclaren_2023_exp_002_assay_008	maclaren_2023_exp2_024_assay2_001	sailfin mollie	Poecilia latipinna	labratory stock from wild population	not_wild	female	atrazine	not reported	1912-24-9	in paper	triazine	15	ppb	12	weeks	DMSO	solvent_used	25	celsius	courting	courtship	time with larger male (intermeditate and large male present)	time spent near potential mate	NA	NA	table1	maclaren_2023_table1	NA	NA	NA	20	240.9200000	65.6956772	NA	NA	14.69	study does not state error type used, so we assumed to be SE	exact sample size provided	NA	NA	NA	20	178.0000000	126.5614475	NA	NA	28.3	study does not state error type used, so we assumed to be SE	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Environmentally Realistic Waterborne Atrazine Exposure Affects Behavior in Poecilia latipinna	10.3390/w15020309	https://www.mdpi.com/2073-4441/15/2/309	Water	maclaren_2023	maclaren_2023_exp_003	maclaren_2023_exp2_025	maclaren_2023_exp_003_assay_005	maclaren_2023_exp2_025_assay2_001	sailfin mollie	Poecilia latipinna	labratory stock from wild population	not_wild	male	atrazine	not reported	1912-24-9	in paper	triazine	1	ppb	12	weeks	DMSO	solvent_used	25	celsius	aggression	aggression	mean time in mirror zone	time spent in aggression zone	zone	NA	fig6	maclaren_2023_fig6	NA	NA	NA	20	405.4809630	NA	NA	NA	NA	study does not report error	exact sample size provided	NA	NA	NA	20	127.7465880	NA	NA	NA	NA	study does not report error	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Environmentally Realistic Waterborne Atrazine Exposure Affects Behavior in Poecilia latipinna	10.3390/w15020309	https://www.mdpi.com/2073-4441/15/2/309	Water	maclaren_2023	maclaren_2023_exp_004	maclaren_2023_exp2_026	maclaren_2023_exp_004_assay_005	maclaren_2023_exp2_026_assay2_001	sailfin mollie	Poecilia latipinna	labratory stock from wild population	not_wild	male	atrazine	not reported	1912-24-9	in paper	triazine	15	ppb	12	weeks	DMSO	solvent_used	25	celsius	aggression	aggression	mean time in mirror zone	time spent in aggression zone	zone	NA	fig6	maclaren_2023_fig6	NA	NA	NA	20	405.4809630	NA	NA	NA	NA	study does not report error	exact sample size provided	NA	NA	NA	20	199.2309630	NA	NA	NA	NA	study does not report error	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Effects of the fungicide carbendazim on the behaviour of the zebrafish Danio rerio (Cypriniformes, Cyprinidae)	10.1007/s10211-024-00438-8	https://link.springer.com/article/10.1007/s10211-024-00438-8#:~:text=The%20results%20indicated%20that%20the,the%20bottom%20to%20the%20surface).	Acta Ethologica	oliveira_2024	oliveira_2024_exp_001	oliveira_2024_exp2_001	oliveira_2024_exp_001_assay_001	oliveira_2024_exp2_001_assay2_001	zebrafish	Danio rerio	not reported	NA	mixed	carbendazim	not reported	10605-21-7	https://commonchemistry.cas.org/detail?cas_rn=10605-21-7&search=carbendazim	carbamate	120	ug/L	7	days	DMSO	solvent_used	26	celsius	aggression	aggression	mean number of recordings	frequency of aggressive behaviour	count	NA	fig2a	oliveira_2024_fig2a	NA	NA	NA	22	18.7992279	14.4762578	NA	NA	3.08634853	study reports boxplot	exact sample size provided	NA	NA	NA	21	14.4543493	9.0628231	NA	NA	1.977670134	study reports boxplot	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Effects of the fungicide carbendazim on the behaviour of the zebrafish Danio rerio (Cypriniformes, Cyprinidae)	10.1007/s10211-024-00438-8	https://link.springer.com/article/10.1007/s10211-024-00438-8#:~:text=The%20results%20indicated%20that%20the,the%20bottom%20to%20the%20surface).	Acta Ethologica	oliveira_2024	oliveira_2024_exp_001	oliveira_2024_exp2_001	oliveira_2024_exp_001_assay_002	oliveira_2024_exp2_001_assay2_002	zebrafish	Danio rerio	not reported	NA	mixed	carbendazim	not reported	10605-21-7	https://commonchemistry.cas.org/detail?cas_rn=10605-21-7&search=carbendazim	carbamate	120	ug/L	14	days	DMSO	solvent_used	26	celsius	aggression	aggression	mean number of recordings	frequency of aggressive behaviour	count	NA	fig2a	oliveira_2024_fig2a	NA	NA	NA	23	18.0526140	9.8309178	NA	NA	2.04988807	study reports boxplot	exact sample size provided	NA	NA	NA	21	15.4394650	9.4246408	NA	NA	2.056625235	study reports boxplot	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Effects of the fungicide carbendazim on the behaviour of the zebrafish Danio rerio (Cypriniformes, Cyprinidae)	10.1007/s10211-024-00438-8	https://link.springer.com/article/10.1007/s10211-024-00438-8#:~:text=The%20results%20indicated%20that%20the,the%20bottom%20to%20the%20surface).	Acta Ethologica	oliveira_2024	oliveira_2024_exp_001	oliveira_2024_exp2_001	oliveira_2024_exp_001_assay_003	oliveira_2024_exp2_001_assay2_003	zebrafish	Danio rerio	not reported	NA	mixed	carbendazim	not reported	10605-21-7	https://commonchemistry.cas.org/detail?cas_rn=10605-21-7&search=carbendazim	carbamate	120	ug/L	21	days	DMSO	solvent_used	26	celsius	aggression	aggression	mean number of recordings	frequency of aggressive behaviour	count	NA	fig2a	oliveira_2024_fig2a	NA	NA	NA	22	8.3777409	4.4756635	NA	NA	0.954214663	study reports boxplot	exact sample size provided	NA	NA	NA	22	5.2668493	1.9110062	NA	NA	0.407427892	study reports boxplot	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Effects of the fungicide carbendazim on the behaviour of the zebrafish Danio rerio (Cypriniformes, Cyprinidae)	10.1007/s10211-024-00438-8	https://link.springer.com/article/10.1007/s10211-024-00438-8#:~:text=The%20results%20indicated%20that%20the,the%20bottom%20to%20the%20surface).	Acta Ethologica	oliveira_2024	oliveira_2024_exp_001	oliveira_2024_exp2_001	oliveira_2024_exp_001_assay_004	oliveira_2024_exp2_001_assay2_004	zebrafish	Danio rerio	not reported	NA	mixed	carbendazim	not reported	10605-21-7	https://commonchemistry.cas.org/detail?cas_rn=10605-21-7&search=carbendazim	carbamate	120	ug/L	28	days	DMSO	solvent_used	26	celsius	aggression	aggression	mean number of recordings	frequency of aggressive behaviour	count	NA	fig2a	oliveira_2024_fig2a	NA	NA	NA	22	9.8398600	3.7105062	NA	NA	0.791082585	study reports boxplot	exact sample size provided	NA	NA	NA	24	4.8313245	1.6858765	NA	NA	0.344128109	study reports boxplot	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Exposure to carbamate fungicide iodocarb does not affect reproductive behavior or milt volumes in precocious male brown trout (Salmo trutta L.) parr	10.1007/s10695-020-00803-x	https://link.springer.com/article/10.1007/s10695-020-00803-x#citeas	Fish Physiology and Biochemistry	olsen_2020	olsen_2020_exp_001	olsen_2020_exp2_001	olsen_2020_exp_001_assay_001	olsen_2020_exp_001_assay2_001	brown trout	Salmo trutta	not reported	NA	male	iodocarb	not reported	NA	NA	carbamate	15	ug/L	96	hours	ethanol	solvent_used	8	celsius	courting	courtship	time with females	time spent near potential mate	NA	NA	fig1	olsen_2020_fig1	NA	NA	NA	5	550.3846154	90.9088724	NA	NA	18.18177448	calculated from scatter plot	counted from the scatter plot	NA	NA	NA	7	825.8241758	991.3480857	NA	NA	141.6211551	calculated from scatter plot	counted from the scatter plot	NA	NA	NA	NA
NA	NA	NA	KM	Behavioral effects of triadimefon in zebrafish are associated with alterations of the dopaminergic and serotonergic pathways	10.1016/j.pnpbp.2018.12.012	https://www.sciencedirect.com/science/article/pii/S0278584618306961?via%3Dihub	Progress in Neuro-Psychopharmacology and Biological Psychiatry	paredes_2019	paredes_2019_exp_001	paredes_2019_exp2_001	paredes_2019_exp_001_assay_001	paredes_2019_exp2_001_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	triadimefon	not reported	43121-43-3	https://commonchemistry.cas.org/detail?cas_rn=43121-43-3&search=triadimefon	triazole	5	mg/L	not reported	not reported	DMSO	solvent_used	28	celsius	aggression	aggression	number of bites towards its reflex	frequency of aggressive behaviour	count	NA	fig7c	paredes_2019_fig7c	NA	NA	NA	7	28.0900922	17.9394845	NA	NA	6.780487805	study reports mean and se	states range of sample sizes so selected lowest	NA	NA	NA	7	40.8934081	15.5769505	NA	NA	5.887533875	study reports mean and se	states range of sample sizes so selected lowest	NA	NA	NA	NA
NA	NA	YY	KM	Glyphosate-based herbicides affect behavioural patterns of the livebearer Jenynsia multidentata	10.1007/s11356-020-11958-8	https://link.springer.com/article/10.1007/s11356-020-11958-8	Environmental Science and Pollution Research	sanchez_2021	sanchez_2021_exp_001	sanchez_2021_exp2_001	sanchez_2021_exp_001_assay_001	sanchez_2021_exp2_001_assay_001	killifish	Jenynsia multidentata	not reported	NA	mixed	roundup	commercial	38641-94-0	https://commonchemistry.cas.org/detail?cas_rn=38641-94-0&search=roundup	organophosphate	0.5	mg/L	96	hours	not reported	NA	21.4	celsius	social interaction	sociality	duration	time spent in social zone	zone	NA	fig2a	sanchez_2021_fig2a	NA	NA	NA	20	525.7969964	61.9000405	NA	NA	13.84126984	study reports mean and se	states 10 males and 10 females	NA	NA	NA	20	497.2493774	87.0469320	NA	NA	19.46428571	study reports mean and se	states 10 males and 10 females	NA	NA	NA	NA
NA	NA	YY	KM	Glyphosate-based herbicides affect behavioural patterns of the livebearer Jenynsia multidentata	10.1007/s11356-020-11958-8	https://link.springer.com/article/10.1007/s11356-020-11958-8	Environmental Science and Pollution Research	sanchez_2021	sanchez_2021_exp_002	sanchez_2021_exp2_002	sanchez_2021_exp_002_assay_001	sanchez_2021_exp2_002_assay_001	killifish	Jenynsia multidentata	not reported	NA	mixed	roundup transorb	commercial	38641-94-0	https://commonchemistry.cas.org/detail?cas_rn=38641-94-0&search=roundup	organophosphate	0.5	mg/L	96	hours	not reported	NA	21.4	celsius	social interaction	sociality	duration	time spent in social zone	zone	NA	fig2a	sanchez_2021_fig2a	NA	NA	NA	20	525.7969964	61.9000405	NA	NA	13.84126984	study reports mean and se	states 10 males and 10 females	NA	NA	NA	20	491.6263615	77.3750507	NA	NA	17.3015873	study reports mean and se	states 10 males and 10 females	NA	NA	NA	NA
NA	NA	YY	KM	Glyphosate-based herbicides affect behavioural patterns of the livebearer Jenynsia multidentata	10.1007/s11356-020-11958-8	https://link.springer.com/article/10.1007/s11356-020-11958-8	Environmental Science and Pollution Research	sanchez_2021	sanchez_2021_exp_003	sanchez_2021_exp2_003	sanchez_2021_exp_003_assay_001	sanchez_2021_exp2_003_assay_001	killifish	Jenynsia multidentata	not reported	NA	mixed	roundup WG	commercial	38641-94-0	https://commonchemistry.cas.org/detail?cas_rn=38641-94-0&search=roundup	organophosphate	0.5	mg/L	96	hours	not reported	NA	21.4	celsius	social interaction	sociality	duration	time spent in social zone	zone	NA	fig2a	sanchez_2021_fig2a	NA	NA	NA	20	525.7969964	61.9000405	NA	NA	13.84126984	study reports mean and se	states 10 males and 10 females	NA	NA	NA	20	442.3168377	87.0469320	NA	NA	19.46428571	study reports mean and se	states 10 males and 10 females	NA	NA	NA	NA
NA	NA	YY	KM	Glyphosate-based herbicides affect behavioural patterns of the livebearer Jenynsia multidentata	10.1007/s11356-020-11958-8	https://link.springer.com/article/10.1007/s11356-020-11958-8	Environmental Science and Pollution Research	sanchez_2021	sanchez_2021_exp_001	sanchez_2021_exp2_004	sanchez_2021_exp_001_assay_002	sanchez_2021_exp2_004_assay_001	killifish	Jenynsia multidentata	not reported	NA	mixed	roundup	commercial	38641-94-0	https://commonchemistry.cas.org/detail?cas_rn=38641-94-0&search=roundup	organophosphate	0.5	mg/L	96	hours	not reported	NA	21.4	celsius	aggression	aggression	time close to mirror	time spent in aggression zone	zone	NA	fig2c	sanchez_2021_fig2c	NA	NA	NA	20	448.8608098	84.6555719	NA	NA	18.92956134	study reports mean and se	states 10 males and 10 females	NA	NA	NA	20	476.5270917	70.5463099	NA	NA	15.77463445	study reports mean and se	states 10 males and 10 females	NA	NA	NA	NA
NA	NA	YY	KM	Glyphosate-based herbicides affect behavioural patterns of the livebearer Jenynsia multidentata	10.1007/s11356-020-11958-8	https://link.springer.com/article/10.1007/s11356-020-11958-8	Environmental Science and Pollution Research	sanchez_2021	sanchez_2021_exp_002	sanchez_2021_exp2_005	sanchez_2021_exp_002_assay_002	sanchez_2021_exp2_005_assay_001	killifish	Jenynsia multidentata	not reported	NA	mixed	roundup transorb	commercial	38641-94-0	https://commonchemistry.cas.org/detail?cas_rn=38641-94-0&search=roundup	organophosphate	0.5	mg/L	96	hours	not reported	NA	21.4	celsius	aggression	aggression	time close to mirror	time spent in aggression zone	zone	NA	fig2c	sanchez_2021_fig2c	NA	NA	NA	20	448.8608098	84.6555719	NA	NA	18.92956134	study reports mean and se	states 10 males and 10 females	NA	NA	NA	20	447.8900630	73.8022934	NA	NA	16.50269451	study reports mean and se	states 10 males and 10 females	NA	NA	NA	NA
NA	NA	YY	KM	Glyphosate-based herbicides affect behavioural patterns of the livebearer Jenynsia multidentata	10.1007/s11356-020-11958-8	https://link.springer.com/article/10.1007/s11356-020-11958-8	Environmental Science and Pollution Research	sanchez_2021	sanchez_2021_exp_003	sanchez_2021_exp2_006	sanchez_2021_exp_003_assay_002	sanchez_2021_exp2_006_assay_001	killifish	Jenynsia multidentata	not reported	NA	mixed	roundup WG	commercial	38641-94-0	https://commonchemistry.cas.org/detail?cas_rn=38641-94-0&search=roundup	organophosphate	0.5	mg/L	96	hours	not reported	NA	21.4	celsius	aggression	aggression	time close to mirror	time spent in aggression zone	zone	NA	fig2c	sanchez_2021_fig2c	NA	NA	NA	20	448.8608098	84.6555719	NA	NA	18.92956134	study reports mean and se	states 10 males and 10 females	NA	NA	NA	20	462.9366374	73.8022934	NA	NA	16.50269451	study reports mean and se	states 10 males and 10 females	NA	NA	NA	NA
NA	NA	YY	KM	Glyphosate-based herbicides affect behavioural patterns of the livebearer Jenynsia multidentata	10.1007/s11356-020-11958-8	https://link.springer.com/article/10.1007/s11356-020-11958-8	Environmental Science and Pollution Research	sanchez_2021	sanchez_2021_exp_001	sanchez_2021_exp2_007	sanchez_2021_exp_001_assay_003	sanchez_2021_exp2_007_assay_001	killifish	Jenynsia multidentata	not reported	NA	mixed	roundup	commercial	38641-94-0	https://commonchemistry.cas.org/detail?cas_rn=38641-94-0&search=roundup	organophosphate	0.5	mg/L	96	hours	not reported	NA	21.4	celsius	sexual activity	courtship	time taken by pursuits	duration of courtship behaviour	NA	NA	table2	sanchez_2021_table2	NA	NA	NA	20	215.9100000	322.1726742	NA	NA	72.04	study reports mean and se	states 10 males and 10 females	NA	NA	NA	20	274.0000000	358.2180900	NA	NA	80.1	study reports mean and se	states 10 males and 10 females	NA	NA	NA	NA
NA	NA	YY	KM	Glyphosate-based herbicides affect behavioural patterns of the livebearer Jenynsia multidentata	10.1007/s11356-020-11958-8	https://link.springer.com/article/10.1007/s11356-020-11958-8	Environmental Science and Pollution Research	sanchez_2021	sanchez_2021_exp_002	sanchez_2021_exp2_008	sanchez_2021_exp_002_assay_003	sanchez_2021_exp2_008_assay_001	killifish	Jenynsia multidentata	not reported	NA	mixed	roundup transorb	commercial	38641-94-0	https://commonchemistry.cas.org/detail?cas_rn=38641-94-0&search=roundup	organophosphate	0.5	mg/L	96	hours	not reported	NA	21.4	celsius	sexual activity	courtship	time taken by pursuits	duration of courtship behaviour	NA	NA	table2	sanchez_2021_table2	NA	NA	NA	20	215.9100000	322.1726742	NA	NA	72.04	study reports mean and se	states 10 males and 10 females	NA	NA	NA	20	98.0800000	109.5673309	NA	NA	24.5	study reports mean and se	states 10 males and 10 females	NA	NA	NA	NA
NA	NA	YY	KM	Glyphosate-based herbicides affect behavioural patterns of the livebearer Jenynsia multidentata	10.1007/s11356-020-11958-8	https://link.springer.com/article/10.1007/s11356-020-11958-8	Environmental Science and Pollution Research	sanchez_2021	sanchez_2021_exp_003	sanchez_2021_exp2_009	sanchez_2021_exp_003_assay_003	sanchez_2021_exp2_009_assay_001	killifish	Jenynsia multidentata	not reported	NA	mixed	roundup WG	commercial	38641-94-0	https://commonchemistry.cas.org/detail?cas_rn=38641-94-0&search=roundup	organophosphate	0.5	mg/L	96	hours	not reported	NA	21.4	celsius	sexual activity	courtship	time taken by pursuits	duration of courtship behaviour	NA	NA	table2	sanchez_2021_table2	NA	NA	NA	20	215.9100000	322.1726742	NA	NA	72.04	study reports mean and se	states 10 males and 10 females	NA	NA	NA	20	158.2600000	188.3663664	NA	NA	42.12	study reports mean and se	states 10 males and 10 females	NA	NA	NA	NA
NA	NA	YY	KM	Glyphosate-based herbicides affect behavioural patterns of the livebearer Jenynsia multidentata	10.1007/s11356-020-11958-8	https://link.springer.com/article/10.1007/s11356-020-11958-8	Environmental Science and Pollution Research	sanchez_2021	sanchez_2021_exp_001	sanchez_2021_exp2_007	sanchez_2021_exp_001_assay_004	sanchez_2021_exp2_007_assay_002	killifish	Jenynsia multidentata	not reported	NA	mixed	roundup	commercial	38641-94-0	https://commonchemistry.cas.org/detail?cas_rn=38641-94-0&search=roundup	organophosphate	0.5	mg/L	96	hours	not reported	NA	21.4	celsius	sexual activity	courtship	number of pursuits	frequency of courtship behaviour	count	NA	table2	sanchez_2021_table2	NA	NA	NA	20	43.7500000	27.3694720	NA	NA	6.12	study reports mean and se	states 10 males and 10 females	NA	NA	NA	20	40.5600000	38.7734187	NA	NA	8.67	study reports mean and se	states 10 males and 10 females	NA	NA	NA	NA
NA	NA	YY	KM	Glyphosate-based herbicides affect behavioural patterns of the livebearer Jenynsia multidentata	10.1007/s11356-020-11958-8	https://link.springer.com/article/10.1007/s11356-020-11958-8	Environmental Science and Pollution Research	sanchez_2021	sanchez_2021_exp_002	sanchez_2021_exp2_008	sanchez_2021_exp_002_assay_004	sanchez_2021_exp2_008_assay_002	killifish	Jenynsia multidentata	not reported	NA	mixed	roundup transorb	commercial	38641-94-0	https://commonchemistry.cas.org/detail?cas_rn=38641-94-0&search=roundup	organophosphate	0.5	mg/L	96	hours	not reported	NA	21.4	celsius	sexual activity	courtship	number of pursuits	frequency of courtship behaviour	count	NA	table2	sanchez_2021_table2	NA	NA	NA	20	43.7500000	27.3694720	NA	NA	6.12	study reports mean and se	states 10 males and 10 females	NA	NA	NA	20	21.3800000	27.2353080	NA	NA	6.09	study reports mean and se	states 10 males and 10 females	NA	NA	NA	NA
NA	NA	YY	KM	Glyphosate-based herbicides affect behavioural patterns of the livebearer Jenynsia multidentata	10.1007/s11356-020-11958-8	https://link.springer.com/article/10.1007/s11356-020-11958-8	Environmental Science and Pollution Research	sanchez_2021	sanchez_2021_exp_003	sanchez_2021_exp2_009	sanchez_2021_exp_003_assay_004	sanchez_2021_exp2_009_assay_002	killifish	Jenynsia multidentata	not reported	NA	mixed	roundup WG	commercial	38641-94-0	https://commonchemistry.cas.org/detail?cas_rn=38641-94-0&search=roundup	organophosphate	0.5	mg/L	96	hours	not reported	NA	21.4	celsius	sexual activity	courtship	number of pursuits	frequency of courtship behaviour	count	NA	table2	sanchez_2021_table2	NA	NA	NA	20	43.7500000	27.3694720	NA	NA	6.12	study reports mean and se	states 10 males and 10 females	NA	NA	NA	20	36.7800000	33.7646265	NA	NA	7.55	study reports mean and se	states 10 males and 10 females	NA	NA	NA	NA
NA	NA	YY	KM	Glyphosate-based herbicides affect behavioural patterns of the livebearer Jenynsia multidentata	10.1007/s11356-020-11958-8	https://link.springer.com/article/10.1007/s11356-020-11958-8	Environmental Science and Pollution Research	sanchez_2021	sanchez_2021_exp_001	sanchez_2021_exp2_007	sanchez_2021_exp_001_assay_005	sanchez_2021_exp2_007_assay_003	killifish	Jenynsia multidentata	not reported	NA	mixed	roundup	commercial	38641-94-0	https://commonchemistry.cas.org/detail?cas_rn=38641-94-0&search=roundup	organophosphate	0.5	mg/L	96	hours	not reported	NA	21.4	celsius	sexual activity	courtship	attempts at copulation	frequency of courtship behaviour	count	NA	table2	sanchez_2021_table2	NA	NA	NA	20	74.7100000	80.5878899	NA	NA	18.02	study reports mean and se	states 10 males and 10 females	NA	NA	NA	20	62.0000000	56.6619625	NA	NA	12.67	study reports mean and se	states 10 males and 10 females	NA	NA	NA	NA
NA	NA	YY	KM	Glyphosate-based herbicides affect behavioural patterns of the livebearer Jenynsia multidentata	10.1007/s11356-020-11958-8	https://link.springer.com/article/10.1007/s11356-020-11958-8	Environmental Science and Pollution Research	sanchez_2021	sanchez_2021_exp_002	sanchez_2021_exp2_008	sanchez_2021_exp_002_assay_005	sanchez_2021_exp2_008_assay_003	killifish	Jenynsia multidentata	not reported	NA	mixed	roundup transorb	commercial	38641-94-0	https://commonchemistry.cas.org/detail?cas_rn=38641-94-0&search=roundup	organophosphate	0.5	mg/L	96	hours	not reported	NA	21.4	celsius	sexual activity	courtship	attempts at copulation	frequency of courtship behaviour	count	NA	table2	sanchez_2021_table2	NA	NA	NA	20	74.7100000	80.5878899	NA	NA	18.02	study reports mean and se	states 10 males and 10 females	NA	NA	NA	20	28.2500000	47.8518547	NA	NA	10.7	study reports mean and se	states 10 males and 10 females	NA	NA	NA	NA
NA	NA	YY	KM	Glyphosate-based herbicides affect behavioural patterns of the livebearer Jenynsia multidentata	10.1007/s11356-020-11958-8	https://link.springer.com/article/10.1007/s11356-020-11958-8	Environmental Science and Pollution Research	sanchez_2021	sanchez_2021_exp_003	sanchez_2021_exp2_009	sanchez_2021_exp_003_assay_005	sanchez_2021_exp2_009_assay_003	killifish	Jenynsia multidentata	not reported	NA	mixed	roundup WG	commercial	38641-94-0	https://commonchemistry.cas.org/detail?cas_rn=38641-94-0&search=roundup	organophosphate	0.5	mg/L	96	hours	not reported	NA	21.4	celsius	sexual activity	courtship	attempts at copulation	frequency of courtship behaviour	count	NA	table2	sanchez_2021_table2	NA	NA	NA	20	74.7100000	80.5878899	NA	NA	18.02	study reports mean and se	states 10 males and 10 females	NA	NA	NA	20	40.2200000	42.9325052	NA	NA	9.6	study reports mean and se	states 10 males and 10 females	NA	NA	NA	NA
NA	NA	YY	KM	Glyphosate-based herbicides affect behavioural patterns of the livebearer Jenynsia multidentata	10.1007/s11356-020-11958-8	https://link.springer.com/article/10.1007/s11356-020-11958-8	Environmental Science and Pollution Research	sanchez_2021	sanchez_2021_exp_001	sanchez_2021_exp2_007	sanchez_2021_exp_001_assay_006	sanchez_2021_exp2_007_assay_004	killifish	Jenynsia multidentata	not reported	NA	mixed	roundup	commercial	38641-94-0	https://commonchemistry.cas.org/detail?cas_rn=38641-94-0&search=roundup	organophosphate	0.5	mg/L	96	hours	not reported	NA	21.4	celsius	sexual activity	courtship	number of actual copulations	frequency of courtship behaviour success	count	NA	table2	sanchez_2021_table2	NA	NA	NA	20	20.1300000	29.0241624	NA	NA	6.49	study reports mean and se	states 10 males and 10 females	NA	NA	NA	20	20.0000000	18.2463147	NA	NA	4.08	study reports mean and se	states 10 males and 10 females	NA	NA	NA	NA
NA	NA	YY	KM	Glyphosate-based herbicides affect behavioural patterns of the livebearer Jenynsia multidentata	10.1007/s11356-020-11958-8	https://link.springer.com/article/10.1007/s11356-020-11958-8	Environmental Science and Pollution Research	sanchez_2021	sanchez_2021_exp_002	sanchez_2021_exp2_008	sanchez_2021_exp_002_assay_006	sanchez_2021_exp2_008_assay_004	killifish	Jenynsia multidentata	not reported	NA	mixed	roundup transorb	commercial	38641-94-0	https://commonchemistry.cas.org/detail?cas_rn=38641-94-0&search=roundup	organophosphate	0.5	mg/L	96	hours	not reported	NA	21.4	celsius	sexual activity	courtship	number of actual copulations	frequency of courtship behaviour success	count	NA	table2	sanchez_2021_table2	NA	NA	NA	20	20.1300000	29.0241624	NA	NA	6.49	study reports mean and se	states 10 males and 10 females	NA	NA	NA	20	6.5000000	8.8548292	NA	NA	1.98	study reports mean and se	states 10 males and 10 females	NA	NA	NA	NA
NA	NA	YY	KM	Glyphosate-based herbicides affect behavioural patterns of the livebearer Jenynsia multidentata	10.1007/s11356-020-11958-8	https://link.springer.com/article/10.1007/s11356-020-11958-8	Environmental Science and Pollution Research	sanchez_2021	sanchez_2021_exp_003	sanchez_2021_exp2_009	sanchez_2021_exp_003_assay_006	sanchez_2021_exp2_009_assay_004	killifish	Jenynsia multidentata	not reported	NA	mixed	roundup WG	commercial	38641-94-0	https://commonchemistry.cas.org/detail?cas_rn=38641-94-0&search=roundup	organophosphate	0.5	mg/L	96	hours	not reported	NA	21.4	celsius	sexual activity	courtship	number of actual copulations	frequency of courtship behaviour success	count	NA	table2	sanchez_2021_table2	NA	NA	NA	20	20.1300000	29.0241624	NA	NA	6.49	study reports mean and se	states 10 males and 10 females	NA	NA	NA	20	11.0000000	9.6598137	NA	NA	2.16	study reports mean and se	states 10 males and 10 females	NA	NA	NA	NA
NA	NA	GM	KM	Subchronic atrazine exposure changes defensive behaviour profile and disrupts brain acetylcholinesterase activity of zebrafish	10.1016/j.ntt.2014.05.006	https://sciencedirect.com/science/article/pii/S0892036214001226	Neurotoxicology and Teratology	schmidel_2014	schmidel_2014_exp_001	schmidel_2014_exp2_001	schmidel_2014_exp_001_assay_001	schmidel_2014_exp2_001_assay2_001	zebrafish	Danio rerio	labratory stock from commercial supplier	not_wild	mixed	atrazine	analytical	1912-24-9	in paper	triazine	10	ug/L	14	days	acetone	solvent_used	27	celsius	shoaling	collective behaviour	distance	group movement	NA	NA	fig1a	schmidel_2014_fig1a	15.058824	128.000000	8	8	5.4751686	0.8400780	0.8400780	3.3603122	0.297012439	study reports mean and se	exact sample size provided	8.500000	8.000000	128	8	5.2221580	0.2800260	0.2800260	1.1201040	0.099004146	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	GM	KM	Subchronic atrazine exposure changes defensive behaviour profile and disrupts brain acetylcholinesterase activity of zebrafish	10.1016/j.ntt.2014.05.006	https://sciencedirect.com/science/article/pii/S0892036214001226	Neurotoxicology and Teratology	schmidel_2014	schmidel_2014_exp_002	schmidel_2014_exp2_002	schmidel_2014_exp_002_assay_001	schmidel_2014_exp2_002_assay2_001	zebrafish	Danio rerio	labratory stock from commercial supplier	not_wild	mixed	atrazine	analytical	1912-24-9	in paper	triazine	1000	ug/L	14	days	acetone	solvent_used	27	celsius	shoaling	collective behaviour	distance	group movement	NA	NA	fig1a	schmidel_2014_fig1a	15.058824	128.000000	8	8	5.4751686	0.8400780	0.8400780	3.3603122	0.297012439	study reports mean and se	exact sample size provided	8.500000	8.000000	128	8	6.8832275	1.8668401	1.8668401	7.4673604	0.660027643	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	GM	KM	Subchronic atrazine exposure changes defensive behaviour profile and disrupts brain acetylcholinesterase activity of zebrafish	10.1016/j.ntt.2014.05.006	https://sciencedirect.com/science/article/pii/S0892036214001226	Neurotoxicology and Teratology	schmidel_2014	schmidel_2014_exp_001	schmidel_2014_exp2_003	schmidel_2014_exp_001_assay_002	schmidel_2014_exp2_003_assay2_001	zebrafish	Danio rerio	labratory stock from commercial supplier	not_wild	mixed	atrazine	analytical	1912-24-9	in paper	triazine	10	ug/L	14	days	acetone	solvent_used	27	celsius	shoaling	collective behaviour	nearest neighbour distance	group arrangment	NA	change	fig1b	schmidel_2014_fig1b	15.058824	128.000000	8	8	2.3326796	0.2681029	0.2681029	1.0724116	0.094788686	study reports mean and se	exact sample size provided	8.500000	8.000000	128	8	2.1009739	0.1638407	0.1638407	0.6553626	0.057926419	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	GM	KM	Subchronic atrazine exposure changes defensive behaviour profile and disrupts brain acetylcholinesterase activity of zebrafish	10.1016/j.ntt.2014.05.006	https://sciencedirect.com/science/article/pii/S0892036214001226	Neurotoxicology and Teratology	schmidel_2014	schmidel_2014_exp_002	schmidel_2014_exp2_004	schmidel_2014_exp_002_assay_002	schmidel_2014_exp2_004_assay2_001	zebrafish	Danio rerio	labratory stock from commercial supplier	not_wild	mixed	atrazine	analytical	1912-24-9	in paper	triazine	1000	ug/L	14	days	acetone	solvent_used	27	celsius	shoaling	collective behaviour	nearest neighbour distance	group arrangment	NA	change	fig1b	schmidel_2014_fig1b	15.058824	128.000000	8	8	2.3326796	0.2681029	0.2681029	1.0724116	0.094788686	study reports mean and se	exact sample size provided	8.500000	8.000000	128	8	2.7960909	0.7894141	0.7894141	3.1576563	0.279100019	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	GM	KM	Subchronic atrazine exposure changes defensive behaviour profile and disrupts brain acetylcholinesterase activity of zebrafish	10.1016/j.ntt.2014.05.006	https://sciencedirect.com/science/article/pii/S0892036214001226	Neurotoxicology and Teratology	schmidel_2014	schmidel_2014_exp_001	schmidel_2014_exp2_005	schmidel_2014_exp_001_assay_003	schmidel_2014_exp2_005_assay2_001	zebrafish	Danio rerio	labratory stock from commercial supplier	not_wild	mixed	atrazine	analytical	1912-24-9	in paper	triazine	10	ug/L	14	days	acetone	solvent_used	27	celsius	shoaling	collective behaviour	farthest neighbour distance	group arrangment	NA	change	fig1c	schmidel_2014_fig1c	15.058824	128.000000	8	8	8.3946118	1.2046017	1.2046017	4.8184068	0.425891015	study reports mean and se	exact sample size provided	8.500000	8.000000	128	8	8.2799488	0.8339550	0.8339550	3.3358201	0.294847626	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	GM	KM	Subchronic atrazine exposure changes defensive behaviour profile and disrupts brain acetylcholinesterase activity of zebrafish	10.1016/j.ntt.2014.05.006	https://sciencedirect.com/science/article/pii/S0892036214001226	Neurotoxicology and Teratology	schmidel_2014	schmidel_2014_exp_002	schmidel_2014_exp2_006	schmidel_2014_exp_002_assay_003	schmidel_2014_exp2_006_assay2_001	zebrafish	Danio rerio	labratory stock from commercial supplier	not_wild	mixed	atrazine	analytical	1912-24-9	in paper	triazine	1000	ug/L	14	days	acetone	solvent_used	27	celsius	shoaling	collective behaviour	farthest neighbour distance	group arrangment	NA	change	fig1c	schmidel_2014_fig1c	15.058824	128.000000	8	8	8.3946118	1.2046017	1.2046017	4.8184068	0.425891015	study reports mean and se	exact sample size provided	8.500000	8.000000	128	8	10.8025340	2.9188426	2.9188426	11.6753703	1.03196669	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	GM	KM	Subchronic atrazine exposure changes defensive behaviour profile and disrupts brain acetylcholinesterase activity of zebrafish	10.1016/j.ntt.2014.05.006	https://sciencedirect.com/science/article/pii/S0892036214001226	Neurotoxicology and Teratology	schmidel_2014	schmidel_2014_exp_001	schmidel_2014_exp2_007	schmidel_2014_exp_001_assay_004	schmidel_2014_exp2_007_assay2_001	zebrafish	Danio rerio	labratory stock from commercial supplier	not_wild	mixed	atrazine	analytical	1912-24-9	in paper	triazine	10	ug/L	14	days	acetone	solvent_used	27	celsius	shoaling	collective behaviour	shoal area	group arrangment	NA	change	fig2	schmidel_2014_fig2	15.058824	128.000000	8	8	17.2624072	4.0968964	4.0968964	16.3875856	1.448471616	study reports mean and se	exact sample size provided	8.500000	8.000000	128	8	14.8327129	2.3788431	2.3788431	9.5153723	0.841048035	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	GM	KM	Subchronic atrazine exposure changes defensive behaviour profile and disrupts brain acetylcholinesterase activity of zebrafish	10.1016/j.ntt.2014.05.006	https://sciencedirect.com/science/article/pii/S0892036214001226	Neurotoxicology and Teratology	schmidel_2014	schmidel_2014_exp_002	schmidel_2014_exp2_008	schmidel_2014_exp_002_assay_004	schmidel_2014_exp2_008_assay2_001	zebrafish	Danio rerio	labratory stock from commercial supplier	not_wild	mixed	atrazine	analytical	1912-24-9	in paper	triazine	1000	ug/L	14	days	acetone	solvent_used	27	celsius	shoaling	collective behaviour	shoal area	group arrangment	NA	change	fig2	schmidel_2014_fig2	15.058824	128.000000	8	8	17.2624072	4.0968964	4.0968964	16.3875856	1.448471616	study reports mean and se	exact sample size provided	8.500000	8.000000	128	8	34.0322517	22.7398130	22.7398130	90.9592520	8.039737991	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	GM	KM	Subchronic atrazine exposure changes defensive behaviour profile and disrupts brain acetylcholinesterase activity of zebrafish	10.1016/j.ntt.2014.05.006	https://sciencedirect.com/science/article/pii/S0892036214001226	Neurotoxicology and Teratology	schmidel_2014	schmidel_2014_exp_001	schmidel_2014_exp2_009	schmidel_2014_exp_001_assay_005	schmidel_2014_exp2_009_assay2_001	zebrafish	Danio rerio	labratory stock from commercial supplier	not_wild	mixed	atrazine	analytical	1912-24-9	in paper	triazine	10	ug/L	14	days	acetone	solvent_used	27	celsius	shoaling	collective behaviour	total number of interactions	group arrangment	NA	NA	fig3b	schmidel_2014_fig3b	15.058824	128.000000	8	8	1432.0737130	253.6275665	253.6275665	1014.5102660	89.67088608	study reports mean and se	exact sample size provided	8.500000	8.000000	128	8	1519.7952320	148.8683542	148.8683542	595.4734169	52.63291139	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	GM	KM	Subchronic atrazine exposure changes defensive behaviour profile and disrupts brain acetylcholinesterase activity of zebrafish	10.1016/j.ntt.2014.05.006	https://sciencedirect.com/science/article/pii/S0892036214001226	Neurotoxicology and Teratology	schmidel_2014	schmidel_2014_exp_002	schmidel_2014_exp2_010	schmidel_2014_exp_002_assay_005	schmidel_2014_exp2_010_assay2_001	zebrafish	Danio rerio	labratory stock from commercial supplier	not_wild	mixed	atrazine	analytical	1912-24-9	in paper	triazine	1000	ug/L	14	days	acetone	solvent_used	27	celsius	shoaling	collective behaviour	total number of interactions	group arrangment	NA	NA	fig3b	schmidel_2014_fig3b	15.058824	128.000000	8	8	1432.0737130	253.6275665	253.6275665	1014.5102660	89.67088608	study reports mean and se	exact sample size provided	8.500000	8.000000	128	8	1067.5420670	358.3867787	358.3867788	1433.5471150	126.7088608	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Environmentally Realistic Exposure to the Herbicide Atrazine Alters Some Sexually Selected Traits in Male Guppies	10.1371/journal.pone.0030611	https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0030611	Plos One	shenoy_2012	shenoy_2012_exp_001	shenoy_2012_exp2_001	shenoy_2012_exp_001_assay_001	shenoy_2012_exp2_001_assay2_001	guppy	Poecilia reticulata	labratory stock from wild population	not_wild	male	atrazine	not reported	1912-24-9	https://commonchemistry.cas.org/detail?cas_rn=1912-24-9&search=1912-24-9	triazine	1	ppb	16	weeks	DMSO	solvent_used	25	celsius	courting	courtship	number of displays in absence of competing male	frequency of courtship behaviour	count	NA	fig2a	shenoy_2012_fig2a	NA	NA	NA	17	19.8917569	8.3330673	NA	NA	2.021065675	study does not state error type used, so we assumed to be SE	exact sample size provided	NA	NA	NA	17	14.1000516	11.8098620	NA	NA	2.864312268	does not report error type	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Environmentally Realistic Exposure to the Herbicide Atrazine Alters Some Sexually Selected Traits in Male Guppies	10.1371/journal.pone.0030611	https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0030611	Plos One	shenoy_2012	shenoy_2012_exp_002	shenoy_2012_exp2_002	shenoy_2012_exp_002_assay_001	shenoy_2012_exp2_002_assay2_001	guppy	Poecilia reticulata	labratory stock from wild population	not_wild	male	atrazine	not reported	1912-24-9	https://commonchemistry.cas.org/detail?cas_rn=1912-24-9&search=1912-24-9	triazine	15	ppb	16	weeks	DMSO	solvent_used	25	celsius	courting	courtship	number of displays in absence of competing male	frequency of courtship behaviour	count	NA	fig2a	shenoy_2012_fig2a	NA	NA	NA	17	19.8917569	8.3330673	NA	NA	2.021065675	study does not state error type used, so we assumed to be SE	exact sample size provided	NA	NA	NA	17	13.2164759	11.4244385	NA	NA	2.770833333	does not report error type	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Environmentally Realistic Exposure to the Herbicide Atrazine Alters Some Sexually Selected Traits in Male Guppies	10.1371/journal.pone.0030611	https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0030611	Plos One	shenoy_2012	shenoy_2012_exp_001	shenoy_2012_exp2_001	shenoy_2012_exp_001_assay_002	shenoy_2012_exp2_001_assay2_002	guppy	Poecilia reticulata	labratory stock from wild population	not_wild	male	atrazine	not reported	1912-24-9	https://commonchemistry.cas.org/detail?cas_rn=1912-24-9&search=1912-24-9	triazine	1	ppb	16	weeks	DMSO	solvent_used	25	celsius	courting	courtship	number of mating attempts in absence of competing male	frequency of courtship behaviour	count	NA	fig2b	shenoy_2012_fig2b	NA	NA	NA	17	0.6531993	0.2939401	NA	NA	0.071290944	study does not state error type used, so we assumed to be SE	exact sample size provided	NA	NA	NA	17	0.7630259	0.5163812	NA	NA	0.125240848	does not report error type	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Environmentally Realistic Exposure to the Herbicide Atrazine Alters Some Sexually Selected Traits in Male Guppies	10.1371/journal.pone.0030611	https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0030611	Plos One	shenoy_2012	shenoy_2012_exp_002	shenoy_2012_exp2_002	shenoy_2012_exp_002_assay_002	shenoy_2012_exp2_002_assay2_002	guppy	Poecilia reticulata	labratory stock from wild population	not_wild	male	atrazine	not reported	1912-24-9	https://commonchemistry.cas.org/detail?cas_rn=1912-24-9&search=1912-24-9	triazine	15	ppb	16	weeks	DMSO	solvent_used	25	celsius	courting	courtship	number of mating attempts in absence of competing male	frequency of courtship behaviour	count	NA	fig2b	shenoy_2012_fig2b	NA	NA	NA	17	0.6531993	0.2939401	NA	NA	0.071290944	study does not state error type used, so we assumed to be SE	exact sample size provided	NA	NA	NA	17	0.5452995	0.4607710	NA	NA	0.111753372	does not report error type	exact sample size provided	NA	NA	NA	NA
NA	NA	GM	KM	Effects of chlorpyrifos on reproductive performances of guppy (Poecilia reticulata)	10.1016/j.chemosphere.2004.10.030	https://www.sciencedirect.com/science/article/pii/S0045653504009919	Chemosphere	silva_2005	silva_2005_exp_001	silva_2005_exp2_001	silva_2005_exp_001_assay_001	silva_2005_exp2_001_assay2_001	guppy	Poecilia reticulata	wild collected	wild	male	chlorpyrifos	commercial	2921-88-2	https://commonchemistry.cas.org/detail?cas_rn=2921-88-2&search=chlorpyrifos	organophosphate	0.002	ug/L	3	days	not reported	NA	26	celsius	mating	courtship	number of gonopodial thrusts	frequency of courtship behaviour	count	NA	fig2	silva_2005_fig2	NA	NA	NA	72	11.4702973	1.5373239	NA	NA	0.181175364	study reports mean and se	exact sample size provided	NA	NA	NA	72	7.7084288	1.2259155	NA	NA	0.144475526	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	GM	KM	Effects of chlorpyrifos on reproductive performances of guppy (Poecilia reticulata)	10.1016/j.chemosphere.2004.10.030	https://www.sciencedirect.com/science/article/pii/S0045653504009919	Chemosphere	silva_2005	silva_2005_exp_002	silva_2005_exp2_002	silva_2005_exp_002_assay_001	silva_2005_exp2_002_assay2_001	guppy	Poecilia reticulata	wild collected	wild	male	chlorpyrifos	commercial	2921-88-2	https://commonchemistry.cas.org/detail?cas_rn=2921-88-2&search=chlorpyrifos	organophosphate	2	ug/L	3	days	not reported	NA	26	celsius	mating	courtship	number of gonopodial thrusts	frequency of courtship behaviour	count	NA	fig2	silva_2005_fig2	NA	NA	NA	72	11.4702973	1.5373239	NA	NA	0.181175364	study reports mean and se	exact sample size provided	NA	NA	NA	72	4.1219704	1.0746479	NA	NA	0.126648468	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_001	stungaru_2019_exp2_001	stungaru_2019_exp_001_assay_001	stungaru_2019_exp_001_assay2_001	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	0.25	ug/L	1	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1b treatment; fig1a control	stungaru_2019_fig1b_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	19.4069384	30.7277226	NA	NA	4.858479532	study reports mean and se	exact sample size provided	NA	NA	NA	40	40.7818852	41.1839444	NA	NA	6.511753372	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_001	stungaru_2019_exp2_001	stungaru_2019_exp_001_assay_002	stungaru_2019_exp_001_assay2_002	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	0.25	ug/L	2	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1b treatment; fig1a control	stungaru_2019_fig1b_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	32.6771138	44.4864043	NA	NA	7.033918129	study reports mean and se	exact sample size provided	NA	NA	NA	40	34.2701318	33.0631667	NA	NA	5.227745665	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_001	stungaru_2019_exp2_001	stungaru_2019_exp_001_assay_003	stungaru_2019_exp_001_assay2_003	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	0.25	ug/L	3	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1b treatment; fig1a control	stungaru_2019_fig1b_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	13.3157103	19.2621544	NA	NA	3.045614035	study reports mean and se	exact sample size provided	NA	NA	NA	40	32.8944092	37.7036111	NA	NA	5.961464355	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_001	stungaru_2019_exp2_001	stungaru_2019_exp_001_assay_004	stungaru_2019_exp_001_assay2_004	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	0.25	ug/L	4	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1b treatment; fig1a control	stungaru_2019_fig1b_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	26.7309150	25.2242499	NA	NA	3.988304094	study reports mean and se	exact sample size provided	NA	NA	NA	40	30.5098235	24.9423889	NA	NA	3.943737958	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_001	stungaru_2019_exp2_001	stungaru_2019_exp_001_assay_005	stungaru_2019_exp_001_assay2_005	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	0.25	ug/L	5	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1b treatment; fig1a control	stungaru_2019_fig1b_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	14.4759442	21.0966454	NA	NA	3.335672515	study reports mean and se	exact sample size provided	NA	NA	NA	40	19.9626173	29.0027778	NA	NA	4.585741811	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_001	stungaru_2019_exp2_001	stungaru_2019_exp_001_assay_006	stungaru_2019_exp_001_assay2_006	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	0.25	ug/L	6	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1b treatment; fig1a control	stungaru_2019_fig1b_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	16.2888097	34.3967044	NA	NA	5.438596491	study reports mean and se	exact sample size provided	NA	NA	NA	40	45.3676270	34.8033333	NA	NA	5.502890173	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_001	stungaru_2019_exp2_001	stungaru_2019_exp_001_assay_007	stungaru_2019_exp_001_assay2_007	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	0.25	ug/L	7	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1b treatment; fig1a control	stungaru_2019_fig1b_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	22.8151255	33.0208362	NA	NA	5.221052632	study reports mean and se	exact sample size provided	NA	NA	NA	40	45.4593418	32.4831111	NA	NA	5.136030829	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_001	stungaru_2019_exp2_001	stungaru_2019_exp_001_assay_008	stungaru_2019_exp_001_assay2_008	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	0.25	ug/L	8	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1b treatment; fig1a control	stungaru_2019_fig1b_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	20.5671723	37.6070634	NA	NA	5.94619883	study reports mean and se	exact sample size provided	NA	NA	NA	40	45.2759121	37.1235555	NA	NA	5.869749518	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_001	stungaru_2019_exp2_001	stungaru_2019_exp_001_assay_009	stungaru_2019_exp_001_assay2_009	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	0.25	ug/L	9	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1b treatment; fig1a control	stungaru_2019_fig1b_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	15.2736050	23.3897590	NA	NA	3.698245614	study reports mean and se	exact sample size provided	NA	NA	NA	40	42.3410374	40.6038889	NA	NA	6.420038536	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_001	stungaru_2019_exp2_001	stungaru_2019_exp_001_assay_010	stungaru_2019_exp_001_assay2_010	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	0.25	ug/L	10	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1b treatment; fig1a control	stungaru_2019_fig1b_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	30.8642483	39.4415543	NA	NA	6.23625731	study reports mean and se	exact sample size provided	NA	NA	NA	40	49.6782243	34.2232778	NA	NA	5.411175337	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_001	stungaru_2019_exp2_001	stungaru_2019_exp_001_assay_011	stungaru_2019_exp_001_assay2_011	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	0.25	ug/L	11	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1b treatment; fig1a control	stungaru_2019_fig1b_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	26.1444819	37.6637749	NA	NA	5.955165692	study reports mean and se	exact sample size provided	NA	NA	NA	40	46.7433495	33.6432222	NA	NA	5.319460501	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_001	stungaru_2019_exp2_001	stungaru_2019_exp_001_assay_012	stungaru_2019_exp_001_assay2_012	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	0.25	ug/L	12	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1b treatment; fig1a control	stungaru_2019_fig1b_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	20.0060804	28.3926918	NA	NA	4.489278752	study reports mean and se	exact sample size provided	NA	NA	NA	40	63.9181618	23.2948361	NA	NA	3.683236994	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_001	stungaru_2019_exp2_001	stungaru_2019_exp_001_assay_013	stungaru_2019_exp_001_assay2_013	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	0.25	ug/L	13	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1b treatment; fig1a control	stungaru_2019_fig1b_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	40.0704078	46.9348579	NA	NA	7.421052632	study reports mean and se	exact sample size provided	NA	NA	NA	40	47.1875260	32.7707017	NA	NA	5.18150289	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_001	stungaru_2019_exp2_001	stungaru_2019_exp_001_assay_014	stungaru_2019_exp_001_assay2_014	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	0.25	ug/L	14	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1b treatment; fig1a control	stungaru_2019_fig1b_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	21.1971135	37.0843322	NA	NA	5.863547758	study reports mean and se	exact sample size provided	NA	NA	NA	40	49.3724971	28.0327689	NA	NA	4.432369942	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_001	stungaru_2019_exp2_001	stungaru_2019_exp_001_assay_015	stungaru_2019_exp_001_assay2_015	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	0.25	ug/L	15	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1b treatment; fig1a control	stungaru_2019_fig1b_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	45.9339556	39.4021029	NA	NA	6.230019493	study reports mean and se	exact sample size provided	NA	NA	NA	40	54.0545780	38.2982899	NA	NA	6.055491329	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_002	stungaru_2019_exp2_002	stungaru_2019_exp_002_assay_001	stungaru_2019_exp_002_assay2_001	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	0.5	ug/L	1	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1c treatment; fig1a control	stungaru_2019_fig1c_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	19.4069384	30.7277226	NA	NA	4.858479532	study reports mean and se	exact sample size provided	NA	NA	NA	40	41.3431110	46.6391789	NA	NA	7.374301676	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_002	stungaru_2019_exp2_002	stungaru_2019_exp_002_assay_002	stungaru_2019_exp_002_assay2_002	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	0.5	ug/L	2	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1c treatment; fig1a control	stungaru_2019_fig1c_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	32.6771138	44.4864043	NA	NA	7.033918129	study reports mean and se	exact sample size provided	NA	NA	NA	40	60.7839819	34.1119553	NA	NA	5.393573711	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_002	stungaru_2019_exp2_002	stungaru_2019_exp_002_assay_003	stungaru_2019_exp_002_assay2_003	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	0.5	ug/L	3	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1c treatment; fig1a control	stungaru_2019_fig1c_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	13.3157103	19.2621544	NA	NA	3.045614035	study reports mean and se	exact sample size provided	NA	NA	NA	40	51.6423315	37.0027990	NA	NA	5.850656229	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_002	stungaru_2019_exp2_002	stungaru_2019_exp_002_assay_004	stungaru_2019_exp_002_assay2_004	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	0.5	ug/L	4	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1c treatment; fig1a control	stungaru_2019_fig1c_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	26.7309150	25.2242499	NA	NA	3.988304094	study reports mean and se	exact sample size provided	NA	NA	NA	40	36.4671920	30.6429429	NA	NA	4.845074689	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_002	stungaru_2019_exp2_002	stungaru_2019_exp_002_assay_005	stungaru_2019_exp_002_assay2_005	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	0.5	ug/L	5	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1c treatment; fig1a control	stungaru_2019_fig1c_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	14.4759442	21.0966454	NA	NA	3.335672515	study reports mean and se	exact sample size provided	NA	NA	NA	40	48.5341704	31.2211116	NA	NA	4.936491193	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_002	stungaru_2019_exp2_002	stungaru_2019_exp_002_assay_006	stungaru_2019_exp_002_assay2_006	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	0.5	ug/L	6	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1c treatment; fig1a control	stungaru_2019_fig1c_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	16.2888097	34.3967044	NA	NA	5.438596491	study reports mean and se	exact sample size provided	NA	NA	NA	40	58.9556518	49.7225111	NA	NA	7.861819307	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_002	stungaru_2019_exp2_002	stungaru_2019_exp_002_assay_007	stungaru_2019_exp_002_assay2_007	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	0.5	ug/L	7	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1c treatment; fig1a control	stungaru_2019_fig1c_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	22.8151255	33.0208362	NA	NA	5.221052632	study reports mean and se	exact sample size provided	NA	NA	NA	40	56.7616557	46.2534987	NA	NA	7.313320286	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_002	stungaru_2019_exp2_002	stungaru_2019_exp_002_assay_008	stungaru_2019_exp_002_assay2_008	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	0.5	ug/L	8	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1c treatment; fig1a control	stungaru_2019_fig1c_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	20.5671723	37.6070634	NA	NA	5.94619883	study reports mean and se	exact sample size provided	NA	NA	NA	40	59.0470683	41.0499801	NA	NA	6.490571754	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_002	stungaru_2019_exp2_002	stungaru_2019_exp_002_assay_009	stungaru_2019_exp_002_assay2_009	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	0.5	ug/L	9	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1c treatment; fig1a control	stungaru_2019_fig1c_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	15.2736050	23.3897590	NA	NA	3.698245614	study reports mean and se	exact sample size provided	NA	NA	NA	40	59.1384848	50.3006799	NA	NA	7.953235811	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_002	stungaru_2019_exp2_002	stungaru_2019_exp_002_assay_010	stungaru_2019_exp_002_assay2_010	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	0.5	ug/L	10	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1c treatment; fig1a control	stungaru_2019_fig1c_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	30.8642483	39.4415543	NA	NA	6.23625731	study reports mean and se	exact sample size provided	NA	NA	NA	40	64.3492255	45.0971613	NA	NA	7.130487279	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_002	stungaru_2019_exp2_002	stungaru_2019_exp_002_assay_011	stungaru_2019_exp_002_assay2_011	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	0.5	ug/L	11	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1c treatment; fig1a control	stungaru_2019_fig1c_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	26.1444819	37.6637749	NA	NA	5.955165692	study reports mean and se	exact sample size provided	NA	NA	NA	40	65.7204731	54.3478610	NA	NA	8.593151336	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_002	stungaru_2019_exp2_002	stungaru_2019_exp_002_assay_012	stungaru_2019_exp_002_assay2_012	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	0.5	ug/L	12	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1c treatment; fig1a control	stungaru_2019_fig1c_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	20.0060804	28.3926918	NA	NA	4.489278752	study reports mean and se	exact sample size provided	NA	NA	NA	40	63.7093100	37.5809677	NA	NA	5.942072732	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_002	stungaru_2019_exp2_002	stungaru_2019_exp_002_assay_013	stungaru_2019_exp_002_assay2_013	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	0.5	ug/L	13	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1c treatment; fig1a control	stungaru_2019_fig1c_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	40.0704078	46.9348579	NA	NA	7.421052632	study reports mean and se	exact sample size provided	NA	NA	NA	40	66.8174711	34.6901240	NA	NA	5.484990214	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_002	stungaru_2019_exp2_002	stungaru_2019_exp_002_assay_014	stungaru_2019_exp_002_assay2_014	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	0.5	ug/L	14	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1c treatment; fig1a control	stungaru_2019_fig1c_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	21.1971135	37.0843322	NA	NA	5.863547758	study reports mean and se	exact sample size provided	NA	NA	NA	40	65.6055131	39.2428647	NA	NA	6.204841713	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_002	stungaru_2019_exp2_002	stungaru_2019_exp_002_assay_015	stungaru_2019_exp_002_assay2_015	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	0.5	ug/L	15	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1c treatment; fig1a control	stungaru_2019_fig1c_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	45.9339556	39.4021029	NA	NA	6.230019493	study reports mean and se	exact sample size provided	NA	NA	NA	40	66.2703176	38.6422086	NA	NA	6.109869646	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_003	stungaru_2019_exp2_003	stungaru_2019_exp_003_assay_001	stungaru_2019_exp_003_assay2_001	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	1	ug/L	1	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1d treatment; fig1a control	stungaru_2019_fig1d_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	19.4069384	30.7277226	NA	NA	4.858479532	study reports mean and se	exact sample size provided	NA	NA	NA	40	29.4996597	20.9557904	NA	NA	3.313401392	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_003	stungaru_2019_exp2_003	stungaru_2019_exp_003_assay_002	stungaru_2019_exp_003_assay2_002	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	1	ug/L	2	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1d treatment; fig1a control	stungaru_2019_fig1d_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	32.6771138	44.4864043	NA	NA	7.033918129	study reports mean and se	exact sample size provided	NA	NA	NA	40	45.8181616	18.8602114	NA	NA	2.982061253	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_003	stungaru_2019_exp2_003	stungaru_2019_exp_003_assay_003	stungaru_2019_exp_003_assay2_003	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	1	ug/L	3	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1d treatment; fig1a control	stungaru_2019_fig1d_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	13.3157103	19.2621544	NA	NA	3.045614035	study reports mean and se	exact sample size provided	NA	NA	NA	40	36.1264625	55.0089498	NA	NA	8.697678654	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_003	stungaru_2019_exp2_003	stungaru_2019_exp_003_assay_004	stungaru_2019_exp_003_assay2_004	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	1	ug/L	4	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1d treatment; fig1a control	stungaru_2019_fig1d_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	26.7309150	25.2242499	NA	NA	3.988304094	study reports mean and se	exact sample size provided	NA	NA	NA	40	28.1742991	30.9097908	NA	NA	4.887267053	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_003	stungaru_2019_exp2_003	stungaru_2019_exp_003_assay_005	stungaru_2019_exp_003_assay2_005	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	1	ug/L	5	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1d treatment; fig1a control	stungaru_2019_fig1d_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	14.4759442	21.0966454	NA	NA	3.335672515	study reports mean and se	exact sample size provided	NA	NA	NA	40	41.6764098	40.3398965	NA	NA	6.37829768	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_003	stungaru_2019_exp2_003	stungaru_2019_exp_003_assay_006	stungaru_2019_exp_003_assay2_006	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	1	ug/L	6	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1d treatment; fig1a control	stungaru_2019_fig1d_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	16.2888097	34.3967044	NA	NA	5.438596491	study reports mean and se	exact sample size provided	NA	NA	NA	40	30.0795049	27.7664223	NA	NA	4.390256844	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_003	stungaru_2019_exp2_003	stungaru_2019_exp_003_assay_007	stungaru_2019_exp_003_assay2_007	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	1	ug/L	7	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1d treatment; fig1a control	stungaru_2019_fig1d_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	22.8151255	33.0208362	NA	NA	5.221052632	study reports mean and se	exact sample size provided	NA	NA	NA	40	48.7173878	34.5770542	NA	NA	5.467112297	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_003	stungaru_2019_exp2_003	stungaru_2019_exp_003_assay_008	stungaru_2019_exp_003_assay2_008	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	1	ug/L	8	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1d treatment; fig1a control	stungaru_2019_fig1d_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	20.5671723	37.6070634	NA	NA	5.94619883	study reports mean and se	exact sample size provided	NA	NA	NA	40	52.2792943	37.7204227	NA	NA	5.964122506	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_003	stungaru_2019_exp2_003	stungaru_2019_exp_003_assay_009	stungaru_2019_exp_003_assay2_009	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	1	ug/L	9	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1d treatment; fig1a control	stungaru_2019_fig1d_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	15.2736050	23.3897590	NA	NA	3.698245614	study reports mean and se	exact sample size provided	NA	NA	NA	40	42.2562551	31.9575804	NA	NA	5.052937123	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_003	stungaru_2019_exp2_003	stungaru_2019_exp_003_assay_010	stungaru_2019_exp_003_assay2_010	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	1	ug/L	10	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1d treatment; fig1a control	stungaru_2019_fig1d_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	30.8642483	39.4415543	NA	NA	6.23625731	study reports mean and se	exact sample size provided	NA	NA	NA	40	44.1614609	41.3876860	NA	NA	6.543967749	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_003	stungaru_2019_exp2_003	stungaru_2019_exp_003_assay_011	stungaru_2019_exp_003_assay2_011	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	1	ug/L	11	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1d treatment; fig1a control	stungaru_2019_fig1d_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	26.1444819	37.6637749	NA	NA	5.955165692	study reports mean and se	exact sample size provided	NA	NA	NA	40	50.6225936	24.6230537	NA	NA	3.893246636	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_003	stungaru_2019_exp2_003	stungaru_2019_exp_003_assay_012	stungaru_2019_exp_003_assay2_012	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	1	ug/L	12	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1d treatment; fig1a control	stungaru_2019_fig1d_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	20.0060804	28.3926918	NA	NA	4.489278752	study reports mean and se	exact sample size provided	NA	NA	NA	40	33.8899165	27.2425275	NA	NA	4.30742181	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_003	stungaru_2019_exp2_003	stungaru_2019_exp_003_assay_013	stungaru_2019_exp_003_assay2_013	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	1	ug/L	13	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1d treatment; fig1a control	stungaru_2019_fig1d_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	40.0704078	46.9348579	NA	NA	7.421052632	study reports mean and se	exact sample size provided	NA	NA	NA	40	48.2203776	30.3858961	NA	NA	4.804432018	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_003	stungaru_2019_exp2_003	stungaru_2019_exp_003_assay_014	stungaru_2019_exp_003_assay2_014	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	1	ug/L	14	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1d treatment; fig1a control	stungaru_2019_fig1d_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	21.1971135	37.0843322	NA	NA	5.863547758	study reports mean and se	exact sample size provided	NA	NA	NA	40	48.3032126	35.6248437	NA	NA	5.632782366	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_003	stungaru_2019_exp2_003	stungaru_2019_exp_003_assay_015	stungaru_2019_exp_003_assay2_015	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	1	ug/L	15	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1d treatment; fig1a control	stungaru_2019_fig1d_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	45.9339556	39.4021029	NA	NA	6.230019493	study reports mean and se	exact sample size provided	NA	NA	NA	40	48.2203776	38.7682122	NA	NA	6.129792575	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_004	stungaru_2019_exp2_004	stungaru_2019_exp_004_assay_001	stungaru_2019_exp_004_assay2_001	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	2	ug/L	1	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1e treatment; fig1a control	stungaru_2019_fig1e_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	19.4069384	30.7277226	NA	NA	4.858479532	study reports mean and se	exact sample size provided	NA	NA	NA	40	35.2396820	45.4287155	NA	NA	7.182910613	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_004	stungaru_2019_exp2_004	stungaru_2019_exp_004_assay_002	stungaru_2019_exp_004_assay2_002	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	2	ug/L	2	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1e treatment; fig1a control	stungaru_2019_fig1e_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	32.6771138	44.4864043	NA	NA	7.033918129	study reports mean and se	exact sample size provided	NA	NA	NA	40	31.1165532	33.8514678	NA	NA	5.352387017	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_004	stungaru_2019_exp2_004	stungaru_2019_exp_004_assay_003	stungaru_2019_exp_004_assay2_003	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	2	ug/L	3	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1e treatment; fig1a control	stungaru_2019_fig1e_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	13.3157103	19.2621544	NA	NA	3.045614035	study reports mean and se	exact sample size provided	NA	NA	NA	40	37.3774530	29.2041743	NA	NA	4.617585394	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_004	stungaru_2019_exp2_004	stungaru_2019_exp_004_assay_004	stungaru_2019_exp_004_assay2_004	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	2	ug/L	4	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1e treatment; fig1a control	stungaru_2019_fig1e_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	26.7309150	25.2242499	NA	NA	3.988304094	study reports mean and se	exact sample size provided	NA	NA	NA	40	26.9451305	32.9899006	NA	NA	5.216161278	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_004	stungaru_2019_exp2_004	stungaru_2019_exp_004_assay_005	stungaru_2019_exp_004_assay2_005	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	2	ug/L	5	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1e treatment; fig1a control	stungaru_2019_fig1e_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	14.4759442	21.0966454	NA	NA	3.335672515	study reports mean and se	exact sample size provided	NA	NA	NA	40	37.9760289	35.1531727	NA	NA	5.558204641	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_004	stungaru_2019_exp2_004	stungaru_2019_exp_004_assay_006	stungaru_2019_exp_004_assay2_006	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	2	ug/L	6	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1e treatment; fig1a control	stungaru_2019_fig1e_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	16.2888097	34.3967044	NA	NA	5.438596491	study reports mean and se	exact sample size provided	NA	NA	NA	40	49.1779490	38.9388990	NA	NA	6.156780525	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_004	stungaru_2019_exp2_004	stungaru_2019_exp_004_assay_007	stungaru_2019_exp_004_assay2_007	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	2	ug/L	7	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1e treatment; fig1a control	stungaru_2019_fig1e_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	22.8151255	33.0208362	NA	NA	5.221052632	study reports mean and se	exact sample size provided	NA	NA	NA	40	50.5461225	34.6123547	NA	NA	5.4726938	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_004	stungaru_2019_exp2_004	stungaru_2019_exp_004_assay_008	stungaru_2019_exp_004_assay2_008	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	2	ug/L	8	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1e treatment; fig1a control	stungaru_2019_fig1e_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	20.5671723	37.6070634	NA	NA	5.94619883	study reports mean and se	exact sample size provided	NA	NA	NA	40	50.1185683	32.9899006	NA	NA	5.216161278	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_004	stungaru_2019_exp2_004	stungaru_2019_exp_004_assay_009	stungaru_2019_exp_004_assay2_009	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	2	ug/L	9	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1e treatment; fig1a control	stungaru_2019_fig1e_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	15.2736050	23.3897590	NA	NA	3.698245614	study reports mean and se	exact sample size provided	NA	NA	NA	40	49.8620358	37.3164449	NA	NA	5.900248003	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_004	stungaru_2019_exp2_004	stungaru_2019_exp_004_assay_010	stungaru_2019_exp_004_assay2_010	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	2	ug/L	10	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1e treatment; fig1a control	stungaru_2019_fig1e_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	30.8642483	39.4415543	NA	NA	6.23625731	study reports mean and se	exact sample size provided	NA	NA	NA	40	54.9926862	29.2041743	NA	NA	4.617585394	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_004	stungaru_2019_exp2_004	stungaru_2019_exp_004_assay_011	stungaru_2019_exp_004_assay2_011	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	2	ug/L	11	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1e treatment; fig1a control	stungaru_2019_fig1e_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	26.1444819	37.6637749	NA	NA	5.955165692	study reports mean and se	exact sample size provided	NA	NA	NA	40	39.9427783	41.6429892	NA	NA	6.584334728	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_004	stungaru_2019_exp2_004	stungaru_2019_exp_004_assay_012	stungaru_2019_exp_004_assay2_012	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	2	ug/L	12	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1e treatment; fig1a control	stungaru_2019_fig1e_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	20.0060804	28.3926918	NA	NA	4.489278752	study reports mean and se	exact sample size provided	NA	NA	NA	40	53.4534911	28.6633562	NA	NA	4.532074553	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_004	stungaru_2019_exp2_004	stungaru_2019_exp_004_assay_013	stungaru_2019_exp_004_assay2_013	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	2	ug/L	13	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1e treatment; fig1a control	stungaru_2019_fig1e_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	40.0704078	46.9348579	NA	NA	7.421052632	study reports mean and se	exact sample size provided	NA	NA	NA	40	50.3751008	36.2348088	NA	NA	5.729226322	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_004	stungaru_2019_exp2_004	stungaru_2019_exp_004_assay_014	stungaru_2019_exp_004_assay2_014	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	2	ug/L	14	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1e treatment; fig1a control	stungaru_2019_fig1e_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	21.1971135	37.0843322	NA	NA	5.863547758	study reports mean and se	exact sample size provided	NA	NA	NA	40	42.5936143	29.2041743	NA	NA	4.617585394	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community	10.1016/j.ecoenv.2019.01.057	https://www.sciencedirect.com/science/article/pii/S0147651319300661?via%3Dihub	Ecotoxicology and Environmental Safety	stungaru_2019	stungaru_2019_exp_004	stungaru_2019_exp2_004	stungaru_2019_exp_004_assay_015	stungaru_2019_exp_004_assay2_015	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	deltamethrin	not reported	52918-63-5	https://commonchemistry.cas.org/detail?cas_rn=52918-63-5&search=deltamethrin	pyrethroid	2	ug/L	15	days	not reported	NA	24	celsius	aggression	aggression	percentage of time in left arm	time spent in aggression zone	zone	NA	fig1e treatment; fig1a control	stungaru_2019_fig1e_treatment; stungaru_2019_fig1a_control	NA	NA	NA	40	45.9339556	39.4021029	NA	NA	6.230019493	study reports mean and se	exact sample size provided	NA	NA	NA	40	49.6910141	29.7449923	NA	NA	4.703096234	study reports mean and se	exact sample size provided	NA	NA	NA	NA
150 across 5 groups - took n = 30	NA	GM	KM	Household based-pyrethroids on adult zebrafish (Danio rerio) exert behavioral and cholinergic changes in different brain regions	10.1016/j.neuro.2023.02.011	https://www.sciencedirect.com/science/article/pii/S0161813X23000323?via%3Dihub	Neurotoxicology	tamagno_2023	tamagno_2023_exp_001	tamagno_2023_exp2_001	tamagno_2023_exp_001_assay_001	tamagno_2023_exp2_001_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	not reported	prallethrin	commercial	23031-36-9	https://commonchemistry.cas.org/detail?cas_rn=23031-36-9&search=prallethrin	pyrethroid	not reported	not reported	7	days	not reported	NA	28	celsius	social interaction	sociality	time in conspecific segment	time spent in social zone	zone	NA	fig3b	tamagno_2023_fig3b	NA	NA	NA	NA	79.1972873	NA	NA	NA	7.943262411	study reports mean and se but no sample size	no sample size reported	NA	NA	NA	NA	62.6017278	NA	NA	NA	5.644208038	study reports mean and se but no sample size	no sample size reported	NA	NA	NA	NA
150 across 5 groups - took n = 30	NA	GM	KM	Household based-pyrethroids on adult zebrafish (Danio rerio) exert behavioral and cholinergic changes in different brain regions	10.1016/j.neuro.2023.02.011	https://www.sciencedirect.com/science/article/pii/S0161813X23000323?via%3Dihub	Neurotoxicology	tamagno_2023	tamagno_2023_exp_002	tamagno_2023_exp2_002	tamagno_2023_exp_002_assay_001	tamagno_2023_exp2_002_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	not reported	prallethrin	commercial	23031-36-9	https://commonchemistry.cas.org/detail?cas_rn=23031-36-9&search=prallethrin	pyrethroid	not reported	not reported	7	days	not reported	NA	28	celsius	social interaction	sociality	time in conspecific segment	time spent in social zone	zone	NA	fig3b	tamagno_2023_fig3b	NA	NA	NA	NA	79.1972873	NA	NA	NA	7.943262411	study reports mean and se but no sample size	no sample size reported	NA	NA	NA	NA	33.4776143	NA	NA	NA	6.885933806	study reports mean and se but no sample size	no sample size reported	NA	NA	NA	NA
150 across 5 groups - took n = 30	NA	GM	KM	Household based-pyrethroids on adult zebrafish (Danio rerio) exert behavioral and cholinergic changes in different brain regions	10.1016/j.neuro.2023.02.011	https://www.sciencedirect.com/science/article/pii/S0161813X23000323?via%3Dihub	Neurotoxicology	tamagno_2023	tamagno_2023_exp_003	tamagno_2023_exp2_003	tamagno_2023_exp_003_assay_001	tamagno_2023_exp2_003_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	not reported	transfluthrin	commercial	118712-89-3	https://commonchemistry.cas.org/detail?cas_rn=118712-89-3&search=transfluthrin	pyrethroid	not reported	not reported	7	days	not reported	NA	28	celsius	social interaction	sociality	time in conspecific segment	time spent in social zone	zone	NA	fig3b	tamagno_2023_fig3b	NA	NA	NA	NA	79.1972873	NA	NA	NA	7.943262411	study reports mean and se but no sample size	no sample size reported	NA	NA	NA	NA	39.6989173	NA	NA	NA	8.441489362	study reports mean and se but no sample size	no sample size reported	NA	NA	NA	NA
150 across 5 groups - took n = 30	NA	GM	KM	Household based-pyrethroids on adult zebrafish (Danio rerio) exert behavioral and cholinergic changes in different brain regions	10.1016/j.neuro.2023.02.011	https://www.sciencedirect.com/science/article/pii/S0161813X23000323?via%3Dihub	Neurotoxicology	tamagno_2023	tamagno_2023_exp_004	tamagno_2023_exp2_004	tamagno_2023_exp_004_assay_001	tamagno_2023_exp2_004_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	not reported	transfluthrin	commercial	118712-89-3	https://commonchemistry.cas.org/detail?cas_rn=118712-89-3&search=transfluthrin	pyrethroid	not reported	not reported	7	days	not reported	NA	28	celsius	social interaction	sociality	time in conspecific segment	time spent in social zone	zone	NA	fig3b	tamagno_2023_fig3b	NA	NA	NA	NA	79.1972873	NA	NA	NA	7.943262411	study reports mean and se but no sample size	no sample size reported	NA	NA	NA	NA	49.2414705	NA	NA	NA	8.196808511	study reports mean and se but no sample size	no sample size reported	NA	NA	NA	NA
NA	NA	GM	KM	Household based-pyrethroids on adult zebrafish (Danio rerio) exert behavioral and cholinergic changes in different brain regions	10.1016/j.neuro.2023.02.011	https://www.sciencedirect.com/science/article/pii/S0161813X23000323?via%3Dihub	Neurotoxicology	tamagno_2023	tamagno_2023_exp_001	tamagno_2023_exp2_005	tamagno_2023_exp_001_assay_002	tamagno_2023_exp2_005_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	not reported	prallethrin	commercial	23031-36-9	https://commonchemistry.cas.org/detail?cas_rn=23031-36-9&search=prallethrin	pyrethroid	not reported	not reported	7	days	not reported	NA	28	celsius	shoaling test	collective behaviour	distance among fish in a shoal	group arrangment	NA	change	fig4	tamagno_2023_fig4	1.600000	1.000000	4	4	10.8954991	1.0286458	0.5143229	1.0286458	0.514322917	study reports mean and se	Four fish of each concentration were placed in the aquarium and were kept for 1<a0>min during the acclimatization period.	1.600000	1.000000	4	4	16.0570202	1.5274306	0.7637153	1.5274306	0.763715278	study reports mean and se but no sample size	no sample size reported	NA	NA	NA	NA
NA	NA	GM	KM	Household based-pyrethroids on adult zebrafish (Danio rerio) exert behavioral and cholinergic changes in different brain regions	10.1016/j.neuro.2023.02.011	https://www.sciencedirect.com/science/article/pii/S0161813X23000323?via%3Dihub	Neurotoxicology	tamagno_2023	tamagno_2023_exp_002	tamagno_2023_exp2_006	tamagno_2023_exp_002_assay_002	tamagno_2023_exp2_006_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	not reported	prallethrin	commercial	23031-36-9	https://commonchemistry.cas.org/detail?cas_rn=23031-36-9&search=prallethrin	pyrethroid	not reported	not reported	7	days	not reported	NA	28	celsius	shoaling test	collective behaviour	distance among fish in a shoal	group arrangment	NA	change	fig4	tamagno_2023_fig4	1.600000	1.000000	4	4	10.8954991	1.0286458	0.5143229	1.0286458	0.514322917	study reports mean and se	Four fish of each concentration were placed in the aquarium and were kept for 1<a0>min during the acclimatization period.	1.600000	1.000000	4	4	16.1352820	1.4444444	0.7222222	1.4444444	0.722222222	study reports mean and se but no sample size	no sample size reported	NA	NA	NA	NA
NA	NA	GM	KM	Household based-pyrethroids on adult zebrafish (Danio rerio) exert behavioral and cholinergic changes in different brain regions	10.1016/j.neuro.2023.02.011	https://www.sciencedirect.com/science/article/pii/S0161813X23000323?via%3Dihub	Neurotoxicology	tamagno_2023	tamagno_2023_exp_003	tamagno_2023_exp2_007	tamagno_2023_exp_003_assay_002	tamagno_2023_exp2_007_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	not reported	transfluthrin	commercial	118712-89-3	https://commonchemistry.cas.org/detail?cas_rn=118712-89-3&search=transfluthrin	pyrethroid	not reported	not reported	7	days	not reported	NA	28	celsius	shoaling test	collective behaviour	distance among fish in a shoal	group arrangment	NA	change	fig4	tamagno_2023_fig4	1.600000	1.000000	4	4	10.8954991	1.0286458	0.5143229	1.0286458	0.514322917	study reports mean and se	Four fish of each concentration were placed in the aquarium and were kept for 1<a0>min during the acclimatization period.	1.600000	1.000000	4	4	15.3541417	1.4875000	0.7437500	1.4875000	0.74375	study reports mean and se but no sample size	no sample size reported	NA	NA	NA	NA
NA	NA	NA	KM	Household based-pyrethroids on adult zebrafish (Danio rerio) exert behavioral and cholinergic changes in different brain regions	10.1016/j.neuro.2023.02.011	https://www.sciencedirect.com/science/article/pii/S0161813X23000323?via%3Dihub	Neurotoxicology	tamagno_2023	tamagno_2023_exp_004	tamagno_2023_exp2_008	tamagno_2023_exp_004_assay_002	tamagno_2023_exp2_008_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	not reported	transfluthrin	commercial	118712-89-3	https://commonchemistry.cas.org/detail?cas_rn=118712-89-3&search=transfluthrin	pyrethroid	not reported	not reported	7	days	not reported	NA	28	celsius	shoaling test	collective behaviour	distance among fish in a shoal	group arrangment	NA	change	fig4	tamagno_2023_fig4	1.600000	1.000000	4	4	10.8954991	1.0286458	0.5143229	1.0286458	0.514322917	study reports mean and se	Four fish of each concentration were placed in the aquarium and were kept for 1<a0>min during the acclimatization period.	1.600000	1.000000	4	4	16.3148369	1.3333333	0.6666667	1.3333333	0.666666667	study reports mean and se but no sample size	no sample size reported	NA	NA	NA	NA
NA	NA	NA	KM	Effects of Acrobat MZ<ae> and Tattoo C<ae> on Japanese medaka (Oryzias latipes) development and adult male behavior	10.1016/S0166-445X(00)00124-7	https://www.sciencedirect.com/science/article/pii/S0166445X00001247	Aquatic Toxicology	teather_2001	teather_2001_exp_001	teather_2001_exp2_001	teather_2001_exp_001_assay_001	teather_2001_exp2_001_assay_001	Japanese medaka	Oryzias latipes	not reported	NA	male	acrobat	commercial	119446-68-3	https://commonchemistry.cas.org/detail?cas_rn=119446-68-3&search=difenoconazole	triazole	0.4	mg/L	28	days	none	none	25	celsius	courting	courtship	number of approaches to female	frequency of courtship behaviour	count	NA	fig3a	teather_2001_fig3a	NA	NA	NA	20	51.1581869	38.3355721	NA	NA	8.572094508	study reports mean and se	exact sample size provided in text (Section 2.3.1)	NA	NA	NA	20	34.3267729	26.2993579	NA	NA	5.880715198	study reports mean and se	exact sample size provided in text (Section 2.3.1)	NA	NA	NA	NA
NA	NA	NA	KM	Effects of Acrobat MZ<ae> and Tattoo C<ae> on Japanese medaka (Oryzias latipes) development and adult male behavior	10.1016/S0166-445X(00)00124-8	https://www.sciencedirect.com/science/article/pii/S0166445X00001247	Aquatic Toxicology	teather_2001	teather_2001_exp_002	teather_2001_exp2_002	teather_2001_exp_002_assay_001	teather_2001_exp2_002_assay_001	Japanese medaka	Oryzias latipes	not reported	NA	male	acrobat	commercial	119446-68-3	https://commonchemistry.cas.org/detail?cas_rn=119446-68-3&search=difenoconazole	triazole	1	mg/L	28	days	none	none	25	celsius	courting	courtship	number of approaches to female	frequency of courtship behaviour	count	NA	fig3a	teather_2001_fig3a	NA	NA	NA	20	51.1581869	38.3355721	NA	NA	8.572094508	study reports mean and se	exact sample size provided in text (Section 2.3.1)	NA	NA	NA	20	17.1201586	10.5614307	NA	NA	2.361607705	study reports mean and se	exact sample size provided in text (Section 2.3.1)	NA	NA	NA	NA
NA	NA	NA	KM	Effects of Acrobat MZ<ae> and Tattoo C<ae> on Japanese medaka (Oryzias latipes) development and adult male behavior	10.1016/S0166-445X(00)00124-9	https://www.sciencedirect.com/science/article/pii/S0166445X00001247	Aquatic Toxicology	teather_2001	teather_2001_exp_003	teather_2001_exp2_003	teather_2001_exp_003_assay_001	teather_2001_exp2_003_assay_001	Japanese medaka	Oryzias latipes	not reported	NA	male	acrobat	commercial	119446-68-3	https://commonchemistry.cas.org/detail?cas_rn=119446-68-3&search=difenoconazole	triazole	2	mg/L	28	days	none	none	25	celsius	courting	courtship	number of approaches to female	frequency of courtship behaviour	count	NA	fig3a	teather_2001_fig3a	NA	NA	NA	20	51.1581869	38.3355721	NA	NA	8.572094508	study reports mean and se	exact sample size provided in text (Section 2.3.1)	NA	NA	NA	20	14.0697487	18.4825038	NA	NA	4.132813484	study reports mean and se	exact sample size provided in text (Section 2.3.1)	NA	NA	NA	NA
NA	NA	NA	KM	Effects of Acrobat MZ<ae> and Tattoo C<ae> on Japanese medaka (Oryzias latipes) development and adult male behavior	10.1016/S0166-445X(00)00124-10	https://www.sciencedirect.com/science/article/pii/S0166445X00001247	Aquatic Toxicology	teather_2001	teather_2001_exp_004	teather_2001_exp2_004	teather_2001_exp_004_assay_001	teather_2001_exp2_004_assay_001	Japanese medaka	Oryzias latipes	not reported	NA	male	tattoo c	commercial	1897-45-6	https://commonchemistry.cas.org/detail?cas_rn=1897-45-6&search=chlorothalonil	organochlorine	0.04	mg/L	28	days	none	none	25	celsius	courting	courtship	number of approaches to female	frequency of courtship behaviour	count	NA	fig3b	teather_2001_fig3b	NA	NA	NA	20	51.1562994	38.3404452	NA	NA	8.573184176	study reports mean and se	exact sample size provided in text (Section 2.3.1)	NA	NA	NA	20	22.5838814	28.8687687	NA	NA	6.455252918	study reports mean and se	exact sample size provided in text (Section 2.3.1)	NA	NA	NA	NA
NA	NA	NA	KM	Effects of Acrobat MZ<ae> and Tattoo C<ae> on Japanese medaka (Oryzias latipes) development and adult male behavior	10.1016/S0166-445X(00)00124-11	https://www.sciencedirect.com/science/article/pii/S0166445X00001247	Aquatic Toxicology	teather_2001	teather_2001_exp_005	teather_2001_exp2_005	teather_2001_exp_005_assay_001	teather_2001_exp2_005_assay_001	Japanese medaka	Oryzias latipes	not reported	NA	male	tattoo c	commercial	1897-45-6	https://commonchemistry.cas.org/detail?cas_rn=1897-45-6&search=chlorothalonil	organochlorine	0.1	mg/L	28	days	none	none	25	celsius	courting	courtship	number of approaches to female	frequency of courtship behaviour	count	NA	fig3b	teather_2001_fig3b	NA	NA	NA	20	51.1562994	38.3404452	NA	NA	8.573184176	study reports mean and se	exact sample size provided in text (Section 2.3.1)	NA	NA	NA	20	30.0891991	40.0955121	NA	NA	8.965629053	study reports mean and se	exact sample size provided in text (Section 2.3.1)	NA	NA	NA	NA
NA	NA	NA	KM	Effects of Acrobat MZ<ae> and Tattoo C<ae> on Japanese medaka (Oryzias latipes) development and adult male behavior	10.1016/S0166-445X(00)00124-12	https://www.sciencedirect.com/science/article/pii/S0166445X00001247	Aquatic Toxicology	teather_2001	teather_2001_exp_006	teather_2001_exp2_006	teather_2001_exp_006_assay_001	teather_2001_exp2_006_assay_001	Japanese medaka	Oryzias latipes	not reported	NA	male	tattoo c	commercial	1897-45-6	https://commonchemistry.cas.org/detail?cas_rn=1897-45-6&search=chlorothalonil	organochlorine	0.2	mg/L	28	days	none	none	25	celsius	courting	courtship	number of approaches to female	frequency of courtship behaviour	count	NA	fig3b	teather_2001_fig3b	NA	NA	NA	20	51.1562994	38.3404452	NA	NA	8.573184176	study reports mean and se	exact sample size provided in text (Section 2.3.1)	NA	NA	NA	20	20.9542790	22.1905820	NA	NA	4.961964981	study reports mean and se	exact sample size provided in text (Section 2.3.1)	NA	NA	NA	NA
NA	NA	NA	KM	Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish	<a0>10.3390/ijerph20053928	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002025/#:~:text=Consequently%2C%20TEB%20might%20influence%20the,affecting%20the%20reproduction%20of%20zebrafish.	Environmental Research and Public Health	yan_2023	yan_2023_exp_001	yan_2023_exp2_001	yan_2023_exp_001_assay_001	yan_2023_exp2_001_assay2_001	zebrafish	Danio rerio	commercial supplier	not_wild	female	tebuconazole	analytical	107534-96-3	in paper	triazole	0.4	mg/L	21	days	none	none	27	celsius	social interaction	sociality	number of contacts	frequency of social behaviour	count	NA	fig4d	yan_2023_fig4d	NA	NA	NA	16	5.0701778	2.0072727	NA	NA	0.501818182	study reports mean and se	exact sample size provided	NA	NA	NA	16	2.0765728	1.0036364	NA	NA	0.250909091	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish	<a0>10.3390/ijerph20053928	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002025/#:~:text=Consequently%2C%20TEB%20might%20influence%20the,affecting%20the%20reproduction%20of%20zebrafish.	Environmental Research and Public Health	yan_2023	yan_2023_exp_001	yan_2023_exp2_001	yan_2023_exp_001_assay_002	yan_2023_exp2_001_assay2_002	zebrafish	Danio rerio	commercial supplier	not_wild	female	tebuconazole	analytical	107534-96-3	in paper	triazole	0.4	mg/L	21	days	DMSO	solvent_used	27	celsius	social interaction	sociality	number of contacts	frequency of social behaviour	count	NA	fig4d	yan_2023_fig4d	NA	NA	NA	16	3.0802092	1.8342320	NA	NA	0.458557994	study reports mean and se	exact sample size provided	NA	NA	NA	16	2.0765728	1.0036364	NA	NA	0.250909091	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish	<a0>10.3390/ijerph20053928	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002025/#:~:text=Consequently%2C%20TEB%20might%20influence%20the,affecting%20the%20reproduction%20of%20zebrafish.	Environmental Research and Public Health	yan_2023	yan_2023_exp_002	yan_2023_exp2_002	yan_2023_exp_002_assay_001	yan_2023_exp2_002_assay2_001	zebrafish	Danio rerio	commercial supplier	not_wild	female	tebuconazole	analytical	107534-96-3	in paper	triazole	0.8	mg/L	21	days	none	none	27	celsius	social interaction	sociality	number of contacts	frequency of social behaviour	count	NA	fig4d	yan_2023_fig4d	NA	NA	NA	16	5.0701778	2.0072727	NA	NA	0.501818182	study reports mean and se	exact sample size provided	NA	NA	NA	16	2.5783910	1.4189342	NA	NA	0.354733542	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish	<a0>10.3390/ijerph20053928	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002025/#:~:text=Consequently%2C%20TEB%20might%20influence%20the,affecting%20the%20reproduction%20of%20zebrafish.	Environmental Research and Public Health	yan_2023	yan_2023_exp_002	yan_2023_exp2_002	yan_2023_exp_002_assay_002	yan_2023_exp2_002_assay2_002	zebrafish	Danio rerio	commercial supplier	not_wild	female	tebuconazole	analytical	107534-96-3	in paper	triazole	0.8	mg/L	21	days	DMSO	solvent_used	27	celsius	social interaction	sociality	number of contacts	frequency of social behaviour	count	NA	fig4d	yan_2023_fig4d	NA	NA	NA	16	3.0802092	1.8342320	NA	NA	0.458557994	study reports mean and se	exact sample size provided	NA	NA	NA	16	2.5783910	1.4189342	NA	NA	0.354733542	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish	<a0>10.3390/ijerph20053928	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002025/#:~:text=Consequently%2C%20TEB%20might%20influence%20the,affecting%20the%20reproduction%20of%20zebrafish.	Environmental Research and Public Health	yan_2023	yan_2023_exp_003	yan_2023_exp2_003	yan_2023_exp_003_assay_001	yan_2023_exp2_003_assay2_001	zebrafish	Danio rerio	commercial supplier	not_wild	female	tebuconazole	analytical	107534-96-3	in paper	triazole	1.6	mg/L	21	days	none	none	27	celsius	social interaction	sociality	number of contacts	frequency of social behaviour	count	NA	fig4d	yan_2023_fig4d	NA	NA	NA	16	5.0701778	2.0072727	NA	NA	0.501818182	study reports mean and se	exact sample size provided	NA	NA	NA	16	2.3400961	1.1680251	NA	NA	0.29200627	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish	<a0>10.3390/ijerph20053928	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002025/#:~:text=Consequently%2C%20TEB%20might%20influence%20the,affecting%20the%20reproduction%20of%20zebrafish.	Environmental Research and Public Health	yan_2023	yan_2023_exp_003	yan_2023_exp2_003	yan_2023_exp_003_assay_002	yan_2023_exp2_003_assay2_002	zebrafish	Danio rerio	commercial supplier	not_wild	female	tebuconazole	analytical	107534-96-3	in paper	triazole	1.6	mg/L	21	days	DMSO	solvent_used	27	celsius	social interaction	sociality	number of contacts	frequency of social behaviour	count	NA	fig4d	yan_2023_fig4d	NA	NA	NA	16	3.0802092	1.8342320	NA	NA	0.458557994	study reports mean and se	exact sample size provided	NA	NA	NA	16	2.3400961	1.1680251	NA	NA	0.29200627	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish	<a0>10.3390/ijerph20053928	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002025/#:~:text=Consequently%2C%20TEB%20might%20influence%20the,affecting%20the%20reproduction%20of%20zebrafish.	Environmental Research and Public Health	yan_2023	yan_2023_exp_004	yan_2023_exp2_004	yan_2023_exp_004_assay_001	yan_2023_exp2_004_assay2_001	zebrafish	Danio rerio	commercial supplier	not_wild	male	tebuconazole	analytical	107534-96-3	in paper	triazole	0.4	mg/L	21	days	none	none	27	celsius	social interaction	sociality	number of contacts	frequency of social behaviour	count	NA	fig4d	yan_2023_fig4d	NA	NA	NA	16	3.5947905	0.9220063	NA	NA	0.230501567	study reports mean and se	exact sample size provided	NA	NA	NA	16	3.0748219	2.0798746	NA	NA	0.519968652	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish	<a0>10.3390/ijerph20053928	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002025/#:~:text=Consequently%2C%20TEB%20might%20influence%20the,affecting%20the%20reproduction%20of%20zebrafish.	Environmental Research and Public Health	yan_2023	yan_2023_exp_004	yan_2023_exp2_004	yan_2023_exp_004_assay_002	yan_2023_exp2_004_assay2_002	zebrafish	Danio rerio	commercial supplier	not_wild	male	tebuconazole	analytical	107534-96-3	in paper	triazole	0.4	mg/L	21	days	DMSO	solvent_used	27	celsius	social interaction	sociality	number of contacts	frequency of social behaviour	count	NA	fig4d	yan_2023_fig4d	NA	NA	NA	16	2.5602137	1.2436364	NA	NA	0.310909091	study reports mean and se	exact sample size provided	NA	NA	NA	16	3.0748219	2.0798746	NA	NA	0.519968652	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish	<a0>10.3390/ijerph20053928	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002025/#:~:text=Consequently%2C%20TEB%20might%20influence%20the,affecting%20the%20reproduction%20of%20zebrafish.	Environmental Research and Public Health	yan_2023	yan_2023_exp_005	yan_2023_exp2_005	yan_2023_exp_005_assay_001	yan_2023_exp2_005_assay2_001	zebrafish	Danio rerio	commercial supplier	not_wild	male	tebuconazole	analytical	107534-96-3	in paper	triazole	0.8	mg/L	21	days	none	none	27	celsius	social interaction	sociality	number of contacts	frequency of social behaviour	count	NA	fig4d	yan_2023_fig4d	NA	NA	NA	16	3.5947905	0.9220063	NA	NA	0.230501567	study reports mean and se	exact sample size provided	NA	NA	NA	16	1.7293360	0.7933542	NA	NA	0.198338558	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish	<a0>10.3390/ijerph20053928	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002025/#:~:text=Consequently%2C%20TEB%20might%20influence%20the,affecting%20the%20reproduction%20of%20zebrafish.	Environmental Research and Public Health	yan_2023	yan_2023_exp_005	yan_2023_exp2_005	yan_2023_exp_005_assay_002	yan_2023_exp2_005_assay2_002	zebrafish	Danio rerio	commercial supplier	not_wild	male	tebuconazole	analytical	107534-96-3	in paper	triazole	0.8	mg/L	21	days	DMSO	solvent_used	27	celsius	social interaction	sociality	number of contacts	frequency of social behaviour	count	NA	fig4d	yan_2023_fig4d	NA	NA	NA	16	2.5602137	1.2436364	NA	NA	0.310909091	study reports mean and se	exact sample size provided	NA	NA	NA	16	1.7293360	0.7933542	NA	NA	0.198338558	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish	<a0>10.3390/ijerph20053928	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002025/#:~:text=Consequently%2C%20TEB%20might%20influence%20the,affecting%20the%20reproduction%20of%20zebrafish.	Environmental Research and Public Health	yan_2023	yan_2023_exp_006	yan_2023_exp2_006	yan_2023_exp_006_assay_001	yan_2023_exp2_006_assay2_001	zebrafish	Danio rerio	commercial supplier	not_wild	male	tebuconazole	analytical	107534-96-3	in paper	triazole	1.6	mg/L	21	days	none	none	27	celsius	social interaction	sociality	number of contacts	frequency of social behaviour	count	NA	fig4d	yan_2023_fig4d	NA	NA	NA	16	3.5947905	0.9220063	NA	NA	0.230501567	study reports mean and se	exact sample size provided	NA	NA	NA	16	2.3779567	1.2007524	NA	NA	0.300188088	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish	<a0>10.3390/ijerph20053928	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002025/#:~:text=Consequently%2C%20TEB%20might%20influence%20the,affecting%20the%20reproduction%20of%20zebrafish.	Environmental Research and Public Health	yan_2023	yan_2023_exp_006	yan_2023_exp2_006	yan_2023_exp_006_assay_002	yan_2023_exp2_006_assay2_002	zebrafish	Danio rerio	commercial supplier	not_wild	male	tebuconazole	analytical	107534-96-3	in paper	triazole	1.6	mg/L	21	days	DMSO	solvent_used	27	celsius	social interaction	sociality	number of contacts	frequency of social behaviour	count	NA	fig4d	yan_2023_fig4d	NA	NA	NA	16	2.5602137	1.2436364	NA	NA	0.310909091	study reports mean and se	exact sample size provided	NA	NA	NA	16	2.3779567	1.2007524	NA	NA	0.300188088	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish	<a0>10.3390/ijerph20053928	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002025/#:~:text=Consequently%2C%20TEB%20might%20influence%20the,affecting%20the%20reproduction%20of%20zebrafish.	Environmental Research and Public Health	yan_2023	yan_2023_exp_007	yan_2023_exp2_007	yan_2023_exp_007_assay_001	yan_2023_exp2_007_assay2_001	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	tebuconazole	analytical	107534-96-3	in paper	triazole	0.4	mg/L	21	days	none	none	27	celsius	social interaction	sociality	number of contacts	frequency of social behaviour	count	NA	fig4d	yan_2023_fig4d	NA	NA	NA	16	2.3643288	0.9630094	NA	NA	0.240752351	study reports mean and se	exact sample size provided	NA	NA	NA	16	1.2884667	0.4815047	NA	NA	0.120376176	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish	<a0>10.3390/ijerph20053928	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002025/#:~:text=Consequently%2C%20TEB%20might%20influence%20the,affecting%20the%20reproduction%20of%20zebrafish.	Environmental Research and Public Health	yan_2023	yan_2023_exp_007	yan_2023_exp2_007	yan_2023_exp_007_assay_002	yan_2023_exp2_007_assay2_002	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	tebuconazole	analytical	107534-96-3	in paper	triazole	0.4	mg/L	21	days	DMSO	solvent_used	27	celsius	social interaction	sociality	number of contacts	frequency of social behaviour	count	NA	fig4d	yan_2023_fig4d	NA	NA	NA	16	2.0821971	0.4664577	NA	NA	0.11661442	study reports mean and se	exact sample size provided	NA	NA	NA	16	1.2884667	0.4815047	NA	NA	0.120376176	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish	<a0>10.3390/ijerph20053928	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002025/#:~:text=Consequently%2C%20TEB%20might%20influence%20the,affecting%20the%20reproduction%20of%20zebrafish.	Environmental Research and Public Health	yan_2023	yan_2023_exp_008	yan_2023_exp2_008	yan_2023_exp_008_assay_001	yan_2023_exp2_008_assay2_001	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	tebuconazole	analytical	107534-96-3	in paper	triazole	0.8	mg/L	21	days	none	none	27	celsius	social interaction	sociality	number of contacts	frequency of social behaviour	count	NA	fig4d	yan_2023_fig4d	NA	NA	NA	16	2.3643288	0.9630094	NA	NA	0.240752351	study reports mean and se	exact sample size provided	NA	NA	NA	16	2.0972441	0.4062696	NA	NA	0.101567398	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish	<a0>10.3390/ijerph20053928	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002025/#:~:text=Consequently%2C%20TEB%20might%20influence%20the,affecting%20the%20reproduction%20of%20zebrafish.	Environmental Research and Public Health	yan_2023	yan_2023_exp_008	yan_2023_exp2_008	yan_2023_exp_008_assay_002	yan_2023_exp2_008_assay2_002	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	tebuconazole	analytical	107534-96-3	in paper	triazole	0.8	mg/L	21	days	DMSO	solvent_used	27	celsius	social interaction	sociality	number of contacts	frequency of social behaviour	count	NA	fig4d	yan_2023_fig4d	NA	NA	NA	16	2.0821971	0.4664577	NA	NA	0.11661442	study reports mean and se	exact sample size provided	NA	NA	NA	16	2.0972441	0.4062696	NA	NA	0.101567398	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish	<a0>10.3390/ijerph20053928	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002025/#:~:text=Consequently%2C%20TEB%20might%20influence%20the,affecting%20the%20reproduction%20of%20zebrafish.	Environmental Research and Public Health	yan_2023	yan_2023_exp_009	yan_2023_exp2_009	yan_2023_exp_009_assay_001	yan_2023_exp2_009_assay2_001	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	tebuconazole	analytical	107534-96-3	in paper	triazole	1.6	mg/L	21	days	none	none	27	celsius	social interaction	sociality	number of contacts	frequency of social behaviour	count	NA	fig4d	yan_2023_fig4d	NA	NA	NA	16	2.3643288	0.9630094	NA	NA	0.240752351	study reports mean and se	exact sample size provided	NA	NA	NA	16	1.4803162	0.3310345	NA	NA	0.082758621	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish	<a0>10.3390/ijerph20053928	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002025/#:~:text=Consequently%2C%20TEB%20might%20influence%20the,affecting%20the%20reproduction%20of%20zebrafish.	Environmental Research and Public Health	yan_2023	yan_2023_exp_009	yan_2023_exp2_009	yan_2023_exp_009_assay_002	yan_2023_exp2_009_assay2_002	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	tebuconazole	analytical	107534-96-3	in paper	triazole	1.6	mg/L	21	days	DMSO	solvent_used	27	celsius	social interaction	sociality	number of contacts	frequency of social behaviour	count	NA	fig4d	yan_2023_fig4d	NA	NA	NA	16	2.0821971	0.4664577	NA	NA	0.11661442	study reports mean and se	exact sample size provided	NA	NA	NA	16	1.4803162	0.3310345	NA	NA	0.082758621	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish	<a0>10.3390/ijerph20053928	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002025/#:~:text=Consequently%2C%20TEB%20might%20influence%20the,affecting%20the%20reproduction%20of%20zebrafish.	Environmental Research and Public Health	yan_2023	yan_2023_exp_001	yan_2023_exp2_001	yan_2023_exp_001_assay_003	yan_2023_exp2_001_assay2_003	zebrafish	Danio rerio	commercial supplier	not_wild	female	tebuconazole	analytical	107534-96-3	in paper	triazole	0.4	mg/L	21	days	none	none	27	celsius	social interaction	sociality	contact time	duration of social behaviour	NA	NA	fig4e	yan_2023_fig4e	NA	NA	NA	16	0.6531373	0.2295338	NA	NA	0.057383459	study reports mean and se	exact sample size provided	NA	NA	NA	16	0.2875834	0.0977644	NA	NA	0.024441103	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish	<a0>10.3390/ijerph20053928	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002025/#:~:text=Consequently%2C%20TEB%20might%20influence%20the,affecting%20the%20reproduction%20of%20zebrafish.	Environmental Research and Public Health	yan_2023	yan_2023_exp_001	yan_2023_exp2_001	yan_2023_exp_001_assay_004	yan_2023_exp2_001_assay2_004	zebrafish	Danio rerio	commercial supplier	not_wild	female	tebuconazole	analytical	107534-96-3	in paper	triazole	0.4	mg/L	21	days	DMSO	solvent_used	27	celsius	social interaction	sociality	contact time	duration of social behaviour	NA	NA	fig4e	yan_2023_fig4e	NA	NA	NA	16	0.3439042	0.6630977	NA	NA	0.165774436	study reports mean and se	exact sample size provided	NA	NA	NA	16	0.2875834	0.0977644	NA	NA	0.024441103	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish	<a0>10.3390/ijerph20053928	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002025/#:~:text=Consequently%2C%20TEB%20might%20influence%20the,affecting%20the%20reproduction%20of%20zebrafish.	Environmental Research and Public Health	yan_2023	yan_2023_exp_002	yan_2023_exp2_002	yan_2023_exp_002_assay_003	yan_2023_exp2_002_assay2_003	zebrafish	Danio rerio	commercial supplier	not_wild	female	tebuconazole	analytical	107534-96-3	in paper	triazole	0.8	mg/L	21	days	none	none	27	celsius	social interaction	sociality	contact time	duration of social behaviour	NA	NA	fig4e	yan_2023_fig4e	NA	NA	NA	16	0.6531373	0.2295338	NA	NA	0.057383459	study reports mean and se	exact sample size provided	NA	NA	NA	16	0.3747213	0.3145464	NA	NA	0.078636591	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish	<a0>10.3390/ijerph20053928	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002025/#:~:text=Consequently%2C%20TEB%20might%20influence%20the,affecting%20the%20reproduction%20of%20zebrafish.	Environmental Research and Public Health	yan_2023	yan_2023_exp_002	yan_2023_exp2_002	yan_2023_exp_002_assay_004	yan_2023_exp2_002_assay2_004	zebrafish	Danio rerio	commercial supplier	not_wild	female	tebuconazole	analytical	107534-96-3	in paper	triazole	0.8	mg/L	21	days	DMSO	solvent_used	27	celsius	social interaction	sociality	contact time	duration of social behaviour	NA	NA	fig4e	yan_2023_fig4e	NA	NA	NA	16	0.3439042	0.6630977	NA	NA	0.165774436	study reports mean and se	exact sample size provided	NA	NA	NA	16	0.3747213	0.3145464	NA	NA	0.078636591	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish	<a0>10.3390/ijerph20053928	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002025/#:~:text=Consequently%2C%20TEB%20might%20influence%20the,affecting%20the%20reproduction%20of%20zebrafish.	Environmental Research and Public Health	yan_2023	yan_2023_exp_003	yan_2023_exp2_003	yan_2023_exp_003_assay_003	yan_2023_exp2_003_assay2_003	zebrafish	Danio rerio	commercial supplier	not_wild	female	tebuconazole	analytical	107534-96-3	in paper	triazole	1.6	mg/L	21	days	none	none	27	celsius	social interaction	sociality	contact time	duration of social behaviour	NA	NA	fig4e	yan_2023_fig4e	NA	NA	NA	16	0.6531373	0.2295338	NA	NA	0.057383459	study reports mean and se	exact sample size provided	NA	NA	NA	16	0.4182902	0.6035890	NA	NA	0.150897243	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish	<a0>10.3390/ijerph20053928	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002025/#:~:text=Consequently%2C%20TEB%20might%20influence%20the,affecting%20the%20reproduction%20of%20zebrafish.	Environmental Research and Public Health	yan_2023	yan_2023_exp_003	yan_2023_exp2_003	yan_2023_exp_003_assay_004	yan_2023_exp2_003_assay2_004	zebrafish	Danio rerio	commercial supplier	not_wild	female	tebuconazole	analytical	107534-96-3	in paper	triazole	1.6	mg/L	21	days	DMSO	solvent_used	27	celsius	social interaction	sociality	contact time	duration of social behaviour	NA	NA	fig4e	yan_2023_fig4e	NA	NA	NA	16	0.3439042	0.6630977	NA	NA	0.165774436	study reports mean and se	exact sample size provided	NA	NA	NA	16	0.4182902	0.6035890	NA	NA	0.150897243	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish	<a0>10.3390/ijerph20053928	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002025/#:~:text=Consequently%2C%20TEB%20might%20influence%20the,affecting%20the%20reproduction%20of%20zebrafish.	Environmental Research and Public Health	yan_2023	yan_2023_exp_004	yan_2023_exp2_004	yan_2023_exp_004_assay_003	yan_2023_exp2_004_assay2_003	zebrafish	Danio rerio	commercial supplier	not_wild	male	tebuconazole	analytical	107534-96-3	in paper	triazole	0.4	mg/L	21	days	none	none	27	celsius	social interaction	sociality	contact time	duration of social behaviour	NA	NA	fig4e	yan_2023_fig4e	NA	NA	NA	16	0.3943922	0.1235288	NA	NA	0.030882206	study reports mean and se	exact sample size provided	NA	NA	NA	16	0.3462970	0.2146566	NA	NA	0.05366416	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish	<a0>10.3390/ijerph20053928	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002025/#:~:text=Consequently%2C%20TEB%20might%20influence%20the,affecting%20the%20reproduction%20of%20zebrafish.	Environmental Research and Public Health	yan_2023	yan_2023_exp_004	yan_2023_exp2_004	yan_2023_exp_004_assay_004	yan_2023_exp2_004_assay2_004	zebrafish	Danio rerio	commercial supplier	not_wild	male	tebuconazole	analytical	107534-96-3	in paper	triazole	0.4	mg/L	21	days	DMSO	solvent_used	27	celsius	social interaction	sociality	contact time	duration of social behaviour	NA	NA	fig4e	yan_2023_fig4e	NA	NA	NA	16	0.3204774	0.1680802	NA	NA	0.04202005	study reports mean and se	exact sample size provided	NA	NA	NA	16	0.3462970	0.2146566	NA	NA	0.05366416	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish	<a0>10.3390/ijerph20053928	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002025/#:~:text=Consequently%2C%20TEB%20might%20influence%20the,affecting%20the%20reproduction%20of%20zebrafish.	Environmental Research and Public Health	yan_2023	yan_2023_exp_005	yan_2023_exp2_005	yan_2023_exp_005_assay_003	yan_2023_exp2_005_assay2_003	zebrafish	Danio rerio	commercial supplier	not_wild	male	tebuconazole	analytical	107534-96-3	in paper	triazole	0.8	mg/L	21	days	none	none	27	celsius	social interaction	sociality	contact time	duration of social behaviour	NA	NA	fig4e	yan_2023_fig4e	NA	NA	NA	16	0.3943922	0.1235288	NA	NA	0.030882206	study reports mean and se	exact sample size provided	NA	NA	NA	16	0.2850388	0.1721303	NA	NA	0.043032581	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish	<a0>10.3390/ijerph20053928	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002025/#:~:text=Consequently%2C%20TEB%20might%20influence%20the,affecting%20the%20reproduction%20of%20zebrafish.	Environmental Research and Public Health	yan_2023	yan_2023_exp_005	yan_2023_exp2_005	yan_2023_exp_005_assay_004	yan_2023_exp2_005_assay2_004	zebrafish	Danio rerio	commercial supplier	not_wild	male	tebuconazole	analytical	107534-96-3	in paper	triazole	0.8	mg/L	21	days	DMSO	solvent_used	27	celsius	social interaction	sociality	contact time	duration of social behaviour	NA	NA	fig4e	yan_2023_fig4e	NA	NA	NA	16	0.3204774	0.1680802	NA	NA	0.04202005	study reports mean and se	exact sample size provided	NA	NA	NA	16	0.2850388	0.1721303	NA	NA	0.043032581	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish	<a0>10.3390/ijerph20053928	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002025/#:~:text=Consequently%2C%20TEB%20might%20influence%20the,affecting%20the%20reproduction%20of%20zebrafish.	Environmental Research and Public Health	yan_2023	yan_2023_exp_006	yan_2023_exp2_006	yan_2023_exp_006_assay_003	yan_2023_exp2_006_assay2_003	zebrafish	Danio rerio	commercial supplier	not_wild	male	tebuconazole	analytical	107534-96-3	in paper	triazole	1.6	mg/L	21	days	none	none	27	celsius	social interaction	sociality	contact time	duration of social behaviour	NA	NA	fig4e	yan_2023_fig4e	NA	NA	NA	16	0.3943922	0.1235288	NA	NA	0.030882206	study reports mean and se	exact sample size provided	NA	NA	NA	16	0.3194649	0.2592080	NA	NA	0.064802005	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish	<a0>10.3390/ijerph20053928	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002025/#:~:text=Consequently%2C%20TEB%20might%20influence%20the,affecting%20the%20reproduction%20of%20zebrafish.	Environmental Research and Public Health	yan_2023	yan_2023_exp_006	yan_2023_exp2_006	yan_2023_exp_006_assay_004	yan_2023_exp2_006_assay2_004	zebrafish	Danio rerio	commercial supplier	not_wild	male	tebuconazole	analytical	107534-96-3	in paper	triazole	1.6	mg/L	21	days	DMSO	solvent_used	27	celsius	social interaction	sociality	contact time	duration of social behaviour	NA	NA	fig4e	yan_2023_fig4e	NA	NA	NA	16	0.3204774	0.1680802	NA	NA	0.04202005	study reports mean and se	exact sample size provided	NA	NA	NA	16	0.3194649	0.2592080	NA	NA	0.064802005	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish	<a0>10.3390/ijerph20053928	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002025/#:~:text=Consequently%2C%20TEB%20might%20influence%20the,affecting%20the%20reproduction%20of%20zebrafish.	Environmental Research and Public Health	yan_2023	yan_2023_exp_007	yan_2023_exp2_007	yan_2023_exp_007_assay_003	yan_2023_exp2_007_assay2_003	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	tebuconazole	analytical	107534-96-3	in paper	triazole	0.4	mg/L	21	days	none	none	27	celsius	social interaction	sociality	contact time	duration of social behaviour	NA	NA	fig4e	yan_2023_fig4e	NA	NA	NA	16	0.4124113	0.1954887	NA	NA	0.04887218	study reports mean and se	exact sample size provided	NA	NA	NA	16	0.2808323	0.0481203	NA	NA	0.012030075	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish	<a0>10.3390/ijerph20053928	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002025/#:~:text=Consequently%2C%20TEB%20might%20influence%20the,affecting%20the%20reproduction%20of%20zebrafish.	Environmental Research and Public Health	yan_2023	yan_2023_exp_007	yan_2023_exp2_007	yan_2023_exp_007_assay_004	yan_2023_exp2_007_assay2_004	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	tebuconazole	analytical	107534-96-3	in paper	triazole	0.4	mg/L	21	days	DMSO	solvent_used	27	celsius	social interaction	sociality	contact time	duration of social behaviour	NA	NA	fig4e	yan_2023_fig4e	NA	NA	NA	16	0.3214338	0.0691729	NA	NA	0.017293233	study reports mean and se	exact sample size provided	NA	NA	NA	16	0.2808323	0.0481203	NA	NA	0.012030075	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish	<a0>10.3390/ijerph20053928	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002025/#:~:text=Consequently%2C%20TEB%20might%20influence%20the,affecting%20the%20reproduction%20of%20zebrafish.	Environmental Research and Public Health	yan_2023	yan_2023_exp_008	yan_2023_exp2_008	yan_2023_exp_008_assay_003	yan_2023_exp2_008_assay2_003	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	tebuconazole	analytical	107534-96-3	in paper	triazole	0.8	mg/L	21	days	none	none	27	celsius	social interaction	sociality	contact time	duration of social behaviour	NA	NA	fig4e	yan_2023_fig4e	NA	NA	NA	16	0.4124113	0.1954887	NA	NA	0.04887218	study reports mean and se	exact sample size provided	NA	NA	NA	16	0.2176744	0.0812030	NA	NA	0.020300752	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish	<a0>10.3390/ijerph20053928	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002025/#:~:text=Consequently%2C%20TEB%20might%20influence%20the,affecting%20the%20reproduction%20of%20zebrafish.	Environmental Research and Public Health	yan_2023	yan_2023_exp_008	yan_2023_exp2_008	yan_2023_exp_008_assay_004	yan_2023_exp2_008_assay2_004	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	tebuconazole	analytical	107534-96-3	in paper	triazole	0.8	mg/L	21	days	DMSO	solvent_used	27	celsius	social interaction	sociality	contact time	duration of social behaviour	NA	NA	fig4e	yan_2023_fig4e	NA	NA	NA	16	0.3214338	0.0691729	NA	NA	0.017293233	study reports mean and se	exact sample size provided	NA	NA	NA	16	0.2176744	0.0812030	NA	NA	0.020300752	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish	<a0>10.3390/ijerph20053928	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002025/#:~:text=Consequently%2C%20TEB%20might%20influence%20the,affecting%20the%20reproduction%20of%20zebrafish.	Environmental Research and Public Health	yan_2023	yan_2023_exp_009	yan_2023_exp2_009	yan_2023_exp_009_assay_003	yan_2023_exp2_009_assay2_003	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	tebuconazole	analytical	107534-96-3	in paper	triazole	1.6	mg/L	21	days	none	none	27	celsius	social interaction	sociality	contact time	duration of social behaviour	NA	NA	fig4e	yan_2023_fig4e	NA	NA	NA	16	0.4124113	0.1954887	NA	NA	0.04887218	study reports mean and se	exact sample size provided	NA	NA	NA	16	0.2748173	0.0751880	NA	NA	0.018796992	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish	<a0>10.3390/ijerph20053928	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002025/#:~:text=Consequently%2C%20TEB%20might%20influence%20the,affecting%20the%20reproduction%20of%20zebrafish.	Environmental Research and Public Health	yan_2023	yan_2023_exp_009	yan_2023_exp2_009	yan_2023_exp_009_assay_004	yan_2023_exp2_009_assay2_004	zebrafish	Danio rerio	commercial supplier	not_wild	mixed	tebuconazole	analytical	107534-96-3	in paper	triazole	1.6	mg/L	21	days	DMSO	solvent_used	27	celsius	social interaction	sociality	contact time	duration of social behaviour	NA	NA	fig4e	yan_2023_fig4e	NA	NA	NA	16	0.3214338	0.0691729	NA	NA	0.017293233	study reports mean and se	exact sample size provided	NA	NA	NA	16	0.2748173	0.0751880	NA	NA	0.018796992	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Effect of thiamethoxam on the behavioral profile alteration and toxicity of adult zebrafish at environmentally relevant concentrations	10.1016/j.scitotenv.2022.159883	https://www.sciencedirect.com/science/article/pii/S0048969722069832#:~:text=This%20result%20showed%20that%20THM,restlessness%20for%20adult%20male%20zebrafish.	Science of The Total Environment	yang_2023	yang_2023_exp_001	yang_2023_exp2_001	yang_2023_exp_001_assay_001	yang_2023_exp2_001_assay_001	zebrafish	Danio rerio	commercial supplier	not_wild	male	thiamethoxam	commercial	153719-23-4	https://commonchemistry.cas.org/detail?cas_rn=153719-23-4&search=thiamethoxam	neonicotinoid	0.1	ug/L	45	days	none	none	not reported	not reported	shoaling	collective behaviour	shoaling average speed	group movement	NA	NA	tables4	yang_2023_tables4	9.600000	6.000000	24	24	5.9100000	0.9800000	0.4900000	0.9800000	0.200041662	study reports mean and sd	exact sample size provided	9.600000	6.000000	24	24	5.8000000	0.9800000	0.4900000	0.9800000	0.200041662	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Effect of thiamethoxam on the behavioral profile alteration and toxicity of adult zebrafish at environmentally relevant concentrations	10.1016/j.scitotenv.2022.159883	https://www.sciencedirect.com/science/article/pii/S0048969722069832#:~:text=This%20result%20showed%20that%20THM,restlessness%20for%20adult%20male%20zebrafish.	Science of The Total Environment	yang_2023	yang_2023_exp_002	yang_2023_exp2_002	yang_2023_exp_002_assay_001	yang_2023_exp2_002_assay_001	zebrafish	Danio rerio	commercial supplier	not_wild	male	thiamethoxam	commercial	153719-23-4	https://commonchemistry.cas.org/detail?cas_rn=153719-23-4&search=thiamethoxam	neonicotinoid	10	ug/L	45	days	none	none	not reported	not reported	shoaling	collective behaviour	shoaling average speed	group movement	NA	NA	tables4	yang_2023_tables4	9.600000	6.000000	24	24	5.9100000	0.9800000	0.4900000	0.9800000	0.200041662	study reports mean and sd	exact sample size provided	9.600000	6.000000	24	24	6.2400000	0.7700000	0.3850000	0.7700000	0.157175592	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Effect of thiamethoxam on the behavioral profile alteration and toxicity of adult zebrafish at environmentally relevant concentrations	10.1016/j.scitotenv.2022.159883	https://www.sciencedirect.com/science/article/pii/S0048969722069832#:~:text=This%20result%20showed%20that%20THM,restlessness%20for%20adult%20male%20zebrafish.	Science of The Total Environment	yang_2023	yang_2023_exp_003	yang_2023_exp2_003	yang_2023_exp_003_assay_001	yang_2023_exp2_003_assay_001	zebrafish	Danio rerio	commercial supplier	not_wild	male	thiamethoxam	commercial	153719-23-4	https://commonchemistry.cas.org/detail?cas_rn=153719-23-4&search=thiamethoxam	neonicotinoid	1000	ug/L	45	days	none	none	not reported	not reported	shoaling	collective behaviour	shoaling average speed	group movement	NA	NA	tables4	yang_2023_tables4	9.600000	6.000000	24	24	5.9100000	0.9800000	0.4900000	0.9800000	0.200041662	study reports mean and sd	exact sample size provided	9.600000	6.000000	24	24	6.7500000	0.9000000	0.4500000	0.9000000	0.183711731	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Effect of thiamethoxam on the behavioral profile alteration and toxicity of adult zebrafish at environmentally relevant concentrations	10.1016/j.scitotenv.2022.159883	https://www.sciencedirect.com/science/article/pii/S0048969722069832#:~:text=This%20result%20showed%20that%20THM,restlessness%20for%20adult%20male%20zebrafish.	Science of The Total Environment	yang_2023	yang_2023_exp_001	yang_2023_exp2_001	yang_2023_exp_001_assay_002	yang_2023_exp2_001_assay_002	zebrafish	Danio rerio	commercial supplier	not_wild	male	thiamethoxam	commercial	153719-23-4	https://commonchemistry.cas.org/detail?cas_rn=153719-23-4&search=thiamethoxam	neonicotinoid	0.1	ug/L	45	days	none	none	not reported	not reported	shoaling	collective behaviour	average fish distance	group arrangment	NA	change	tables4	yang_2023_tables4	9.600000	6.000000	24	24	6.3100000	0.8100000	0.4050000	0.8100000	0.165340558	study reports mean and sd	exact sample size provided	9.600000	6.000000	24	24	5.6700000	0.5800000	0.2900000	0.5800000	0.118392004	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Effect of thiamethoxam on the behavioral profile alteration and toxicity of adult zebrafish at environmentally relevant concentrations	10.1016/j.scitotenv.2022.159883	https://www.sciencedirect.com/science/article/pii/S0048969722069832#:~:text=This%20result%20showed%20that%20THM,restlessness%20for%20adult%20male%20zebrafish.	Science of The Total Environment	yang_2023	yang_2023_exp_002	yang_2023_exp2_002	yang_2023_exp_002_assay_002	yang_2023_exp2_002_assay_002	zebrafish	Danio rerio	commercial supplier	not_wild	male	thiamethoxam	commercial	153719-23-4	https://commonchemistry.cas.org/detail?cas_rn=153719-23-4&search=thiamethoxam	neonicotinoid	10	ug/L	45	days	none	none	not reported	not reported	shoaling	collective behaviour	average fish distance	group arrangment	NA	change	tables4	yang_2023_tables4	9.600000	6.000000	24	24	6.3100000	0.8100000	0.4050000	0.8100000	0.165340558	study reports mean and sd	exact sample size provided	9.600000	6.000000	24	24	5.8700000	0.6200000	0.3100000	0.6200000	0.12655697	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Effect of thiamethoxam on the behavioral profile alteration and toxicity of adult zebrafish at environmentally relevant concentrations	10.1016/j.scitotenv.2022.159883	https://www.sciencedirect.com/science/article/pii/S0048969722069832#:~:text=This%20result%20showed%20that%20THM,restlessness%20for%20adult%20male%20zebrafish.	Science of The Total Environment	yang_2023	yang_2023_exp_003	yang_2023_exp2_003	yang_2023_exp_003_assay_002	yang_2023_exp2_003_assay_002	zebrafish	Danio rerio	commercial supplier	not_wild	male	thiamethoxam	commercial	153719-23-4	https://commonchemistry.cas.org/detail?cas_rn=153719-23-4&search=thiamethoxam	neonicotinoid	1000	ug/L	45	days	none	none	not reported	not reported	shoaling	collective behaviour	average fish distance	group arrangment	NA	change	tables4	yang_2023_tables4	9.600000	6.000000	24	24	6.3100000	0.8100000	0.4050000	0.8100000	0.165340558	study reports mean and sd	exact sample size provided	9.600000	6.000000	24	24	4.8400000	1.0400000	0.5200000	1.0400000	0.212289111	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Effect of thiamethoxam on the behavioral profile alteration and toxicity of adult zebrafish at environmentally relevant concentrations	10.1016/j.scitotenv.2022.159883	https://www.sciencedirect.com/science/article/pii/S0048969722069832#:~:text=This%20result%20showed%20that%20THM,restlessness%20for%20adult%20male%20zebrafish.	Science of The Total Environment	yang_2023	yang_2023_exp_001	yang_2023_exp2_001	yang_2023_exp_001_assay_003	yang_2023_exp2_001_assay_003	zebrafish	Danio rerio	commercial supplier	not_wild	male	thiamethoxam	commercial	153719-23-4	https://commonchemistry.cas.org/detail?cas_rn=153719-23-4&search=thiamethoxam	neonicotinoid	0.1	ug/L	45	days	none	none	not reported	not reported	shoaling	collective behaviour	maximum inter-fish difference	group arrangment	NA	change	tables4	yang_2023_tables4	9.600000	6.000000	24	24	18.2300000	0.7300000	0.3650000	0.7300000	0.149010626	study reports mean and sd	exact sample size provided	9.600000	6.000000	24	24	17.6400000	0.7200000	0.3600000	0.7200000	0.146969385	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Effect of thiamethoxam on the behavioral profile alteration and toxicity of adult zebrafish at environmentally relevant concentrations	10.1016/j.scitotenv.2022.159883	https://www.sciencedirect.com/science/article/pii/S0048969722069832#:~:text=This%20result%20showed%20that%20THM,restlessness%20for%20adult%20male%20zebrafish.	Science of The Total Environment	yang_2023	yang_2023_exp_002	yang_2023_exp2_002	yang_2023_exp_002_assay_003	yang_2023_exp2_002_assay_003	zebrafish	Danio rerio	commercial supplier	not_wild	male	thiamethoxam	commercial	153719-23-4	https://commonchemistry.cas.org/detail?cas_rn=153719-23-4&search=thiamethoxam	neonicotinoid	10	ug/L	45	days	none	none	not reported	not reported	shoaling	collective behaviour	maximum inter-fish difference	group arrangment	NA	change	tables4	yang_2023_tables4	9.600000	6.000000	24	24	18.2300000	0.7300000	0.3650000	0.7300000	0.149010626	study reports mean and sd	exact sample size provided	9.600000	6.000000	24	24	18.1300000	0.6600000	0.3300000	0.6600000	0.134721936	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Effect of thiamethoxam on the behavioral profile alteration and toxicity of adult zebrafish at environmentally relevant concentrations	10.1016/j.scitotenv.2022.159883	https://www.sciencedirect.com/science/article/pii/S0048969722069832#:~:text=This%20result%20showed%20that%20THM,restlessness%20for%20adult%20male%20zebrafish.	Science of The Total Environment	yang_2023	yang_2023_exp_003	yang_2023_exp2_003	yang_2023_exp_003_assay_003	yang_2023_exp2_003_assay_003	zebrafish	Danio rerio	commercial supplier	not_wild	male	thiamethoxam	commercial	153719-23-4	https://commonchemistry.cas.org/detail?cas_rn=153719-23-4&search=thiamethoxam	neonicotinoid	1000	ug/L	45	days	none	none	not reported	not reported	shoaling	collective behaviour	maximum inter-fish difference	group arrangment	NA	change	tables4	yang_2023_tables4	9.600000	6.000000	24	24	18.2300000	0.7300000	0.3650000	0.7300000	0.149010626	study reports mean and sd	exact sample size provided	9.600000	6.000000	24	24	17.5100000	1.2800000	0.6400000	1.2800000	0.261278906	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Effect of thiamethoxam on the behavioral profile alteration and toxicity of adult zebrafish at environmentally relevant concentrations	10.1016/j.scitotenv.2022.159883	https://www.sciencedirect.com/science/article/pii/S0048969722069832#:~:text=This%20result%20showed%20that%20THM,restlessness%20for%20adult%20male%20zebrafish.	Science of The Total Environment	yang_2023	yang_2023_exp_001	yang_2023_exp2_004	yang_2023_exp_001_assay_004	yang_2023_exp2_004_assay_001	zebrafish	Danio rerio	commercial supplier	not_wild	male	thiamethoxam	commercial	153719-23-4	https://commonchemistry.cas.org/detail?cas_rn=153719-23-4&search=thiamethoxam	neonicotinoid	0.1	ug/L	45	days	none	none	not reported	not reported	social preference	sociality	time spent in social zone	time spent in social zone	zone	NA	tables4	yang_2023_tables4	NA	NA	NA	18	482.7000000	92.8100000	NA	NA	21.87552679	study reports mean and sd	exact sample size provided	NA	NA	NA	18	535.7000000	80.7200000	NA	NA	19.02588646	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Effect of thiamethoxam on the behavioral profile alteration and toxicity of adult zebrafish at environmentally relevant concentrations	10.1016/j.scitotenv.2022.159883	https://www.sciencedirect.com/science/article/pii/S0048969722069832#:~:text=This%20result%20showed%20that%20THM,restlessness%20for%20adult%20male%20zebrafish.	Science of The Total Environment	yang_2023	yang_2023_exp_002	yang_2023_exp2_005	yang_2023_exp_002_assay_004	yang_2023_exp2_005_assay_001	zebrafish	Danio rerio	commercial supplier	not_wild	male	thiamethoxam	commercial	153719-23-4	https://commonchemistry.cas.org/detail?cas_rn=153719-23-4&search=thiamethoxam	neonicotinoid	10	ug/L	45	days	none	none	not reported	not reported	social preference	sociality	time spent in social zone	time spent in social zone	zone	NA	tables4	yang_2023_tables4	NA	NA	NA	18	482.7000000	92.8100000	NA	NA	21.87552679	study reports mean and sd	exact sample size provided	NA	NA	NA	18	675.1000000	85.5800000	NA	NA	20.17139944	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Effect of thiamethoxam on the behavioral profile alteration and toxicity of adult zebrafish at environmentally relevant concentrations	10.1016/j.scitotenv.2022.159883	https://www.sciencedirect.com/science/article/pii/S0048969722069832#:~:text=This%20result%20showed%20that%20THM,restlessness%20for%20adult%20male%20zebrafish.	Science of The Total Environment	yang_2023	yang_2023_exp_003	yang_2023_exp2_006	yang_2023_exp_003_assay_004	yang_2023_exp2_006_assay_001	zebrafish	Danio rerio	commercial supplier	not_wild	male	thiamethoxam	commercial	153719-23-4	https://commonchemistry.cas.org/detail?cas_rn=153719-23-4&search=thiamethoxam	neonicotinoid	1000	ug/L	45	days	none	none	not reported	not reported	social preference	sociality	time spent in social zone	time spent in social zone	zone	NA	tables4	yang_2023_tables4	NA	NA	NA	18	482.7000000	92.8100000	NA	NA	21.87552679	study reports mean and sd	exact sample size provided	NA	NA	NA	18	495.1000000	96.2800000	NA	NA	22.69341363	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Effect of thiamethoxam on the behavioral profile alteration and toxicity of adult zebrafish at environmentally relevant concentrations	10.1016/j.scitotenv.2022.159883	https://www.sciencedirect.com/science/article/pii/S0048969722069832#:~:text=This%20result%20showed%20that%20THM,restlessness%20for%20adult%20male%20zebrafish.	Science of The Total Environment	yang_2023	yang_2023_exp_001	yang_2023_exp2_004	yang_2023_exp_001_assay_005	yang_2023_exp2_004_assay_002	zebrafish	Danio rerio	commercial supplier	not_wild	male	thiamethoxam	commercial	153719-23-4	https://commonchemistry.cas.org/detail?cas_rn=153719-23-4&search=thiamethoxam	neonicotinoid	0.1	ug/L	45	days	none	none	not reported	not reported	social recognition	sociality	time spent in social zone with familiar fish	time spent in social zone	zone	NA	tables4	yang_2023_tables4	NA	NA	NA	18	348.0000000	89.6300000	NA	NA	21.1259936	study reports mean and sd	exact sample size provided	NA	NA	NA	18	312.1000000	61.5900000	NA	NA	14.51690222	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Effect of thiamethoxam on the behavioral profile alteration and toxicity of adult zebrafish at environmentally relevant concentrations	10.1016/j.scitotenv.2022.159883	https://www.sciencedirect.com/science/article/pii/S0048969722069832#:~:text=This%20result%20showed%20that%20THM,restlessness%20for%20adult%20male%20zebrafish.	Science of The Total Environment	yang_2023	yang_2023_exp_002	yang_2023_exp2_005	yang_2023_exp_002_assay_005	yang_2023_exp2_005_assay_002	zebrafish	Danio rerio	commercial supplier	not_wild	male	thiamethoxam	commercial	153719-23-4	https://commonchemistry.cas.org/detail?cas_rn=153719-23-4&search=thiamethoxam	neonicotinoid	10	ug/L	45	days	none	none	not reported	not reported	social recognition	sociality	time spent in social zone with familiar fish	time spent in social zone	zone	NA	tables4	yang_2023_tables4	NA	NA	NA	18	348.0000000	89.6300000	NA	NA	21.1259936	study reports mean and sd	exact sample size provided	NA	NA	NA	18	444.6000000	111.1000000	NA	NA	26.18652113	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Effect of thiamethoxam on the behavioral profile alteration and toxicity of adult zebrafish at environmentally relevant concentrations	10.1016/j.scitotenv.2022.159883	https://www.sciencedirect.com/science/article/pii/S0048969722069832#:~:text=This%20result%20showed%20that%20THM,restlessness%20for%20adult%20male%20zebrafish.	Science of The Total Environment	yang_2023	yang_2023_exp_003	yang_2023_exp2_006	yang_2023_exp_003_assay_005	yang_2023_exp2_006_assay_002	zebrafish	Danio rerio	commercial supplier	not_wild	male	thiamethoxam	commercial	153719-23-4	https://commonchemistry.cas.org/detail?cas_rn=153719-23-4&search=thiamethoxam	neonicotinoid	1000	ug/L	45	days	none	none	not reported	not reported	social recognition	sociality	time spent in social zone with familiar fish	time spent in social zone	zone	NA	tables4	yang_2023_tables4	NA	NA	NA	18	348.0000000	89.6300000	NA	NA	21.1259936	study reports mean and sd	exact sample size provided	NA	NA	NA	18	475.4000000	88.0900000	NA	NA	20.76301212	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Effect of thiamethoxam on the behavioral profile alteration and toxicity of adult zebrafish at environmentally relevant concentrations	10.1016/j.scitotenv.2022.159883	https://www.sciencedirect.com/science/article/pii/S0048969722069832#:~:text=This%20result%20showed%20that%20THM,restlessness%20for%20adult%20male%20zebrafish.	Science of The Total Environment	yang_2023	yang_2023_exp_001	yang_2023_exp2_004	yang_2023_exp_001_assay_006	yang_2023_exp2_004_assay_003	zebrafish	Danio rerio	commercial supplier	not_wild	male	thiamethoxam	commercial	153719-23-4	https://commonchemistry.cas.org/detail?cas_rn=153719-23-4&search=thiamethoxam	neonicotinoid	0.1	ug/L	45	days	none	none	not reported	not reported	social recognition	sociality	distance to familiar fish	distance to conspecific	count	change	tables4	yang_2023_tables4	NA	NA	NA	18	4.5200000	0.9100000	NA	NA	0.214489057	study reports mean and sd	exact sample size provided	NA	NA	NA	18	4.6200000	0.9800000	NA	NA	0.230988215	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Effect of thiamethoxam on the behavioral profile alteration and toxicity of adult zebrafish at environmentally relevant concentrations	10.1016/j.scitotenv.2022.159883	https://www.sciencedirect.com/science/article/pii/S0048969722069832#:~:text=This%20result%20showed%20that%20THM,restlessness%20for%20adult%20male%20zebrafish.	Science of The Total Environment	yang_2023	yang_2023_exp_002	yang_2023_exp2_005	yang_2023_exp_002_assay_006	yang_2023_exp2_005_assay_003	zebrafish	Danio rerio	commercial supplier	not_wild	male	thiamethoxam	commercial	153719-23-4	https://commonchemistry.cas.org/detail?cas_rn=153719-23-4&search=thiamethoxam	neonicotinoid	10	ug/L	45	days	none	none	not reported	not reported	social recognition	sociality	distance to familiar fish	distance to conspecific	count	change	tables4	yang_2023_tables4	NA	NA	NA	18	4.5200000	0.9100000	NA	NA	0.214489057	study reports mean and sd	exact sample size provided	NA	NA	NA	18	3.2500000	1.0500000	NA	NA	0.247487373	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Effect of thiamethoxam on the behavioral profile alteration and toxicity of adult zebrafish at environmentally relevant concentrations	10.1016/j.scitotenv.2022.159883	https://www.sciencedirect.com/science/article/pii/S0048969722069832#:~:text=This%20result%20showed%20that%20THM,restlessness%20for%20adult%20male%20zebrafish.	Science of The Total Environment	yang_2023	yang_2023_exp_003	yang_2023_exp2_006	yang_2023_exp_003_assay_006	yang_2023_exp2_006_assay_003	zebrafish	Danio rerio	commercial supplier	not_wild	male	thiamethoxam	commercial	153719-23-4	https://commonchemistry.cas.org/detail?cas_rn=153719-23-4&search=thiamethoxam	neonicotinoid	1000	ug/L	45	days	none	none	not reported	not reported	social recognition	sociality	distance to familiar fish	distance to conspecific	count	change	tables4	yang_2023_tables4	NA	NA	NA	18	4.5200000	0.9100000	NA	NA	0.214489057	study reports mean and sd	exact sample size provided	NA	NA	NA	18	2.7200000	0.9700000	NA	NA	0.228631193	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Effect of thiamethoxam on the behavioral profile alteration and toxicity of adult zebrafish at environmentally relevant concentrations	10.1016/j.scitotenv.2022.159883	https://www.sciencedirect.com/science/article/pii/S0048969722069832#:~:text=This%20result%20showed%20that%20THM,restlessness%20for%20adult%20male%20zebrafish.	Science of The Total Environment	yang_2023	yang_2023_exp_001	yang_2023_exp2_007	yang_2023_exp_001_assay_007	yang_2023_exp2_007_assay_001	zebrafish	Danio rerio	commercial supplier	not_wild	male	thiamethoxam	commercial	153719-23-4	https://commonchemistry.cas.org/detail?cas_rn=153719-23-4&search=thiamethoxam	neonicotinoid	0.1	ug/L	45	days	none	none	not reported	not reported	aggression	aggression	number of transition to the attack zone	frequency of entries into aggression zone	zone	NA	fig3g	yang_2023_tables4	NA	NA	NA	24	51.0000000	20.0000000	NA	NA	4.082482905	study reports mean and sd	exact sample size provided	NA	NA	NA	24	55.0000000	18.0000000	NA	NA	3.674234614	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Effect of thiamethoxam on the behavioral profile alteration and toxicity of adult zebrafish at environmentally relevant concentrations	10.1016/j.scitotenv.2022.159883	https://www.sciencedirect.com/science/article/pii/S0048969722069832#:~:text=This%20result%20showed%20that%20THM,restlessness%20for%20adult%20male%20zebrafish.	Science of The Total Environment	yang_2023	yang_2023_exp_002	yang_2023_exp2_008	yang_2023_exp_002_assay_007	yang_2023_exp2_008_assay_001	zebrafish	Danio rerio	commercial supplier	not_wild	male	thiamethoxam	commercial	153719-23-4	https://commonchemistry.cas.org/detail?cas_rn=153719-23-4&search=thiamethoxam	neonicotinoid	10	ug/L	45	days	none	none	not reported	not reported	aggression	aggression	number of transition to the attack zone	frequency of entries into aggression zone	zone	NA	fig3g	yang_2023_tables4	NA	NA	NA	24	51.0000000	20.0000000	NA	NA	4.082482905	study reports mean and sd	exact sample size provided	NA	NA	NA	24	51.0000000	18.0000000	NA	NA	3.674234614	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Effect of thiamethoxam on the behavioral profile alteration and toxicity of adult zebrafish at environmentally relevant concentrations	10.1016/j.scitotenv.2022.159883	https://www.sciencedirect.com/science/article/pii/S0048969722069832#:~:text=This%20result%20showed%20that%20THM,restlessness%20for%20adult%20male%20zebrafish.	Science of The Total Environment	yang_2023	yang_2023_exp_003	yang_2023_exp2_009	yang_2023_exp_003_assay_007	yang_2023_exp2_009_assay_001	zebrafish	Danio rerio	commercial supplier	not_wild	male	thiamethoxam	commercial	153719-23-4	https://commonchemistry.cas.org/detail?cas_rn=153719-23-4&search=thiamethoxam	neonicotinoid	1000	ug/L	45	days	none	none	not reported	not reported	aggression	aggression	number of transition to the attack zone	frequency of entries into aggression zone	zone	NA	fig3g	yang_2023_tables4	NA	NA	NA	24	51.0000000	20.0000000	NA	NA	4.082482905	study reports mean and sd	exact sample size provided	NA	NA	NA	24	70.0000000	28.0000000	NA	NA	5.715476066	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Effect of thiamethoxam on the behavioral profile alteration and toxicity of adult zebrafish at environmentally relevant concentrations	10.1016/j.scitotenv.2022.159883	https://www.sciencedirect.com/science/article/pii/S0048969722069832#:~:text=This%20result%20showed%20that%20THM,restlessness%20for%20adult%20male%20zebrafish.	Science of The Total Environment	yang_2023	yang_2023_exp_001	yang_2023_exp2_007	yang_2023_exp_001_assay_008	yang_2023_exp2_007_assay_002	zebrafish	Danio rerio	commercial supplier	not_wild	male	thiamethoxam	commercial	153719-23-4	https://commonchemistry.cas.org/detail?cas_rn=153719-23-4&search=thiamethoxam	neonicotinoid	0.1	ug/L	45	days	none	none	not reported	not reported	aggression	aggression	biting time	duration of aggressive behaviour	NA	NA	fig3h	yang_2023_tables4	NA	NA	NA	24	104.7000000	73.2100000	NA	NA	14.94392867	study reports mean and sd	exact sample size provided	NA	NA	NA	24	87.1400000	45.3300000	NA	NA	9.252947503	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Effect of thiamethoxam on the behavioral profile alteration and toxicity of adult zebrafish at environmentally relevant concentrations	10.1016/j.scitotenv.2022.159883	https://www.sciencedirect.com/science/article/pii/S0048969722069832#:~:text=This%20result%20showed%20that%20THM,restlessness%20for%20adult%20male%20zebrafish.	Science of The Total Environment	yang_2023	yang_2023_exp_002	yang_2023_exp2_008	yang_2023_exp_002_assay_008	yang_2023_exp2_008_assay_002	zebrafish	Danio rerio	commercial supplier	not_wild	male	thiamethoxam	commercial	153719-23-4	https://commonchemistry.cas.org/detail?cas_rn=153719-23-4&search=thiamethoxam	neonicotinoid	10	ug/L	45	days	none	none	not reported	not reported	aggression	aggression	biting time	duration of aggressive behaviour	NA	NA	fig3h	yang_2023_tables4	NA	NA	NA	24	104.7000000	73.2100000	NA	NA	14.94392867	study reports mean and sd	exact sample size provided	NA	NA	NA	24	82.6000000	59.2600000	NA	NA	12.09639685	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Effect of thiamethoxam on the behavioral profile alteration and toxicity of adult zebrafish at environmentally relevant concentrations	10.1016/j.scitotenv.2022.159883	https://www.sciencedirect.com/science/article/pii/S0048969722069832#:~:text=This%20result%20showed%20that%20THM,restlessness%20for%20adult%20male%20zebrafish.	Science of The Total Environment	yang_2023	yang_2023_exp_003	yang_2023_exp2_009	yang_2023_exp_003_assay_008	yang_2023_exp2_009_assay_002	zebrafish	Danio rerio	commercial supplier	not_wild	male	thiamethoxam	commercial	153719-23-4	https://commonchemistry.cas.org/detail?cas_rn=153719-23-4&search=thiamethoxam	neonicotinoid	1000	ug/L	45	days	none	none	not reported	not reported	aggression	aggression	biting time	duration of aggressive behaviour	NA	NA	fig3h	yang_2023_tables4	NA	NA	NA	24	104.7000000	73.2100000	NA	NA	14.94392867	study reports mean and sd	exact sample size provided	NA	NA	NA	24	155.8000000	111.9000000	NA	NA	22.84149185	study reports mean and sd	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Atrazine and Diuron Effects on Survival, Embryo Development, and Behavior in Larvae and Adult Zebrafish	10.3389/fphar.2022.841826	https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.841826/full	Frontiers in<a0>Pharmacology	zaluski_2022	zaluski_2022_exp_001	zaluski_2022_exp2_001	zaluski_2022_exp_001_assay_001	zaluski_2022_exp2_001_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	atrazine	commercial	1912-24-9	https://commonchemistry.cas.org/detail?cas_rn=1912-24-9&search=atrazine	triazine	0.5	mg/L	96	hours	none	none	28	celsius	aggression	aggression	time in stimulus zone close to mirror	time spent in aggression zone	zone	NA	fig7a	zaluski_2022_fig7a	NA	NA	NA	18	191.1742446	65.0538239	NA	NA	15.33333333	study reports mean and se	exact sample size provided	NA	NA	NA	18	230.6130256	58.5029846	NA	NA	13.78928571	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Atrazine and Diuron Effects on Survival, Embryo Development, and Behavior in Larvae and Adult Zebrafish	10.3389/fphar.2022.841826	https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.841826/full	Frontiers in<a0>Pharmacology	zaluski_2022	zaluski_2022_exp_002	zaluski_2022_exp2_002	zaluski_2022_exp_002_assay_001	zaluski_2022_exp2_002_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	atrazine	commercial	1912-24-9	https://commonchemistry.cas.org/detail?cas_rn=1912-24-9&search=atrazine	triazine	1	mg/L	96	hours	none	none	28	celsius	aggression	aggression	time in stimulus zone close to mirror	time spent in aggression zone	zone	NA	fig7a	zaluski_2022_fig7a	NA	NA	NA	18	191.1742446	65.0538239	NA	NA	15.33333333	study reports mean and se	exact sample size provided	NA	NA	NA	18	228.8290159	59.4938649	NA	NA	14.02283845	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Atrazine and Diuron Effects on Survival, Embryo Development, and Behavior in Larvae and Adult Zebrafish	10.3389/fphar.2022.841826	https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.841826/full	Frontiers in<a0>Pharmacology	zaluski_2022	zaluski_2022_exp_003	zaluski_2022_exp2_003	zaluski_2022_exp_003_assay_001	zaluski_2022_exp2_003_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	atrazine	commercial	1912-24-9	https://commonchemistry.cas.org/detail?cas_rn=1912-24-9&search=atrazine	triazine	2	mg/L	96	hours	none	none	28	celsius	aggression	aggression	time in stimulus zone close to mirror	time spent in aggression zone	zone	NA	fig7a	zaluski_2022_fig7a	NA	NA	NA	18	191.1742446	65.0538239	NA	NA	15.33333333	study reports mean and se	exact sample size provided	NA	NA	NA	18	232.2568209	54.2055214	NA	NA	12.77636392	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Atrazine and Diuron Effects on Survival, Embryo Development, and Behavior in Larvae and Adult Zebrafish	10.3389/fphar.2022.841826	https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.841826/full	Frontiers in<a0>Pharmacology	zaluski_2022	zaluski_2022_exp_004	zaluski_2022_exp2_004	zaluski_2022_exp_004_assay_001	zaluski_2022_exp2_004_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	atrazine	commercial	1912-24-9	https://commonchemistry.cas.org/detail?cas_rn=1912-24-9&search=atrazine	triazine	2.5	mg/L	96	hours	none	none	28	celsius	aggression	aggression	time in stimulus zone close to mirror	time spent in aggression zone	zone	NA	fig7a	zaluski_2022_fig7a	NA	NA	NA	18	191.1742446	65.0538239	NA	NA	15.33333333	study reports mean and se	exact sample size provided	NA	NA	NA	18	226.4558090	68.0943830	NA	NA	16.05	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Atrazine and Diuron Effects on Survival, Embryo Development, and Behavior in Larvae and Adult Zebrafish	10.3389/fphar.2022.841826	https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.841826/full	Frontiers in<a0>Pharmacology	zaluski_2022	zaluski_2022_exp_005	zaluski_2022_exp2_005	zaluski_2022_exp_005_assay_001	zaluski_2022_exp2_005_assay2_001	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	atrazine	commercial	1912-24-9	https://commonchemistry.cas.org/detail?cas_rn=1912-24-9&search=atrazine	triazine	5	mg/L	96	hours	none	none	28	celsius	aggression	aggression	time in stimulus zone close to mirror	time spent in aggression zone	zone	NA	fig7a	zaluski_2022_fig7a	NA	NA	NA	18	191.1742446	65.0538239	NA	NA	15.33333333	study reports mean and se	exact sample size provided	NA	NA	NA	18	209.3558090	72.5491558	NA	NA	17.1	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Atrazine and Diuron Effects on Survival, Embryo Development, and Behavior in Larvae and Adult Zebrafish	10.3389/fphar.2022.841826	https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.841826/full	Frontiers in<a0>Pharmacology	zaluski_2022	zaluski_2022_exp_001	zaluski_2022_exp2_001	zaluski_2022_exp_001_assay_002	zaluski_2022_exp2_001_assay2_002	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	atrazine	commercial	1912-24-9	https://commonchemistry.cas.org/detail?cas_rn=1912-24-9&search=atrazine	triazine	0.5	mg/L	96	hours	none	none	28	celsius	aggression	aggression	number of bites	frequency of aggressive behaviour	count	NA	fig7b	zaluski_2022_fig7b	NA	NA	NA	18	238.1687637	81.6973497	NA	NA	19.25625	study reports mean and se	exact sample size provided	NA	NA	NA	18	252.6040943	62.2554488	NA	NA	14.67375	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Atrazine and Diuron Effects on Survival, Embryo Development, and Behavior in Larvae and Adult Zebrafish	10.3389/fphar.2022.841826	https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.841826/full	Frontiers in<a0>Pharmacology	zaluski_2022	zaluski_2022_exp_002	zaluski_2022_exp2_002	zaluski_2022_exp_002_assay_002	zaluski_2022_exp2_002_assay2_002	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	atrazine	commercial	1912-24-9	https://commonchemistry.cas.org/detail?cas_rn=1912-24-9&search=atrazine	triazine	1	mg/L	96	hours	none	none	28	celsius	aggression	aggression	number of bites	frequency of aggressive behaviour	count	NA	fig7b	zaluski_2022_fig7b	NA	NA	NA	18	238.1687637	81.6973497	NA	NA	19.25625	study reports mean and se	exact sample size provided	NA	NA	NA	18	255.7298922	67.5889318	NA	NA	15.93086401	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Atrazine and Diuron Effects on Survival, Embryo Development, and Behavior in Larvae and Adult Zebrafish	10.3389/fphar.2022.841826	https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.841826/full	Frontiers in<a0>Pharmacology	zaluski_2022	zaluski_2022_exp_003	zaluski_2022_exp2_003	zaluski_2022_exp_003_assay_002	zaluski_2022_exp2_003_assay2_002	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	atrazine	commercial	1912-24-9	https://commonchemistry.cas.org/detail?cas_rn=1912-24-9&search=atrazine	triazine	2	mg/L	96	hours	none	none	28	celsius	aggression	aggression	number of bites	frequency of aggressive behaviour	count	NA	fig7b	zaluski_2022_fig7b	NA	NA	NA	18	238.1687637	81.6973497	NA	NA	19.25625	study reports mean and se	exact sample size provided	NA	NA	NA	18	253.6647802	41.3043472	NA	NA	9.735528004	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Atrazine and Diuron Effects on Survival, Embryo Development, and Behavior in Larvae and Adult Zebrafish	10.3389/fphar.2022.841826	https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.841826/full	Frontiers in<a0>Pharmacology	zaluski_2022	zaluski_2022_exp_004	zaluski_2022_exp2_004	zaluski_2022_exp_004_assay_002	zaluski_2022_exp2_004_assay2_002	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	atrazine	commercial	1912-24-9	https://commonchemistry.cas.org/detail?cas_rn=1912-24-9&search=atrazine	triazine	2.5	mg/L	96	hours	none	none	28	celsius	aggression	aggression	number of bites	frequency of aggressive behaviour	count	NA	fig7b	zaluski_2022_fig7b	NA	NA	NA	18	238.1687637	81.6973497	NA	NA	19.25625	study reports mean and se	exact sample size provided	NA	NA	NA	18	270.4806922	46.3109348	NA	NA	10.915592	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Atrazine and Diuron Effects on Survival, Embryo Development, and Behavior in Larvae and Adult Zebrafish	10.3389/fphar.2022.841826	https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.841826/full	Frontiers in<a0>Pharmacology	zaluski_2022	zaluski_2022_exp_005	zaluski_2022_exp2_005	zaluski_2022_exp_005_assay_002	zaluski_2022_exp2_005_assay2_002	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	atrazine	commercial	1912-24-9	https://commonchemistry.cas.org/detail?cas_rn=1912-24-9&search=atrazine	triazine	5	mg/L	96	hours	none	none	28	celsius	aggression	aggression	number of bites	frequency of aggressive behaviour	count	NA	fig7b	zaluski_2022_fig7b	NA	NA	NA	18	238.1687637	81.6973497	NA	NA	19.25625	study reports mean and se	exact sample size provided	NA	NA	NA	18	258.9750682	56.3241098	NA	NA	13.27572001	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Atrazine and Diuron Effects on Survival, Embryo Development, and Behavior in Larvae and Adult Zebrafish	10.3389/fphar.2022.841826	https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.841826/full	Frontiers in<a0>Pharmacology	zaluski_2022	zaluski_2022_exp_001	zaluski_2022_exp2_001	zaluski_2022_exp_001_assay_003	zaluski_2022_exp2_001_assay2_003	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	atrazine	commercial	1912-24-9	https://commonchemistry.cas.org/detail?cas_rn=1912-24-9&search=atrazine	triazine	0.5	mg/L	96	hours	none	none	28	celsius	social interaction	sociality	time in stimulus zone close to mirror	time spent in social zone	zone	NA	fig7e	zaluski_2022_fig7e	NA	NA	NA	18	121.2528529	88.9421300	NA	NA	20.9638611	study reports mean and se	exact sample size provided	NA	NA	NA	18	112.9625963	86.9447732	NA	NA	20.49307958	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Atrazine and Diuron Effects on Survival, Embryo Development, and Behavior in Larvae and Adult Zebrafish	10.3389/fphar.2022.841826	https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.841826/full	Frontiers in<a0>Pharmacology	zaluski_2022	zaluski_2022_exp_002	zaluski_2022_exp2_002	zaluski_2022_exp_002_assay_003	zaluski_2022_exp2_002_assay2_003	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	atrazine	commercial	1912-24-9	https://commonchemistry.cas.org/detail?cas_rn=1912-24-9&search=atrazine	triazine	1	mg/L	96	hours	none	none	28	celsius	social interaction	sociality	time in stimulus zone close to mirror	time spent in social zone	zone	NA	fig7e	zaluski_2022_fig7e	NA	NA	NA	18	121.2528529	88.9421300	NA	NA	20.9638611	study reports mean and se	exact sample size provided	NA	NA	NA	18	94.4191107	55.7370682	NA	NA	13.13735295	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Atrazine and Diuron Effects on Survival, Embryo Development, and Behavior in Larvae and Adult Zebrafish	10.3389/fphar.2022.841826	https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.841826/full	Frontiers in<a0>Pharmacology	zaluski_2022	zaluski_2022_exp_003	zaluski_2022_exp2_003	zaluski_2022_exp_003_assay_003	zaluski_2022_exp2_003_assay2_003	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	atrazine	commercial	1912-24-9	https://commonchemistry.cas.org/detail?cas_rn=1912-24-9&search=atrazine	triazine	2	mg/L	96	hours	none	none	28	celsius	social interaction	sociality	time in stimulus zone close to mirror	time spent in social zone	zone	NA	fig7e	zaluski_2022_fig7e	NA	NA	NA	18	121.2528529	88.9421300	NA	NA	20.9638611	study reports mean and se	exact sample size provided	NA	NA	NA	18	96.9347741	72.3395991	NA	NA	17.05060703	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Atrazine and Diuron Effects on Survival, Embryo Development, and Behavior in Larvae and Adult Zebrafish	10.3389/fphar.2022.841826	https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.841826/full	Frontiers in<a0>Pharmacology	zaluski_2022	zaluski_2022_exp_004	zaluski_2022_exp2_004	zaluski_2022_exp_004_assay_003	zaluski_2022_exp2_004_assay2_003	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	atrazine	commercial	1912-24-9	https://commonchemistry.cas.org/detail?cas_rn=1912-24-9&search=atrazine	triazine	2.5	mg/L	96	hours	none	none	28	celsius	social interaction	sociality	time in stimulus zone close to mirror	time spent in social zone	zone	NA	fig7e	zaluski_2022_fig7e	NA	NA	NA	18	121.2528529	88.9421300	NA	NA	20.9638611	study reports mean and se	exact sample size provided	NA	NA	NA	18	97.2142922	43.8781175	NA	NA	10.34217147	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Atrazine and Diuron Effects on Survival, Embryo Development, and Behavior in Larvae and Adult Zebrafish	10.3389/fphar.2022.841826	https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.841826/full	Frontiers in<a0>Pharmacology	zaluski_2022	zaluski_2022_exp_005	zaluski_2022_exp2_005	zaluski_2022_exp_005_assay_003	zaluski_2022_exp2_005_assay2_003	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	atrazine	commercial	1912-24-9	https://commonchemistry.cas.org/detail?cas_rn=1912-24-9&search=atrazine	triazine	5	mg/L	96	hours	none	none	28	celsius	social interaction	sociality	time in stimulus zone close to mirror	time spent in social zone	zone	NA	fig7e	zaluski_2022_fig7e	NA	NA	NA	18	121.2528529	88.9421300	NA	NA	20.9638611	study reports mean and se	exact sample size provided	NA	NA	NA	18	65.9082597	50.9934879	NA	NA	12.01928036	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Atrazine and Diuron Effects on Survival, Embryo Development, and Behavior in Larvae and Adult Zebrafish	10.3389/fphar.2022.841826	https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.841826/full	Frontiers in<a0>Pharmacology	zaluski_2022	zaluski_2022_exp_001	zaluski_2022_exp2_001	zaluski_2022_exp_001_assay_004	zaluski_2022_exp2_001_assay2_003	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	diuron	commercial	330-54-1	https://commonchemistry.cas.org/detail?cas_rn=330-54-1&search=diuron	urea	0.5	mg/L	96	hours	none	none	28	celsius	aggression	aggression	time in stimulus zone close to mirror	time spent in social zone	zone	NA	fig7c	zaluski_2022_fig7c	NA	NA	NA	18	63.5261868	59.0181751	NA	NA	13.91071727	study reports mean and se	exact sample size provided	NA	NA	NA	18	76.1722934	61.3175845	NA	NA	14.45269327	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Atrazine and Diuron Effects on Survival, Embryo Development, and Behavior in Larvae and Adult Zebrafish	10.3389/fphar.2022.841826	https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.841826/full	Frontiers in<a0>Pharmacology	zaluski_2022	zaluski_2022_exp_002	zaluski_2022_exp2_002	zaluski_2022_exp_002_assay_004	zaluski_2022_exp2_002_assay2_003	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	diuron	commercial	330-54-1	https://commonchemistry.cas.org/detail?cas_rn=330-54-1&search=diuron	urea	1	mg/L	96	hours	none	none	28	celsius	aggression	aggression	time in stimulus zone close to mirror	time spent in social zone	zone	NA	fig7c	zaluski_2022_fig7c	NA	NA	NA	18	63.5261868	59.0181751	NA	NA	13.91071727	study reports mean and se	exact sample size provided	NA	NA	NA	18	75.0883414	63.6169939	NA	NA	14.99466926	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Atrazine and Diuron Effects on Survival, Embryo Development, and Behavior in Larvae and Adult Zebrafish	10.3389/fphar.2022.841826	https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.841826/full	Frontiers in<a0>Pharmacology	zaluski_2022	zaluski_2022_exp_003	zaluski_2022_exp2_003	zaluski_2022_exp_003_assay_004	zaluski_2022_exp2_003_assay2_003	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	diuron	commercial	330-54-1	https://commonchemistry.cas.org/detail?cas_rn=330-54-1&search=diuron	urea	2	mg/L	96	hours	none	none	28	celsius	aggression	aggression	time in stimulus zone close to mirror	time spent in social zone	zone	NA	fig7c	zaluski_2022_fig7c	NA	NA	NA	18	63.5261868	59.0181751	NA	NA	13.91071727	study reports mean and se	exact sample size provided	NA	NA	NA	18	77.6175628	52.8864166	NA	NA	12.46544794	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Atrazine and Diuron Effects on Survival, Embryo Development, and Behavior in Larvae and Adult Zebrafish	10.3389/fphar.2022.841826	https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.841826/full	Frontiers in<a0>Pharmacology	zaluski_2022	zaluski_2022_exp_004	zaluski_2022_exp2_004	zaluski_2022_exp_004_assay_004	zaluski_2022_exp2_004_assay2_003	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	diuron	commercial	330-54-1	https://commonchemistry.cas.org/detail?cas_rn=330-54-1&search=diuron	urea	2.5	mg/L	96	hours	none	none	28	celsius	aggression	aggression	time in stimulus zone close to mirror	time spent in social zone	zone	NA	fig7c	zaluski_2022_fig7c	NA	NA	NA	18	63.5261868	59.0181751	NA	NA	13.91071727	study reports mean and se	exact sample size provided	NA	NA	NA	18	113.1954355	64.1601215	NA	NA	15.12268567	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Atrazine and Diuron Effects on Survival, Embryo Development, and Behavior in Larvae and Adult Zebrafish	10.3389/fphar.2022.841826	https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.841826/full	Frontiers in<a0>Pharmacology	zaluski_2022	zaluski_2022_exp_005	zaluski_2022_exp2_005	zaluski_2022_exp_005_assay_004	zaluski_2022_exp2_005_assay2_003	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	diuron	commercial	330-54-1	https://commonchemistry.cas.org/detail?cas_rn=330-54-1&search=diuron	urea	5	mg/L	96	hours	none	none	28	celsius	aggression	aggression	time in stimulus zone close to mirror	time spent in social zone	zone	NA	fig7c	zaluski_2022_fig7c	NA	NA	NA	18	63.5261868	59.0181751	NA	NA	13.91071727	study reports mean and se	exact sample size provided	NA	NA	NA	18	99.5850184	72.1801367	NA	NA	17.01302138	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Atrazine and Diuron Effects on Survival, Embryo Development, and Behavior in Larvae and Adult Zebrafish	10.3389/fphar.2022.841826	https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.841826/full	Frontiers in<a0>Pharmacology	zaluski_2022	zaluski_2022_exp_001	zaluski_2022_exp2_001	zaluski_2022_exp_001_assay_005	zaluski_2022_exp2_001_assay2_004	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	diuron	commercial	330-54-1	https://commonchemistry.cas.org/detail?cas_rn=330-54-1&search=diuron	urea	0.5	mg/L	96	hours	none	none	28	celsius	aggression	aggression	number of bites	frequency of aggressive behaviour	count	NA	fig7d	zaluski_2022_fig7d	NA	NA	NA	18	1.6396186	2.6436709	NA	NA	0.623119213	study reports mean and se	exact sample size provided	NA	NA	NA	18	2.2366158	3.1366815	NA	NA	0.739322917	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Atrazine and Diuron Effects on Survival, Embryo Development, and Behavior in Larvae and Adult Zebrafish	10.3389/fphar.2022.841826	https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.841826/full	Frontiers in<a0>Pharmacology	zaluski_2022	zaluski_2022_exp_002	zaluski_2022_exp2_002	zaluski_2022_exp_002_assay_005	zaluski_2022_exp2_002_assay2_004	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	diuron	commercial	330-54-1	https://commonchemistry.cas.org/detail?cas_rn=330-54-1&search=diuron	urea	1	mg/L	96	hours	none	none	28	celsius	aggression	aggression	number of bites	frequency of aggressive behaviour	count	NA	fig7d	zaluski_2022_fig7d	NA	NA	NA	18	1.6396186	2.6436709	NA	NA	0.623119213	study reports mean and se	exact sample size provided	NA	NA	NA	18	2.4004179	4.0570252	NA	NA	0.95625	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Atrazine and Diuron Effects on Survival, Embryo Development, and Behavior in Larvae and Adult Zebrafish	10.3389/fphar.2022.841826	https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.841826/full	Frontiers in<a0>Pharmacology	zaluski_2022	zaluski_2022_exp_003	zaluski_2022_exp2_003	zaluski_2022_exp_003_assay_005	zaluski_2022_exp2_003_assay2_004	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	diuron	commercial	330-54-1	https://commonchemistry.cas.org/detail?cas_rn=330-54-1&search=diuron	urea	2	mg/L	96	hours	none	none	28	celsius	aggression	aggression	number of bites	frequency of aggressive behaviour	count	NA	fig7d	zaluski_2022_fig7d	NA	NA	NA	18	1.6396186	2.6436709	NA	NA	0.623119213	study reports mean and se	exact sample size provided	NA	NA	NA	18	3.3457322	3.9111844	NA	NA	0.921875	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Atrazine and Diuron Effects on Survival, Embryo Development, and Behavior in Larvae and Adult Zebrafish	10.3389/fphar.2022.841826	https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.841826/full	Frontiers in<a0>Pharmacology	zaluski_2022	zaluski_2022_exp_004	zaluski_2022_exp2_004	zaluski_2022_exp_004_assay_005	zaluski_2022_exp2_004_assay2_004	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	diuron	commercial	330-54-1	https://commonchemistry.cas.org/detail?cas_rn=330-54-1&search=diuron	urea	2.5	mg/L	96	hours	none	none	28	celsius	aggression	aggression	number of bites	frequency of aggressive behaviour	count	NA	fig7d	zaluski_2022_fig7d	NA	NA	NA	18	1.6396186	2.6436709	NA	NA	0.623119213	study reports mean and se	exact sample size provided	NA	NA	NA	18	3.0218627	3.9688823	NA	NA	0.935474537	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Atrazine and Diuron Effects on Survival, Embryo Development, and Behavior in Larvae and Adult Zebrafish	10.3389/fphar.2022.841826	https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.841826/full	Frontiers in<a0>Pharmacology	zaluski_2022	zaluski_2022_exp_005	zaluski_2022_exp2_005	zaluski_2022_exp_005_assay_005	zaluski_2022_exp2_005_assay2_004	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	diuron	commercial	330-54-1	https://commonchemistry.cas.org/detail?cas_rn=330-54-1&search=diuron	urea	5	mg/L	96	hours	none	none	28	celsius	aggression	aggression	number of bites	frequency of aggressive behaviour	count	NA	fig7d	zaluski_2022_fig7d	NA	NA	NA	18	1.6396186	2.6436709	NA	NA	0.623119213	study reports mean and se	exact sample size provided	NA	NA	NA	18	2.2284545	2.8697978	NA	NA	0.676417824	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Atrazine and Diuron Effects on Survival, Embryo Development, and Behavior in Larvae and Adult Zebrafish	10.3389/fphar.2022.841826	https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.841826/full	Frontiers in<a0>Pharmacology	zaluski_2022	zaluski_2022_exp_001	zaluski_2022_exp2_001	zaluski_2022_exp_001_assay_006	zaluski_2022_exp2_001_assay2_005	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	diuron	commercial	330-54-1	https://commonchemistry.cas.org/detail?cas_rn=330-54-1&search=diuron	urea	0.5	mg/L	96	hours	none	none	28	celsius	social interaction	sociality	time in stimulus zone close to mirror	time spent in social zone	zone	NA	fig7f	zaluski_2022_fig7f	NA	NA	NA	18	1.5801555	2.0427529	NA	NA	0.481481481	study reports mean and se	exact sample size provided	NA	NA	NA	18	1.0767885	3.2188834	NA	NA	0.758698092	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Atrazine and Diuron Effects on Survival, Embryo Development, and Behavior in Larvae and Adult Zebrafish	10.3389/fphar.2022.841826	https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.841826/full	Frontiers in<a0>Pharmacology	zaluski_2022	zaluski_2022_exp_002	zaluski_2022_exp2_002	zaluski_2022_exp_002_assay_006	zaluski_2022_exp2_002_assay2_005	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	diuron	commercial	330-54-1	https://commonchemistry.cas.org/detail?cas_rn=330-54-1&search=diuron	urea	1	mg/L	96	hours	none	none	28	celsius	social interaction	sociality	time in stimulus zone close to mirror	time spent in social zone	zone	NA	fig7f	zaluski_2022_fig7f	NA	NA	NA	18	1.5801555	2.0427529	NA	NA	0.481481481	study reports mean and se	exact sample size provided	NA	NA	NA	18	2.5961782	4.3748958	NA	NA	1.03117284	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Atrazine and Diuron Effects on Survival, Embryo Development, and Behavior in Larvae and Adult Zebrafish	10.3389/fphar.2022.841826	https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.841826/full	Frontiers in<a0>Pharmacology	zaluski_2022	zaluski_2022_exp_003	zaluski_2022_exp2_003	zaluski_2022_exp_003_assay_006	zaluski_2022_exp2_003_assay2_005	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	diuron	commercial	330-54-1	https://commonchemistry.cas.org/detail?cas_rn=330-54-1&search=diuron	urea	2	mg/L	96	hours	none	none	28	celsius	social interaction	sociality	time in stimulus zone close to mirror	time spent in social zone	zone	NA	fig7f	zaluski_2022_fig7f	NA	NA	NA	18	1.5801555	2.0427529	NA	NA	0.481481481	study reports mean and se	exact sample size provided	NA	NA	NA	18	2.4637707	3.5067259	NA	NA	0.82654321	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Atrazine and Diuron Effects on Survival, Embryo Development, and Behavior in Larvae and Adult Zebrafish	10.3389/fphar.2022.841826	https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.841826/full	Frontiers in<a0>Pharmacology	zaluski_2022	zaluski_2022_exp_004	zaluski_2022_exp2_004	zaluski_2022_exp_004_assay_006	zaluski_2022_exp2_004_assay2_005	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	diuron	commercial	330-54-1	https://commonchemistry.cas.org/detail?cas_rn=330-54-1&search=diuron	urea	2.5	mg/L	96	hours	none	none	28	celsius	social interaction	sociality	time in stimulus zone close to mirror	time spent in social zone	zone	NA	fig7f	zaluski_2022_fig7f	NA	NA	NA	18	1.5801555	2.0427529	NA	NA	0.481481481	study reports mean and se	exact sample size provided	NA	NA	NA	18	2.4646725	3.5079163	NA	NA	0.826823793	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	NA	KM	Atrazine and Diuron Effects on Survival, Embryo Development, and Behavior in Larvae and Adult Zebrafish	10.3389/fphar.2022.841826	https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.841826/full	Frontiers in<a0>Pharmacology	zaluski_2022	zaluski_2022_exp_005	zaluski_2022_exp2_005	zaluski_2022_exp_005_assay_006	zaluski_2022_exp2_005_assay2_005	zebrafish	Danio rerio	laboratory stock from not specified source	not_wild	mixed	diuron	commercial	330-54-1	https://commonchemistry.cas.org/detail?cas_rn=330-54-1&search=diuron	urea	5	mg/L	96	hours	none	none	28	celsius	social interaction	sociality	time in stimulus zone close to mirror	time spent in social zone	zone	NA	fig7f	zaluski_2022_fig7f	NA	NA	NA	18	1.5801555	2.0427529	NA	NA	0.481481481	study reports mean and se	exact sample size provided	NA	NA	NA	18	0.1847449	0.6333010	NA	NA	0.149270483	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	SN	KM	Chronic exposure to environmentally realistic levels of diuron impacts the behaviour of adult marine medaka (Oryzias melastigma)	10.1016/j.aquatox.2021.105917	https://www.sciencedirect.com/science/article/pii/S0166445X21001764?via%3Dihub	Aquatic Toxicology	zhou_2021	zhou_2021_exp_001	zhou_2021_exp2_001	zhou_2021_exp_001_assay_001	zhou_2021_exp2_001_assay2_001	marine medaka	Oryzias melastigma	laboratory stock from not specified source	not_wild	mixed	diuron	analytical	330-54-1	in paper	urea	5	ng/L	105	days	DMSO	solvent_used	28	celsius	aggression	aggression	time spent on the side closest to the mirror	time spent in aggression zone	zone	NA	fig3e	zhou_2021_fig3e	NA	NA	NA	22	108.2053673	76.4392733	NA	NA	16.29690783	study reports mean and se	exact sample size provided	NA	NA	NA	22	93.3168342	35.8603998	NA	NA	7.645462935	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	SN	KM	Chronic exposure to environmentally realistic levels of diuron impacts the behaviour of adult marine medaka (Oryzias melastigma)	10.1016/j.aquatox.2021.105917	https://www.sciencedirect.com/science/article/pii/S0166445X21001764?via%3Dihub	Aquatic Toxicology	zhou_2021	zhou_2021_exp_002	zhou_2021_exp2_002	zhou_2021_exp_002_assay_001	zhou_2021_exp2_002_assay2_001	marine medaka	Oryzias melastigma	laboratory stock from not specified source	not_wild	mixed	diuron	analytical	330-54-1	in paper	urea	50	ng/L	105	days	DMSO	solvent_used	28	celsius	aggression	aggression	time spent on the side closest to the mirror	time spent in aggression zone	zone	NA	fig3e	zhou_2021_fig3e	NA	NA	NA	22	108.2053673	76.4392733	NA	NA	16.29690783	study reports mean and se	exact sample size provided	NA	NA	NA	22	80.0378723	48.1284314	NA	NA	10.26101604	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	SN	KM	Chronic exposure to environmentally realistic levels of diuron impacts the behaviour of adult marine medaka (Oryzias melastigma)	10.1016/j.aquatox.2021.105917	https://www.sciencedirect.com/science/article/pii/S0166445X21001764?via%3Dihub	Aquatic Toxicology	zhou_2021	zhou_2021_exp_003	zhou_2021_exp2_003	zhou_2021_exp_003_assay_001	zhou_2021_exp2_003_assay2_001	marine medaka	Oryzias melastigma	laboratory stock from not specified source	not_wild	mixed	diuron	analytical	330-54-1	in paper	urea	500	ng/L	105	days	DMSO	solvent_used	28	celsius	aggression	aggression	time spent on the side closest to the mirror	time spent in aggression zone	zone	NA	fig3e	zhou_2021_fig3e	NA	NA	NA	22	108.2053673	76.4392733	NA	NA	16.29690783	study reports mean and se	exact sample size provided	NA	NA	NA	22	68.9720707	14.1554210	NA	NA	3.017945895	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	SN	KM	Chronic exposure to environmentally realistic levels of diuron impacts the behaviour of adult marine medaka (Oryzias melastigma)	10.1016/j.aquatox.2021.105917	https://www.sciencedirect.com/science/article/pii/S0166445X21001764?via%3Dihub	Aquatic Toxicology	zhou_2021	zhou_2021_exp_004	zhou_2021_exp2_004	zhou_2021_exp_004_assay_001	zhou_2021_exp2_004_assay2_001	marine medaka	Oryzias melastigma	laboratory stock from not specified source	not_wild	mixed	diuron	analytical	330-54-1	in paper	urea	5000	ng/L	105	days	DMSO	solvent_used	28	celsius	aggression	aggression	time spent on the side closest to the mirror	time spent in aggression zone	zone	NA	fig3e	zhou_2021_fig3e	NA	NA	NA	22	108.2053673	76.4392733	NA	NA	16.29690783	study reports mean and se	exact sample size provided	NA	NA	NA	22	92.9144414	47.1847366	NA	NA	10.05981965	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	SN	KM	Chronic exposure to environmentally realistic levels of diuron impacts the behaviour of adult marine medaka (Oryzias melastigma)	10.1016/j.aquatox.2021.105917	https://www.sciencedirect.com/science/article/pii/S0166445X21001764?via%3Dihub	Aquatic Toxicology	zhou_2021	zhou_2021_exp_001	zhou_2021_exp2_001	zhou_2021_exp_001_assay_002	zhou_2021_exp2_001_assay2_002	marine medaka	Oryzias melastigma	laboratory stock from not specified source	not_wild	mixed	diuron	analytical	330-54-1	in paper	urea	5	ng/L	105	days	DMSO	solvent_used	28	celsius	aggression	aggression	mirror biting frequency	frequency of aggressive behaviour	count	NA	fig3f	zhou_2021_fig3f	NA	NA	NA	22	25.2365820	12.0032838	NA	NA	2.559108705	study reports mean and se	exact sample size provided	NA	NA	NA	22	28.3344504	15.1620427	NA	NA	3.232558364	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	SN	KM	Chronic exposure to environmentally realistic levels of diuron impacts the behaviour of adult marine medaka (Oryzias melastigma)	10.1016/j.aquatox.2021.105917	https://www.sciencedirect.com/science/article/pii/S0166445X21001764?via%3Dihub	Aquatic Toxicology	zhou_2021	zhou_2021_exp_002	zhou_2021_exp2_002	zhou_2021_exp_002_assay_002	zhou_2021_exp2_002_assay2_002	marine medaka	Oryzias melastigma	laboratory stock from not specified source	not_wild	mixed	diuron	analytical	330-54-1	in paper	urea	50	ng/L	105	days	DMSO	solvent_used	28	celsius	aggression	aggression	mirror biting frequency	frequency of aggressive behaviour	count	NA	fig3f	zhou_2021_fig3f	NA	NA	NA	22	25.2365820	12.0032838	NA	NA	2.559108705	study reports mean and se	exact sample size provided	NA	NA	NA	22	22.4080934	12.0032838	NA	NA	2.559108705	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	SN	KM	Chronic exposure to environmentally realistic levels of diuron impacts the behaviour of adult marine medaka (Oryzias melastigma)	10.1016/j.aquatox.2021.105917	https://www.sciencedirect.com/science/article/pii/S0166445X21001764?via%3Dihub	Aquatic Toxicology	zhou_2021	zhou_2021_exp_003	zhou_2021_exp2_003	zhou_2021_exp_003_assay_002	zhou_2021_exp2_003_assay2_002	marine medaka	Oryzias melastigma	laboratory stock from not specified source	not_wild	mixed	diuron	analytical	330-54-1	in paper	urea	500	ng/L	105	days	DMSO	solvent_used	28	celsius	aggression	aggression	mirror biting frequency	frequency of aggressive behaviour	count	NA	fig3f	zhou_2021_fig3f	NA	NA	NA	22	25.2365820	12.0032838	NA	NA	2.559108705	study reports mean and se	exact sample size provided	NA	NA	NA	22	20.8816075	7.1598535	NA	NA	1.526485894	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	SN	KM	Chronic exposure to environmentally realistic levels of diuron impacts the behaviour of adult marine medaka (Oryzias melastigma)	10.1016/j.aquatox.2021.105917	https://www.sciencedirect.com/science/article/pii/S0166445X21001764?via%3Dihub	Aquatic Toxicology	zhou_2021	zhou_2021_exp_004	zhou_2021_exp2_004	zhou_2021_exp_004_assay_002	zhou_2021_exp2_004_assay2_002	marine medaka	Oryzias melastigma	laboratory stock from not specified source	not_wild	mixed	diuron	analytical	330-54-1	in paper	urea	5000	ng/L	105	days	DMSO	solvent_used	28	celsius	aggression	aggression	mirror biting frequency	frequency of aggressive behaviour	count	NA	fig3f	zhou_2021_fig3f	NA	NA	NA	22	25.2365820	12.0032838	NA	NA	2.559108705	study reports mean and se	exact sample size provided	NA	NA	NA	22	26.2692048	6.3175178	NA	NA	1.346899319	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	SN	KM	Chronic exposure to environmentally realistic levels of diuron impacts the behaviour of adult marine medaka (Oryzias melastigma)	10.1016/j.aquatox.2021.105917	https://www.sciencedirect.com/science/article/pii/S0166445X21001764?via%3Dihub	Aquatic Toxicology	zhou_2021	zhou_2021_exp_001	zhou_2021_exp2_005	zhou_2021_exp_001_assay_003	zhou_2021_exp2_005_assay2_001	marine medaka	Oryzias melastigma	laboratory stock from not specified source	not_wild	mixed	diuron	analytical	330-54-1	in paper	urea	5	ng/L	122	days	DMSO	solvent_used	28	celsius	shoaling	collective behaviour	cluster score	group arrangment	NA	NA	fig5b	zhou_2021_fig5b	9.428571	6.000000	22	6	2.5778057	1.6201614	0.8461017	1.6201614	0.34541958	study reports mean and se	exact sample size provided	9.428571	6.000000	22	6	3.0959351	2.3426659	1.2234174	2.3426659	0.499458042	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	SN	KM	Chronic exposure to environmentally realistic levels of diuron impacts the behaviour of adult marine medaka (Oryzias melastigma)	10.1016/j.aquatox.2021.105917	https://www.sciencedirect.com/science/article/pii/S0166445X21001764?via%3Dihub	Aquatic Toxicology	zhou_2021	zhou_2021_exp_002	zhou_2021_exp2_006	zhou_2021_exp_002_assay_003	zhou_2021_exp2_006_assay2_001	marine medaka	Oryzias melastigma	laboratory stock from not specified source	not_wild	mixed	diuron	analytical	330-54-1	in paper	urea	50	ng/L	122	days	DMSO	solvent_used	28	celsius	shoaling	collective behaviour	cluster score	group arrangment	NA	NA	fig5b	zhou_2021_fig5b	9.428571	6.000000	22	6	2.5778057	1.6201614	0.8461017	1.6201614	0.34541958	study reports mean and se	exact sample size provided	9.428571	6.000000	22	6	2.4050959	0.5692459	0.2972790	0.5692459	0.121363636	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	SN	KM	Chronic exposure to environmentally realistic levels of diuron impacts the behaviour of adult marine medaka (Oryzias melastigma)	10.1016/j.aquatox.2021.105917	https://www.sciencedirect.com/science/article/pii/S0166445X21001764?via%3Dihub	Aquatic Toxicology	zhou_2021	zhou_2021_exp_003	zhou_2021_exp2_007	zhou_2021_exp_003_assay_003	zhou_2021_exp2_007_assay2_001	marine medaka	Oryzias melastigma	laboratory stock from not specified source	not_wild	mixed	diuron	analytical	330-54-1	in paper	urea	500	ng/L	122	days	DMSO	solvent_used	28	celsius	shoaling	collective behaviour	cluster score	group arrangment	NA	NA	fig5b	zhou_2021_fig5b	9.428571	6.000000	22	6	2.5778057	1.6201614	0.8461017	1.6201614	0.34541958	study reports mean and se	exact sample size provided	9.428571	6.000000	22	6	1.9289770	1.1822800	0.6174256	1.1822800	0.252062937	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	SN	KM	Chronic exposure to environmentally realistic levels of diuron impacts the behaviour of adult marine medaka (Oryzias melastigma)	10.1016/j.aquatox.2021.105917	https://www.sciencedirect.com/science/article/pii/S0166445X21001764?via%3Dihub	Aquatic Toxicology	zhou_2021	zhou_2021_exp_004	zhou_2021_exp2_008	zhou_2021_exp_004_assay_003	zhou_2021_exp2_008_assay2_001	marine medaka	Oryzias melastigma	laboratory stock from not specified source	not_wild	mixed	diuron	analytical	330-54-1	in paper	urea	5000	ng/L	122	days	DMSO	solvent_used	28	celsius	shoaling	collective behaviour	cluster score	group arrangment	NA	NA	fig5b	zhou_2021_fig5b	9.428571	6.000000	22	6	2.5778057	1.6201614	0.8461017	1.6201614	0.34541958	study reports mean and se	exact sample size provided	9.428571	6.000000	22	6	1.5135400	1.0071274	0.5259551	1.0071274	0.21472028	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	SN	KM	Chronic exposure to environmentally realistic levels of diuron impacts the behaviour of adult marine medaka (Oryzias melastigma)	10.1016/j.aquatox.2021.105917	https://www.sciencedirect.com/science/article/pii/S0166445X21001764?via%3Dihub	Aquatic Toxicology	zhou_2021	zhou_2021_exp_001	zhou_2021_exp2_009	zhou_2021_exp_001_assay_004	zhou_2021_exp2_009_assay2_001	marine medaka	Oryzias melastigma	laboratory stock from not specified source	not_wild	mixed	diuron	analytical	330-54-1	in paper	urea	5	ng/L	130	days	DMSO	solvent_used	28	celsius	social interaction	sociality	time spent on the side closest to the seperator	time spent in social zone	zone	NA	fig6b	zhou_2021_fig6b	NA	NA	NA	20	167.4650762	67.9064632	NA	NA	15.18434677	study reports mean and se	exact sample size provided	NA	NA	NA	20	160.4884845	64.2358435	NA	NA	14.36357127	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	SN	KM	Chronic exposure to environmentally realistic levels of diuron impacts the behaviour of adult marine medaka (Oryzias melastigma)	10.1016/j.aquatox.2021.105917	https://www.sciencedirect.com/science/article/pii/S0166445X21001764?via%3Dihub	Aquatic Toxicology	zhou_2021	zhou_2021_exp_002	zhou_2021_exp2_010	zhou_2021_exp_002_assay_004	zhou_2021_exp2_010_assay2_001	marine medaka	Oryzias melastigma	laboratory stock from not specified source	not_wild	mixed	diuron	analytical	330-54-1	in paper	urea	50	ng/L	130	days	DMSO	solvent_used	28	celsius	social interaction	sociality	time spent on the side closest to the seperator	time spent in social zone	zone	NA	fig6b	zhou_2021_fig6b	NA	NA	NA	20	167.4650762	67.9064632	NA	NA	15.18434677	study reports mean and se	exact sample size provided	NA	NA	NA	20	144.2781683	55.0592945	NA	NA	12.31163252	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	SN	KM	Chronic exposure to environmentally realistic levels of diuron impacts the behaviour of adult marine medaka (Oryzias melastigma)	10.1016/j.aquatox.2021.105917	https://www.sciencedirect.com/science/article/pii/S0166445X21001764?via%3Dihub	Aquatic Toxicology	zhou_2021	zhou_2021_exp_003	zhou_2021_exp2_011	zhou_2021_exp_003_assay_004	zhou_2021_exp2_011_assay2_001	marine medaka	Oryzias melastigma	laboratory stock from not specified source	not_wild	mixed	diuron	analytical	330-54-1	in paper	urea	500	ng/L	130	days	DMSO	solvent_used	28	celsius	social interaction	sociality	time spent on the side closest to the seperator	time spent in social zone	zone	NA	fig6b	zhou_2021_fig6b	NA	NA	NA	20	167.4650762	67.9064632	NA	NA	15.18434677	study reports mean and se	exact sample size provided	NA	NA	NA	20	124.3743624	57.8122592	NA	NA	12.92721415	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	SN	KM	Chronic exposure to environmentally realistic levels of diuron impacts the behaviour of adult marine medaka (Oryzias melastigma)	10.1016/j.aquatox.2021.105917	https://www.sciencedirect.com/science/article/pii/S0166445X21001764?via%3Dihub	Aquatic Toxicology	zhou_2021	zhou_2021_exp_004	zhou_2021_exp2_012	zhou_2021_exp_004_assay_004	zhou_2021_exp2_012_assay2_001	marine medaka	Oryzias melastigma	laboratory stock from not specified source	not_wild	mixed	diuron	analytical	330-54-1	in paper	urea	5000	ng/L	130	days	DMSO	solvent_used	28	celsius	social interaction	sociality	time spent on the side closest to the seperator	time spent in social zone	zone	NA	fig6b	zhou_2021_fig6b	NA	NA	NA	20	167.4650762	67.9064632	NA	NA	15.18434677	study reports mean and se	exact sample size provided	NA	NA	NA	20	165.0027497	87.1772162	NA	NA	19.49341816	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	SN	KM	Chronic exposure to environmentally realistic levels of diuron impacts the behaviour of adult marine medaka (Oryzias melastigma)	10.1016/j.aquatox.2021.105917	https://www.sciencedirect.com/science/article/pii/S0166445X21001764?via%3Dihub	Aquatic Toxicology	zhou_2021	zhou_2021_exp_001	zhou_2021_exp2_009	zhou_2021_exp_001_assay_005	zhou_2021_exp2_009_assay2_002	marine medaka	Oryzias melastigma	laboratory stock from not specified source	not_wild	mixed	diuron	analytical	330-54-1	in paper	urea	5	ng/L	130	days	DMSO	solvent_used	28	celsius	social interaction	sociality	interaction frequency	frequency of social behaviour	count	NA	fig6c	zhou_2021_fig6c	NA	NA	NA	20	28.5921715	5.5469371	NA	NA	1.240332846	study reports mean and se	exact sample size provided	NA	NA	NA	20	39.0464055	12.1504337	NA	NA	2.716919568	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	SN	KM	Chronic exposure to environmentally realistic levels of diuron impacts the behaviour of adult marine medaka (Oryzias melastigma)	10.1016/j.aquatox.2021.105917	https://www.sciencedirect.com/science/article/pii/S0166445X21001764?via%3Dihub	Aquatic Toxicology	zhou_2021	zhou_2021_exp_002	zhou_2021_exp2_010	zhou_2021_exp_002_assay_005	zhou_2021_exp2_010_assay2_002	marine medaka	Oryzias melastigma	laboratory stock from not specified source	not_wild	mixed	diuron	analytical	330-54-1	in paper	urea	50	ng/L	130	days	DMSO	solvent_used	28	celsius	social interaction	sociality	interaction frequency	frequency of social behaviour	count	NA	fig6c	zhou_2021_fig6c	NA	NA	NA	20	28.5921715	5.5469371	NA	NA	1.240332846	study reports mean and se	exact sample size provided	NA	NA	NA	20	40.5229923	13.9994127	NA	NA	3.13036385	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	SN	KM	Chronic exposure to environmentally realistic levels of diuron impacts the behaviour of adult marine medaka (Oryzias melastigma)	10.1016/j.aquatox.2021.105917	https://www.sciencedirect.com/science/article/pii/S0166445X21001764?via%3Dihub	Aquatic Toxicology	zhou_2021	zhou_2021_exp_003	zhou_2021_exp2_011	zhou_2021_exp_003_assay_005	zhou_2021_exp2_011_assay2_002	marine medaka	Oryzias melastigma	laboratory stock from not specified source	not_wild	mixed	diuron	analytical	330-54-1	in paper	urea	500	ng/L	130	days	DMSO	solvent_used	28	celsius	social interaction	sociality	interaction frequency	frequency of social behaviour	count	NA	fig6c	zhou_2021_fig6c	NA	NA	NA	20	28.5921715	5.5469371	NA	NA	1.240332846	study reports mean and se	exact sample size provided	NA	NA	NA	20	33.3172491	10.8297344	NA	NA	2.421602224	study reports mean and se	exact sample size provided	NA	NA	NA	NA
NA	NA	SN	KM	Chronic exposure to environmentally realistic levels of diuron impacts the behaviour of adult marine medaka (Oryzias melastigma)	10.1016/j.aquatox.2021.105917	https://www.sciencedirect.com/science/article/pii/S0166445X21001764?via%3Dihub	Aquatic Toxicology	zhou_2021	zhou_2021_exp_004	zhou_2021_exp2_012	zhou_2021_exp_004_assay_005	zhou_2021_exp2_012_assay2_002	marine medaka	Oryzias melastigma	laboratory stock from not specified source	not_wild	mixed	diuron	analytical	330-54-1	in paper	urea	5000	ng/L	130	days	DMSO	solvent_used	28	celsius	social interaction	sociality	interaction frequency	frequency of social behaviour	count	NA	fig6c	zhou_2021_fig6c	NA	NA	NA	20	28.5921715	5.5469371	NA	NA	1.240332846	study reports mean and se	exact sample size provided	NA	NA	NA	20	30.4231391	10.3014546	NA	NA	2.303475286	study reports mean and se	exact sample size provided	NA	NA	NA	NA

# Summary of the data set
kable(summary(data), "html") %>%
    kable_styling("bordered", position = "left") %>%
    scroll_box(width = "250%", height = "500px")

	comment_checker	comment_extractor	initials_checker	initials_extractor	title	doi	url	journal	study_id	exp_id	exp2_id	assay_id	assay2_id	species_english	species_latin	source	source2	sex	pesticide	pesticide_grade	cas_id	cas_id_comment	pesticide_chemical_class	dosage	dosage_unit	duration	duration_unit	control_solvent	solvent2	temperature	temperature_unit	behaviour_measured	behaviour_measured_standardised	behaviour_assay	behavioural_assay_standardised	behavioural_assay_standardised2	effect_direction	data_source	data_file	control_effective_n	control_shoal_n	control_fish_n	control_n	control_mean	control_sd	control_shoal_sd	control_fish_sd	control_se	statistics_comment_control	sample_size_comment_control	treatment_effective_n	treatment_shoal_n	treatment_fish_n	treatment_n	treatment_mean	treatment_sd	treatment_shoal_sd	treatment_fish_sd	treatment_se	statistics_comment_treatment	sample_size_comment_treatment	contact_author	contacted_date	contact_response	contact_comments
	Length:461	Mode:logical	Length:461	Length:461	Length:461	Length:461	Length:461	Length:461	Length:461	Length:461	Length:461	Length:461	Length:461	Length:461	Length:461	Length:461	Length:461	Length:461	Length:461	Length:461	Length:461	Length:461	Length:461	Length:461	Length:461	Length:461	Length:461	Length:461	Length:461	Length:461	Length:461	Length:461	Length:461	Length:461	Length:461	Length:461	Length:461	Length:461	Length:461	Min. : 1.600	Min. : 1.00	Min. : 4.00	Min. : 2.00	Min. : -0.20	Min. : 0.0228	Min. : 0.0359	Min. : 0.1016	Length:461	Length:461	Length:461	Min. : 1.600	Min. : 1.000	Min. : 4.00	Min. : 2.00	Min. : 0.11	Min. : 0.0185	Min. : 0.0199	Min. : 0.0563	Length:461	Length:461	Length:461	Mode:logical	Mode:logical	Mode:logical	Mode:logical
	Class :character	NA’s:461	Class :character	Class :character	Class :character	Class :character	Class :character	Class :character	Class :character	Class :character	Class :character	Class :character	Class :character	Class :character	Class :character	Class :character	Class :character	Class :character	Class :character	Class :character	Class :character	Class :character	Class :character	Class :character	Class :character	Class :character	Class :character	Class :character	Class :character	Class :character	Class :character	Class :character	Class :character	Class :character	Class :character	Class :character	Class :character	Class :character	Class :character	1st Qu.: 1.714	1st Qu.: 1.00	1st Qu.: 6.00	1st Qu.:15.00	1st Qu.: 6.31	1st Qu.: 2.6437	1st Qu.: 0.4760	1st Qu.: 0.9800	Class :character	Class :character	Class :character	1st Qu.: 1.714	1st Qu.: 1.000	1st Qu.: 6.00	1st Qu.:14.00	1st Qu.: 6.24	1st Qu.: 2.6824	1st Qu.: 0.3770	1st Qu.: 0.8731	Class :character	Class :character	Class :character	NA’s:461	NA’s:461	NA’s:461	NA’s:461
	Mode :character	NA	Mode :character	Mode :character	Mode :character	Mode :character	Mode :character	Mode :character	Mode :character	Mode :character	Mode :character	Mode :character	Mode :character	Mode :character	Mode :character	Mode :character	Mode :character	Mode :character	Mode :character	Mode :character	Mode :character	Mode :character	Mode :character	Mode :character	Mode :character	Mode :character	Mode :character	Mode :character	Mode :character	Mode :character	Mode :character	Mode :character	Mode :character	Mode :character	Mode :character	Mode :character	Mode :character	Mode :character	Mode :character	Median : 9.500	Median : 6.00	Median :19.00	Median :18.00	Median : 30.86	Median : 25.2242	Median : 1.5793	Median : 3.3584	Mode :character	Mode :character	Mode :character	Median : 8.500	Median : 6.000	Median : 23.00	Median :18.00	Median : 40.89	Median : 24.9424	Median : 1.0233	Median : 2.0768	Mode :character	Mode :character	Mode :character	NA	NA	NA	NA
	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	Mean : 9.084	Mean : 18.35	Mean :17.84	Mean :20.35	Mean : 138.09	Mean : 43.0893	Mean : 16.0316	Mean : 40.7438	NA	NA	NA	Mean : 8.036	Mean : 5.523	Mean : 29.89	Mean :20.08	Mean : 130.37	Mean : 47.4361	Mean : 11.6351	Mean : 32.4113	NA	NA	NA	NA	NA	NA	NA
	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	3rd Qu.:15.000	3rd Qu.: 10.00	3rd Qu.:24.00	3rd Qu.:24.00	3rd Qu.: 144.69	3rd Qu.: 59.2010	3rd Qu.: 3.2719	3rd Qu.: 6.2733	NA	NA	NA	3rd Qu.:10.750	3rd Qu.: 8.000	3rd Qu.: 30.00	3rd Qu.:24.00	3rd Qu.: 137.55	3rd Qu.: 55.8427	3rd Qu.: 3.1970	3rd Qu.: 6.8992	NA	NA	NA	NA	NA	NA	NA
	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	Max. :23.000	Max. :128.00	Max. :46.00	Max. :72.00	Max. :2013.65	Max. :535.6481	Max. :309.2566	Max. :1014.5103	NA	NA	NA	Max. :23.500	Max. :15.667	Max. :128.00	Max. :72.00	Max. :1847.54	Max. :991.3481	Max. :358.3868	Max. :1433.5471	NA	NA	NA	NA	NA	NA	NA
	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA’s :366	NA’s :366	NA’s :366	NA’s :4	NA	NA’s :18	NA’s :366	NA’s :366	NA	NA	NA	NA’s :366	NA’s :366	NA’s :366	NA’s :8	NA	NA’s :18	NA’s :366	NA’s :366	NA	NA	NA	NA	NA	NA	NA

Data exploration and reporting of methodological items

Figure 1B & 1C

2. A bubble plot showing the number of effect sizes of each pesticide class per conspecific interaction behaviour described
3. A bar chart showing the total number of effect sizes per species

# Summarize data by grouping on pesticide chemical class and behavior measured,
# then count entries.
pc_cb_summary <- data %>%
    group_by(pesticide_chemical_class, behaviour_measured_standardised) %>%
    summarise(n = n(), .groups = "drop")

# Determine the top 9 pesticide classes based on the number of records.
top_pesticide_class <- pc_cb_summary %>%
    group_by(pesticide_chemical_class) %>%
    summarise(total_count = sum(n)) %>%
    top_n(9, total_count) %>%
    pull(pesticide_chemical_class)

# Adjust category names to 'Other pesticide classes' for those pesticide
# classes not in the top 9
pc_cb_summary_filtered <- pc_cb_summary %>%
    mutate(pesticide_chemical_class = ifelse(pesticide_chemical_class %in% top_pesticide_class,
        pesticide_chemical_class, "Other Pesticide Classes")) %>%
    group_by(pesticide_chemical_class, behaviour_measured_standardised) %>%
    summarise(n = sum(n), .groups = "drop")

# Create the bubble plot
behaviour_pesticide_class_bubble_plot <- pc_cb_summary_filtered %>%
    ggplot(aes(x = fct_rev(fct_reorder(str_wrap(str_to_title(behaviour_measured_standardised),
        width = 15), n, .fun = "sum")), y = fct_reorder(str_to_title(pesticide_chemical_class),
        n, .fun = "sum"), size = n)) + geom_point(alpha = 0.5, color = RColorBrewer::brewer.pal(n = 8,
    name = "Dark2")[3]) + scale_size_continuous(range = c(5, 20)) + theme_bw() +
    guides(size = "none") + theme(legend.position = "none", axis.text = element_text(size = 12,
    color = "black"), axis.title = element_text(size = 12, face = "bold", color = "black"),
    plot.caption = element_text(size = 12, color = "gray10", face = "italic")) +
    geom_text(aes(label = as.character(n)), size = 5, color = "gray10") + labs(caption = "The value in each cell is the total number of effect sizes",
    x = "Behaviour Measured", y = "Pesticide Chemical Class", tag = "B")

# Group data by species, count entries, and drop groups post-summary.
sp_summary <- data %>%
    group_by(species_english) %>%
    summarise(n = n(), .groups = "drop")

# Calculate proportion and percentage of total counts for each species.
species_pct <- sp_summary %>%
    mutate(proportion = n/sum(n), percentage = proportion * 100)

# Create the bar plot
species_effect_size_count_bar_plot <- sp_summary %>%
    ggplot(aes(x = n, y = reorder(str_to_title(species_english), n))) + geom_bar(stat = "identity",
    width = 0.8, alpha = 0.5, fill = RColorBrewer::brewer.pal(n = 8, name = "Dark2")[2]) +
    geom_text(aes(label = ifelse(n < 9, "", n), x = n/2, y = reorder(str_to_title(species_english),
        n)), hjust = 0.5, size = 5, color = "black") + geom_text(data = species_pct,
    aes(label = paste0("(", round(percentage, 1), "%)"), x = n), hjust = -0.1, size = 6,
    color = "black", fontface = "bold") + scale_x_continuous(expand = c(0, 0), limits = c(0,
    max(sp_summary$n) * 1.2)) + theme_bw() + guides(size = "none") + theme(legend.position = "none",
    axis.text = element_text(size = 12, color = "black"), axis.title = element_text(size = 12,
        face = "bold", color = "black"), plot.caption = element_text(size = 12, color = "gray10",
        face = "italic")) + labs(caption = "The value in each bar is the total number of effect sizes",
    x = "Total number of effect size estimates", y = "Species", tag = "C")

# Combine both plots into a single figure.
main_text_figure_1 <- behaviour_pesticide_class_bubble_plot/species_effect_size_count_bar_plot

print(main_text_figure_1)

ggsave(here("figures", "main_text_figure_1.pdf"), width = 10, height = 13, units = "cm",
    scale = 2, dpi = 800)
ggsave(here("figures", "main_text_figure_1.jpg"), width = 10, height = 13, units = "cm",
    scale = 2, dpi = 800)

Figure s2

A bubble plot showing the number of effect sizes of each species per conspecific interaction behaviour described

# Group data by species, count entries, and drop groups post-summary.
species_summary <- data %>%
  group_by(species_english, behaviour_measured_standardised) %>%
  summarise(
    n = n(),
    pesticide_chemical_class = first(pesticide_chemical_class),
    .groups = "drop"
  )

# Determine the top 20 species based on the number of records.
top_species <- species_summary %>%
  group_by(species_english, behaviour_measured_standardised) %>%
  summarise(total_count = sum(n), .groups = "drop") %>%
  top_n(20, total_count) %>%
  pull(species_english)

# Adjust category names to 'Other' for all but the top species, then re-summarize.
# species_summary_filtered <- species_summary %>%
#   mutate(species_english = ifelse(species_english %in% top_species,
#                                   species_english,
#                                   "Other Species")) %>%
#   group_by(species_english, behaviour_measured_standardised) %>%
#   summarise(n = sum(n), .groups = "drop")

# Create the bubble plot the behaviours assessed per species (number of effect size as count)

behaviour_species_bubble_plot <- species_summary %>% # can add _filtered if needed
  ggplot(aes(x = fct_rev(fct_reorder(str_to_title(behaviour_measured_standardised), n, .fun = 'sum')),
             y = fct_reorder(str_to_title(species_english), n, .fun = 'sum'),
             size = n)) +
  geom_point(alpha = 0.5, color = RColorBrewer::brewer.pal(n = 8, name = "Dark2")[2]) +
  scale_size_continuous(range = c(8, 25)) +
  theme_bw() +
  guides(size = "none") +
theme(legend.position = "none",
        axis.text = element_text(color = "black"),
        axis.title = element_text(face = "bold", color = "black"),
        plot.caption = element_text(size = 10, color = "gray10", face = "italic")) + 
  geom_text(aes(label = as.character(n)), size = 4, color = "gray10") +
  labs(caption = "The value in each cell is the number of effect sizes",
       x = "Behaviour Measured",
       y = "Species") +
  scale_color_brewer(palette = "Dark2", name = "Chemical Class")

print(behaviour_species_bubble_plot)

# ggsave(here("figures", "behaviour_species_bubble_plot.pdf"), width = 8, height = 6, units = "cm", scale = 2, dpi = 800)
# ggsave(here("figures", "behaviour_species_bubble_plot.jpg"), width = 8, height = 6, units = "cm", scale = 2, dpi = 800)

Figure s3

A bar chart showing the sex of fish used in the literature

# Group data by 'sex of fish' and count entries, then drop grouping for further
# analysis.
sex_summary <- data %>%
    group_by(sex) %>%
    summarise(n = n(), .groups = "drop")

# Calculate proportions and percentages of total studies for each sex.
sex_pct <- sex_summary %>%
    mutate(proportion = n/sum(n), percentage = proportion * 100)

# Create a bar plot visualizing the number of studies per sex, with annotations
# for counts and percentages.
fish_sex_study_count_bar_plot <- sex_summary %>%
    ggplot(aes(x = n, y = reorder(str_to_title(sex), n))) + geom_bar(stat = "identity",
    width = 0.8, alpha = 0.5, fill = RColorBrewer::brewer.pal(n = 8, name = "Dark2")[2]) +
    geom_text(aes(label = n, x = n/2, y = reorder(str_to_title(sex), n)), hjust = 0.5,
        size = 4, color = "black") + geom_text(data = sex_pct, aes(label = paste0("(",
    round(percentage, 1), "%)"), x = n), hjust = -0.1, size = 4, color = "black",
    fontface = "bold") + scale_x_continuous(expand = c(0, 0), limits = c(0, max(sex_summary$n) *
    1.2)) + theme_bw() + guides(size = "none") + theme(legend.position = "none",
    axis.text = element_text(color = "black"), axis.title = element_text(face = "bold",
        color = "black"), plot.caption = element_text(size = 10, color = "gray10",
        face = "italic")) + labs(caption = "The value in each bar is the total number of studies",
    x = "Total number of effect sizes", y = "Sex of fish")

print(fish_sex_study_count_bar_plot)

# ggsave(here('figures', 'fish_sex_study_count_bar_plot.pdf'), width = 10,
# height = 5, units = 'cm', scale = 2, dpi = 800) ggsave(here('figures',
# 'fish_sex_study_count_bar_plot.jpg'), width = 10, height = 5, units = 'cm',
# scale = 2, dpi = 800)

Figure s4

A bar chart showing the reporting of the source of fish used in the literature

# Extracts unique records from the dataset based on 'study_id', retaining all other associated data.
data_study <- data %>%
  distinct(study_id, .keep_all = TRUE) 

# Groups the filtered data by 'source of fish' and counts the number of studies per source, removing grouping afterwards.
source_summary <- data %>% 
  group_by(source) %>% 
  summarise(n = n(), .groups = "drop")

# Calculates the proportion and percentage of total studies for each source of fish.
source_pct <- source_summary %>% 
  mutate(proportion = n / sum(n),  # number of studies
         percentage = proportion * 100)

# Create the bar plot for the source of fish study count
fish_source_study_count_bar_plot <- source_summary %>%
  ggplot(aes(x = n, y = reorder(str_to_title(source), n))) + 
  geom_bar(stat = "identity", width = 0.8, alpha = 0.5, fill = RColorBrewer::brewer.pal(n = 8, name = "Dark2")[1]) +
  geom_text(aes(label = n, x = n / 2, y = reorder(str_to_title(source), n)), hjust = 0.5, size = 4, color = "black") +
  geom_text(data = source_pct, aes(label = paste0("(", round(percentage, 1), "%)"), x = n), 
            hjust = -0.1, size = 4, color = "black", fontface = "bold") +
  scale_x_continuous(expand = c(0, 0), limits = c(0, max(source_summary$n) * 1.2)) +
  theme_bw() +
  guides(size = "none") +
  theme(legend.position = "none",
        axis.text = element_text(color = "black"),
        axis.title = element_text(face = "bold", color = "black"),
        plot.caption = element_text(size = 10, color = "gray10", face = "italic")) +
  labs(caption = "The value in each bar is the total number of studies",
       x = "Total number of studies",
       y = "Source of fish") 

print(fish_source_study_count_bar_plot)

# ggsave(here("figures", "fish_source_study_count_bar_plot.pdf"), width = 10, height = 5, units = "cm", scale = 2, dpi = 800)
# ggsave(here("figures", "fish_source_study_count_bar_plot.jpg"), width = 10, height = 5, units = "cm", scale = 2, dpi = 800)

Figure s5

A bubble plot showing the number of effect sizes of each pesticide per conspecific interaction behaviour described

# Group data by species, count entries, and drop groups post-summary.
p_cb_summary <- data %>%
  group_by(pesticide, behaviour_measured_standardised) %>%
  summarise(
    n = n(),
    pesticide_chemical_class = first(pesticide_chemical_class),
    .groups = "drop"
  )
# Determine the top 8 pesticide classes based on the number of records.
top_pesticides <- p_cb_summary %>%
  group_by(pesticide, behaviour_measured_standardised) %>%
  summarise(total_count = sum(n), .groups = "drop") %>%
  top_n(20, total_count) %>%
  pull(pesticide)

# Adjust category names to 'Other Pesticides' for all but the top pesticide, then re-summarize.
# p_cb_summary_filtered <- p_cb_summary %>%
# mutate(pesticide = ifelse(pesticide %in% top_pesticides,
#                                          pesticide,
#                                          "Other Pesticides")) %>%
#  group_by(pesticide, behaviour_measured_standardised) %>%
#  summarise(n = sum(n), .groups = "drop")


# Create the bubble plot for the behaviours assessed per pesticide (effect size as count)

behaviour_pesticide_bubble_plot <- p_cb_summary %>% # can add _filtered if needed
   ggplot(aes(x = fct_rev(fct_reorder(str_to_title(behaviour_measured_standardised), n, .fun = 'sum')),
             y = fct_reorder(str_to_title(pesticide), n, .fun = 'sum'),
             size = n)) +
  geom_point(alpha = 0.5, color = RColorBrewer::brewer.pal(n = 8, name = "Dark2")[5]) +
  scale_size_continuous(range = c(4, 20)) +
  theme_bw() +
  guides(size = "none") +
theme(legend.position = "none",
        axis.text = element_text(color = "black"),
        axis.title = element_text(face = "bold", color = "black"),
        plot.caption = element_text(size = 10, color = "gray10", face = "italic")) +
  geom_text(aes(label = as.character(n)), size = 4, color = "gray10") +
  labs(caption = "The value in each cell is the number of effect sizes",
       x = "Behaviour Measured",
       y = "Pesticide Chemical Class") +
      scale_y_discrete(labels = function(x) ifelse(x %in% c("Ddt", "Dca", "Dcpmu"), toupper(x), x))

print(behaviour_pesticide_bubble_plot)

# ggsave(here("figures", "behaviour_pesticide_bubble_plot.pdf"), width = 8, height = 12, units = "cm", scale = 2, dpi = 800)
# ggsave(here("figures", "behaviour_pesticide_bubble_plot.jpg"), width = 8, height = 12, units = "cm", scale = 2, dpi = 800)

Figure s6

A box and violin plot showing the distribution of pesticide dosages used in the literature

# making dosages consistent for dosage comparisons
data_dosage <- data %>%
    filter(dosage != "not reported") %>%
    filter(dosage_unit != "not reported") %>%
    filter(!dosage_unit %in% c("nm", "um", "nM")) %>%
    mutate(dosage = as.numeric(dosage), dosage_unit = as.character(dosage_unit),
        dosage_unit_consistent = case_when(dosage_unit == "mg/L" ~ "ug/L", dosage_unit ==
            "ng/L" ~ "ug/L", dosage_unit == "g/L" ~ "ug/L", dosage_unit == "ppb" ~
            "ug/L", dosage_unit == "ppm" ~ "ug/L", TRUE ~ dosage_unit), dosage_convert_ugL = case_when(dosage_unit ==
            "mg/L" ~ dosage * 1000, dosage_unit == "ng/L" ~ dosage/1000, dosage_unit ==
            "g/L" ~ dosage/1e+06, dosage_unit == "ppm" ~ dosage * 1000, TRUE ~ dosage))

# Summary table for the dosage converted
summary_data_dosage <- summary(data_dosage$dosage_convert_ugL)

# Filter the data for dosage_convert_ugL less than 5000
filtered_data_dosage <- data_dosage %>%
    filter(dosage_convert_ugL < 3000)

# Create the violin plot
pesticide_dosage_violin_plot <- ggplot(filtered_data_dosage, aes(y = dosage_unit_consistent,
    x = dosage_convert_ugL)) + geom_violin(fill = RColorBrewer::brewer.pal(n = 8,
    name = "Set2")[1], alpha = 0.4, color = NA, trim = FALSE) + geom_boxplot(width = 0.1,
    fill = "white", color = RColorBrewer::brewer.pal(n = 8, name = "Set2")[2], outlier.shape = NA) +
    geom_jitter(width = 0.3, height = 0.09, color = RColorBrewer::brewer.pal(n = 8,
        name = "Set2")[1], alpha = 0.8) + theme_bw() + theme(legend.position = "none",
    plot.title = element_text(face = "bold", hjust = 0.5), axis.title.x = element_blank(),
    axis.title.y = element_text(face = "bold"), axis.text.x = element_text(color = "black"),
    axis.text.y = element_blank(), axis.ticks = element_line(color = "black"), plot.caption = element_text(size = 10,
        color = "gray10", face = "italic")) + labs(caption = "Plot filtered for less than 3000 ug/L\nMedian = 12, 1st Quartile = 1, 3rd Quartile = 500",
    y = "Dosage Unit [ug/L]")

print(pesticide_dosage_violin_plot)

# ggsave(here('figures', 'pesticide_dosage_violin_plot.pdf'), plot =
# pesticide_dosage_violin_plot, width = 10, height = 5, units = 'cm', scale =
# 2, dpi = 800) ggsave(here('figures', 'pesticide_dosage_violin_plot.jpg'),
# plot = pesticide_dosage_violin_plot, width = 10, height = 5, units = 'cm',
# scale = 2, dpi = 800)

Figure s7

A box and violin plot the distribution of durations of pesticide exposure

# making durations consistent for duration comparisons
data_duration <- data %>%
    filter(!is.na(duration), duration != "not reported") %>%
    mutate(duration = as.numeric(duration), duration_unit = as.character(duration_unit),
        duration_unit_consistent = case_when(duration_unit == "minutes" ~ "hours",
            duration_unit == "days" ~ "hours", duration_unit == "weeks" ~ "hours",
            TRUE ~ duration_unit), duration_convert = case_when(duration_unit ==
            "minutes" ~ duration/60, duration_unit == "days" ~ duration * 24, duration_unit ==
            "weeks" ~ duration * 168, TRUE ~ duration))

summary(data_duration$duration_convert)

##    Min. 1st Qu.  Median    Mean 3rd Qu.    Max. 
##     2.0    96.0   336.0   651.6   960.0  3120.0

# Create the violin plot
pesticide_duration_violin_plot <- ggplot(data_duration, aes(y = duration_unit_consistent,
    x = duration_convert)) + geom_violin(fill = RColorBrewer::brewer.pal(n = 8, name = "Set2")[1],
    alpha = 0.4, color = NA, trim = FALSE) + geom_boxplot(width = 0.1, fill = "white",
    color = RColorBrewer::brewer.pal(n = 8, name = "Set2")[2], outlier.shape = NA) +
    geom_jitter(width = 0.3, height = 0.09, color = RColorBrewer::brewer.pal(n = 8,
        name = "Set2")[1], alpha = 0.8) + theme_bw() + theme(legend.position = "none",
    plot.title = element_text(face = "bold", hjust = 0.5), axis.title.x = element_blank(),
    axis.title.y = element_text(face = "bold"), axis.text.x = element_text(color = "black"),
    axis.text.y = element_blank(), axis.ticks = element_line(color = "black"), plot.caption = element_text(size = 10,
        color = "gray10", face = "italic")) + labs(caption = "Median = 336, 1st Quartile = 96, 3rd Quartile = 960",
    y = "Duration [hours]")

print(pesticide_duration_violin_plot)

# ggsave(here('figures', 'pesticide_duration_violin_plot.pdf'), plot =
# pesticide_duration_violin_plot, width = 10, height = 5, units = 'cm', scale =
# 2, dpi = 800) ggsave(here('figures', 'pesticide_duration_violin_plot.jpg'),
# plot = pesticide_duration_violin_plot, width = 10, height = 5, units = 'cm',
# scale = 2, dpi = 800)

Figure s8

A bar plot showing the control solvents used in the literature

# Group data by 'control solvent' and count entries, then drop the group
# structure for further analysis.
solvent_summary <- data %>%
    group_by(control_solvent) %>%
    summarise(n = n(), .groups = "drop")

# Calculate the proportion and percentage of total studies for each control
# solvent.
solvent_pct <- solvent_summary %>%
    mutate(proportion = n/sum(n), percentage = proportion * 100)

# Create a bar plot visualizing the number of studies per control solvent,
# annotated with counts and percentages.
control_solvent_study_count_bar_plot <- solvent_summary %>%
    ggplot(aes(x = n, y = reorder(str_to_title(control_solvent), n))) + geom_bar(stat = "identity",
    width = 0.8, alpha = 0.5, fill = RColorBrewer::brewer.pal(n = 8, name = "Dark2")[3]) +
    geom_text(aes(label = n, x = n/2, y = reorder(str_to_title(control_solvent),
        n)), hjust = 0.5, size = 4, color = "black") + geom_text(data = solvent_pct,
    aes(label = paste0("(", round(percentage, 1), "%)"), x = n), hjust = -0.1, size = 4,
    color = "black", fontface = "bold") + scale_x_continuous(expand = c(0, 0), limits = c(0,
    max(solvent_summary$n) * 1.3)) + theme_bw() + guides(size = "none") + theme(legend.position = "none",
    axis.text = element_text(color = "black"), axis.title = element_text(face = "bold",
        color = "black"), plot.caption = element_text(size = 10, color = "gray10",
        face = "italic")) + labs(caption = "The value in each bar is the total number of studies",
    x = "Total number of studies", y = "Control Solvent") + scale_y_discrete(labels = function(x) ifelse(x ==
    "Dmso", toupper(x), ifelse(x == "Dtnb", toupper(x), x)))

print(control_solvent_study_count_bar_plot)

# ggsave(here('figures', 'control_solvent_study_count_bar_plot.pdf'), width =
# 10, height = 5, units = 'cm', scale = 2, dpi = 800) ggsave(here('figures',
# 'control_solvent_study_count_bar_plot.jpg'), width = 10, height = 5, units =
# 'cm', scale = 2, dpi = 800)

Figure s9

A bar plot showing the behavioural assays used to quantify sociality in the literature

# Filter data for entries containing 'sociality' in
# behaviour_measure_standardised
sociality_data <- data %>%
    filter(grepl("sociality", behaviour_measured_standardised, ignore.case = TRUE))

# Group data by behavioural_assay_standardized and count occurrences
sociality_assay_summary <- sociality_data %>%
    group_by(behavioural_assay_standardised) %>%
    summarise(n = n(), .groups = "drop")

# Calculate proportion of effect sizes for each control solvent
sociality_assay_pct <- sociality_assay_summary %>%
    mutate(proportion = n/sum(n), percentage = proportion * 100)

# Create a bar plot visualizing the number of studies quantifying pesticide
# impacts on aggression
sociality_assay_effect_size_count_bar_plot <- sociality_assay_summary %>%
    ggplot(aes(x = n, y = reorder(str_to_title(behavioural_assay_standardised), n))) +
    geom_bar(stat = "identity", width = 0.8, alpha = 0.5, fill = RColorBrewer::brewer.pal(n = 8,
        name = "Dark2")[5]) + geom_text(aes(label = ifelse(n < 0, "", n), x = n/2,
    y = reorder(str_to_title(behavioural_assay_standardised), n)), hjust = 0.5, size = 4,
    color = "black") + geom_text(data = sociality_assay_pct, aes(label = paste0("(",
    round(percentage, 1), "%)"), x = n), hjust = -0.1, size = 4, color = "black",
    fontface = "bold") + scale_x_continuous(expand = c(0, 0), limits = c(0, max(sociality_assay_summary$n) *
    1.3)) + theme_bw() + guides(size = "none") + theme(legend.position = "none",
    axis.text = element_text(color = "black"), axis.title = element_text(face = "bold",
        color = "black"), plot.caption = element_text(size = 10, color = "gray10",
        face = "italic")) + labs(caption = "The value in each bar is the total number of effect sizes",
    x = "Total Number of Effect Sizes", y = "Sociality Assay")

print(sociality_assay_effect_size_count_bar_plot)

# ggsave(here('figures', 'sociality_assay_effect_size_count_bar_plot.pdf'),
# width = 10, height = 5, units = 'cm', scale = 2, dpi = 800)
# ggsave(here('figures', 'sociality_assay_effect_size_count_bar_plot.jpg'),
# width = 10, height = 5, units = 'cm', scale = 2, dpi = 800)

Figure s10

A bar plot showing the behavioural assays used to quantify aggression in the literature

# Filter data for entries containing 'aggression' in
# behaviour_measure_standardised
aggression_data <- data %>%
    filter(grepl("aggression", behaviour_measured_standardised, ignore.case = TRUE))

# Group data by behavioural_assay_standardised and count occurrences
aggression_assay_summary <- aggression_data %>%
    group_by(behavioural_assay_standardised) %>%
    summarise(n = n(), .groups = "drop")

# Calculate proportion of effect sizes for each behavioural assay
aggression_assay_pct <- aggression_assay_summary %>%
    mutate(proportion = n/sum(n), percentage = proportion * 100)

# Create a bar plot visualizing the number of studies quantifying pesticide
# impacts on aggression, annotated with counts and percentages.
aggression_assay_effect_size_count_bar_plot <- aggression_assay_summary %>%
    ggplot(aes(x = n, y = reorder(str_to_title(behavioural_assay_standardised), n))) +
    geom_bar(stat = "identity", width = 0.8, alpha = 0.5, fill = RColorBrewer::brewer.pal(n = 8,
        name = "Dark2")[6]) + geom_text(aes(label = ifelse(n < 0, "", n), x = n/2,
    y = reorder(str_to_title(behavioural_assay_standardised), n)), hjust = 0.5, size = 4,
    color = "black") + geom_text(data = aggression_assay_pct, aes(label = paste0("(",
    round(percentage, 1), "%)"), x = n), hjust = -0.1, size = 4, color = "black",
    fontface = "bold") + scale_x_continuous(expand = c(0, 0), limits = c(0, max(aggression_assay_summary$n) *
    1.3)) + theme_bw() + guides(size = "none") + theme(legend.position = "none",
    axis.text = element_text(color = "black"), axis.title = element_text(face = "bold",
        color = "black"), plot.caption = element_text(size = 10, color = "gray10",
        face = "italic")) + labs(caption = "The value in each bar is the total number of effect sizes",
    x = "Total Number of Effect Sizes", y = "Aggression Assay")

print(aggression_assay_effect_size_count_bar_plot)

# ggsave(here('figures', 'aggression_assay_effect_size_count_bar_plot.pdf'),
# width = 10, height = 5, units = 'cm', scale = 2, dpi = 800)
# ggsave(here('figures', 'aggression_assay_effect_size_count_bar_plot.jpg'),
# width = 10, height = 5, units = 'cm', scale = 2, dpi = 800)

Figure s11

A bar plot showing the behavioural assays used to quantify courtship in the literature

# Filter data for entries containing "courtship" in behaviour_measure_standardised
courtship_data <- data %>% 
  filter(grepl("courtship", behaviour_measured_standardised, ignore.case = TRUE))

# Group data by behavioural_assay_standardised and count occurrences
courtship_assay_summary <- courtship_data %>% 
  group_by(behavioural_assay_standardised) %>%
  summarise(n = n(), .groups = "drop")

# Calculate proportion of effect sizes for each behavioural assay
courtship_assay_pct <- courtship_assay_summary %>% 
  mutate(proportion = n / sum(n), # Adjust total number of observations
         percentage = proportion * 100)

# Create a bar plot visualizing the number of studies quantifying pesticide impacts on courtship, annotated with counts and percentages.
courtship_assay_effect_size_count_bar_plot <- courtship_assay_summary %>%
  ggplot(aes(x = n, y = reorder(str_to_title(behavioural_assay_standardised), n))) +
  geom_bar(stat = "identity", width = 0.8, alpha = 0.5, fill = RColorBrewer::brewer.pal(n = 8, name = "Dark2")[7]) +
  geom_text(aes(label = ifelse(n < 0, "", n), x = n / 2, y = reorder(str_to_title(behavioural_assay_standardised), n)), 
            hjust = 0.5, size = 4, color = "black") +
  geom_text(data = courtship_assay_pct, aes(label = paste0("(", round(percentage, 1), "%)"), x = n),
            hjust = -0.1, size = 4, color = "black", fontface = "bold") +
  scale_x_continuous(expand = c(0, 0), limits = c(0, max(courtship_assay_summary$n) * 1.3)) +
  theme_bw() +
  guides(size = "none") +
  theme(legend.position = "none",
        axis.text = element_text(color = "black"),
        axis.title = element_text(face = "bold", color = "black"),
        plot.caption = element_text(size = 10, color = "gray10", face = "italic")) +
  labs(caption = "The value in each bar is the total number of effect sizes",
       x = "Total Number of Effect Sizes",
       y = "Courtship Assay")

print(courtship_assay_effect_size_count_bar_plot)

# ggsave(here("figures", "courtship_assay_effect_size_count_bar_plot.pdf"), width = 10, height = 5, units = "cm", scale = 2, dpi = 800)
# ggsave(here("figures", "courtship_assay_effect_size_count_bar_plot.jpg"), width = 10, height = 5, units = "cm", scale = 2, dpi = 800)

Figure s12

A bar plot showing the behavioural assays used to quantify collective behaviour (i.e., behaviours measure at collective level) in the literature

# Filter data for entries containing "collective behaviour" in behaviour_measure_standardised
collective_behaviour_data <- data %>% 
  filter(grepl("collective behaviour", behaviour_measured_standardised, ignore.case = TRUE))

# Group data by behavioural_assay_standardised and count occurrences
collective_behaviour_assay_summary <- collective_behaviour_data %>% 
  group_by(behavioural_assay_standardised) %>%
  summarise(n = n(), .groups = "drop")

# Calculate proportion of effect sizes for each behavioural assay
collective_behaviour_assay_pct <- collective_behaviour_assay_summary %>% 
  mutate(proportion = n / sum(n), # Adjust total number of observations
         percentage = proportion * 100)

# Create a bar plot visualizing the number of studies quantifying pesticide impacts on collective behaviour, annotated with counts and percentages.
collective_behaviour_assay_effect_size_count_bar_plot <- collective_behaviour_assay_summary %>%
  ggplot(aes(x = n, y = reorder(str_to_sentence(behavioural_assay_standardised), n))) +
  geom_bar(stat = "identity", width = 0.8, alpha = 0.5, fill = RColorBrewer::brewer.pal(n = 8, name = "Dark2")[8]) +
  geom_text(aes(label = ifelse(n < 9, "", n), x = n / 2, y = reorder(str_to_sentence(behavioural_assay_standardised), n)), 
            hjust = 0.5, size = 4, color = "black") +
  geom_text(data = collective_behaviour_assay_pct, aes(label = paste0("(", round(percentage, 1), "%)"), x = n),
            hjust = -0.1, size = 4, color = "black", fontface = "bold") +
  scale_x_continuous(expand = c(0, 0), limits = c(0, max(collective_behaviour_assay_summary$n) * 1.3)) +
  theme_bw() +
  guides(size = "none") +
  theme(legend.position = "none",
        axis.text = element_text(color = "black"),
        axis.title = element_text(face = "bold", color = "black"),
        plot.caption = element_text(size = 10, color = "gray10", face = "italic")) +
  labs(caption = "The value in each bar is the total number of effect sizes",
       x = "Total Number of Effect Sizes",
       y = "Collective Behaviour Assay")

print(collective_behaviour_assay_effect_size_count_bar_plot)

# ggsave(here("figures", "collective_behaviour_assay_effect_size_count_bar_plot.pdf"), width = 10, height = 5, units = "cm", scale = 2, dpi = 800)
# ggsave(here("figures", "collective_behaviour_assay_effect_size_count_bar_plot.jpg"), width = 10, height = 5, units = "cm", scale = 2, dpi = 800)

Figure s13

Visual representation of the characteristics of the primary studies included in the dataset. The vertical bars indicate key categorical variables. The widths of the vertical bars indicate the numbers of effect sizes represented by each level of the categorical variable. The flow lines between vertical bars indicate the connections and overlaps of different levels of the categorical variables.

# Select relevant columns and replace NA values with 'Not Reported'
data_sankey <- data %>%
    select(c(behaviour_measured_standardised, behavioural_assay_standardised2, pesticide_chemical_class,
        control_solvent, species_english, sex, source)) %>%
    mutate(across(c(behaviour_measured_standardised, behavioural_assay_standardised2,
        pesticide_chemical_class, control_solvent, species_english, sex, source),
        ~replace_na(., "Not Reported")))

# Transform data into a long format for the Sankey plot
sankey_df <- data_sankey %>%
    ggsankey::make_long(behaviour_measured_standardised, behavioural_assay_standardised2,
        pesticide_chemical_class, control_solvent, species_english, sex, source)

# Create the Sankey plot
ggplot(sankey_df, aes(x = x, next_x = next_x, node = node, next_node = next_node,
    fill = factor(node), label = node)) + geom_sankey(flow.alpha = 0.6, node.color = "gray30") +
    geom_sankey_label(size = 3, color = "white", fill = "gray40") + scale_fill_viridis_d() +
    scale_x_discrete(labels = c("Behaviour Measured", "Assay Type", "Pesticide Class",
        "Control Solvent", "Species", "Sex", "Source"), position = "top") + theme_sankey(base_size = 10) +
    labs(x = NULL) + theme(legend.position = "none", plot.title = element_text(hjust = 0.5),
    axis.text.x = element_text(color = "black", size = 9))

# ggsave(here('figures', 'sankey_plot.pdf'), width = 10, height = 5, units =
# 'cm', scale = 2, dpi = 800) ggsave(here('figures', 'sankey_plot.jpg'), width
# = 10, height = 5, units = 'cm', scale = 2, dpi = 800)

Calculate effect size estimates & dependency

Find SD/Mean ratio

A bar plot showing the SD/Mean ratio of the control and treatment groups in each primary study

sd_mean_ratio <- data %>%
    mutate(control_sd = as.numeric(control_sd), treatment_sd = as.numeric(treatment_sd)) %>%
    group_by(study_id) %>%
    mutate(within_study_control_mean = mean(control_mean, na.rm = TRUE), within_study_treatment_mean = mean(treatment_mean,
        na.rm = TRUE), within_study_control_sd = mean(control_sd, na.rm = TRUE),
        within_study_treatment_sd = mean(treatment_sd, na.rm = TRUE), sd_mean_ratio_control = within_study_control_sd/within_study_control_mean,
        sd_mean_ratio_treatment = within_study_treatment_sd/within_study_treatment_mean)

sd_mean_ratio_bar_plot <- sd_mean_ratio %>%
    ggplot() + geom_histogram(aes(x = sd_mean_ratio_control), fill = "blue", alpha = 0.4) +
    geom_histogram(aes(x = sd_mean_ratio_treatment), fill = "red", alpha = 0.4) +
    scale_x_continuous(expand = c(0, 0)) + scale_y_continuous(expand = c(0, 0)) +
    theme_bw() + guides(size = "none") + theme(legend.position = "none", axis.text = element_text(color = "black"),
    axis.title = element_text(face = "bold", color = "black"), plot.caption = element_text(size = 10,
        color = "gray10", face = "italic")) + labs(caption = "Red = Control, Blue = Treatment, Purple = Both",
    x = "SD/Mean Ratio", y = "Frequency")

print(sd_mean_ratio_bar_plot)

# ggsave(here('figures', 'sd_mean_ratio_bar_plot.pdf'), plot =
# sd_mean_ratio_bar_plot, width = 10, height = 5, units = 'cm', scale = 2, dpi
# = 800) ggsave(here('figures', 'sd_mean_ratio_bar_plot.jpg'), plot =
# sd_mean_ratio_bar_plot, width = 10, height = 5, units = 'cm', scale = 2, dpi
# = 800)

Impute missing standard deviations & plot

We imputed the missing standard deviations using the formula provided in section 13.1 (p. 199) of the Handbook of Meta-analysis in Ecology and Evolution (Koricheva, Gurevitch, and Mengersen, 2013).

To ensure consistency in treatments subjected to repeated stepwise multiple comparisons (i.e., the same data used multiple times to calculate different effect sizes), we maintained the same imputed standard deviations (or standard errors) for the repeated data.

# Indicate which individuals are used in more than one control or treatment to
# calculate sampling variances of non-independent observations differently.
data_shared_indiv <- group_by(data, exp_id) %>%
    summarise(number_treatment = n())
data <- left_join(data, data_shared_indiv, by = "exp_id")


# Calculate the within and between study impacts of pesticides on fish social
# behaviour
data <- data %>%
    group_by(study_id) %>%
    mutate(control_sd = as.numeric(control_sd), treatment_sd = as.numeric(treatment_sd)) %>%
    group_by(study_id) %>%
    mutate(within_study_control_mean = mean(control_mean, na.rm = TRUE), within_study_treatment_mean = mean(treatment_mean,
        na.rm = TRUE), within_study_control_sd = mean(control_sd, na.rm = TRUE),
        within_study_treatment_sd = mean(treatment_sd, na.rm = TRUE), sd_mean_ratio_control = within_study_control_sd/within_study_control_mean,
        sd_mean_ratio_treatment = within_study_treatment_sd/within_study_treatment_mean) %>%
    ungroup() %>%
    mutate(between_study_control_mean = mean(within_study_control_mean, na.rm = T),
        between_study_treatment_mean = mean(within_study_treatment_mean, na.rm = T),
        between_study_control_sd = mean(within_study_control_sd, na.rm = T), between_study_treatment_sd = mean(within_study_treatment_sd,
            na.rm = T))


# label missing location
data$control_sd_report <- ifelse(is.na(data$control_sd), "Yes", "No")
data$treatment_sd_report <- ifelse(is.na(data$treatment_sd), "Yes", "No")

data %>%
    select(control_sd, treatment_sd) %>%
    impute_missingness()  # Missing SD == 3.9%, 36 imputations needed 

## 
## Summary of missingness:
## 
##        COLUMN PERCENT_MISSINGNESS IMPUTATIONS
##    control_sd                 3.9          18
##  treatment_sd                 3.9          18
## 
## Total missingness: 3.9% (36 imputations needed)

##                    COLUMN PERCENT_MISSINGNESS IMPUTATIONS
## control_sd     control_sd            3.904555          18
## treatment_sd treatment_sd            3.904555          18

data <- as.data.frame(data)  # convert into dataframe
data <- impute_SD(data, columnSDnames = c("control_sd", "treatment_sd"), columnXnames = c("control_mean",
    "treatment_mean"), method = "Bracken1992")


# Convert sd columns to log10 and create a combined dataframe for plotting
data_long <- data %>%
    mutate(log_control_sd = log10(control_sd), log_treatment_sd = log10(treatment_sd)) %>%
    pivot_longer(cols = c(log_control_sd, log_treatment_sd), names_to = "type", values_to = "log_sd") %>%
    mutate(reported = ifelse(type == "log_control_sd", control_sd_report, treatment_sd_report))

# Create the plot
imputed_sd_plot <- ggplot(data_long, aes(x = factor(study_id), y = log_sd, color = control_sd_report)) +
    geom_point(size = 2, alpha = 0.5) + scale_color_manual(values = RColorBrewer::brewer.pal(n = 8,
    name = "Dark2")[c(1, 2)]) + theme_bw() + theme(legend.position = "none", axis.text = element_text(color = "black"),
    axis.title = element_text(face = "bold", color = "black"), plot.caption = element_text(size = 10,
        color = "gray10", face = "italic"), axis.text.x = element_text(angle = 90,
        hjust = 1, vjust = 0.5)) + labs(caption = "Points with 'red' indicate missing standard deviations that were imputed",
    x = "Study ID", y = "Log10(SD Value)")

# Print the plot
print(imputed_sd_plot)

# ggsave(here('figures', 'imputed_sd_plot.pdf'), plot = imputed_sd_plot, width
# = 10, height = 5, units = 'cm', scale = 2, dpi = 800) ggsave(here('figures',
# 'imputed_sd_plot.jpg'), plot = imputed_sd_plot, width = 10, height = 5, units
# = 'cm', scale = 2, dpi = 800)

Calculate effect sizes and sampling variances

# Make sure all data is numeric
data <- data %>%
    mutate(treatment_mean = as.numeric(treatment_mean), treatment_sd = as.numeric(treatment_sd),
        treatment_n = as.numeric(treatment_n), control_mean = as.numeric(control_mean),
        control_sd = as.numeric(control_sd), control_n = as.numeric(control_n))
# Calculate log response ratio (lnRR)
lnRR <- escalc(measure = "ROM", m1i = treatment_mean, sd1i = treatment_sd, n1i = treatment_n,
    m2i = control_mean, sd2i = control_sd, n2i = control_n, data = data)

# Calculate log coefficient variation ratio (lnCVR)
lnCVR <- escalc(measure = "CVR", m1i = treatment_mean, sd1i = treatment_sd, n1i = treatment_n,
    m2i = control_mean, sd2i = control_sd, n2i = control_n, data = data)

# Calculate the standardised mean difference for sensitivity analysis
SMD <- escalc(measure = "SMD", m1i = treatment_mean, sd1i = treatment_sd, n1i = treatment_n,
    m2i = control_mean, sd2i = control_sd, n2i = control_n, data = data)

# Calculate log variation ratio (lnVR)
lnVR <- escalc(measure = "VR", m1i = treatment_mean, sd1i = treatment_sd, n1i = treatment_n,
    m2i = control_mean, sd2i = control_sd, n2i = control_n, data = data)

# Summary statistics of effect size estimates
effect_size_summaries <- list(lnRR = summary(lnRR$yi), lnCVR = summary(lnCVR$yi),
    SMD = summary(SMD$yi), VR = summary(lnVR$yi))

# Summary statistics of sampling variances
sampling_variance_summaries <- list(lnRR = summary(lnRR$vi), lnCVR = summary(lnCVR$vi),
    SMD = summary(SMD$vi), VR = summary(lnVR$vi))

# Calculate precision for each effect size estimate with checks
lnRR$precision <- ifelse(lnRR$vi > 0, 1/sqrt(lnRR$vi), NA)
lnCVR$precision <- ifelse(lnCVR$vi > 0, 1/sqrt(lnCVR$vi), NA)
SMD$precision <- ifelse(SMD$vi > 0, 1/sqrt(SMD$vi), NA)
lnVR$precision <- ifelse(lnVR$vi > 0, 1/sqrt(lnVR$vi), NA)

# Merge each of the effect size with precision
effect_size_metrics_set <- data.frame(lnRR = lnRR$yi, lnRRv = lnRR$vi, lnRR_precision = lnRR$precision,
    lnVR = lnVR$yi, lnVRv = lnVR$vi, lnVR_precision = lnVR$precision, lnCVR = lnCVR$yi,
    lnCVRv = lnCVR$vi, lnCVR_precision = lnCVR$precision, SMD = SMD$yi, SMDv = SMD$vi,
    SMD_precision = SMD$precision, control_imputed = data$control_sd_report, treatment_imputed = data$treatment_sd_report)

# Bind the effect size metrics set to the main data
data <- cbind(data, effect_size_metrics_set)

# Check if `effect_direction` is 'change' and not NA, then multiply `lnRR` by
# -1; otherwise, keep original `lnRR`
data$lnRR <- ifelse(!is.na(data$effect_direction) & data$effect_direction == "change",
    -1 * data$lnRR, data$lnRR)

# Select specific columns including the new precision columns
effect_size_metrics_set_kable <- data[, which(colnames(data) %in% c("study_id", "exp_id",
    "assay_id", "species_english", "pesticide", "behaviour_assay", "effect_direction",
    "lnRR", "lnRRv", "lnRR_precision", "lnCVR", "lnCVRv", "lnCVR_precision", "lnVR",
    "lnVRv", "lnVR_precision", "SMD", "SMDv", "SMD_precision", "control_imputed",
    "treatment_imputed"))] %>%
    dfround(digits = 3)

# Table of the effect sizes
kable(effect_size_metrics_set_kable, "html") %>%
    kable_styling("bordered", position = "left") %>%
    scroll_box(width = "250%", height = "800px")

study_id	exp_id	assay_id	species_english	pesticide	behaviour_assay	effect_direction	lnRR	lnRRv	lnRR_precision	lnVR	lnVRv	lnVR_precision	lnCVR	lnCVRv	lnCVR_precision	SMD	SMDv	SMD_precision	control_imputed	treatment_imputed
bellot_2024	bellot_2024_exp_001	bellot_2024_exp_001_assay_001	zebrafish	glyphosate	time spent in conspecific zone	NA	-0.290	0.011	9.632	-0.567	0.069	3.806	-0.278	0.080	3.539	-0.937	0.143	2.641	No	No
bellot_2024	bellot_2024_exp_002	bellot_2024_exp_002_assay_001	zebrafish	glyphosate	time spent in conspecific zone	NA	-0.298	0.014	8.482	-0.275	0.069	3.806	0.023	0.083	3.472	-0.876	0.142	2.658	No	No
boscolo_2018	boscolo_2018_exp_001	boscolo_2018_exp_001_assay_001	Nile tilapia	diuron	total frequency of aggressive interactions	NA	0.056	0.113	2.975	-0.005	0.091	3.317	-0.061	0.204	2.215	0.066	0.167	2.449	No	No
boscolo_2018	boscolo_2018_exp_002	boscolo_2018_exp_002_assay_001	Nile tilapia	DCPMU	total frequency of aggressive interactions	NA	-0.701	0.096	3.224	-0.952	0.091	3.317	-0.251	0.187	2.312	-0.757	0.179	2.366	No	No
boscolo_2018	boscolo_2018_exp_003	boscolo_2018_exp_003_assay_001	Nile tilapia	DCA	total frequency of aggressive interactions	NA	-1.127	0.096	3.224	-1.378	0.091	3.317	-0.251	0.187	2.312	-1.055	0.190	2.295	No	No
bridi_2017	bridi_2017_exp_001	bridi_2017_exp_001_assay_001	zebrafish	glyphosate	time spent close to stimulus	NA	-0.293	0.006	12.766	0.016	0.040	5.000	0.310	0.046	4.656	-1.051	0.088	3.380	No	No
bridi_2017	bridi_2017_exp_002	bridi_2017_exp_002_assay_001	zebrafish	glyphosate	time spent close to stimulus	NA	-0.269	0.008	11.494	0.194	0.040	5.000	0.463	0.048	4.585	-0.884	0.084	3.441	No	No
bridi_2017	bridi_2017_exp_003	bridi_2017_exp_003_assay_001	zebrafish	glyphosate	time spent close to stimulus	NA	-0.267	0.009	10.446	0.324	0.040	5.000	0.592	0.049	4.510	-0.810	0.083	3.466	No	No
bridi_2017	bridi_2017_exp_004	bridi_2017_exp_004_assay_001	zebrafish	roundup	time spent close to stimulus	NA	-0.353	0.004	16.167	-0.476	0.040	5.000	-0.123	0.044	4.777	-1.490	0.098	3.190	No	No
bridi_2017	bridi_2017_exp_005	bridi_2017_exp_005_assay_001	zebrafish	roundup	time spent close to stimulus	NA	-0.347	0.009	10.312	0.261	0.040	5.000	0.609	0.049	4.499	-1.056	0.088	3.378	No	No
bridi_2017	bridi_2017_exp_006	bridi_2017_exp_006_assay_001	zebrafish	roundup	time spent close to stimulus	NA	-0.256	0.003	17.437	-0.572	0.040	5.000	-0.316	0.043	4.806	-1.158	0.090	3.337	No	No
bridi_2017	bridi_2017_exp_001	bridi_2017_exp_001_assay_002	zebrafish	glyphosate	number of enteries	NA	-0.353	0.014	8.332	-0.567	0.040	5.000	-0.214	0.054	4.287	-0.756	0.082	3.483	No	No
bridi_2017	bridi_2017_exp_002	bridi_2017_exp_002_assay_002	zebrafish	glyphosate	number of enteries	NA	-0.464	0.019	7.284	-0.390	0.040	5.000	0.074	0.059	4.122	-0.899	0.085	3.436	No	No
bridi_2017	bridi_2017_exp_003	bridi_2017_exp_003_assay_002	zebrafish	glyphosate	number of enteries	NA	-0.585	0.012	9.227	-1.115	0.040	5.000	-0.530	0.052	4.396	-1.231	0.091	3.306	No	No
bridi_2017	bridi_2017_exp_004	bridi_2017_exp_004_assay_002	zebrafish	roundup	number of enteries	NA	-0.464	0.014	8.355	-0.685	0.040	5.000	-0.221	0.054	4.290	-0.969	0.086	3.411	No	No
bridi_2017	bridi_2017_exp_005	bridi_2017_exp_005_assay_002	zebrafish	roundup	number of enteries	NA	-0.522	0.012	9.183	-1.033	0.040	5.000	-0.512	0.052	4.391	-1.120	0.089	3.352	No	No
bridi_2017	bridi_2017_exp_006	bridi_2017_exp_006_assay_002	zebrafish	roundup	number of enteries	NA	-0.469	0.011	9.573	-1.160	0.040	5.000	-0.691	0.051	4.432	-1.044	0.087	3.382	No	No
chen_2022	chen_2022_exp_001	chen_2022_exp_001_assay_001	zebrafish	difenoconazole	contact time	NA	-0.356	0.005	13.918	-0.166	0.143	2.646	0.190	0.148	2.599	-2.362	0.424	1.535	No	No
chen_2022	chen_2022_exp_002	chen_2022_exp_002_assay_001	zebrafish	difenoconazole	contact time	NA	0.046	0.015	8.073	0.968	0.143	2.646	0.922	0.158	2.514	0.174	0.251	1.996	No	No
chen_2022	chen_2022_exp_003	chen_2022_exp_003_assay_001	zebrafish	difenoconazole	contact time	NA	-0.972	0.022	6.739	0.154	0.143	2.646	1.126	0.165	2.463	-4.176	0.795	1.122	No	No
chen_2022	chen_2022_exp_001	chen_2022_exp_001_assay_002	zebrafish	difenoconazole	contact time	NA	-0.019	0.008	10.923	0.335	0.143	2.646	0.354	0.151	2.571	-0.097	0.250	1.999	No	No
chen_2022	chen_2022_exp_002	chen_2022_exp_002_assay_002	zebrafish	difenoconazole	contact time	NA	-0.026	0.005	14.810	-0.243	0.143	2.646	-0.218	0.147	2.605	-0.179	0.251	1.996	No	No
chen_2022	chen_2022_exp_003	chen_2022_exp_003_assay_002	zebrafish	difenoconazole	contact time	NA	0.110	0.006	13.188	0.148	0.143	2.646	0.037	0.149	2.594	0.685	0.265	1.944	No	No
chen_2022	chen_2022_exp_001	chen_2022_exp_001_assay_003	zebrafish	difenoconazole	contact time	NA	-0.178	0.006	13.198	1.578	0.143	2.646	1.756	0.149	2.594	-1.205	0.295	1.840	No	No
chen_2022	chen_2022_exp_002	chen_2022_exp_002_assay_003	zebrafish	difenoconazole	contact time	NA	-0.059	0.001	30.618	0.785	0.143	2.646	0.844	0.144	2.636	-0.875	0.274	1.911	No	No
chen_2022	chen_2022_exp_003	chen_2022_exp_003_assay_003	zebrafish	difenoconazole	contact time	NA	-0.301	0.000	49.758	-0.123	0.143	2.646	0.178	0.143	2.642	-7.125	1.836	0.738	No	No
chung_2023	chung_2023_exp_001	chung_2023_exp_001_assay_001	zebrafish	imidacloprid	distance between male and female	change	-0.838	0.039	5.076	0.932	0.111	3.000	0.094	0.150	2.583	1.553	0.260	1.960	No	No
chung_2023	chung_2023_exp_002	chung_2023_exp_002_assay_001	zebrafish	imidacloprid	distance between male and female	change	-0.948	0.036	5.240	0.982	0.111	3.000	0.034	0.148	2.603	1.791	0.280	1.889	No	No
chung_2023	chung_2023_exp_003	chung_2023_exp_003_assay_001	zebrafish	imidacloprid	distance between male and female	change	-1.193	0.029	5.881	0.972	0.111	3.000	-0.221	0.140	2.672	2.624	0.372	1.639	No	No
chung_2023	chung_2023_exp_001	chung_2023_exp_001_assay_002	zebrafish	imidacloprid	male confrontation distance	change	0.209	0.022	6.698	-0.011	0.111	3.000	0.198	0.133	2.738	-0.607	0.209	2.186	No	No
chung_2023	chung_2023_exp_002	chung_2023_exp_002_assay_002	zebrafish	imidacloprid	male confrontation distance	change	0.298	0.023	6.603	-0.077	0.111	3.000	0.222	0.134	2.731	-0.856	0.218	2.140	No	No
chung_2023	chung_2023_exp_003	chung_2023_exp_003_assay_002	zebrafish	imidacloprid	male confrontation distance	change	0.293	0.024	6.432	-0.029	0.111	3.000	0.264	0.135	2.719	-0.825	0.217	2.147	No	No
faria_2021	faria_2021_exp_001	faria_2021_exp_001_assay_001	zebrafish	glyphosate	average interfish distance	change	0.322	0.012	9.045	-0.116	0.053	4.353	0.206	0.065	3.922	-0.914	0.111	3.006	No	No
faria_2021	faria_2021_exp_002	faria_2021_exp_002_assay_001	zebrafish	glyphosate	average interfish distance	change	0.416	0.009	10.454	-0.542	0.056	4.243	-0.126	0.065	3.931	-1.304	0.128	2.799	No	No
faria_2021	faria_2021_exp_001	faria_2021_exp_001_assay_002	zebrafish	glyphosate	farthest distance	change	0.171	0.012	9.302	-0.217	0.053	4.359	-0.045	0.064	3.947	-0.489	0.103	3.116	No	No
faria_2021	faria_2021_exp_002	faria_2021_exp_002_assay_002	zebrafish	glyphosate	farthest distance	change	0.334	0.010	9.915	-0.548	0.054	4.300	-0.214	0.064	3.945	-0.975	0.115	2.951	No	No
guo_2023	guo_2023_exp_001	guo_2023_exp_001_assay_001	zebrafish	azoxystrobin	distance in region of attraction	NA	-0.078	0.010	10.036	-0.071	0.059	4.123	0.007	0.069	3.814	-0.255	0.112	2.988	No	No
guo_2023	guo_2023_exp_002	guo_2023_exp_002_assay_001	zebrafish	azoxystrobin	distance in region of attraction	NA	-0.170	0.008	10.898	-0.343	0.059	4.123	-0.173	0.067	3.856	-0.592	0.116	2.936	No	No
guo_2023	guo_2023_exp_003	guo_2023_exp_003_assay_001	zebrafish	azoxystrobin	distance in region of attraction	NA	-0.369	0.008	11.510	-0.686	0.059	4.123	-0.317	0.066	3.882	-1.278	0.134	2.734	No	No
guo_2023	guo_2023_exp_001	guo_2023_exp_001_assay_002	zebrafish	azoxystrobin	frequency in region of attraction	NA	-0.041	0.003	17.903	0.184	0.059	4.123	0.225	0.062	4.018	-0.242	0.112	2.989	No	No
guo_2023	guo_2023_exp_002	guo_2023_exp_002_assay_002	zebrafish	azoxystrobin	frequency in region of attraction	NA	-0.168	0.004	15.245	0.299	0.059	4.123	0.467	0.063	3.980	-0.859	0.121	2.870	No	No
guo_2023	guo_2023_exp_003	guo_2023_exp_003_assay_002	zebrafish	azoxystrobin	frequency in region of attraction	NA	-0.301	0.002	22.047	-0.483	0.059	4.123	-0.182	0.061	4.053	-2.069	0.171	2.422	No	No
guo_2023	guo_2023_exp_001	guo_2023_exp_001_assay_003	zebrafish	azoxystrobin	distance in region of attraction	NA	-0.020	0.003	18.875	0.373	0.059	4.123	0.392	0.062	4.028	-0.122	0.111	2.997	No	No
guo_2023	guo_2023_exp_002	guo_2023_exp_002_assay_003	zebrafish	azoxystrobin	distance in region of attraction	NA	-0.145	0.002	20.546	0.119	0.059	4.123	0.264	0.061	4.043	-0.982	0.125	2.834	No	No
guo_2023	guo_2023_exp_003	guo_2023_exp_003_assay_003	zebrafish	azoxystrobin	distance in region of attraction	NA	-0.195	0.002	20.942	0.038	0.059	4.123	0.233	0.061	4.045	-1.348	0.136	2.708	No	No
guo_2023	guo_2023_exp_001	guo_2023_exp_001_assay_004	zebrafish	azoxystrobin	frequency in region of attraction	NA	-0.155	0.008	10.982	0.131	0.059	4.123	0.286	0.067	3.860	-0.565	0.116	2.942	No	No
guo_2023	guo_2023_exp_002	guo_2023_exp_002_assay_004	zebrafish	azoxystrobin	frequency in region of attraction	NA	-0.251	0.004	15.548	-0.731	0.059	4.123	-0.480	0.063	3.985	-1.193	0.131	2.764	No	No
guo_2023	guo_2023_exp_003	guo_2023_exp_003_assay_004	zebrafish	azoxystrobin	frequency in region of attraction	NA	-0.505	0.004	15.270	-0.923	0.059	4.123	-0.418	0.063	3.981	-2.196	0.178	2.370	No	No
guo_2023	guo_2023_exp_001	guo_2023_exp_001_assay_005	zebrafish	azoxystrobin	time near female	NA	-0.134	0.005	14.261	-1.166	0.059	4.123	-1.032	0.064	3.961	-0.592	0.116	2.936	No	No
guo_2023	guo_2023_exp_002	guo_2023_exp_002_assay_005	zebrafish	azoxystrobin	time near female	NA	-0.202	0.005	14.907	-1.931	0.059	4.123	-1.729	0.063	3.974	-0.895	0.122	2.860	No	No
guo_2023	guo_2023_exp_003	guo_2023_exp_003_assay_005	zebrafish	azoxystrobin	time near female	NA	-0.369	0.006	13.171	-0.937	0.059	4.123	-0.568	0.065	3.935	-1.417	0.139	2.682	No	No
guo_2023	guo_2023_exp_001	guo_2023_exp_001_assay_006	zebrafish	azoxystrobin	time near male	NA	-0.068	0.001	27.074	-1.718	0.059	4.123	-1.649	0.060	4.076	-0.583	0.116	2.938	No	No
guo_2023	guo_2023_exp_002	guo_2023_exp_002_assay_006	zebrafish	azoxystrobin	time near male	NA	-0.228	0.002	24.211	-0.836	0.059	4.123	-0.608	0.061	4.065	-1.680	0.150	2.579	No	No
guo_2023	guo_2023_exp_003	guo_2023_exp_003_assay_006	zebrafish	azoxystrobin	time near male	NA	-0.266	0.002	21.141	-0.444	0.059	4.123	-0.178	0.061	4.047	-1.764	0.154	2.546	No	No
guo_2023	guo_2023_exp_001	guo_2023_exp_001_assay_007	zebrafish	azoxystrobin	distance in region of contact	NA	0.038	0.000	70.325	0.676	0.059	4.123	0.638	0.059	4.116	0.866	0.122	2.869	No	No
guo_2023	guo_2023_exp_002	guo_2023_exp_002_assay_007	zebrafish	azoxystrobin	distance in region of contact	NA	0.054	0.000	51.146	1.072	0.059	4.123	1.018	0.059	4.110	0.888	0.122	2.862	No	No
guo_2023	guo_2023_exp_003	guo_2023_exp_003_assay_007	zebrafish	azoxystrobin	distance in region of contact	NA	0.110	0.000	63.192	0.881	0.059	4.123	0.771	0.059	4.114	2.181	0.177	2.376	No	No
guo_2023	guo_2023_exp_001	guo_2023_exp_001_assay_008	zebrafish	azoxystrobin	distance in region of contact	NA	0.121	0.007	12.370	1.071	0.059	4.123	0.950	0.065	3.912	0.466	0.114	2.960	No	No
guo_2023	guo_2023_exp_002	guo_2023_exp_002_assay_008	zebrafish	azoxystrobin	distance in region of contact	NA	0.301	0.009	10.666	1.418	0.059	4.123	1.117	0.068	3.846	0.923	0.123	2.852	No	No
guo_2023	guo_2023_exp_003	guo_2023_exp_003_assay_008	zebrafish	azoxystrobin	distance in region of contact	NA	0.400	0.008	11.311	1.451	0.059	4.123	1.051	0.067	3.874	1.253	0.133	2.743	No	No
guo_2023	guo_2023_exp_001	guo_2023_exp_001_assay_009	zebrafish	azoxystrobin	frequency in region of contact	NA	0.021	0.003	17.229	0.007	0.059	4.123	-0.014	0.062	4.010	0.120	0.111	2.997	No	No
guo_2023	guo_2023_exp_002	guo_2023_exp_002_assay_009	zebrafish	azoxystrobin	frequency in region of contact	NA	0.112	0.002	21.033	-0.452	0.059	4.123	-0.565	0.061	4.046	0.792	0.120	2.889	No	No
guo_2023	guo_2023_exp_003	guo_2023_exp_003_assay_009	zebrafish	azoxystrobin	frequency in region of contact	NA	0.236	0.002	21.244	-0.371	0.059	4.123	-0.607	0.061	4.048	1.728	0.153	2.560	No	No
guo_2023	guo_2023_exp_001	guo_2023_exp_001_assay_010	zebrafish	azoxystrobin	frequency in region of contact	NA	0.007	0.001	31.868	-0.518	0.059	4.123	-0.525	0.060	4.089	0.071	0.111	2.999	No	No
guo_2023	guo_2023_exp_002	guo_2023_exp_002_assay_010	zebrafish	azoxystrobin	frequency in region of contact	NA	0.123	0.004	15.072	0.932	0.059	4.123	0.808	0.063	3.977	0.581	0.116	2.939	No	No
guo_2023	guo_2023_exp_003	guo_2023_exp_003_assay_010	zebrafish	azoxystrobin	frequency in region of contact	NA	0.233	0.002	24.017	0.393	0.059	4.123	0.160	0.061	4.064	1.769	0.155	2.543	No	No
gusso_2020	gusso_2020_exp_001	gusso_2020_exp_001_assay_001	zebrafish	pyriproxyfen	total aggressive behaviours towards mirror	NA	-0.135	0.056	4.230	0.085	0.077	3.606	0.220	0.133	2.744	-0.211	0.144	2.638	No	No
gusso_2020	gusso_2020_exp_002	gusso_2020_exp_002_assay_001	zebrafish	pyriproxyfen	total aggressive behaviours towards mirror	NA	0.036	0.039	5.085	-0.098	0.077	3.606	-0.134	0.116	2.941	0.067	0.143	2.645	No	No
gusso_2020	gusso_2020_exp_003	gusso_2020_exp_003_assay_001	zebrafish	pyriproxyfen	total aggressive behaviours towards mirror	NA	-0.217	0.064	3.958	0.107	0.077	3.606	0.325	0.141	2.665	-0.323	0.145	2.629	No	No
gusso_2020	gusso_2020_exp_001	gusso_2020_exp_001_assay_002	zebrafish	pyriproxyfen	total aggressive behaviours towards mirror	NA	0.133	0.062	4.001	0.221	0.077	3.606	0.089	0.139	2.678	0.193	0.144	2.640	No	No
gusso_2020	gusso_2020_exp_002	gusso_2020_exp_002_assay_002	zebrafish	pyriproxyfen	total aggressive behaviours towards mirror	NA	0.303	0.045	4.702	0.039	0.077	3.606	-0.265	0.122	2.861	0.534	0.148	2.600	No	No
gusso_2020	gusso_2020_exp_003	gusso_2020_exp_003_assay_002	zebrafish	pyriproxyfen	total aggressive behaviours towards mirror	NA	0.050	0.070	3.769	0.244	0.077	3.606	0.194	0.147	2.605	0.069	0.143	2.645	No	No
gusso_2020	gusso_2020_exp_001	gusso_2020_exp_001_assay_003	zebrafish	pyriproxyfen	time spent in the area closest to the stimulus aquarium	NA	-0.019	0.017	7.656	0.334	0.083	3.464	0.352	0.100	3.156	-0.054	0.154	2.549	No	No
gusso_2020	gusso_2020_exp_002	gusso_2020_exp_002_assay_003	zebrafish	pyriproxyfen	time spent in the area closest to the stimulus aquarium	NA	-0.089	0.016	7.961	0.204	0.083	3.464	0.293	0.099	3.176	-0.272	0.155	2.538	No	No
gusso_2020	gusso_2020_exp_003	gusso_2020_exp_003_assay_003	zebrafish	pyriproxyfen	time spent in the area closest to the stimulus aquarium	NA	0.055	0.009	10.742	-0.257	0.083	3.464	-0.312	0.092	3.297	0.227	0.155	2.541	No	No
gusso_2020	gusso_2020_exp_001	gusso_2020_exp_001_assay_004	zebrafish	pyriproxyfen	time spent in the area closest to the stimulus aquarium	NA	-0.019	0.017	7.656	0.334	0.083	3.464	0.352	0.100	3.156	-0.054	0.154	2.549	No	No
gusso_2020	gusso_2020_exp_002	gusso_2020_exp_002_assay_004	zebrafish	pyriproxyfen	time spent in the area closest to the stimulus aquarium	NA	-0.089	0.016	7.961	0.204	0.083	3.464	0.293	0.099	3.176	-0.272	0.155	2.538	No	No
gusso_2020	gusso_2020_exp_003	gusso_2020_exp_003_assay_004	zebrafish	pyriproxyfen	time spent in the area closest to the stimulus aquarium	NA	0.055	0.009	10.742	-0.257	0.083	3.464	-0.312	0.092	3.297	0.227	0.155	2.541	No	No
hawkey_2020	hawkey_2020_exp_001	hawkey_2020_exp_001_assay_001	zebrafish	DDT	total distance moved	NA	-0.298	0.008	11.177	0.250	0.029	5.873	0.548	0.037	5.199	-0.834	0.061	4.041	No	No
hawkey_2020	hawkey_2020_exp_002	hawkey_2020_exp_002_assay_001	zebrafish	DDT	total distance moved	NA	-0.145	0.005	14.077	0.066	0.029	5.873	0.211	0.034	5.420	-0.486	0.058	4.152	No	No
hawkey_2020	hawkey_2020_exp_003	hawkey_2020_exp_003_assay_001	zebrafish	chlorpyrifos	change in position	NA	0.733	0.412	1.558	-0.171	0.053	4.335	-0.904	0.465	1.466	0.414	0.103	3.114	No	No
hawkey_2020	hawkey_2020_exp_004	hawkey_2020_exp_004_assay_001	zebrafish	chlorpyrifos	change in position	NA	1.127	0.378	1.626	-0.024	0.048	4.583	-1.150	0.426	1.533	0.754	0.097	3.205	No	No
hawkey_2020	hawkey_2020_exp_005	hawkey_2020_exp_005_assay_001	zebrafish	chlorpyrifos	change in position	NA	1.458	0.381	1.621	0.298	0.050	4.467	-1.161	0.431	1.524	1.001	0.107	3.051	No	No
hawkey_2021	hawkey_2021_exp_001	hawkey_2021_exp_001_assay_001	zebrafish	chlorpyrifos	distance	NA	-0.095	0.007	12.325	-0.208	0.022	6.745	-0.113	0.029	5.917	-0.240	0.043	4.804	No	No
hawkey_2021	hawkey_2021_exp_002	hawkey_2021_exp_002_assay_001	zebrafish	DDT	distance	NA	0.038	0.009	10.761	0.138	0.023	6.550	0.101	0.032	5.595	0.086	0.046	4.683	No	No
hawkey_2021	hawkey_2021_exp_003	hawkey_2021_exp_003_assay_001	zebrafish	chlorpyrifos ; DDT	distance	NA	0.206	0.007	12.349	-0.098	0.027	6.059	-0.304	0.034	5.439	0.572	0.055	4.261	No	No
hawkey_2021	hawkey_2021_exp_001	hawkey_2021_exp_001_assay_002	zebrafish	chlorpyrifos	change in position	NA	0.435	0.082	3.498	0.195	0.022	6.745	-0.240	0.104	3.105	0.317	0.044	4.792	No	No
hawkey_2021	hawkey_2021_exp_002	hawkey_2021_exp_002_assay_002	zebrafish	DDT	change in position	NA	0.486	0.085	3.439	0.234	0.023	6.550	-0.252	0.108	3.045	0.358	0.046	4.649	No	No
hawkey_2021	hawkey_2021_exp_003	hawkey_2021_exp_003_assay_002	zebrafish	chlorpyrifos ; DDT	change in position	NA	-0.576	0.524	1.381	0.363	0.027	6.059	0.938	0.552	1.347	-0.237	0.053	4.329	No	No
hawkey_2021	hawkey_2021_exp_004	hawkey_2021_exp_004_assay_001	zebrafish	chlorpyrifos	change in position	NA	0.361	0.100	3.158	-0.063	0.029	5.914	-0.424	0.129	2.786	0.277	0.056	4.221	No	No
hawkey_2021	hawkey_2021_exp_005	hawkey_2021_exp_005_assay_001	zebrafish	DDT	change in position	NA	-1.696	3.273	0.553	0.249	0.027	6.081	1.944	3.300	0.550	-0.438	0.054	4.306	No	No
hawkey_2021	hawkey_2021_exp_006	hawkey_2021_exp_006_assay_001	zebrafish	chlorpyrifos ; DDT	change in position	NA	-0.850	0.412	1.558	-0.278	0.037	5.226	0.572	0.448	1.493	-0.387	0.072	3.733	No	No
hued_2011	hued_2011_exp_001	hued_2011_exp_001_assay_001	killifish	roundup	number of persecutions	NA	-0.345	0.066	3.885	-0.325	0.125	2.828	0.020	0.191	2.287	-0.589	0.232	2.077	No	No
hued_2011	hued_2011_exp_001	hued_2011_exp_001_assay_002	killifish	roundup	number of persecutions	NA	-0.276	0.064	3.961	-0.294	0.125	2.828	-0.019	0.189	2.302	-0.482	0.229	2.091	No	No
hued_2011	hued_2011_exp_001	hued_2011_exp_001_assay_003	killifish	roundup	number of copulation attempts	NA	-0.629	0.140	2.671	-1.030	0.125	2.828	-0.401	0.265	1.942	-0.634	0.233	2.070	No	No
hued_2011	hued_2011_exp_001	hued_2011_exp_001_assay_004	killifish	roundup	number of copulation attempts	NA	-0.457	0.126	2.813	-1.050	0.125	2.828	-0.593	0.251	1.995	-0.499	0.229	2.089	No	No
hued_2011	hued_2011_exp_001	hued_2011_exp_001_assay_005	killifish	roundup	number of copulations	NA	-0.860	0.068	3.843	-0.522	0.125	2.828	0.338	0.193	2.278	-1.475	0.283	1.881	No	No
hued_2011	hued_2011_exp_001	hued_2011_exp_001_assay_006	killifish	roundup	number of copulations	NA	-0.935	0.066	3.894	-0.616	0.125	2.828	0.318	0.191	2.288	-1.588	0.292	1.850	No	No
hued_2011	hued_2011_exp_001	hued_2011_exp_001_assay_007	killifish	roundup	mating success	NA	-0.268	0.036	5.294	0.847	0.125	2.828	1.116	0.161	2.495	-0.707	0.236	2.058	No	No
hued_2011	hued_2011_exp_001	hued_2011_exp_001_assay_008	killifish	roundup	mating success	NA	-0.435	0.048	4.543	0.847	0.125	2.828	1.283	0.173	2.401	-1.061	0.253	1.986	No	No
hussian_2020	hussian_2020_exp_001	hussian_2020_exp_001_assay_001	zebrafish	paclobutrazol	mirror biting time	NA	-0.686	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	No	No
hussian_2020	hussian_2020_exp_002	hussian_2020_exp_002_assay_001	zebrafish	paclobutrazol	mirror biting time	NA	-0.805	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	No	No
hussian_2020	hussian_2020_exp_001	hussian_2020_exp_001_assay_002	zebrafish	paclobutrazol	duration of stay on mirror side	NA	-1.644	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	No	No
hussian_2020	hussian_2020_exp_002	hussian_2020_exp_002_assay_002	zebrafish	paclobutrazol	duration of stay on mirror side	NA	-1.669	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	No	No
hussian_2020	hussian_2020_exp_001	hussian_2020_exp_001_assay_003	zebrafish	paclobutrazol	interaction time percentage	NA	-0.154	0.075	3.654	0.383	0.034	5.385	0.536	0.109	3.023	-0.148	0.067	3.868	No	No
hussian_2020	hussian_2020_exp_002	hussian_2020_exp_002_assay_003	zebrafish	paclobutrazol	interaction time percentage	NA	-0.292	0.338	1.720	1.116	0.034	5.385	1.408	0.372	1.639	-0.145	0.067	3.868	No	No
hussian_2020	hussian_2020_exp_001	hussian_2020_exp_001_assay_004	zebrafish	paclobutrazol	longest duration of stay in seperator side	NA	-0.072	4.307	0.482	0.028	0.034	5.385	0.100	4.341	0.480	-0.009	0.067	3.873	No	No
hussian_2020	hussian_2020_exp_002	hussian_2020_exp_002_assay_004	zebrafish	paclobutrazol	longest duration of stay in seperator side	NA	-0.387	3.936	0.504	-0.372	0.034	5.385	0.015	3.971	0.502	-0.048	0.067	3.872	No	No
hussian_2020	hussian_2020_exp_001	hussian_2020_exp_001_assay_006	zebrafish	paclobutrazol	average distance to seperator	change	-0.384	0.686	1.208	0.069	0.034	5.385	-0.315	0.720	1.178	0.122	0.067	3.869	No	No
hussian_2020	hussian_2020_exp_002	hussian_2020_exp_002_assay_006	zebrafish	paclobutrazol	average distance to seperator	change	-0.487	0.524	1.381	-0.393	0.034	5.385	-0.880	0.559	1.338	0.198	0.067	3.864	No	No
hussian_2020	hussian_2020_exp_001	hussian_2020_exp_001_assay_007	zebrafish	paclobutrazol	average speed	NA	-0.429	0.141	2.664	-0.086	0.034	5.385	0.343	0.175	2.388	-0.301	0.067	3.851	No	No
hussian_2020	hussian_2020_exp_002	hussian_2020_exp_002_assay_007	zebrafish	paclobutrazol	average speed	NA	-0.403	0.072	3.719	-0.719	0.034	5.385	-0.316	0.107	3.060	-0.350	0.068	3.844	No	No
hussian_2020	hussian_2020_exp_001	hussian_2020_exp_001_assay_008	zebrafish	paclobutrazol	time in top	NA	-1.558	5.893	0.412	0.403	0.034	5.385	1.961	5.928	0.411	-0.331	0.068	3.847	No	No
hussian_2020	hussian_2020_exp_002	hussian_2020_exp_002_assay_008	zebrafish	paclobutrazol	time in top	NA	-0.245	0.516	1.392	0.383	0.034	5.385	0.628	0.551	1.348	-0.092	0.067	3.871	No	No
hussian_2020	hussian_2020_exp_001	hussian_2020_exp_001_assay_009	zebrafish	paclobutrazol	distance between individuals	change	-0.020	0.047	4.611	-0.228	0.034	5.385	-0.248	0.082	3.502	0.024	0.067	3.873	No	No
hussian_2020	hussian_2020_exp_002	hussian_2020_exp_002_assay_009	zebrafish	paclobutrazol	distance between individuals	change	0.035	0.070	3.770	0.136	0.034	5.385	0.170	0.105	3.089	-0.034	0.067	3.873	No	No
hussian_2020	hussian_2020_exp_001	hussian_2020_exp_001_assay_010	zebrafish	paclobutrazol	average shoal area	change	-0.089	0.043	4.838	-1.375	0.034	5.385	-1.464	0.077	3.599	0.114	0.067	3.870	No	No
hussian_2020	hussian_2020_exp_002	hussian_2020_exp_002_assay_010	zebrafish	paclobutrazol	average shoal area	change	-0.127	0.045	4.716	-0.982	0.034	5.385	-1.109	0.079	3.548	0.160	0.067	3.867	No	No
hussian_2020	hussian_2020_exp_001	hussian_2020_exp_001_assay_011	zebrafish	paclobutrazol	average nearest neighbor distance	change	-0.065	0.086	3.415	-0.382	0.034	5.385	-0.448	0.120	2.884	0.058	0.067	3.872	No	No
hussian_2020	hussian_2020_exp_002	hussian_2020_exp_002_assay_011	zebrafish	paclobutrazol	average nearest neighbor distance	change	0.001	0.122	2.863	0.001	0.034	5.385	0.002	0.156	2.528	0.000	0.067	3.873	No	No
hussian_2020	hussian_2020_exp_001	hussian_2020_exp_001_assay_012	zebrafish	paclobutrazol	average farthest neighbor distance	change	0.266	0.074	3.685	-0.687	0.034	5.385	-0.421	0.108	3.041	-0.234	0.067	3.860	No	No
hussian_2020	hussian_2020_exp_002	hussian_2020_exp_002_assay_012	zebrafish	paclobutrazol	average farthest neighbor distance	change	0.085	0.109	3.033	-0.032	0.034	5.385	0.053	0.143	2.643	-0.065	0.067	3.872	No	No
ibrahim_2023	ibrahim_2023_exp_001	ibrahim_2023_exp_001_assay_001	Nile tilapia	mancozeb	number of chases	NA	NA	NA	NA	2.565	0.111	3.000	NA	NA	NA	4.599	0.729	1.171	No	No
ibrahim_2023	ibrahim_2023_exp_002	ibrahim_2023_exp_001_assay_002	Nile tilapia	mancozeb	number of chases	NA	NA	NA	NA	2.197	0.111	3.000	NA	NA	NA	8.513	2.012	0.705	No	No
ibrahim_2023	ibrahim_2023_exp_003	ibrahim_2023_exp_001_assay_003	Nile tilapia	mancozeb	number of chases	NA	NA	NA	NA	1.946	0.111	3.000	NA	NA	NA	12.719	4.244	0.485	No	No
ibrahim_2023	ibrahim_2023_exp_004	ibrahim_2023_exp_001_assay_004	Nile tilapia	mancozeb	number of chases	NA	NA	NA	NA	2.398	0.111	3.000	NA	NA	NA	8.375	1.954	0.715	No	No
ibrahim_2023	ibrahim_2023_exp_005	ibrahim_2023_exp_001_assay_005	Nile tilapia	mancozeb	number of chases	NA	NA	NA	NA	2.708	0.111	3.000	NA	NA	NA	6.581	1.283	0.883	No	No
ilie_2021	ilie_2021_exp_001	ilie_2021_exp_001_assay_001	zebrafish	rotenone	time spent in the left arm	NA	-0.313	0.071	3.765	-0.534	0.071	3.742	-0.221	0.142	2.654	-0.397	0.136	2.712	No	No
ilie_2021	ilie_2021_exp_001	ilie_2021_exp_001_assay_002	zebrafish	rotenone	time spent in the left arm	NA	0.128	0.094	3.260	-0.436	0.071	3.742	-0.564	0.166	2.458	0.152	0.134	2.735	No	No
ilie_2021	ilie_2021_exp_001	ilie_2021_exp_001_assay_003	zebrafish	rotenone	time spent in the left arm	NA	0.035	0.078	3.583	-0.050	0.071	3.742	-0.085	0.149	2.588	0.044	0.133	2.738	No	No
ilie_2021	ilie_2021_exp_001	ilie_2021_exp_001_assay_004	zebrafish	rotenone	time spent in the left arm	NA	0.533	0.027	6.069	-0.532	0.071	3.742	-1.065	0.099	3.185	1.385	0.165	2.460	No	No
ilie_2021	ilie_2021_exp_001	ilie_2021_exp_001_assay_005	zebrafish	rotenone	time spent in the left arm	NA	-0.129	0.018	7.548	-0.498	0.071	3.742	-0.369	0.089	3.352	-0.337	0.135	2.719	No	No
ilie_2021	ilie_2021_exp_001	ilie_2021_exp_001_assay_006	zebrafish	rotenone	time spent in the left arm	NA	-0.737	0.191	2.288	0.590	0.071	3.742	1.327	0.262	1.952	-0.801	0.144	2.635	No	No
ilie_2021	ilie_2021_exp_001	ilie_2021_exp_001_assay_007	zebrafish	rotenone	time spent in the left arm	NA	0.001	0.027	6.038	0.357	0.071	3.742	0.355	0.099	3.180	0.003	0.133	2.739	No	No
ilie_2021	ilie_2021_exp_001	ilie_2021_exp_001_assay_008	zebrafish	rotenone	time spent in the left arm	NA	-0.424	0.044	4.759	-0.095	0.071	3.742	0.329	0.116	2.941	-0.741	0.142	2.649	No	No
ilie_2021	ilie_2021_exp_001	ilie_2021_exp_001_assay_009	zebrafish	rotenone	time spent in the left arm	NA	0.185	0.085	3.435	0.578	0.071	3.742	0.394	0.156	2.531	0.217	0.134	2.731	No	No
ilie_2021	ilie_2021_exp_001	ilie_2021_exp_001_assay_010	zebrafish	rotenone	time spent in the left arm	NA	-0.301	0.118	2.906	-0.076	0.071	3.742	0.226	0.190	2.295	-0.316	0.135	2.722	No	No
ilie_2021	ilie_2021_exp_001	ilie_2021_exp_001_assay_011	zebrafish	rotenone	time spent in the left arm	NA	-0.150	0.047	4.590	1.422	0.071	3.742	1.572	0.119	2.900	-0.261	0.134	2.727	No	No
ilie_2021	ilie_2021_exp_001	ilie_2021_exp_001_assay_012	zebrafish	rotenone	time spent in the left arm	NA	-0.005	0.035	5.351	-0.808	0.071	3.742	-0.803	0.106	3.066	-0.010	0.133	2.739	No	No
ilie_2021	ilie_2021_exp_001	ilie_2021_exp_001_assay_013	zebrafish	rotenone	time spent in the left arm	NA	-0.288	0.171	2.418	0.526	0.071	3.742	0.814	0.242	2.031	-0.270	0.135	2.726	No	No
ilie_2021	ilie_2021_exp_001	ilie_2021_exp_001_assay_014	zebrafish	rotenone	time spent in the left arm	NA	-0.325	0.078	3.573	0.736	0.071	3.742	1.061	0.150	2.584	-0.465	0.137	2.702	No	No
ilie_2021	ilie_2021_exp_001	ilie_2021_exp_001_assay_015	zebrafish	rotenone	time spent in the left arm	NA	0.260	0.025	6.302	0.938	0.071	3.742	0.679	0.097	3.217	0.534	0.138	2.691	No	No
ilie_2021	ilie_2021_exp_001	ilie_2021_exp_001_assay_016	zebrafish	rotenone	time spent in the left arm	NA	-0.292	0.179	2.362	0.581	0.071	3.742	0.872	0.251	1.997	-0.269	0.135	2.726	No	No
ilie_2021	ilie_2021_exp_001	ilie_2021_exp_001_assay_017	zebrafish	rotenone	time spent in the left arm	NA	-0.110	0.053	4.351	0.065	0.071	3.742	0.175	0.124	2.837	-0.172	0.134	2.734	No	No
ilie_2021	ilie_2021_exp_001	ilie_2021_exp_001_assay_018	zebrafish	rotenone	time spent in the left arm	NA	0.221	0.056	4.219	0.123	0.071	3.742	-0.098	0.128	2.799	0.332	0.135	2.720	No	No
ilie_2021	ilie_2021_exp_001	ilie_2021_exp_001_assay_019	zebrafish	rotenone	time spent in the left arm	NA	0.218	0.131	2.759	-0.162	0.071	3.742	-0.380	0.203	2.221	0.220	0.134	2.730	No	No
ilie_2021	ilie_2021_exp_001	ilie_2021_exp_001_assay_020	zebrafish	rotenone	time spent in the left arm	NA	0.529	0.061	4.044	0.265	0.071	3.742	-0.264	0.133	2.746	0.769	0.143	2.643	No	No
ilie_2021	ilie_2021_exp_001	ilie_2021_exp_001_assay_021	zebrafish	rotenone	time spent in the left arm	NA	0.362	0.032	5.565	0.439	0.071	3.742	0.077	0.104	3.105	0.688	0.141	2.661	No	No
ilie_2022	ilie_2022_exp_001	ilie_2022_exp_001_assay_001	zebrafish	rotenone	percentage of time in left arm	NA	0.810	0.036	5.305	1.083	0.250	2.000	0.274	0.286	1.871	2.000	0.600	1.291	No	No
ilie_2022	ilie_2022_exp_001	ilie_2022_exp_001_assay_002	zebrafish	rotenone	percentage of time in left arm	NA	0.935	0.485	1.436	1.285	0.250	2.000	0.350	0.735	1.166	0.587	0.417	1.548	No	No
ilie_2022	ilie_2022_exp_001	ilie_2022_exp_001_assay_003	zebrafish	rotenone	percentage of time in left arm	NA	0.916	0.089	3.353	0.795	0.250	2.000	-0.121	0.339	1.718	1.578	0.524	1.381	No	No
ilie_2022	ilie_2022_exp_001	ilie_2022_exp_001_assay_004	zebrafish	rotenone	percentage of time in left arm	NA	-0.937	0.538	1.363	-0.290	0.250	2.000	0.647	0.788	1.126	-0.817	0.433	1.519	No	No
ilie_2022	ilie_2022_exp_001	ilie_2022_exp_001_assay_005	zebrafish	rotenone	percentage of time in left arm	NA	0.208	0.517	1.391	0.156	0.250	2.000	-0.052	0.767	1.142	0.165	0.401	1.578	No	No
ilie_2022	ilie_2022_exp_001	ilie_2022_exp_001_assay_006	zebrafish	rotenone	percentage of time in left arm	NA	-0.264	0.376	1.630	0.802	0.250	2.000	1.065	0.626	1.264	-0.271	0.404	1.574	No	No
ilie_2022	ilie_2022_exp_001	ilie_2022_exp_001_assay_007	zebrafish	rotenone	percentage of time in left arm	NA	-0.565	0.208	2.192	0.045	0.250	2.000	0.610	0.458	1.477	-0.781	0.431	1.524	No	No
ilie_2022	ilie_2022_exp_001	ilie_2022_exp_001_assay_008	zebrafish	rotenone	percentage of time in left arm	NA	-1.592	0.312	1.790	-1.332	0.250	2.000	0.260	0.562	1.334	-1.289	0.483	1.439	No	No
ilie_2022	ilie_2022_exp_001	ilie_2022_exp_001_assay_009	zebrafish	rotenone	percentage of time in left arm	NA	-1.359	0.310	1.797	-1.441	0.250	2.000	-0.081	0.560	1.337	-1.009	0.451	1.489	No	No
jaensson_2007	jaensson_2007_exp_001	jaensson_2007_exp_001_assay_001	brown trout	cypermethrin	number of courting events per six minutes	NA	0.468	0.254	1.985	0.379	0.067	3.858	-0.089	0.321	1.765	0.330	0.127	2.811	No	No
jaensson_2007	jaensson_2007_exp_002	jaensson_2007_exp_002_assay_001	brown trout	cypermethrin	time near female	NA	0.622	0.177	2.379	0.232	0.119	2.898	-0.391	0.296	1.839	0.659	0.219	2.135	No	No
jaensson_2007	jaensson_2007_exp_003	jaensson_2007_exp_002_assay_002	brown trout	cypermethrin	time near female	NA	-1.544	0.241	2.037	-1.776	0.161	2.494	-0.232	0.402	1.578	-0.719	0.280	1.891	No	No
khalil_2013	khalil_2013_exp_001	khalil_2013_exp_001_assay_001	Japanese medaka	chlorpyrifos	swimming speed	NA	-0.069	0.058	4.137	-0.270	0.200	2.236	-0.201	0.258	1.967	-0.151	0.334	1.730	No	No
khalil_2013	khalil_2013_exp_001	khalil_2013_exp_001_assay_002	Japanese medaka	chlorpyrifos	swimming speed	NA	0.685	0.026	6.230	1.276	0.200	2.236	0.591	0.226	2.105	1.812	0.470	1.458	No	No
khalil_2013	khalil_2013_exp_001	khalil_2013_exp_001_assay_003	Japanese medaka	chlorpyrifos	duration	NA	-0.226	0.075	3.662	-0.604	0.200	2.236	-0.377	0.275	1.908	-0.420	0.341	1.713	No	No
khalil_2013	khalil_2013_exp_001	khalil_2013_exp_001_assay_004	Japanese medaka	chlorpyrifos	duration	NA	-0.672	0.122	2.868	-1.229	0.200	2.236	-0.557	0.322	1.763	-0.827	0.362	1.662	No	No
khalil_2013	khalil_2013_exp_001	khalil_2013_exp_001_assay_005	Japanese medaka	chlorpyrifos	frequency	NA	0.654	0.359	1.669	-0.288	0.200	2.236	-0.942	0.559	1.337	0.705	0.354	1.681	No	No
khalil_2013	khalil_2013_exp_001	khalil_2013_exp_001_assay_006	Japanese medaka	chlorpyrifos	frequency	NA	0.325	0.030	5.791	0.528	0.200	2.236	0.203	0.230	2.086	0.951	0.371	1.642	No	No
khalil_2013	khalil_2013_exp_001	khalil_2013_exp_001_assay_007	Japanese medaka	chlorpyrifos	duration	NA	0.527	0.161	2.489	-1.528	0.200	2.236	-2.056	0.361	1.663	0.907	0.368	1.649	No	No
khalil_2013	khalil_2013_exp_001	khalil_2013_exp_001_assay_008	Japanese medaka	chlorpyrifos	duration	NA	0.097	0.011	9.391	-0.995	0.200	2.236	-1.093	0.211	2.175	0.506	0.344	1.705	No	No
khalil_2013	khalil_2013_exp_001	khalil_2013_exp_001_assay_009	Japanese medaka	chlorpyrifos	frequency	NA	0.222	0.128	2.799	-0.772	0.200	2.236	-0.994	0.328	1.747	0.358	0.339	1.718	No	No
khalil_2013	khalil_2013_exp_001	khalil_2013_exp_001_assay_010	Japanese medaka	chlorpyrifos	frequency	NA	0.026	0.022	6.773	-0.987	0.200	2.236	-1.014	0.222	2.123	0.096	0.334	1.731	No	No
khalil_2017	khalil_2017_exp_001	khalil_2017_exp_001_assay_001	Japanese medaka	chlorpyrifos	frequency	NA	-0.152	0.036	5.281	-0.095	0.333	1.732	0.057	0.369	1.646	-0.492	0.515	1.393	No	No
khalil_2017	khalil_2017_exp_001	khalil_2017_exp_001_assay_002	Japanese medaka	chlorpyrifos	frequency	NA	0.314	0.020	7.034	1.070	0.333	1.732	0.757	0.354	1.682	1.216	0.592	1.299	No	No
khalil_2017	khalil_2017_exp_001	khalil_2017_exp_001_assay_003	Japanese medaka	chlorpyrifos	frequency	NA	-1.068	0.017	7.719	-2.148	0.333	1.732	-1.080	0.350	1.690	-3.264	1.166	0.926	No	No
khalil_2017	khalil_2017_exp_002	khalil_2017_exp_002_assay_001	Japanese medaka	chlorpyrifos	frequency	NA	-1.191	0.036	5.263	-1.127	0.333	1.732	0.063	0.369	1.645	-3.127	1.111	0.949	No	No
khalil_2017	khalil_2017_exp_001	khalil_2017_exp_001_assay_004	Japanese medaka	chlorpyrifos	duration	NA	0.000	0.062	4.022	0.000	0.333	1.732	0.000	0.395	1.591	0.000	0.500	1.414	No	No
khalil_2017	khalil_2017_exp_001	khalil_2017_exp_001_assay_005	Japanese medaka	chlorpyrifos	duration	NA	0.000	0.028	5.999	0.000	0.333	1.732	0.000	0.361	1.664	0.000	0.500	1.414	No	No
khalil_2017	khalil_2017_exp_001	khalil_2017_exp_001_assay_006	Japanese medaka	chlorpyrifos	duration	NA	0.000	0.026	6.175	0.000	0.333	1.732	0.000	0.360	1.668	0.000	0.500	1.414	No	No
khalil_2017	khalil_2017_exp_002	khalil_2017_exp_002_assay_002	Japanese medaka	chlorpyrifos	duration	NA	0.000	0.062	4.022	0.000	0.333	1.732	0.000	0.395	1.591	0.000	0.500	1.414	No	No
khalil_2017	khalil_2017_exp_001	khalil_2017_exp_001_assay_007	Japanese medaka	chlorpyrifos	frequency	NA	-0.147	0.020	7.007	0.230	0.333	1.732	0.377	0.354	1.681	-0.648	0.526	1.379	No	No
khalil_2017	khalil_2017_exp_001	khalil_2017_exp_001_assay_008	Japanese medaka	chlorpyrifos	frequency	NA	0.032	0.025	6.332	0.981	0.333	1.732	0.949	0.358	1.671	0.122	0.501	1.413	No	No
khalil_2017	khalil_2017_exp_001	khalil_2017_exp_001_assay_009	Japanese medaka	chlorpyrifos	frequency	NA	-0.067	0.023	6.541	-0.117	0.333	1.732	-0.050	0.357	1.674	-0.269	0.505	1.408	No	No
khalil_2017	khalil_2017_exp_002	khalil_2017_exp_002_assay_003	Japanese medaka	chlorpyrifos	frequency	NA	-0.917	0.036	5.252	-0.158	0.333	1.732	0.759	0.370	1.645	-3.473	1.254	0.893	No	No
khalil_2017	khalil_2017_exp_001	khalil_2017_exp_001_assay_010	Japanese medaka	chlorpyrifos	duration	NA	-0.147	0.020	7.007	0.230	0.333	1.732	0.377	0.354	1.681	-0.648	0.526	1.379	No	No
khalil_2017	khalil_2017_exp_001	khalil_2017_exp_001_assay_011	Japanese medaka	chlorpyrifos	duration	NA	0.032	0.025	6.332	0.981	0.333	1.732	0.949	0.358	1.671	0.122	0.501	1.413	No	No
khalil_2017	khalil_2017_exp_001	khalil_2017_exp_001_assay_012	Japanese medaka	chlorpyrifos	duration	NA	-0.067	0.023	6.541	-0.117	0.333	1.732	-0.050	0.357	1.674	-0.269	0.505	1.408	No	No
khalil_2017	khalil_2017_exp_002	khalil_2017_exp_002_assay_004	Japanese medaka	chlorpyrifos	duration	NA	-0.917	0.036	5.252	-0.158	0.333	1.732	0.759	0.370	1.645	-3.473	1.254	0.893	No	No
lei_2022	lei_2022_exp_001	lei_2022_exp_001_assay_001	zebrafish	deltamethrin	proportion of time in near zone	NA	0.055	0.001	38.992	-0.256	0.067	3.873	-0.310	0.067	3.854	0.743	0.134	2.736	No	No
lei_2022	lei_2022_exp_002	lei_2022_exp_002_assay_001	zebrafish	deltamethrin	proportion of time in near zone	NA	0.057	0.001	40.021	-0.331	0.067	3.873	-0.389	0.067	3.855	0.800	0.135	2.722	No	No
lei_2022	lei_2022_exp_003	lei_2022_exp_003_assay_001	zebrafish	deltamethrin	proportion of time in near zone	NA	0.045	0.001	37.855	-0.185	0.067	3.873	-0.230	0.067	3.853	0.585	0.130	2.770	No	No
lei_2022	lei_2022_exp_001	lei_2022_exp_001_assay_002	zebrafish	deltamethrin	nearest neighbour distance	change	-0.109	0.002	22.202	0.210	0.043	4.796	0.102	0.046	4.688	0.679	0.088	3.368	No	No
lei_2022	lei_2022_exp_002	lei_2022_exp_002_assay_002	zebrafish	deltamethrin	nearest neighbour distance	change	0.061	0.001	28.213	-0.547	0.043	4.796	-0.486	0.045	4.728	-0.483	0.086	3.415	No	No
lei_2022	lei_2022_exp_003	lei_2022_exp_003_assay_002	zebrafish	deltamethrin	nearest neighbour distance	change	-0.042	0.001	27.245	-0.327	0.043	4.796	-0.369	0.045	4.723	0.328	0.084	3.441	No	No
lei_2022	lei_2022_exp_001	lei_2022_exp_001_assay_003	zebrafish	deltamethrin	inter individual difference	change	-0.355	0.003	16.971	0.355	0.043	4.796	0.000	0.047	4.615	1.670	0.112	2.983	No	No
lei_2022	lei_2022_exp_002	lei_2022_exp_002_assay_003	zebrafish	deltamethrin	inter individual difference	change	-0.302	0.003	16.971	0.302	0.043	4.796	0.000	0.047	4.615	1.426	0.105	3.093	No	No
lei_2022	lei_2022_exp_003	lei_2022_exp_003_assay_003	zebrafish	deltamethrin	inter individual difference	change	-0.057	0.003	16.971	0.057	0.043	4.796	0.000	0.047	4.615	0.272	0.084	3.448	No	No
leite_2023	leite_2023_exp_001	leite_2023_exp_001_assay_001	Iberian barbel	esfenvalerate	cohesion	change	0.143	0.062	4.002	0.029	0.091	3.317	0.171	0.153	2.554	-0.227	0.168	2.442	No	No
leite_2023	leite_2023_exp_002	leite_2023_exp_002_assay_001	Iberian barbel	esfenvalerate	cohesion	change	0.134	0.061	4.044	0.019	0.091	3.317	0.153	0.152	2.564	-0.215	0.168	2.442	No	No
leite_2023	leite_2023_exp_003	leite_2023_exp_003_assay_001	Bleak	esfenvalerate	cohesion	change	-1.125	0.078	3.575	0.091	0.091	3.317	-1.034	0.169	2.432	2.097	0.258	1.968	No	No
leite_2023	leite_2023_exp_004	leite_2023_exp_004_assay_001	Bleak	esfenvalerate	cohesion	change	-1.058	0.086	3.404	0.350	0.091	3.317	-0.708	0.177	2.375	1.619	0.221	2.126	No	No
lin_2024	lin_2024_exp_001	lin_2024_exp_001_assay_001	zebrafish	DDT	inter-individual distance	change	0.167	0.001	36.457	0.032	1.000	1.000	0.199	1.001	1.000	-3.474	2.509	0.631	No	No
lin_2024	lin_2024_exp_002	lin_2024_exp_002_assay_001	zebrafish	DDT	inter-individual distance	change	0.020	0.001	39.448	0.160	1.000	1.000	0.180	1.001	1.000	-0.442	1.024	0.988	No	No
lin_2024	lin_2024_exp_001	lin_2024_exp_001_assay_002	zebrafish	DDT	time in contact percentage	NA	-0.019	0.000	84.865	-0.129	0.143	2.646	-0.110	0.143	2.644	-0.762	0.268	1.931	No	No
lin_2024	lin_2024_exp_002	lin_2024_exp_002_assay_002	zebrafish	DDT	time in contact percentage	NA	-0.091	0.000	82.316	0.452	0.143	2.646	0.543	0.143	2.644	-3.609	0.657	1.234	No	No
lin_2024	lin_2024_exp_001	lin_2024_exp_001_assay_003	zebrafish	DDT	mirror attack per minute	NA	0.399	0.002	21.302	0.395	0.091	3.317	-0.005	0.093	3.277	3.249	0.387	1.608	No	No
lin_2024	lin_2024_exp_002	lin_2024_exp_002_assay_003	zebrafish	DDT	mirror attack per minute	NA	-0.254	0.003	18.610	-0.271	0.091	3.317	-0.017	0.094	3.265	-1.836	0.237	2.055	No	No
liu_2023	liu_2023_exp_001	liu_2023_exp_001_assay_001	zebrafish	fenpropathrin	time in conspecific segment	NA	0.283	0.219	2.137	0.327	0.111	3.000	0.045	0.330	1.741	0.253	0.202	2.227	No	No
liu_2023	liu_2023_exp_001	liu_2023_exp_001_assay_002	zebrafish	fenpropathrin	duration of fight control vs fenpropathrin	NA	-0.600	0.094	3.269	-0.109	0.097	3.207	0.491	0.191	2.289	-0.867	0.193	2.275	No	No
liu_2023	liu_2023_exp_001	liu_2023_exp_001_assay_003	zebrafish	fenpropathrin	biting numbers	NA	-0.234	0.026	6.253	-0.086	0.127	2.806	0.148	0.153	2.560	-0.664	0.237	2.053	No	No
liu_2023a	liu_2023a_exp_001	liu_2023a_exp_001_assay_001	zebrafish	imidacloprid	time spent in conspecific zone	NA	0.021	0.002	21.258	0.087	0.077	3.606	0.066	0.079	3.555	0.166	0.143	2.641	No	No
liu_2023a	liu_2023a_exp_002	liu_2023a_exp_002_assay_001	zebrafish	imidacloprid	time spent in conspecific zone	NA	0.048	0.003	19.374	0.276	0.077	3.606	0.228	0.080	3.545	0.342	0.145	2.627	No	No
liu_2023a	liu_2023a_exp_003	liu_2023a_exp_003_assay_001	zebrafish	imidacloprid	time spent in conspecific zone	NA	0.117	0.001	27.527	-0.526	0.077	3.606	-0.643	0.078	3.575	1.214	0.169	2.431	No	No
maclaren_2023	maclaren_2023_exp_001	maclaren_2023_exp_001_assay_001	sailfin mollie	atrazine	time in preference zone of female	NA	0.022	0.011	9.709	0.176	0.053	4.359	0.154	0.063	3.977	0.066	0.100	3.161	Yes	Yes
maclaren_2023	maclaren_2023_exp_002	maclaren_2023_exp_002_assay_001	sailfin mollie	atrazine	time in preference zone of female	NA	-0.051	0.011	9.709	0.103	0.053	4.359	0.154	0.063	3.977	-0.154	0.100	3.158	Yes	Yes
maclaren_2023	maclaren_2023_exp_001	maclaren_2023_exp_001_assay_002	sailfin mollie	atrazine	time in preference zone of male	NA	-0.553	0.011	9.709	-0.400	0.053	4.359	0.154	0.063	3.977	-1.632	0.133	2.739	Yes	Yes
maclaren_2023	maclaren_2023_exp_002	maclaren_2023_exp_002_assay_002	sailfin mollie	atrazine	time in preference zone of male	NA	-0.299	0.011	9.709	-0.145	0.053	4.359	0.154	0.063	3.977	-0.903	0.110	3.012	Yes	Yes
maclaren_2023	maclaren_2023_exp_003	maclaren_2023_exp_003_assay_001	sailfin mollie	atrazine	time in preference zone of female	NA	-0.383	0.011	9.709	-0.229	0.053	4.359	0.154	0.063	3.977	-1.150	0.117	2.929	Yes	Yes
maclaren_2023	maclaren_2023_exp_004	maclaren_2023_exp_004_assay_001	sailfin mollie	atrazine	time in preference zone of female	NA	-0.363	0.011	9.709	-0.209	0.053	4.359	0.154	0.063	3.977	-1.092	0.115	2.950	Yes	Yes
maclaren_2023	maclaren_2023_exp_003	maclaren_2023_exp_003_assay_002	sailfin mollie	atrazine	time in preference zone of male	NA	-0.373	0.011	9.709	-0.220	0.053	4.359	0.154	0.063	3.977	-1.123	0.116	2.939	Yes	Yes
maclaren_2023	maclaren_2023_exp_004	maclaren_2023_exp_004_assay_002	sailfin mollie	atrazine	time in preference zone of male	NA	-0.303	0.011	9.709	-0.149	0.053	4.359	0.154	0.063	3.977	-0.915	0.110	3.009	Yes	Yes
maclaren_2023	maclaren_2023_exp_003	maclaren_2023_exp_003_assay_003	sailfin mollie	atrazine	mean total time with dummy	NA	-0.269	0.011	9.709	-0.115	0.053	4.359	0.154	0.063	3.977	-0.813	0.108	3.039	Yes	Yes
maclaren_2023	maclaren_2023_exp_004	maclaren_2023_exp_004_assay_003	sailfin mollie	atrazine	mean total time with dummy	NA	-0.187	0.011	9.709	-0.033	0.053	4.359	0.154	0.063	3.977	-0.567	0.104	3.101	Yes	Yes
maclaren_2023	maclaren_2023_exp_003	maclaren_2023_exp_003_assay_004	sailfin mollie	atrazine	mean total time with dummy	NA	-0.376	0.011	9.709	-0.223	0.053	4.359	0.154	0.063	3.977	-1.132	0.116	2.936	Yes	Yes
maclaren_2023	maclaren_2023_exp_004	maclaren_2023_exp_004_assay_004	sailfin mollie	atrazine	mean total time with dummy	NA	-0.336	0.011	9.709	-0.183	0.053	4.359	0.154	0.063	3.977	-1.015	0.113	2.977	Yes	Yes
maclaren_2023	maclaren_2023_exp_001	maclaren_2023_exp_001_assay_003	sailfin mollie	atrazine	time with smaller male (small and intermediate male present)	NA	0.257	0.046	4.683	0.838	0.053	4.359	0.581	0.098	3.191	0.346	0.101	3.139	No	No
maclaren_2023	maclaren_2023_exp_002	maclaren_2023_exp_002_assay_003	sailfin mollie	atrazine	time with smaller male (small and intermediate male present)	NA	0.292	0.038	5.161	0.742	0.053	4.359	0.449	0.090	3.330	0.434	0.102	3.126	No	No
maclaren_2023	maclaren_2023_exp_001	maclaren_2023_exp_001_assay_004	sailfin mollie	atrazine	time with larger male (small and intermediate male present)	NA	-0.176	0.035	5.358	0.686	0.053	4.359	0.861	0.087	3.381	-0.309	0.101	3.144	No	No
maclaren_2023	maclaren_2023_exp_002	maclaren_2023_exp_002_assay_004	sailfin mollie	atrazine	time with larger male (small and intermediate male present)	NA	0.011	0.023	6.594	0.617	0.053	4.359	0.606	0.076	3.636	0.022	0.100	3.162	No	No
maclaren_2023	maclaren_2023_exp_001	maclaren_2023_exp_001_assay_005	sailfin mollie	atrazine	time with smaller male (small and large male present)	NA	0.059	0.070	3.793	1.297	0.053	4.359	1.238	0.122	2.861	0.068	0.100	3.161	No	No
maclaren_2023	maclaren_2023_exp_002	maclaren_2023_exp_002_assay_005	sailfin mollie	atrazine	time with smaller male (small and large male present)	NA	0.000	0.024	6.449	0.621	0.053	4.359	0.620	0.077	3.611	0.000	0.100	3.162	No	No
maclaren_2023	maclaren_2023_exp_001	maclaren_2023_exp_001_assay_006	sailfin mollie	atrazine	time with larger male (small and large male present)	NA	-0.225	0.038	5.117	1.087	0.053	4.359	1.313	0.091	3.318	-0.394	0.102	3.132	No	No
maclaren_2023	maclaren_2023_exp_002	maclaren_2023_exp_002_assay_006	sailfin mollie	atrazine	time with larger male (small and large male present)	NA	-0.225	0.038	5.117	1.087	0.053	4.359	1.313	0.091	3.318	-0.394	0.102	3.132	No	No
maclaren_2023	maclaren_2023_exp_001	maclaren_2023_exp_001_assay_007	sailfin mollie	atrazine	time with smaller male (intermediate and large male present)	NA	0.002	0.046	4.680	0.850	0.053	4.359	0.848	0.098	3.190	0.003	0.100	3.162	No	No
maclaren_2023	maclaren_2023_exp_002	maclaren_2023_exp_002_assay_007	sailfin mollie	atrazine	time with smaller male (intermediate and large male present)	NA	0.219	0.032	5.559	0.855	0.053	4.359	0.637	0.085	3.430	0.353	0.102	3.138	No	No
maclaren_2023	maclaren_2023_exp_001	maclaren_2023_exp_001_assay_008	sailfin mollie	atrazine	time with larger male (intermediate and large male present)	NA	-0.519	0.042	4.863	0.650	0.053	4.359	1.170	0.095	3.246	-0.953	0.111	2.997	No	No
maclaren_2023	maclaren_2023_exp_002	maclaren_2023_exp_002_assay_008	sailfin mollie	atrazine	time with larger male (intermeditate and large male present)	NA	-0.303	0.029	5.873	0.656	0.053	4.359	0.958	0.082	3.500	-0.612	0.105	3.091	No	No
maclaren_2023	maclaren_2023_exp_003	maclaren_2023_exp_003_assay_005	sailfin mollie	atrazine	mean time in mirror zone	NA	-1.155	0.011	9.709	-1.001	0.053	4.359	0.154	0.063	3.977	-2.972	0.210	2.180	Yes	Yes
maclaren_2023	maclaren_2023_exp_004	maclaren_2023_exp_004_assay_005	sailfin mollie	atrazine	mean time in mirror zone	NA	-0.711	0.011	9.709	-0.557	0.053	4.359	0.154	0.063	3.977	-2.040	0.152	2.565	Yes	Yes
oliveira_2024	oliveira_2024_exp_001	oliveira_2024_exp_001_assay_001	zebrafish	carbendazim	mean number of recordings	NA	-0.263	0.046	4.679	-0.467	0.049	4.526	-0.204	0.094	3.253	-0.351	0.095	3.253	No	No
oliveira_2024	oliveira_2024_exp_001	oliveira_2024_exp_001_assay_002	zebrafish	carbendazim	mean number of recordings	NA	-0.156	0.031	5.713	-0.040	0.048	4.577	0.116	0.078	3.572	-0.266	0.092	3.299	No	No
oliveira_2024	oliveira_2024_exp_001	oliveira_2024_exp_001_assay_003	zebrafish	carbendazim	mean number of recordings	NA	-0.464	0.019	7.263	-0.851	0.048	4.583	-0.387	0.067	3.876	-0.888	0.100	3.164	No	No
oliveira_2024	oliveira_2024_exp_001	oliveira_2024_exp_001_assay_004	zebrafish	carbendazim	mean number of recordings	NA	-0.711	0.012	9.310	-0.791	0.046	4.686	-0.080	0.057	4.185	-1.734	0.120	2.889	No	No
olsen_2020	olsen_2020_exp_001	olsen_2020_exp_001_assay_001	brown trout	iodocarb	time with females	NA	0.406	0.211	2.175	2.348	0.208	2.191	1.942	0.420	1.544	0.330	0.347	1.697	No	No
paredes_2019	paredes_2019_exp_001	paredes_2019_exp_001_assay_001	zebrafish	triadimefon	number of bites towards its reflex	NA	0.376	0.079	3.558	-0.141	0.167	2.449	-0.517	0.246	2.018	0.713	0.304	1.814	No	No
sanchez_2021	sanchez_2021_exp_001	sanchez_2021_exp_001_assay_001	killifish	roundup	duration	NA	-0.056	0.002	21.199	0.341	0.053	4.359	0.397	0.055	4.270	-0.370	0.102	3.135	No	No
sanchez_2021	sanchez_2021_exp_002	sanchez_2021_exp_002_assay_001	killifish	roundup transorb	duration	NA	-0.067	0.002	22.754	0.223	0.053	4.359	0.290	0.055	4.281	-0.478	0.103	3.118	No	No
sanchez_2021	sanchez_2021_exp_003	sanchez_2021_exp_003_assay_001	killifish	roundup WG	duration	NA	-0.173	0.003	19.502	0.341	0.053	4.359	0.514	0.055	4.254	-1.083	0.115	2.953	No	No
sanchez_2021	sanchez_2021_exp_001	sanchez_2021_exp_001_assay_002	killifish	roundup	time close to mirror	NA	0.060	0.003	18.652	-0.182	0.053	4.359	-0.242	0.056	4.245	0.348	0.102	3.139	No	No
sanchez_2021	sanchez_2021_exp_002	sanchez_2021_exp_002_assay_002	killifish	roundup transorb	time close to mirror	NA	-0.002	0.003	17.857	-0.137	0.053	4.359	-0.135	0.056	4.235	-0.012	0.100	3.162	No	No
sanchez_2021	sanchez_2021_exp_003	sanchez_2021_exp_003_assay_002	killifish	roundup WG	time close to mirror	NA	0.031	0.003	18.109	-0.137	0.053	4.359	-0.168	0.056	4.238	0.174	0.100	3.156	No	No
sanchez_2021	sanchez_2021_exp_001	sanchez_2021_exp_001_assay_003	killifish	roundup	time taken by pursuits	NA	0.238	0.197	2.254	0.106	0.053	4.359	-0.132	0.249	2.002	0.167	0.100	3.157	No	No
sanchez_2021	sanchez_2021_exp_002	sanchez_2021_exp_002_assay_003	killifish	roundup transorb	time taken by pursuits	NA	-0.789	0.174	2.399	-1.079	0.053	4.359	-0.289	0.226	2.102	-0.480	0.103	3.118	No	No
sanchez_2021	sanchez_2021_exp_003	sanchez_2021_exp_003_assay_003	killifish	roundup WG	time taken by pursuits	NA	-0.311	0.182	2.343	-0.537	0.053	4.359	-0.226	0.235	2.064	-0.214	0.101	3.153	No	No
sanchez_2021	sanchez_2021_exp_001	sanchez_2021_exp_001_assay_004	killifish	roundup	number of pursuits	NA	-0.076	0.065	3.914	0.348	0.053	4.359	0.424	0.118	2.912	-0.093	0.100	3.161	No	No
sanchez_2021	sanchez_2021_exp_002	sanchez_2021_exp_002_assay_004	killifish	roundup transorb	number of pursuits	NA	-0.716	0.101	3.151	-0.005	0.053	4.359	0.711	0.153	2.554	-0.803	0.108	3.042	No	No
sanchez_2021	sanchez_2021_exp_003	sanchez_2021_exp_003_assay_004	killifish	roundup WG	number of pursuits	NA	-0.174	0.062	4.026	0.210	0.053	4.359	0.384	0.114	2.957	-0.222	0.101	3.153	No	No
sanchez_2021	sanchez_2021_exp_001	sanchez_2021_exp_001_assay_005	killifish	roundup	attempts at copulation	NA	-0.186	0.100	3.163	-0.352	0.053	4.359	-0.166	0.153	2.560	-0.179	0.100	3.156	No	No
sanchez_2021	sanchez_2021_exp_002	sanchez_2021_exp_002_assay_005	killifish	roundup transorb	attempts at copulation	NA	-0.973	0.202	2.227	-0.521	0.053	4.359	0.451	0.254	1.983	-0.687	0.106	3.073	No	No
sanchez_2021	sanchez_2021_exp_003	sanchez_2021_exp_003_assay_005	killifish	roundup WG	attempts at copulation	NA	-0.619	0.115	2.947	-0.630	0.053	4.359	-0.010	0.168	2.441	-0.524	0.103	3.109	No	No
sanchez_2021	sanchez_2021_exp_001	sanchez_2021_exp_001_assay_006	killifish	roundup	number of actual copulations	NA	-0.006	0.146	2.621	-0.464	0.053	4.359	-0.458	0.198	2.246	-0.005	0.100	3.162	No	No
sanchez_2021	sanchez_2021_exp_002	sanchez_2021_exp_002_assay_006	killifish	roundup transorb	number of actual copulations	NA	-1.130	0.197	2.255	-1.187	0.053	4.359	-0.057	0.249	2.003	-0.623	0.105	3.088	No	No
sanchez_2021	sanchez_2021_exp_003	sanchez_2021_exp_003_assay_006	killifish	roundup WG	number of actual copulations	NA	-0.604	0.143	2.649	-1.100	0.053	4.359	-0.496	0.195	2.264	-0.414	0.102	3.129	No	No
schmidel_2014	schmidel_2014_exp_001	schmidel_2014_exp_001_assay_001	zebrafish	atrazine	distance	NA	-0.047	0.003	17.402	-1.099	0.143	2.646	-1.051	0.146	2.616	-0.382	0.255	1.982	No	No
schmidel_2014	schmidel_2014_exp_002	schmidel_2014_exp_002_assay_001	zebrafish	atrazine	distance	NA	0.229	0.012	9.077	0.799	0.143	2.646	0.570	0.155	2.540	0.919	0.276	1.902	No	No
schmidel_2014	schmidel_2014_exp_001	schmidel_2014_exp_001_assay_002	zebrafish	atrazine	nearest neighbour distance	change	0.105	0.002	20.364	-0.492	0.143	2.646	-0.388	0.145	2.624	-0.986	0.280	1.889	No	No
schmidel_2014	schmidel_2014_exp_002	schmidel_2014_exp_002_assay_002	zebrafish	atrazine	nearest neighbour distance	change	-0.181	0.012	9.279	1.080	0.143	2.646	0.899	0.154	2.544	0.743	0.267	1.934	No	No
schmidel_2014	schmidel_2014_exp_001	schmidel_2014_exp_001_assay_003	zebrafish	atrazine	farthest neighbour distance	change	0.014	0.004	16.133	-0.368	0.143	2.646	-0.354	0.147	2.611	-0.105	0.250	1.999	No	No
schmidel_2014	schmidel_2014_exp_002	schmidel_2014_exp_002_assay_003	zebrafish	atrazine	farthest neighbour distance	change	-0.252	0.012	9.245	0.885	0.143	2.646	0.633	0.155	2.544	1.019	0.282	1.882	No	No
schmidel_2014	schmidel_2014_exp_001	schmidel_2014_exp_001_assay_004	zebrafish	atrazine	shoal area	change	0.152	0.010	9.874	-0.544	0.143	2.646	-0.392	0.153	2.556	-0.686	0.265	1.944	No	No
schmidel_2014	schmidel_2014_exp_002	schmidel_2014_exp_002_assay_004	zebrafish	atrazine	shoal area	change	-0.679	0.063	3.989	1.714	0.143	2.646	1.035	0.206	2.205	0.970	0.279	1.892	No	No
schmidel_2014	schmidel_2014_exp_001	schmidel_2014_exp_001_assay_005	zebrafish	atrazine	total number of interactions	NA	0.059	0.005	13.975	-0.533	0.143	2.646	-0.592	0.148	2.600	0.399	0.255	1.980	No	No
schmidel_2014	schmidel_2014_exp_002	schmidel_2014_exp_002_assay_005	zebrafish	atrazine	total number of interactions	NA	-0.294	0.018	7.452	0.346	0.143	2.646	0.640	0.161	2.493	-1.110	0.288	1.862	No	No
shenoy_2012	shenoy_2012_exp_001	shenoy_2012_exp_001_assay_001	guppy	atrazine	number of displays in absence of competing male	NA	-0.344	0.052	4.403	0.349	0.062	4.000	0.693	0.114	2.961	-0.553	0.122	2.861	No	No
shenoy_2012	shenoy_2012_exp_002	shenoy_2012_exp_002_assay_001	guppy	atrazine	number of displays in absence of competing male	NA	-0.409	0.054	4.292	0.316	0.062	4.000	0.724	0.117	2.926	-0.652	0.124	2.841	No	No
shenoy_2012	shenoy_2012_exp_001	shenoy_2012_exp_001_assay_002	guppy	atrazine	number of mating attempts in absence of competing male	NA	0.155	0.039	5.073	0.563	0.062	4.000	0.408	0.101	3.141	0.255	0.119	2.904	No	No
shenoy_2012	shenoy_2012_exp_002	shenoy_2012_exp_002_assay_002	guppy	atrazine	number of mating attempts in absence of competing male	NA	-0.181	0.054	4.307	0.450	0.062	4.000	0.630	0.116	2.931	-0.273	0.119	2.902	No	No
silva_2005	silva_2005_exp_001	silva_2005_exp_001_assay_001	guppy	chlorpyrifos	number of gonopodial thrusts	NA	-0.397	0.001	40.799	-0.226	0.014	8.426	0.171	0.015	8.252	-2.691	0.053	4.347	No	No
silva_2005	silva_2005_exp_002	silva_2005_exp_002_assay_001	guppy	chlorpyrifos	number of gonopodial thrusts	NA	-1.023	0.001	28.946	-0.358	0.014	8.426	0.665	0.015	8.090	-5.511	0.133	2.740	No	No
stungaru_2019	stungaru_2019_exp_001	stungaru_2019_exp_001_assay_001	zebrafish	deltamethrin	percentage of time in left arm	NA	0.743	0.088	3.368	0.293	0.026	6.245	-0.450	0.114	2.964	0.583	0.052	4.380	No	No
stungaru_2019	stungaru_2019_exp_001	stungaru_2019_exp_001_assay_002	zebrafish	deltamethrin	percentage of time in left arm	NA	0.048	0.070	3.790	-0.297	0.026	6.245	-0.344	0.095	3.240	0.040	0.050	4.472	No	No
stungaru_2019	stungaru_2019_exp_001	stungaru_2019_exp_001_assay_003	zebrafish	deltamethrin	percentage of time in left arm	NA	0.904	0.085	3.427	0.672	0.026	6.245	-0.233	0.111	3.004	0.648	0.053	4.359	No	No
stungaru_2019	stungaru_2019_exp_001	stungaru_2019_exp_001_assay_004	zebrafish	deltamethrin	percentage of time in left arm	NA	0.132	0.039	5.066	-0.011	0.026	6.245	-0.143	0.065	3.934	0.149	0.050	4.466	No	No
stungaru_2019	stungaru_2019_exp_001	stungaru_2019_exp_001_assay_005	zebrafish	deltamethrin	percentage of time in left arm	NA	0.321	0.106	3.073	0.318	0.026	6.245	-0.003	0.132	2.758	0.214	0.050	4.459	No	No
stungaru_2019	stungaru_2019_exp_001	stungaru_2019_exp_001_assay_006	zebrafish	deltamethrin	percentage of time in left arm	NA	1.024	0.126	2.815	0.012	0.026	6.245	-1.013	0.152	2.566	0.832	0.054	4.290	No	No
stungaru_2019	stungaru_2019_exp_001	stungaru_2019_exp_001_assay_007	zebrafish	deltamethrin	percentage of time in left arm	NA	0.689	0.065	3.918	-0.016	0.026	6.245	-0.706	0.091	3.319	0.685	0.053	4.347	No	No
stungaru_2019	stungaru_2019_exp_001	stungaru_2019_exp_001_assay_008	zebrafish	deltamethrin	percentage of time in left arm	NA	0.789	0.100	3.156	-0.013	0.026	6.245	-0.802	0.126	2.817	0.655	0.053	4.357	No	No
stungaru_2019	stungaru_2019_exp_001	stungaru_2019_exp_001_assay_009	zebrafish	deltamethrin	percentage of time in left arm	NA	1.020	0.082	3.500	0.552	0.026	6.245	-0.468	0.107	3.053	0.809	0.054	4.300	No	No
stungaru_2019	stungaru_2019_exp_001	stungaru_2019_exp_001_assay_010	zebrafish	deltamethrin	percentage of time in left arm	NA	0.476	0.053	4.356	-0.142	0.026	6.245	-0.618	0.078	3.573	0.505	0.052	4.403	No	No
stungaru_2019	stungaru_2019_exp_001	stungaru_2019_exp_001_assay_011	zebrafish	deltamethrin	percentage of time in left arm	NA	0.581	0.065	3.927	-0.113	0.026	6.245	-0.694	0.090	3.325	0.571	0.052	4.384	No	No
stungaru_2019	stungaru_2019_exp_001	stungaru_2019_exp_001_assay_012	zebrafish	deltamethrin	percentage of time in left arm	NA	1.162	0.054	4.316	-0.198	0.026	6.245	-1.359	0.079	3.551	1.675	0.068	3.848	No	No
stungaru_2019	stungaru_2019_exp_001	stungaru_2019_exp_001_assay_013	zebrafish	deltamethrin	percentage of time in left arm	NA	0.163	0.046	4.645	-0.359	0.026	6.245	-0.523	0.072	3.727	0.174	0.050	4.464	No	No
stungaru_2019	stungaru_2019_exp_001	stungaru_2019_exp_001_assay_014	zebrafish	deltamethrin	percentage of time in left arm	NA	0.846	0.085	3.439	-0.280	0.026	6.245	-1.125	0.110	3.012	0.849	0.055	4.283	No	No
stungaru_2019	stungaru_2019_exp_001	stungaru_2019_exp_001_assay_015	zebrafish	deltamethrin	percentage of time in left arm	NA	0.163	0.031	5.685	-0.028	0.026	6.245	-0.191	0.057	4.204	0.207	0.050	4.460	No	No
stungaru_2019	stungaru_2019_exp_002	stungaru_2019_exp_002_assay_001	zebrafish	deltamethrin	percentage of time in left arm	NA	0.756	0.094	3.253	0.417	0.026	6.245	-0.339	0.120	2.885	0.550	0.052	4.390	No	No
stungaru_2019	stungaru_2019_exp_002	stungaru_2019_exp_002_assay_002	zebrafish	deltamethrin	percentage of time in left arm	NA	0.621	0.054	4.295	-0.266	0.026	6.245	-0.886	0.080	3.539	0.702	0.053	4.340	No	No
stungaru_2019	stungaru_2019_exp_002	stungaru_2019_exp_002_assay_003	zebrafish	deltamethrin	percentage of time in left arm	NA	1.355	0.065	3.918	0.653	0.026	6.245	-0.703	0.091	3.319	1.287	0.060	4.071	No	No
stungaru_2019	stungaru_2019_exp_002	stungaru_2019_exp_002_assay_004	zebrafish	deltamethrin	percentage of time in left arm	NA	0.311	0.040	5.005	0.195	0.026	6.245	-0.116	0.066	3.906	0.344	0.051	4.440	No	No
stungaru_2019	stungaru_2019_exp_002	stungaru_2019_exp_002_assay_005	zebrafish	deltamethrin	percentage of time in left arm	NA	1.210	0.063	3.970	0.392	0.026	6.245	-0.818	0.089	3.350	1.266	0.060	4.082	No	No
stungaru_2019	stungaru_2019_exp_002	stungaru_2019_exp_002_assay_006	zebrafish	deltamethrin	percentage of time in left arm	NA	1.286	0.129	2.781	0.368	0.026	6.245	-0.918	0.155	2.541	0.988	0.056	4.222	No	No
stungaru_2019	stungaru_2019_exp_002	stungaru_2019_exp_002_assay_007	zebrafish	deltamethrin	percentage of time in left arm	NA	0.911	0.069	3.808	0.337	0.026	6.245	-0.574	0.095	3.251	0.837	0.054	4.288	No	No
stungaru_2019	stungaru_2019_exp_002	stungaru_2019_exp_002_assay_008	zebrafish	deltamethrin	percentage of time in left arm	NA	1.055	0.096	3.233	0.088	0.026	6.245	-0.967	0.121	2.871	0.968	0.056	4.231	No	No
stungaru_2019	stungaru_2019_exp_002	stungaru_2019_exp_002_assay_009	zebrafish	deltamethrin	percentage of time in left arm	NA	1.354	0.077	3.610	0.766	0.026	6.245	-0.588	0.102	3.126	1.107	0.058	4.164	No	No
stungaru_2019	stungaru_2019_exp_002	stungaru_2019_exp_002_assay_010	zebrafish	deltamethrin	percentage of time in left arm	NA	0.735	0.053	4.339	0.134	0.026	6.245	-0.601	0.079	3.564	0.783	0.054	4.310	No	No
stungaru_2019	stungaru_2019_exp_002	stungaru_2019_exp_002_assay_011	zebrafish	deltamethrin	percentage of time in left arm	NA	0.922	0.069	3.807	0.367	0.026	6.245	-0.555	0.095	3.251	0.838	0.054	4.288	No	No
stungaru_2019	stungaru_2019_exp_002	stungaru_2019_exp_002_assay_012	zebrafish	deltamethrin	percentage of time in left arm	NA	1.158	0.059	4.115	0.280	0.026	6.245	-0.878	0.085	3.436	1.300	0.061	4.064	No	No
stungaru_2019	stungaru_2019_exp_002	stungaru_2019_exp_002_assay_013	zebrafish	deltamethrin	percentage of time in left arm	NA	0.511	0.041	4.936	-0.302	0.026	6.245	-0.814	0.067	3.873	0.642	0.053	4.361	No	No
stungaru_2019	stungaru_2019_exp_002	stungaru_2019_exp_002_assay_014	zebrafish	deltamethrin	percentage of time in left arm	NA	1.130	0.085	3.421	0.057	0.026	6.245	-1.073	0.111	3.000	1.152	0.058	4.142	No	No
stungaru_2019	stungaru_2019_exp_002	stungaru_2019_exp_002_assay_015	zebrafish	deltamethrin	percentage of time in left arm	NA	0.367	0.027	6.098	-0.019	0.026	6.245	-0.386	0.053	4.363	0.516	0.052	4.399	No	No
stungaru_2019	stungaru_2019_exp_003	stungaru_2019_exp_003_assay_001	zebrafish	deltamethrin	percentage of time in left arm	NA	0.419	0.075	3.644	-0.383	0.026	6.245	-0.801	0.101	3.148	0.380	0.051	4.432	No	No
stungaru_2019	stungaru_2019_exp_003	stungaru_2019_exp_003_assay_002	zebrafish	deltamethrin	percentage of time in left arm	NA	0.338	0.051	4.447	-0.858	0.026	6.245	-1.196	0.076	3.622	0.381	0.051	4.432	No	No
stungaru_2019	stungaru_2019_exp_003	stungaru_2019_exp_003_assay_003	zebrafish	deltamethrin	percentage of time in left arm	NA	0.998	0.110	3.011	1.049	0.026	6.245	0.051	0.136	2.712	0.548	0.052	4.390	No	No
stungaru_2019	stungaru_2019_exp_003	stungaru_2019_exp_003_assay_004	zebrafish	deltamethrin	percentage of time in left arm	NA	0.053	0.052	4.371	0.203	0.026	6.245	0.151	0.078	3.581	0.051	0.050	4.471	No	No
stungaru_2019	stungaru_2019_exp_003	stungaru_2019_exp_003_assay_005	zebrafish	deltamethrin	percentage of time in left arm	NA	1.057	0.077	3.615	0.648	0.026	6.245	-0.409	0.102	3.129	0.837	0.054	4.288	No	No
stungaru_2019	stungaru_2019_exp_003	stungaru_2019_exp_003_assay_006	zebrafish	deltamethrin	percentage of time in left arm	NA	0.613	0.133	2.744	-0.214	0.026	6.245	-0.827	0.158	2.512	0.437	0.051	4.420	No	No
stungaru_2019	stungaru_2019_exp_003	stungaru_2019_exp_003_assay_007	zebrafish	deltamethrin	percentage of time in left arm	NA	0.759	0.065	3.923	0.046	0.026	6.245	-0.713	0.091	3.322	0.759	0.054	4.319	No	No
stungaru_2019	stungaru_2019_exp_003	stungaru_2019_exp_003_assay_008	zebrafish	deltamethrin	percentage of time in left arm	NA	0.933	0.097	3.217	0.003	0.026	6.245	-0.930	0.122	2.860	0.834	0.054	4.290	No	No
stungaru_2019	stungaru_2019_exp_003	stungaru_2019_exp_003_assay_009	zebrafish	deltamethrin	percentage of time in left arm	NA	1.018	0.073	3.703	0.312	0.026	6.245	-0.706	0.099	3.185	0.954	0.056	4.237	No	No
stungaru_2019	stungaru_2019_exp_003	stungaru_2019_exp_003_assay_010	zebrafish	deltamethrin	percentage of time in left arm	NA	0.358	0.063	3.991	0.048	0.026	6.245	-0.310	0.088	3.363	0.326	0.051	4.443	No	No
stungaru_2019	stungaru_2019_exp_003	stungaru_2019_exp_003_assay_011	zebrafish	deltamethrin	percentage of time in left arm	NA	0.661	0.058	4.160	-0.425	0.026	6.245	-1.086	0.083	3.462	0.762	0.054	4.318	No	No
stungaru_2019	stungaru_2019_exp_003	stungaru_2019_exp_003_assay_012	zebrafish	deltamethrin	percentage of time in left arm	NA	0.527	0.067	3.878	-0.041	0.026	6.245	-0.568	0.092	3.294	0.494	0.052	4.405	No	No
stungaru_2019	stungaru_2019_exp_003	stungaru_2019_exp_003_assay_013	zebrafish	deltamethrin	percentage of time in left arm	NA	0.185	0.044	4.755	-0.435	0.026	6.245	-0.620	0.070	3.783	0.204	0.050	4.461	No	No
stungaru_2019	stungaru_2019_exp_003	stungaru_2019_exp_003_assay_014	zebrafish	deltamethrin	percentage of time in left arm	NA	0.824	0.090	3.331	-0.040	0.026	6.245	-0.864	0.116	2.939	0.738	0.053	4.327	No	No
stungaru_2019	stungaru_2019_exp_003	stungaru_2019_exp_003_assay_015	zebrafish	deltamethrin	percentage of time in left arm	NA	0.049	0.035	5.380	-0.016	0.026	6.245	-0.065	0.060	4.076	0.058	0.050	4.471	No	No
stungaru_2019	stungaru_2019_exp_004	stungaru_2019_exp_004_assay_001	zebrafish	deltamethrin	percentage of time in left arm	NA	0.597	0.104	3.098	0.391	0.026	6.245	-0.206	0.130	2.775	0.404	0.051	4.427	No	No
stungaru_2019	stungaru_2019_exp_004	stungaru_2019_exp_004_assay_002	zebrafish	deltamethrin	percentage of time in left arm	NA	-0.049	0.076	3.629	-0.273	0.026	6.245	-0.224	0.102	3.138	-0.039	0.050	4.472	No	No
stungaru_2019	stungaru_2019_exp_004	stungaru_2019_exp_004_assay_003	zebrafish	deltamethrin	percentage of time in left arm	NA	1.032	0.068	3.847	0.416	0.026	6.245	-0.616	0.093	3.275	0.963	0.056	4.233	No	No
stungaru_2019	stungaru_2019_exp_004	stungaru_2019_exp_004_assay_004	zebrafish	deltamethrin	percentage of time in left arm	NA	0.008	0.060	4.091	0.268	0.026	6.245	0.260	0.085	3.422	0.007	0.050	4.472	No	No
stungaru_2019	stungaru_2019_exp_004	stungaru_2019_exp_004_assay_005	zebrafish	deltamethrin	percentage of time in left arm	NA	0.964	0.075	3.663	0.511	0.026	6.245	-0.454	0.100	3.160	0.803	0.054	4.302	No	No
stungaru_2019	stungaru_2019_exp_004	stungaru_2019_exp_004_assay_006	zebrafish	deltamethrin	percentage of time in left arm	NA	1.105	0.127	2.804	0.124	0.026	6.245	-0.981	0.153	2.558	0.887	0.055	4.267	No	No
stungaru_2019	stungaru_2019_exp_004	stungaru_2019_exp_004_assay_007	zebrafish	deltamethrin	percentage of time in left arm	NA	0.795	0.064	3.950	0.047	0.026	6.245	-0.748	0.090	3.338	0.812	0.054	4.299	No	No
stungaru_2019	stungaru_2019_exp_004	stungaru_2019_exp_004_assay_008	zebrafish	deltamethrin	percentage of time in left arm	NA	0.891	0.094	3.254	-0.131	0.026	6.245	-1.022	0.120	2.886	0.827	0.054	4.292	No	No
stungaru_2019	stungaru_2019_exp_004	stungaru_2019_exp_004_assay_009	zebrafish	deltamethrin	percentage of time in left arm	NA	1.183	0.073	3.711	0.467	0.026	6.245	-0.716	0.098	3.190	1.100	0.058	4.168	No	No
stungaru_2019	stungaru_2019_exp_004	stungaru_2019_exp_004_assay_010	zebrafish	deltamethrin	percentage of time in left arm	NA	0.578	0.048	4.570	-0.301	0.026	6.245	-0.878	0.074	3.688	0.689	0.053	4.345	No	No
stungaru_2019	stungaru_2019_exp_004	stungaru_2019_exp_004_assay_011	zebrafish	deltamethrin	percentage of time in left arm	NA	0.424	0.079	3.557	0.100	0.026	6.245	-0.323	0.105	3.091	0.344	0.051	4.439	No	No
stungaru_2019	stungaru_2019_exp_004	stungaru_2019_exp_004_assay_012	zebrafish	deltamethrin	percentage of time in left arm	NA	0.983	0.058	4.169	0.009	0.026	6.245	-0.973	0.083	3.467	1.161	0.058	4.137	No	No
stungaru_2019	stungaru_2019_exp_004	stungaru_2019_exp_004_assay_013	zebrafish	deltamethrin	percentage of time in left arm	NA	0.229	0.047	4.601	-0.259	0.026	6.245	-0.488	0.073	3.704	0.243	0.050	4.456	No	No
stungaru_2019	stungaru_2019_exp_004	stungaru_2019_exp_004_assay_014	zebrafish	deltamethrin	percentage of time in left arm	NA	0.698	0.088	3.366	-0.239	0.026	6.245	-0.937	0.114	2.963	0.635	0.053	4.364	No	No
stungaru_2019	stungaru_2019_exp_004	stungaru_2019_exp_004_assay_015	zebrafish	deltamethrin	percentage of time in left arm	NA	0.079	0.027	6.046	-0.281	0.026	6.245	-0.360	0.053	4.344	0.107	0.050	4.469	No	No
tamagno_2023	tamagno_2023_exp_001	tamagno_2023_exp_001_assay_001	zebrafish	prallethrin	time in conspecific segment	NA	-0.235	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	Yes	Yes
tamagno_2023	tamagno_2023_exp_002	tamagno_2023_exp_002_assay_001	zebrafish	prallethrin	time in conspecific segment	NA	-0.861	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	Yes	Yes
tamagno_2023	tamagno_2023_exp_003	tamagno_2023_exp_003_assay_001	zebrafish	transfluthrin	time in conspecific segment	NA	-0.691	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	Yes	Yes
tamagno_2023	tamagno_2023_exp_004	tamagno_2023_exp_004_assay_001	zebrafish	transfluthrin	time in conspecific segment	NA	-0.475	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	Yes	Yes
tamagno_2023	tamagno_2023_exp_001	tamagno_2023_exp_001_assay_002	zebrafish	prallethrin	distance among fish in a shoal	change	-0.388	0.004	14.923	0.395	0.333	1.732	0.008	0.338	1.721	3.443	1.241	0.898	No	No
tamagno_2023	tamagno_2023_exp_002	tamagno_2023_exp_002_assay_002	zebrafish	prallethrin	distance among fish in a shoal	change	-0.393	0.004	15.372	0.339	0.333	1.732	-0.053	0.338	1.721	3.630	1.323	0.869	No	No
tamagno_2023	tamagno_2023_exp_003	tamagno_2023_exp_003_assay_002	zebrafish	transfluthrin	distance among fish in a shoal	change	-0.343	0.005	14.785	0.369	0.333	1.732	0.026	0.338	1.720	3.028	1.073	0.965	No	No
tamagno_2023	tamagno_2023_exp_004	tamagno_2023_exp_004_assay_002	zebrafish	transfluthrin	distance among fish in a shoal	change	-0.404	0.004	16.017	0.259	0.333	1.732	-0.144	0.337	1.722	3.953	1.477	0.823	No	No
teather_2001	teather_2001_exp_001	teather_2001_exp_001_assay_001	Japanese medaka	acrobat	number of approaches to female	NA	-0.399	0.057	4.173	-0.377	0.053	4.359	0.022	0.110	3.014	-0.502	0.103	3.114	No	No
teather_2001	teather_2001_exp_002	teather_2001_exp_002_assay_001	Japanese medaka	acrobat	number of approaches to female	NA	-1.095	0.047	4.608	-1.289	0.053	4.359	-0.195	0.100	3.166	-1.186	0.118	2.916	No	No
teather_2001	teather_2001_exp_003	teather_2001_exp_003_assay_001	Japanese medaka	acrobat	number of approaches to female	NA	-1.291	0.114	2.957	-0.730	0.053	4.359	0.561	0.167	2.447	-1.208	0.118	2.908	No	No
teather_2001	teather_2001_exp_004	teather_2001_exp_004_assay_001	Japanese medaka	tattoo c	number of approaches to female	NA	-0.818	0.110	3.018	-0.284	0.053	4.359	0.534	0.162	2.481	-0.825	0.109	3.036	No	No
teather_2001	teather_2001_exp_005	teather_2001_exp_005_assay_001	Japanese medaka	tattoo c	number of approaches to female	NA	-0.531	0.117	2.925	0.045	0.053	4.359	0.575	0.170	2.429	-0.526	0.103	3.109	No	No
teather_2001	teather_2001_exp_006	teather_2001_exp_006_assay_001	Japanese medaka	tattoo c	number of approaches to female	NA	-0.893	0.084	3.447	-0.547	0.053	4.359	0.346	0.137	2.704	-0.945	0.111	2.999	No	No
yan_2023	yan_2023_exp_001	yan_2023_exp_001_assay_001	zebrafish	tebuconazole	number of contacts	NA	-0.893	0.024	6.402	-0.693	0.067	3.873	0.200	0.091	3.314	-1.839	0.178	2.371	No	No
yan_2023	yan_2023_exp_001	yan_2023_exp_001_assay_002	zebrafish	tebuconazole	number of contacts	NA	-0.394	0.037	5.216	-0.603	0.067	3.873	-0.209	0.103	3.109	-0.662	0.132	2.754	No	No
yan_2023	yan_2023_exp_002	yan_2023_exp_002_assay_001	zebrafish	tebuconazole	number of contacts	NA	-0.676	0.029	5.900	-0.347	0.067	3.873	0.329	0.095	3.238	-1.397	0.156	2.536	No	No
yan_2023	yan_2023_exp_002	yan_2023_exp_002_assay_002	zebrafish	tebuconazole	number of contacts	NA	-0.178	0.041	4.933	-0.257	0.067	3.873	-0.079	0.108	3.046	-0.298	0.126	2.813	No	No
yan_2023	yan_2023_exp_003	yan_2023_exp_003_assay_001	zebrafish	tebuconazole	number of contacts	NA	-0.773	0.025	6.279	-0.541	0.067	3.873	0.232	0.092	3.296	-1.621	0.166	2.454	No	No
yan_2023	yan_2023_exp_003	yan_2023_exp_003_assay_002	zebrafish	tebuconazole	number of contacts	NA	-0.275	0.038	5.148	-0.451	0.067	3.873	-0.177	0.104	3.095	-0.469	0.128	2.790	No	No
yan_2023	yan_2023_exp_004	yan_2023_exp_004_assay_001	zebrafish	tebuconazole	number of contacts	NA	-0.156	0.033	5.529	0.814	0.067	3.873	0.970	0.099	3.172	-0.315	0.127	2.811	No	No
yan_2023	yan_2023_exp_004	yan_2023_exp_004_assay_002	zebrafish	tebuconazole	number of contacts	NA	0.183	0.043	4.803	0.514	0.067	3.873	0.331	0.110	3.015	0.293	0.126	2.813	No	No
yan_2023	yan_2023_exp_005	yan_2023_exp_005_assay_001	zebrafish	tebuconazole	number of contacts	NA	-0.732	0.017	7.610	-0.150	0.067	3.873	0.581	0.084	3.452	-2.114	0.195	2.265	No	No
yan_2023	yan_2023_exp_005	yan_2023_exp_005_assay_002	zebrafish	tebuconazole	number of contacts	NA	-0.392	0.028	5.987	-0.450	0.067	3.873	-0.057	0.095	3.252	-0.776	0.134	2.728	No	No
yan_2023	yan_2023_exp_006	yan_2023_exp_006_assay_001	zebrafish	tebuconazole	number of contacts	NA	-0.413	0.020	7.063	0.264	0.067	3.873	0.677	0.087	3.396	-1.108	0.144	2.634	No	No
yan_2023	yan_2023_exp_006	yan_2023_exp_006_assay_002	zebrafish	tebuconazole	number of contacts	NA	-0.074	0.031	5.709	-0.035	0.067	3.873	0.039	0.097	3.205	-0.145	0.125	2.825	No	No
yan_2023	yan_2023_exp_007	yan_2023_exp_007_assay_001	zebrafish	tebuconazole	number of contacts	NA	-0.607	0.019	7.236	-0.693	0.067	3.873	-0.086	0.086	3.415	-1.377	0.155	2.543	No	No
yan_2023	yan_2023_exp_007	yan_2023_exp_007_assay_002	zebrafish	tebuconazole	number of contacts	NA	-0.480	0.012	9.180	0.032	0.067	3.873	0.512	0.079	3.568	-1.632	0.167	2.450	No	No
yan_2023	yan_2023_exp_008	yan_2023_exp_008_assay_001	zebrafish	tebuconazole	number of contacts	NA	-0.120	0.013	8.869	-0.863	0.067	3.873	-0.743	0.079	3.549	-0.352	0.127	2.807	No	No
yan_2023	yan_2023_exp_008	yan_2023_exp_008_assay_002	zebrafish	tebuconazole	number of contacts	NA	0.007	0.005	13.506	-0.138	0.067	3.873	-0.145	0.072	3.723	0.034	0.125	2.828	No	No
yan_2023	yan_2023_exp_009	yan_2023_exp_009_assay_001	zebrafish	tebuconazole	number of contacts	NA	-0.468	0.013	8.608	-1.068	0.067	3.873	-0.600	0.080	3.532	-1.197	0.147	2.605	No	No
yan_2023	yan_2023_exp_009	yan_2023_exp_009_assay_002	zebrafish	tebuconazole	number of contacts	NA	-0.341	0.006	12.637	-0.343	0.067	3.873	-0.002	0.073	3.703	-1.451	0.158	2.517	No	No
yan_2023	yan_2023_exp_001	yan_2023_exp_001_assay_003	zebrafish	tebuconazole	contact time	NA	-0.820	0.015	8.181	-0.853	0.067	3.873	-0.033	0.082	3.501	-2.020	0.189	2.302	No	No
yan_2023	yan_2023_exp_001	yan_2023_exp_001_assay_004	zebrafish	tebuconazole	contact time	NA	-0.179	0.240	2.043	-1.914	0.067	3.873	-1.736	0.306	1.807	-0.116	0.125	2.826	No	No
yan_2023	yan_2023_exp_002	yan_2023_exp_002_assay_003	zebrafish	tebuconazole	contact time	NA	-0.556	0.052	4.396	0.315	0.067	3.873	0.871	0.118	2.906	-0.986	0.140	2.671	No	No
yan_2023	yan_2023_exp_002	yan_2023_exp_002_assay_004	zebrafish	tebuconazole	contact time	NA	0.086	0.276	1.902	-0.746	0.067	3.873	-0.832	0.343	1.707	0.058	0.125	2.828	No	No
yan_2023	yan_2023_exp_003	yan_2023_exp_003_assay_003	zebrafish	tebuconazole	contact time	NA	-0.446	0.138	2.693	0.967	0.067	3.873	1.412	0.205	2.211	-0.501	0.129	2.785	No	No
yan_2023	yan_2023_exp_003	yan_2023_exp_003_assay_004	zebrafish	tebuconazole	contact time	NA	0.196	0.362	1.661	-0.094	0.067	3.873	-0.290	0.429	1.526	0.114	0.125	2.826	No	No
yan_2023	yan_2023_exp_004	yan_2023_exp_004_assay_003	zebrafish	tebuconazole	contact time	NA	-0.130	0.030	5.760	0.553	0.067	3.873	0.683	0.097	3.214	-0.268	0.126	2.816	No	No
yan_2023	yan_2023_exp_004	yan_2023_exp_004_assay_004	zebrafish	tebuconazole	contact time	NA	0.077	0.041	4.926	0.245	0.067	3.873	0.167	0.108	3.045	0.131	0.125	2.825	No	No
yan_2023	yan_2023_exp_005	yan_2023_exp_005_assay_003	zebrafish	tebuconazole	contact time	NA	-0.325	0.029	5.880	0.332	0.067	3.873	0.656	0.096	3.234	-0.712	0.133	2.743	No	No
yan_2023	yan_2023_exp_005	yan_2023_exp_005_assay_004	zebrafish	tebuconazole	contact time	NA	-0.117	0.040	5.001	0.024	0.067	3.873	0.141	0.107	3.062	-0.203	0.126	2.821	No	No
yan_2023	yan_2023_exp_006	yan_2023_exp_006_assay_003	zebrafish	tebuconazole	contact time	NA	-0.211	0.047	4.599	0.741	0.067	3.873	0.952	0.114	2.962	-0.360	0.127	2.806	No	No
yan_2023	yan_2023_exp_006	yan_2023_exp_006_assay_004	zebrafish	tebuconazole	contact time	NA	-0.003	0.058	4.140	0.433	0.067	3.873	0.436	0.125	2.828	-0.005	0.125	2.828	No	No
yan_2023	yan_2023_exp_007	yan_2023_exp_007_assay_003	zebrafish	tebuconazole	contact time	NA	-0.384	0.016	7.936	-1.402	0.067	3.873	-1.018	0.083	3.481	-0.901	0.138	2.695	No	No
yan_2023	yan_2023_exp_007	yan_2023_exp_007_assay_004	zebrafish	tebuconazole	contact time	NA	-0.135	0.005	14.541	-0.363	0.067	3.873	-0.228	0.071	3.743	-0.664	0.132	2.754	No	No
yan_2023	yan_2023_exp_008	yan_2023_exp_008_assay_003	zebrafish	tebuconazole	contact time	NA	-0.639	0.023	6.631	-0.879	0.067	3.873	-0.240	0.089	3.344	-1.268	0.150	2.581	No	No
yan_2023	yan_2023_exp_008	yan_2023_exp_008_assay_004	zebrafish	tebuconazole	contact time	NA	-0.390	0.012	9.288	0.160	0.067	3.873	0.550	0.078	3.575	-1.341	0.153	2.556	No	No
yan_2023	yan_2023_exp_009	yan_2023_exp_009_assay_003	zebrafish	tebuconazole	contact time	NA	-0.406	0.019	7.309	-0.956	0.067	3.873	-0.550	0.085	3.422	-0.906	0.138	2.694	No	No
yan_2023	yan_2023_exp_009	yan_2023_exp_009_assay_004	zebrafish	tebuconazole	contact time	NA	-0.157	0.008	11.491	0.083	0.067	3.873	0.240	0.074	3.670	-0.629	0.131	2.761	No	No
yang_2023	yang_2023_exp_001	yang_2023_exp_001_assay_001	zebrafish	thiamethoxam	shoaling average speed	NA	-0.019	0.002	20.694	0.000	0.043	4.796	0.019	0.046	4.672	-0.110	0.083	3.461	No	No
yang_2023	yang_2023_exp_002	yang_2023_exp_002_assay_001	zebrafish	thiamethoxam	shoaling average speed	NA	0.054	0.002	23.701	-0.241	0.043	4.796	-0.295	0.045	4.701	0.368	0.085	3.435	No	No
yang_2023	yang_2023_exp_003	yang_2023_exp_003_assay_001	zebrafish	thiamethoxam	shoaling average speed	NA	0.133	0.002	23.024	-0.085	0.043	4.796	-0.218	0.045	4.695	0.878	0.091	3.308	No	No
yang_2023	yang_2023_exp_001	yang_2023_exp_001_assay_002	zebrafish	thiamethoxam	average fish distance	change	0.107	0.001	29.846	-0.334	0.043	4.796	-0.227	0.045	4.735	-0.894	0.092	3.303	No	No
yang_2023	yang_2023_exp_002	yang_2023_exp_002_assay_002	zebrafish	thiamethoxam	average fish distance	change	0.072	0.001	29.470	-0.267	0.043	4.796	-0.195	0.045	4.734	-0.600	0.087	3.389	No	No
yang_2023	yang_2023_exp_003	yang_2023_exp_003_assay_002	zebrafish	thiamethoxam	average fish distance	change	0.265	0.003	19.572	0.250	0.043	4.796	0.515	0.046	4.658	-1.551	0.108	3.037	No	No
yang_2023	yang_2023_exp_001	yang_2023_exp_001_assay_003	zebrafish	thiamethoxam	maximum inter-fish difference	change	0.033	0.000	85.677	-0.014	0.043	4.796	0.019	0.044	4.788	-0.800	0.090	3.333	No	No
yang_2023	yang_2023_exp_002	yang_2023_exp_002_assay_003	zebrafish	thiamethoxam	maximum inter-fish difference	change	0.006	0.000	90.524	-0.101	0.043	4.796	-0.095	0.044	4.789	-0.141	0.084	3.460	No	No
yang_2023	yang_2023_exp_003	yang_2023_exp_003_assay_003	zebrafish	thiamethoxam	maximum inter-fish difference	change	0.040	0.000	58.776	0.562	0.043	4.796	0.602	0.044	4.780	-0.680	0.088	3.368	No	No
yang_2023	yang_2023_exp_001	yang_2023_exp_001_assay_004	zebrafish	thiamethoxam	time spent in social zone	NA	0.104	0.003	17.368	-0.140	0.059	4.123	-0.244	0.062	4.012	0.596	0.116	2.936	No	No
yang_2023	yang_2023_exp_002	yang_2023_exp_002_assay_004	zebrafish	thiamethoxam	time spent in social zone	NA	0.335	0.003	18.422	-0.081	0.059	4.123	-0.417	0.062	4.024	2.107	0.173	2.406	No	No
yang_2023	yang_2023_exp_003	yang_2023_exp_003_assay_004	zebrafish	thiamethoxam	time spent in social zone	NA	0.025	0.004	15.514	0.037	0.059	4.123	0.011	0.063	3.985	0.128	0.111	2.997	No	No
yang_2023	yang_2023_exp_001	yang_2023_exp_001_assay_005	zebrafish	thiamethoxam	time spent in social zone with familiar fish	NA	-0.109	0.006	13.076	-0.375	0.059	4.123	-0.266	0.065	3.932	-0.456	0.114	2.962	No	No
yang_2023	yang_2023_exp_002	yang_2023_exp_002_assay_005	zebrafish	thiamethoxam	time spent in social zone with familiar fish	NA	0.245	0.007	11.823	0.215	0.059	4.123	-0.030	0.066	3.893	0.936	0.123	2.848	No	No
yang_2023	yang_2023_exp_003	yang_2023_exp_003_assay_005	zebrafish	thiamethoxam	time spent in social zone with familiar fish	NA	0.312	0.006	13.372	-0.017	0.059	4.123	-0.329	0.064	3.940	1.402	0.138	2.688	No	No
yang_2023	yang_2023_exp_001	yang_2023_exp_001_assay_006	zebrafish	thiamethoxam	distance to familiar fish	change	-0.022	0.005	14.507	0.074	0.059	4.123	0.052	0.064	3.966	0.103	0.111	2.998	No	No
yang_2023	yang_2023_exp_002	yang_2023_exp_002_assay_006	zebrafish	thiamethoxam	distance to familiar fish	change	0.330	0.008	11.145	0.143	0.059	4.123	0.473	0.067	3.867	-1.264	0.133	2.739	No	No
yang_2023	yang_2023_exp_003	yang_2023_exp_003_assay_006	zebrafish	thiamethoxam	distance to familiar fish	change	0.508	0.009	10.360	0.064	0.059	4.123	0.572	0.068	3.831	-1.871	0.160	2.502	No	No
yang_2023	yang_2023_exp_001	yang_2023_exp_001_assay_007	zebrafish	thiamethoxam	number of transition to the attack zone	NA	0.076	0.011	9.591	-0.105	0.043	4.796	-0.181	0.054	4.289	0.207	0.084	3.455	No	No
yang_2023	yang_2023_exp_002	yang_2023_exp_002_assay_007	zebrafish	thiamethoxam	number of transition to the attack zone	NA	0.000	0.012	9.286	-0.105	0.043	4.796	-0.105	0.055	4.261	0.000	0.083	3.464	No	No
yang_2023	yang_2023_exp_003	yang_2023_exp_003_assay_007	zebrafish	thiamethoxam	number of transition to the attack zone	NA	0.317	0.013	8.746	0.336	0.043	4.796	0.020	0.057	4.205	0.768	0.089	3.343	No	No
yang_2023	yang_2023_exp_001	yang_2023_exp_001_assay_008	zebrafish	thiamethoxam	biting time	NA	-0.184	0.032	5.621	-0.479	0.043	4.796	-0.296	0.075	3.648	-0.284	0.084	3.447	No	No
yang_2023	yang_2023_exp_002	yang_2023_exp_002_assay_008	zebrafish	thiamethoxam	biting time	NA	-0.237	0.042	4.890	-0.211	0.043	4.796	0.026	0.085	3.424	-0.326	0.084	3.441	No	No
yang_2023	yang_2023_exp_003	yang_2023_exp_003_assay_008	zebrafish	thiamethoxam	biting time	NA	0.397	0.042	4.887	0.424	0.043	4.796	0.027	0.085	3.423	0.532	0.086	3.405	No	No
zaluski_2022	zaluski_2022_exp_001	zaluski_2022_exp_001_assay_001	zebrafish	atrazine	time in stimulus zone close to mirror	NA	0.188	0.010	9.996	-0.106	0.059	4.123	-0.294	0.069	3.812	0.623	0.117	2.930	No	No
zaluski_2022	zaluski_2022_exp_002	zaluski_2022_exp_002_assay_001	zebrafish	atrazine	time in stimulus zone close to mirror	NA	0.180	0.010	9.907	-0.089	0.059	4.123	-0.269	0.069	3.807	0.591	0.116	2.937	No	No
zaluski_2022	zaluski_2022_exp_003	zaluski_2022_exp_003_assay_001	zebrafish	atrazine	time in stimulus zone close to mirror	NA	0.195	0.009	10.282	-0.182	0.059	4.123	-0.377	0.068	3.827	0.671	0.117	2.919	No	No
zaluski_2022	zaluski_2022_exp_004	zaluski_2022_exp_004_assay_001	zebrafish	atrazine	time in stimulus zone close to mirror	NA	0.169	0.011	9.343	0.046	0.059	4.123	-0.124	0.070	3.772	0.518	0.115	2.951	No	No
zaluski_2022	zaluski_2022_exp_005	zaluski_2022_exp_005_assay_001	zebrafish	atrazine	time in stimulus zone close to mirror	NA	0.091	0.013	8.736	0.109	0.059	4.123	0.018	0.072	3.729	0.258	0.112	2.988	No	No
zaluski_2022	zaluski_2022_exp_001	zaluski_2022_exp_001_assay_002	zebrafish	atrazine	number of bites	NA	0.059	0.010	10.045	-0.272	0.059	4.123	-0.331	0.069	3.814	0.194	0.112	2.993	No	No
zaluski_2022	zaluski_2022_exp_002	zaluski_2022_exp_002_assay_002	zebrafish	atrazine	number of bites	NA	0.071	0.010	9.797	-0.190	0.059	4.123	-0.261	0.069	3.800	0.229	0.112	2.990	No	No
zaluski_2022	zaluski_2022_exp_003	zaluski_2022_exp_003_assay_002	zebrafish	atrazine	number of bites	NA	0.063	0.008	11.173	-0.682	0.059	4.123	-0.745	0.067	3.868	0.234	0.112	2.990	No	No
zaluski_2022	zaluski_2022_exp_004	zaluski_2022_exp_004_assay_002	zebrafish	atrazine	number of bites	NA	0.127	0.008	11.066	-0.568	0.059	4.123	-0.695	0.067	3.864	0.476	0.114	2.958	No	No
zaluski_2022	zaluski_2022_exp_005	zaluski_2022_exp_005_assay_002	zebrafish	atrazine	number of bites	NA	0.084	0.009	10.446	-0.372	0.059	4.123	-0.456	0.068	3.835	0.290	0.112	2.984	No	No
zaluski_2022	zaluski_2022_exp_001	zaluski_2022_exp_001_assay_003	zebrafish	atrazine	time in stimulus zone close to mirror	NA	-0.071	0.063	3.990	-0.023	0.059	4.123	0.048	0.122	2.867	-0.092	0.111	2.998	No	No
zaluski_2022	zaluski_2022_exp_002	zaluski_2022_exp_002_assay_003	zebrafish	atrazine	time in stimulus zone close to mirror	NA	-0.250	0.049	4.506	-0.467	0.059	4.123	-0.217	0.108	3.042	-0.353	0.113	2.977	No	No
zaluski_2022	zaluski_2022_exp_003	zaluski_2022_exp_003_assay_003	zebrafish	atrazine	time in stimulus zone close to mirror	NA	-0.224	0.061	4.054	-0.207	0.059	4.123	0.017	0.120	2.891	-0.293	0.112	2.984	No	No
zaluski_2022	zaluski_2022_exp_004	zaluski_2022_exp_004_assay_003	zebrafish	atrazine	time in stimulus zone close to mirror	NA	-0.221	0.041	4.926	-0.707	0.059	4.123	-0.486	0.100	3.162	-0.335	0.113	2.979	No	No
zaluski_2022	zaluski_2022_exp_005	zaluski_2022_exp_005_assay_003	zebrafish	atrazine	time in stimulus zone close to mirror	NA	-0.610	0.063	3.979	-0.556	0.059	4.123	0.053	0.122	2.863	-0.746	0.119	2.901	No	No
zaluski_2022	zaluski_2022_exp_001	zaluski_2022_exp_001_assay_004	zebrafish	diuron	time in stimulus zone close to mirror	NA	0.182	0.084	3.451	0.038	0.059	4.123	-0.143	0.143	2.647	0.205	0.112	2.992	No	No
zaluski_2022	zaluski_2022_exp_002	zaluski_2022_exp_002_assay_004	zebrafish	diuron	time in stimulus zone close to mirror	NA	0.167	0.088	3.374	0.075	0.059	4.123	-0.092	0.147	2.611	0.184	0.112	2.994	No	No
zaluski_2022	zaluski_2022_exp_003	zaluski_2022_exp_003_assay_004	zebrafish	diuron	time in stimulus zone close to mirror	NA	0.200	0.074	3.682	-0.110	0.059	4.123	-0.310	0.133	2.747	0.246	0.112	2.989	No	No
zaluski_2022	zaluski_2022_exp_004	zaluski_2022_exp_004_assay_004	zebrafish	diuron	time in stimulus zone close to mirror	NA	0.578	0.066	3.898	0.084	0.059	4.123	-0.494	0.125	2.833	0.788	0.120	2.890	No	No
zaluski_2022	zaluski_2022_exp_005	zaluski_2022_exp_005_assay_004	zebrafish	diuron	time in stimulus zone close to mirror	NA	0.450	0.077	3.601	0.201	0.059	4.123	-0.248	0.136	2.712	0.535	0.115	2.948	No	No
zaluski_2022	zaluski_2022_exp_001	zaluski_2022_exp_001_assay_005	zebrafish	diuron	number of bites	NA	0.311	0.254	1.985	0.171	0.059	4.123	-0.140	0.313	1.789	0.201	0.112	2.992	No	No
zaluski_2022	zaluski_2022_exp_002	zaluski_2022_exp_002_assay_005	zebrafish	diuron	number of bites	NA	0.381	0.303	1.816	0.428	0.059	4.123	0.047	0.362	1.662	0.217	0.112	2.991	No	No
zaluski_2022	zaluski_2022_exp_003	zaluski_2022_exp_003_assay_005	zebrafish	diuron	number of bites	NA	0.713	0.220	2.130	0.392	0.059	4.123	-0.322	0.279	1.893	0.500	0.115	2.954	No	No
zaluski_2022	zaluski_2022_exp_004	zaluski_2022_exp_004_assay_005	zebrafish	diuron	number of bites	NA	0.611	0.240	2.040	0.406	0.059	4.123	-0.205	0.299	1.829	0.401	0.113	2.970	No	No
zaluski_2022	zaluski_2022_exp_005	zaluski_2022_exp_005_assay_005	zebrafish	diuron	number of bites	NA	0.307	0.237	2.056	0.082	0.059	4.123	-0.225	0.295	1.840	0.209	0.112	2.992	No	No
zaluski_2022	zaluski_2022_exp_001	zaluski_2022_exp_001_assay_006	zebrafish	diuron	time in stimulus zone close to mirror	NA	-0.384	0.589	1.303	0.455	0.059	4.123	0.838	0.648	1.242	-0.183	0.112	2.994	No	No
zaluski_2022	zaluski_2022_exp_002	zaluski_2022_exp_002_assay_006	zebrafish	diuron	time in stimulus zone close to mirror	NA	0.497	0.251	1.998	0.762	0.059	4.123	0.265	0.309	1.798	0.291	0.112	2.984	No	No
zaluski_2022	zaluski_2022_exp_003	zaluski_2022_exp_003_assay_006	zebrafish	diuron	time in stimulus zone close to mirror	NA	0.444	0.205	2.207	0.540	0.059	4.123	0.096	0.264	1.945	0.301	0.112	2.983	No	No
zaluski_2022	zaluski_2022_exp_004	zaluski_2022_exp_004_assay_006	zebrafish	diuron	time in stimulus zone close to mirror	NA	0.445	0.205	2.207	0.541	0.059	4.123	0.096	0.264	1.945	0.301	0.112	2.983	No	No
zaluski_2022	zaluski_2022_exp_005	zaluski_2022_exp_005_assay_006	zebrafish	diuron	time in stimulus zone close to mirror	NA	-2.146	0.746	1.158	-1.171	0.059	4.123	0.975	0.805	1.115	-0.902	0.122	2.858	No	No
zhou_2021	zhou_2021_exp_001	zhou_2021_exp_001_assay_001	marine medaka	diuron	time spent on the side closest to the mirror	NA	-0.148	0.029	5.832	-0.757	0.048	4.583	-0.609	0.077	3.603	-0.245	0.092	3.304	No	No
zhou_2021	zhou_2021_exp_002	zhou_2021_exp_002_assay_001	marine medaka	diuron	time spent on the side closest to the mirror	NA	-0.302	0.039	5.056	-0.463	0.048	4.583	-0.161	0.087	3.395	-0.433	0.093	3.278	No	No
zhou_2021	zhou_2021_exp_003	zhou_2021_exp_003_assay_001	marine medaka	diuron	time spent on the side closest to the mirror	NA	-0.450	0.025	6.376	-1.686	0.048	4.583	-1.236	0.072	3.721	-0.701	0.096	3.219	No	No
zhou_2021	zhou_2021_exp_004	zhou_2021_exp_004_assay_001	marine medaka	diuron	time spent on the side closest to the mirror	NA	-0.152	0.034	5.391	-0.482	0.048	4.583	-0.330	0.082	3.492	-0.236	0.092	3.305	No	No
zhou_2021	zhou_2021_exp_001	zhou_2021_exp_001_assay_002	marine medaka	diuron	mirror biting frequency	NA	0.116	0.023	6.551	0.234	0.048	4.583	0.118	0.071	3.755	0.222	0.091	3.306	No	No
zhou_2021	zhou_2021_exp_002	zhou_2021_exp_002_assay_002	marine medaka	diuron	mirror biting frequency	NA	-0.119	0.023	6.548	0.000	0.048	4.583	0.119	0.071	3.754	-0.231	0.092	3.306	No	No
zhou_2021	zhou_2021_exp_003	zhou_2021_exp_003_assay_002	marine medaka	diuron	mirror biting frequency	NA	-0.189	0.016	8.000	-0.517	0.048	4.583	-0.327	0.063	3.976	-0.433	0.093	3.278	No	No
zhou_2021	zhou_2021_exp_004	zhou_2021_exp_004_assay_002	marine medaka	diuron	mirror biting frequency	NA	0.040	0.013	8.800	-0.642	0.048	4.583	-0.682	0.061	4.065	0.106	0.091	3.314	No	No
zhou_2021	zhou_2021_exp_001	zhou_2021_exp_001_assay_003	marine medaka	diuron	cluster score	NA	0.183	0.161	2.490	0.369	0.200	2.236	0.186	0.361	1.664	0.237	0.336	1.726	No	No
zhou_2021	zhou_2021_exp_002	zhou_2021_exp_002_assay_003	marine medaka	diuron	cluster score	NA	-0.069	0.075	3.647	-1.046	0.200	2.236	-0.977	0.275	1.906	-0.131	0.334	1.730	No	No
zhou_2021	zhou_2021_exp_003	zhou_2021_exp_003_assay_003	marine medaka	diuron	cluster score	NA	-0.290	0.128	2.790	-0.315	0.200	2.236	-0.025	0.328	1.745	-0.422	0.341	1.713	No	No
zhou_2021	zhou_2021_exp_004	zhou_2021_exp_004_assay_003	marine medaka	diuron	cluster score	NA	-0.532	0.140	2.676	-0.475	0.200	2.236	0.057	0.340	1.716	-0.728	0.355	1.677	No	No
zhou_2021	zhou_2021_exp_001	zhou_2021_exp_001_assay_004	marine medaka	diuron	time spent on the side closest to the seperator	NA	-0.043	0.016	7.849	-0.056	0.053	4.359	-0.013	0.069	3.811	-0.103	0.100	3.160	No	No
zhou_2021	zhou_2021_exp_002	zhou_2021_exp_002_assay_004	marine medaka	diuron	time spent on the side closest to the seperator	NA	-0.149	0.016	8.031	-0.210	0.053	4.359	-0.061	0.068	3.831	-0.368	0.102	3.136	No	No
zhou_2021	zhou_2021_exp_003	zhou_2021_exp_003_assay_004	marine medaka	diuron	time spent on the side closest to the seperator	NA	-0.297	0.019	7.250	-0.161	0.053	4.359	0.137	0.072	3.736	-0.670	0.106	3.077	No	No
zhou_2021	zhou_2021_exp_004	zhou_2021_exp_004_assay_004	marine medaka	diuron	time spent on the side closest to the seperator	NA	-0.015	0.022	6.715	0.250	0.053	4.359	0.265	0.075	3.656	-0.031	0.100	3.162	No	No
zhou_2021	zhou_2021_exp_001	zhou_2021_exp_001_assay_005	marine medaka	diuron	interaction frequency	NA	0.312	0.007	12.196	0.784	0.053	4.359	0.473	0.059	4.105	1.085	0.115	2.953	No	No
zhou_2021	zhou_2021_exp_002	zhou_2021_exp_002_assay_005	marine medaka	diuron	interaction frequency	NA	0.349	0.008	11.287	0.926	0.053	4.359	0.577	0.060	4.066	1.098	0.115	2.948	No	No
zhou_2021	zhou_2021_exp_003	zhou_2021_exp_003_assay_005	marine medaka	diuron	interaction frequency	NA	0.153	0.007	11.814	0.669	0.053	4.359	0.516	0.060	4.089	0.538	0.104	3.107	No	No
zhou_2021	zhou_2021_exp_004	zhou_2021_exp_004_assay_005	marine medaka	diuron	interaction frequency	NA	0.062	0.008	11.460	0.619	0.053	4.359	0.557	0.060	4.074	0.217	0.101	3.153	No	No

# Plot the distribution of effect size estimates (lnRR)
lnRR_dist_plot <- effect_size_metrics_set_kable %>%
    ggplot(aes(lnRR)) + geom_histogram(fill = RColorBrewer::brewer.pal(n = 8, name = "Set2")[2],
    col = "black", binwidth = 0.1, alpha = 0.4) + theme_bw() + theme(legend.position = "none",
    plot.title = element_text(face = "bold", hjust = 0.5), axis.title.x = element_text(face = "bold"),
    axis.title.y = element_text(face = "bold"), axis.text.x = element_text(color = "black"),
    axis.text.y = element_text(color = "black"), axis.ticks = element_line(color = "black"),
    plot.caption = element_text(size = 10, color = "gray10", face = "italic")) +
    labs(caption = "Distribution of Effect Size Estimates (lnRR)", x = "lnRR", y = "Frequency")

print(lnRR_dist_plot)

# ggsave(here('figures', 'lnRR_dist_plot.pdf'), plot = lnRR_dist_plot, width =
# 10, height = 5, units = 'cm', scale = 2, dpi = 800) ggsave(here('figures',
# 'lnRR_dist_plot.jpg'), plot = lnRR_dist_plot, width = 10, height = 5, units =
# 'cm', scale = 2, dpi = 800)

# Plot the distribution of effect size estimates (lnVR)
lnVR_dist_plot <- effect_size_metrics_set_kable %>%
    ggplot(aes(lnCVR)) + geom_histogram(fill = RColorBrewer::brewer.pal(n = 8, name = "Set2")[3],
    col = "black", binwidth = 0.1, alpha = 0.4) + theme_bw() + theme(legend.position = "none",
    plot.title = element_text(face = "bold", hjust = 0.5), axis.title.x = element_text(face = "bold"),
    axis.title.y = element_text(face = "bold"), axis.text.x = element_text(color = "black"),
    axis.text.y = element_text(color = "black"), axis.ticks = element_line(color = "black"),
    plot.caption = element_text(size = 10, color = "gray10", face = "italic")) +
    labs(caption = "Distribution of Effect Size Estimates (lnVR)", x = "lnVR", y = "Frequency")

print(lnVR_dist_plot)

# ggsave(here('figures', 'lnVR_dist_plot.pdf'), plot = lnVR_dist_plot, width =
# 10, height = 5, units = 'cm', scale = 2, dpi = 800) ggsave(here('figures',
# 'lnVR_dist_plot.jpg'), plot = lnVR_dist_plot, width = 10, height = 5, units =
# 'cm', scale = 2, dpi = 800)

Dependent effect size estimates

Create phylogentic tree

We used the rotl package (https://peerj.com/preprints/1471/) to retrieve synthetic species tree from Open Tree of Life (https://opentreeoflife.org/).

data <- as.data.frame(data)

data$species_latin = as.factor(data$species_latin)

taxa <- tnrs_match_names(names = levels(data$species_latin), context = "Animals")  # Match species names to the Open Tree of Life taxonomy

kable(taxa)  # Display matched species, ensuring each species has a unique match in the Open Tree of Life

search_string	unique_name	approximate_match	score	ott_id	is_synonym	flags	number_matches
alburnus alburnus	Alburnus alburnus	FALSE	1	957577	FALSE		1
danio rerio	Danio rerio	FALSE	1	1005914	FALSE		1
jenynsia multidentata	Jenynsia multidentata	FALSE	1	834785	FALSE		1
luciobarbus bocagei	Luciobarbus bocagei	FALSE	1	134749	FALSE		1
oreochromis niloticus	Oreochromis niloticus	FALSE	1	288063	FALSE	sibling_higher	1
oryzias latipes	Oryzias latipes	FALSE	1	942673	FALSE		1
oryzias melastigma	Oryzias melastigma	FALSE	1	179491	FALSE		2
poecilia latipinna	Poecilia latipinna	FALSE	1	998174	FALSE		1
poecilia reticulata	Poecilia reticulata	FALSE	1	312452	FALSE		1
salmo trutta	Salmo trutta	FALSE	1	688332	FALSE		1

taxa$unique_name <- gsub(" ", "_", taxa$unique_name)  # Replace spaces in species names with underscores

phylo_tree <- tol_induced_subtree(ott_ids = taxa$ott_id, label_format = "name")  # Generate a phylogenetic tree based on the Open Tree of Life taxonomy

ott_in_tree <- ott_id(taxa)[is_in_tree(ott_id(taxa))]  # Ensure all identifiers are present in the taxonomy

phylo_tree <- tol_induced_subtree(ott_ids = ott_in_tree)  # Generate a phylogenetic tree including all species present in the taxonomy

is.binary(phylo_tree)  # Check if tree is binary 

## [1] TRUE

# Plot for the phylogenetic tree
plot(phylo_tree,
     cex= 1, #font size
     label.offset =.1,
     no.margin = TRUE)

# Compute branch length
phylo_branched <- compute.brlen(phylo_tree, method = "Grafen", power = 1)  # compute branch lengths using Grafen's method

phylo_branched$tip.label <- strip_ott_ids(phylo_branched$tip.label, remove_underscores = FALSE)  # remove ott ID from species name to match it to the data set

phylo_matrix <- vcv(phylo_branched, cor = T)  # Generate variance covariance matrix to correlate species relatedness 

data <- as.data.frame(data)

# Convert species_latin to lowercase
data <- mutate(data, search_string = tolower(species_latin))

data <- left_join(data, select(taxa, search_string, unique_name, ott_id), by = "search_string")  # Join data sets

data <- data[data$unique_name %in% phylo_branched$tip.label, ]  # Check that species names are well matched with the phylogenetic tree


data$phylogeny <- data$unique_name  # Rename 'unique_name' to 'phylogeny' for the models

Variance covariance matrices

To account for the dependency of effect sizes estimates due to being in the same exposure group (cohort) we constructed a series of vcv matrices.

#------------------------------lnRR------------------------------#
data <- data[!is.na(data$lnRRv), ]

lnRRVCV <- metafor::vcalc(vi = lnRRv, cluster = exp_id, obs = assay_id, data = data,
    rho = 0.5)

lnRRVCV2 <- metafor::vcalc(vi = lnRRv, cluster = exp2_id, obs = assay_id, data = data,
    rho = 0.5)

#------------------------------lnVR------------------------------#
data <- data[!is.na(data$lnVRv), ]

lnVRVCV <- metafor::vcalc(vi = lnVRv, cluster = exp_id, obs = assay_id, data = data,
    rho = 0.5)

lnVRVCV2 <- metafor::vcalc(vi = lnVRv, cluster = exp2_id, obs = assay2_id, data = data,
    rho = 0.5)

Selection of random-effect structure

Select the “most appropriate” structure for the subsequent statistical modelling.

The potential random effect were:

• 1. Observation (assay_id) - A unique id for each pairwise comparison for effect size calculation
• 2. Cohort (exp_id) - A unique id for each exposure group in each primary study
• 3. Study (study_id) - A unique id for each included primary study
• 4. Pesticide (pesticide) - Each pesticide used in the primary study
• 5. Species (species) - Each species used in the primary study
• 6. Phylogeny (phylogeny) - The phylogenetic relatedness for each species in the primary studies

We start from fitting a null model without including the above random effects candidates as the default reduced model, and build upon more complex models by adding random-effects a candidate one time. We use the likelihood ratio test to compare the quality of two nested models in terms of information criteria indices (AIC, BIC, AICc).

Null model with no random effects (lnRR)

# fit a null model as default model
null_mod_lnRR <- rma.mv(yi = lnRR, V = lnRRVCV, method = "ML", test = "t", data = data,
    sparse = TRUE)  # Use ML to compare information criteria

summary(null_mod_lnRR)

## 
## Multivariate Meta-Analysis Model (k = 448; method: ML)
## 
##     logLik    Deviance         AIC         BIC        AICc   
## -2076.4225   5125.7373   4154.8450   4158.9498   4154.8539   
## 
## Variance Components: none
## 
## Test for Heterogeneity:
## Q(df = 447) = 5125.7373, p-val < .0001
## 
## Model Results:
## 
## estimate      se     tval   df    pval    ci.lb    ci.ub      
##  -0.0306  0.0035  -8.7653  447  <.0001  -0.0375  -0.0238  *** 
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

Add assay_id as a random effect and compare with the null model (lnRR)

mod_lnRR.assay_id <- rma.mv(yi = lnRR, V = lnRRVCV, random = ~1 | assay_id, method = "ML",
    test = "t", data = data, sparse = T)

summary(mod_lnRR.assay_id)

## 
## Multivariate Meta-Analysis Model (k = 448; method: ML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -218.8077  1410.5078   441.6154   449.8250   441.6424   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed    factor 
## sigma^2    0.0847  0.2910    448     no  assay_id 
## 
## Test for Heterogeneity:
## Q(df = 447) = 5125.7373, p-val < .0001
## 
## Model Results:
## 
## estimate      se     tval   df    pval    ci.lb    ci.ub      
##  -0.1010  0.0196  -5.1398  447  <.0001  -0.1396  -0.0624  *** 
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

anova(null_mod_lnRR, mod_lnRR.assay_id)

## 
##         df       AIC       BIC      AICc     logLik       LRT   pval        QE 
## Full     2  441.6154  449.8250  441.6424  -218.8077                  5125.7373 
## Reduced  1 4154.8450 4158.9498 4154.8539 -2076.4225 3715.2295 <.0001 5125.7373

Add study_id as a random effect to the above better model (that used obs_ID a random effect) (lnRR)

mod_lnRR.assay_id.study_id <- rma.mv(yi = lnRR, V = lnRRVCV, random = list(~1 | study_id,
    ~1 | assay_id), method = "ML", test = "t", data = data, sparse = T)

summary(mod_lnRR.assay_id.study_id)

## 
## Multivariate Meta-Analysis Model (k = 448; method: ML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -174.0307  1320.9537   354.0614   366.3757   354.1154   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed    factor 
## sigma^2.1  0.0647  0.2543     37     no  study_id 
## sigma^2.2  0.0599  0.2448    448     no  assay_id 
## 
## Test for Heterogeneity:
## Q(df = 447) = 5125.7373, p-val < .0001
## 
## Model Results:
## 
## estimate      se     tval   df    pval    ci.lb    ci.ub    
##  -0.1189  0.0485  -2.4535  447  0.0145  -0.2142  -0.0237  * 
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

anova(mod_lnRR.assay_id, mod_lnRR.assay_id.study_id)

## 
##         df      AIC      BIC     AICc    logLik     LRT   pval        QE 
## Full     3 354.0614 366.3757 354.1154 -174.0307                5125.7373 
## Reduced  2 441.6154 449.8250 441.6424 -218.8077 89.5541 <.0001 5125.7373

Add exp_id as a random effect to the above model (that used assay_id and study_id as random effets) (lnRR)

mod_lnRR.assay_id.study_id.exp_id <- rma.mv(yi = lnRR, V = lnRRVCV, random = list(~1 |
    study_id, ~1 | exp_id, ~1 | assay_id), method = "ML", test = "t", data = data,
    sparse = T)

summary(mod_lnRR.assay_id.study_id.exp_id)

## 
## Multivariate Meta-Analysis Model (k = 448; method: ML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -174.0307  1320.9537   356.0614   372.4805   356.1516   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed    factor 
## sigma^2.1  0.0647  0.2543     37     no  study_id 
## sigma^2.2  0.0000  0.0000    111     no    exp_id 
## sigma^2.3  0.0599  0.2448    448     no  assay_id 
## 
## Test for Heterogeneity:
## Q(df = 447) = 5125.7373, p-val < .0001
## 
## Model Results:
## 
## estimate      se     tval   df    pval    ci.lb    ci.ub    
##  -0.1189  0.0485  -2.4535  447  0.0145  -0.2142  -0.0237  * 
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

anova(mod_lnRR.assay_id.study_id, mod_lnRR.assay_id.study_id.exp_id)

## 
##         df      AIC      BIC     AICc    logLik    LRT   pval        QE 
## Full     4 356.0614 372.4805 356.1516 -174.0307               5125.7373 
## Reduced  3 354.0614 366.3757 354.1154 -174.0307 0.0000 1.0000 5125.7373

Add species as a random effect to the better model (that used assay_id and study_id as random effets) (lnRR)

mod_lnRR.assay_id.study_id.species <- rma.mv(yi = lnRR, V = lnRRVCV, random = list(~1 |
    study_id, ~1 | assay_id, ~1 | species_latin), method = "ML", test = "t", data = data,
    sparse = T)

summary(mod_lnRR.assay_id.study_id.species)

## 
## Multivariate Meta-Analysis Model (k = 448; method: ML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -171.7538  1316.3998   351.5075   367.9267   351.5978   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor 
## sigma^2.1  0.0543  0.2331     37     no       study_id 
## sigma^2.2  0.0589  0.2427    448     no       assay_id 
## sigma^2.3  0.0454  0.2130     10     no  species_latin 
## 
## Test for Heterogeneity:
## Q(df = 447) = 5125.7373, p-val < .0001
## 
## Model Results:
## 
## estimate      se     tval   df    pval    ci.lb    ci.ub    
##  -0.2467  0.1001  -2.4637  447  0.0141  -0.4436  -0.0499  * 
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

anova(mod_lnRR.assay_id.study_id, mod_lnRR.assay_id.study_id.species)

## 
##         df      AIC      BIC     AICc    logLik    LRT   pval        QE 
## Full     4 351.5075 367.9267 351.5978 -171.7538               5125.7373 
## Reduced  3 354.0614 366.3757 354.1154 -174.0307 4.5538 0.0328 5125.7373

i2_ml(mod_lnRR.assay_id.study_id.species)

##         I2_Total      I2_study_id      I2_assay_id I2_species_latin 
##         97.07031         33.24977         36.04941         27.77113

Add phylogeny as a random effect to the better model (that used assay_id , study_id and species as random effects) (lnRR)

mod_lnRR.assay_id.study_id.species.phylogeny <- rma.mv(yi = lnRR, V = lnRRVCV, random = list(~1 |
    study_id, ~1 | assay_id, ~1 | species_latin, ~1 | phylogeny), method = "ML",
    test = "t", data = data, sparse = T, R = list(phylogeny = phylo_matrix))

summary(mod_lnRR.assay_id.study_id.species.phylogeny)

## 
## Multivariate Meta-Analysis Model (k = 448; method: ML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -171.7538  1316.3998   353.5075   374.0315   353.6433   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor    R 
## sigma^2.1  0.0543  0.2331     37     no       study_id   no 
## sigma^2.2  0.0589  0.2427    448     no       assay_id   no 
## sigma^2.3  0.0454  0.2130     10     no  species_latin   no 
## sigma^2.4  0.0000  0.0000     10     no      phylogeny  yes 
## 
## Test for Heterogeneity:
## Q(df = 447) = 5125.7373, p-val < .0001
## 
## Model Results:
## 
## estimate      se     tval   df    pval    ci.lb    ci.ub    
##  -0.2467  0.1001  -2.4637  447  0.0141  -0.4436  -0.0499  * 
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

fitstats(mod_lnRR.assay_id.study_id.species, mod_lnRR.assay_id.study_id.species.phylogeny)

##           mod_lnRR.assay_id.study_id.species
## logLik:                            -171.7538
## deviance:                          1316.3998
## AIC:                                351.5075
## BIC:                                367.9267
## AICc:                               351.5978
##           mod_lnRR.assay_id.study_id.species.phylogeny
## logLik:                                      -171.7538
## deviance:                                    1316.3998
## AIC:                                          353.5075
## BIC:                                          374.0315
## AICc:                                         353.6433

i2_ml(mod_lnRR.assay_id.study_id.species.phylogeny)

##         I2_Total      I2_study_id      I2_assay_id I2_species_latin 
##     9.707031e+01     3.324977e+01     3.604941e+01     2.777113e+01 
##     I2_phylogeny 
##     3.442931e-07

Add pesticide as a random effect to the above model (that used assay_id , study_id, species and phylogeny as random effects) (lnRR)

mod_lnRR.assay_id.study_id.species.pesticide <- rma.mv(yi = lnRR, V = lnRRVCV, random = list(~1 |
    study_id, ~1 | assay_id, ~1 | species_latin, ~1 | pesticide), method = "ML",
    test = "t", data = data, sparse = T)

summary(mod_lnRR.assay_id.study_id.species.pesticide)

## 
## Multivariate Meta-Analysis Model (k = 448; method: ML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -171.1338  1315.1600   352.2677   372.7916   352.4034   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor 
## sigma^2.1  0.0520  0.2280     37     no       study_id 
## sigma^2.2  0.0583  0.2414    448     no       assay_id 
## sigma^2.3  0.0478  0.2187     10     no  species_latin 
## sigma^2.4  0.0076  0.0873     30     no      pesticide 
## 
## Test for Heterogeneity:
## Q(df = 447) = 5125.7373, p-val < .0001
## 
## Model Results:
## 
## estimate      se     tval   df    pval    ci.lb    ci.ub    
##  -0.2609  0.1040  -2.5094  447  0.0124  -0.4652  -0.0566  * 
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

anova(mod_lnRR.assay_id.study_id.species, mod_lnRR.assay_id.study_id.species.pesticide)

## 
##         df      AIC      BIC     AICc    logLik    LRT   pval        QE 
## Full     5 352.2677 372.7916 352.4034 -171.1338               5125.7373 
## Reduced  4 351.5075 367.9267 351.5978 -171.7538 1.2398 0.2655 5125.7373

i2_ml(mod_lnRR.assay_id.study_id.species.pesticide)

##         I2_Total      I2_study_id      I2_assay_id I2_species_latin 
##        97.193337        30.486413        34.179792        28.056365 
##     I2_pesticide 
##         4.470767

Null model with no random effects (lnVR)

# fit a null model as default model
null_mod_lnVR <- rma.mv(yi = lnVR, V = lnVRVCV, method = "ML", test = "t", data = data,
    sparse = TRUE)

summary(null_mod_lnVR)

## 
## Multivariate Meta-Analysis Model (k = 448; method: ML)
## 
##     logLik    Deviance         AIC         BIC        AICc   
## -1523.4543   3617.6450   3048.9087   3053.0135   3048.9176   
## 
## Variance Components: none
## 
## Test for Heterogeneity:
## Q(df = 447) = 3617.6450, p-val < .0001
## 
## Model Results:
## 
## estimate      se     tval   df    pval    ci.lb    ci.ub      
##  -0.0862  0.0187  -4.6111  447  <.0001  -0.1229  -0.0494  *** 
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

Add assay_id as a random effect and compare with the null model (lnVR)

mod_lnVR.assay_id <- rma.mv(yi = lnVR, V = lnVRVCV, random = ~1 | assay_id, method = "ML",
    test = "t", data = data, sparse = T)

summary(mod_lnVR.assay_id)

## 
## Multivariate Meta-Analysis Model (k = 448; method: ML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -393.0636  1356.8635   790.1271   798.3367   790.1541   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed    factor 
## sigma^2    0.2591  0.5090    448     no  assay_id 
## 
## Test for Heterogeneity:
## Q(df = 447) = 3617.6450, p-val < .0001
## 
## Model Results:
## 
## estimate      se     tval   df    pval    ci.lb   ci.ub    
##  -0.0520  0.0329  -1.5825  447  0.1143  -0.1166  0.0126    
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

anova(null_mod_lnVR, mod_lnVR.assay_id)

## 
##         df       AIC       BIC      AICc     logLik       LRT   pval        QE 
## Full     2  790.1271  798.3367  790.1541  -393.0636                  3617.6450 
## Reduced  1 3048.9087 3053.0135 3048.9176 -1523.4543 2260.7815 <.0001 3617.6450

Add study_id as a random effect to the above better model (that used assay_id a random effect) (lnVR)

mod_lnVR.assay_id.study_id <- rma.mv(yi = lnVR, V = lnVRVCV, random = list(~1 | study_id,
    ~1 | assay_id), method = "ML", test = "t", data = data, sparse = T)

summary(mod_lnVR.assay_id.study_id)

## 
## Multivariate Meta-Analysis Model (k = 448; method: ML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -391.7199  1354.1762   789.4398   801.7542   789.4939   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed    factor 
## sigma^2.1  0.0157  0.1252     37     no  study_id 
## sigma^2.2  0.2513  0.5013    448     no  assay_id 
## 
## Test for Heterogeneity:
## Q(df = 447) = 3617.6450, p-val < .0001
## 
## Model Results:
## 
## estimate      se     tval   df    pval    ci.lb   ci.ub    
##  -0.0552  0.0420  -1.3136  447  0.1897  -0.1378  0.0274    
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

anova(mod_lnVR.assay_id, mod_lnVR.assay_id.study_id)

## 
##         df      AIC      BIC     AICc    logLik    LRT   pval        QE 
## Full     3 789.4398 801.7542 789.4939 -391.7199               3617.6450 
## Reduced  2 790.1271 798.3367 790.1541 -393.0636 2.6873 0.1012 3617.6450

Add exp_id as a random effect to the above better model (that used assay_id and study_id as random effets) (lnVR)

mod_lnVR.assay_id.study_id.exp_id <- rma.mv(yi = lnVR, V = lnVRVCV, random = list(~1 |
    study_id, ~1 | exp_id, ~1 | assay_id), method = "ML", test = "t", data = data,
    sparse = T)

summary(mod_lnVR.assay_id.study_id.exp_id)

## 
## Multivariate Meta-Analysis Model (k = 448; method: ML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -391.7199  1354.1762   791.4398   807.8590   791.5301   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed    factor 
## sigma^2.1  0.0157  0.1252     37     no  study_id 
## sigma^2.2  0.0000  0.0000    111     no    exp_id 
## sigma^2.3  0.2513  0.5013    448     no  assay_id 
## 
## Test for Heterogeneity:
## Q(df = 447) = 3617.6450, p-val < .0001
## 
## Model Results:
## 
## estimate      se     tval   df    pval    ci.lb   ci.ub    
##  -0.0552  0.0420  -1.3136  447  0.1897  -0.1378  0.0274    
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

anova(mod_lnVR.assay_id.study_id, mod_lnVR.assay_id.study_id.exp_id)

## 
##         df      AIC      BIC     AICc    logLik    LRT   pval        QE 
## Full     4 791.4398 807.8590 791.5301 -391.7199               3617.6450 
## Reduced  3 789.4398 801.7542 789.4939 -391.7199 0.0000 1.0000 3617.6450

Add species as a random effect to the above better model (that used assay_id and study_id as random effets) (lnVR)

mod_lnVR.assay_id.study_id.species <- rma.mv(yi = lnVR, V = lnVRVCV, random = list(~1 |
    study_id, ~1 | assay_id, ~1 | species_latin), method = "ML", test = "t", data = data,
    sparse = T)

summary(mod_lnVR.assay_id.study_id.species)

## 
## Multivariate Meta-Analysis Model (k = 448; method: ML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -391.7199  1354.1762   791.4398   807.8590   791.5301   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor 
## sigma^2.1  0.0157  0.1252     37     no       study_id 
## sigma^2.2  0.2513  0.5013    448     no       assay_id 
## sigma^2.3  0.0000  0.0000     10     no  species_latin 
## 
## Test for Heterogeneity:
## Q(df = 447) = 3617.6450, p-val < .0001
## 
## Model Results:
## 
## estimate      se     tval   df    pval    ci.lb   ci.ub    
##  -0.0552  0.0420  -1.3136  447  0.1897  -0.1378  0.0274    
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

anova(mod_lnVR.assay_id.study_id, mod_lnVR.assay_id.study_id.species)

## 
##         df      AIC      BIC     AICc    logLik    LRT   pval        QE 
## Full     4 791.4398 807.8590 791.5301 -391.7199               3617.6450 
## Reduced  3 789.4398 801.7542 789.4939 -391.7199 0.0000 1.0000 3617.6450

Add phylogeny as a random effect to the above better model (that used assay_id , study_id and species as random effects) (lnVR)

mod_lnVR.assay_id.study_id.species.phylogeny <- rma.mv(yi = lnVR, V = lnVRVCV, random = list(~1 |
    study_id, ~1 | assay_id, ~1 | species_latin, ~1 | phylogeny), method = "ML",
    test = "t", data = data, sparse = T, R = list(phylogeny = phylo_matrix))

summary(mod_lnVR.assay_id.study_id.species.phylogeny)

## 
## Multivariate Meta-Analysis Model (k = 448; method: ML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -391.7199  1354.1762   793.4398   813.9638   793.5756   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor    R 
## sigma^2.1  0.0157  0.1252     37     no       study_id   no 
## sigma^2.2  0.2513  0.5013    448     no       assay_id   no 
## sigma^2.3  0.0000  0.0000     10     no  species_latin   no 
## sigma^2.4  0.0000  0.0000     10     no      phylogeny  yes 
## 
## Test for Heterogeneity:
## Q(df = 447) = 3617.6450, p-val < .0001
## 
## Model Results:
## 
## estimate      se     tval   df    pval    ci.lb   ci.ub    
##  -0.0552  0.0420  -1.3136  447  0.1897  -0.1378  0.0274    
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

anova(mod_lnVR.assay_id.study_id.species, mod_lnVR.assay_id.study_id.species.phylogeny)

## 
##         df      AIC      BIC     AICc    logLik    LRT   pval        QE 
## Full     5 793.4398 813.9638 793.5756 -391.7199               3617.6450 
## Reduced  4 791.4398 807.8590 791.5301 -391.7199 0.0000 0.9999 3617.6450

Add pesticide as a random effect to the above better model (that used assay_id , study_id, species and phylogeny as random effects) (lnVR)

mod_lnVR.assay_id.study_id.species.phylogeny.pesticide <- rma.mv(yi = lnCVR, V = lnCVRVCV,
    random = list(~1 | study_id, ~1 | assay_id, ~1 | species_latin, ~1 | phylogeny,
        ~1 | pesticide), method = "ML", test = "t", data = data, sparse = T, R = list(phylogeny = phylo_matrix))

summary(mod_lnVR.assay_id.study_id.species.phylogeny.pesticide)

## 
## Multivariate Meta-Analysis Model (k = 448; method: ML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -348.6810   986.4516   709.3620   733.9907   709.5525   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor    R 
## sigma^2.1  0.0212  0.1455     37     no       study_id   no 
## sigma^2.2  0.1591  0.3988    448     no       assay_id   no 
## sigma^2.3  0.0000  0.0000     10     no  species_latin   no 
## sigma^2.4  0.0221  0.1486     10     no      phylogeny  yes 
## sigma^2.5  0.0030  0.0547     30     no      pesticide   no 
## 
## Test for Heterogeneity:
## Q(df = 447) = 1797.4539, p-val < .0001
## 
## Model Results:
## 
## estimate      se    tval   df    pval    ci.lb   ci.ub    
##   0.0637  0.1080  0.5897  447  0.5557  -0.1485  0.2758    
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

Intercept only meta-analysis models

Intercept only model (lnRR)

# Model
lnRR_intercept_only <- rma.mv(yi = lnRR, V = lnRRVCV, random = list(~1 | study_id,
    ~1 | assay_id, ~1 | species_latin, ~1 | pesticide, ~1 | phylogeny), method = "REML",
    test = "t", data = data, sparse = T, R = list(phylogeny = phylo_matrix))

# Summary statistics
summary(lnRR_intercept_only)

## 
## Multivariate Meta-Analysis Model (k = 448; method: REML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -169.3896   338.7792   350.7792   375.3946   350.9702   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor    R 
## sigma^2.1  0.0532  0.2308     37     no       study_id   no 
## sigma^2.2  0.0582  0.2412    448     no       assay_id   no 
## sigma^2.3  0.0613  0.2477     10     no  species_latin   no 
## sigma^2.4  0.0080  0.0897     30     no      pesticide   no 
## sigma^2.5  0.0000  0.0000     10     no      phylogeny  yes 
## 
## Test for Heterogeneity:
## Q(df = 447) = 5125.7373, p-val < .0001
## 
## Model Results:
## 
## estimate      se     tval   df    pval    ci.lb    ci.ub    
##  -0.2669  0.1119  -2.3862  447  0.0174  -0.4868  -0.0471  * 
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

mod_results(lnRR_intercept_only, mod = "1", data = data, group = "study_id")  # For prediction intervals

##      name   estimate    lowerCL    upperCL   lowerPR   upperPR
## 1 Intrcpt -0.2669387 -0.4867922 -0.0470853 -1.131058 0.5971801

i2_ml(lnRR_intercept_only)

##         I2_Total      I2_study_id      I2_assay_id I2_species_latin 
##     9.742099e+01     2.868989e+01     3.134000e+01     3.305457e+01 
##     I2_pesticide     I2_phylogeny 
##     4.336519e+00     5.423849e-07

# Given point estimate of lnRR
lnRR_point <- -0.2669

# Calculate the percentage change
lnRR_percentage_change <- (1 - exp(lnRR_point)) * 100
lnRR_percentage_change

## [1] 23.42504

Intercept only model (lnVR)

# Model
lnVR_intercept_only <- rma.mv(yi = lnVR, V = lnVRVCV, random = list(~1 | study_id,
    ~1 | assay_id, ~1 | species_latin, ~1 | pesticide, ~1 | phylogeny), method = "REML",
    test = "t", data = data, sparse = T, R = list(phylogeny = phylo_matrix))




# Summary statistics
summary(lnVR_intercept_only)

## 
## Multivariate Meta-Analysis Model (k = 448; method: REML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -390.5853   781.1705   793.1705   817.7859   793.3614   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor    R 
## sigma^2.1  0.0013  0.0355     37     no       study_id   no 
## sigma^2.2  0.2482  0.4982    448     no       assay_id   no 
## sigma^2.3  0.0000  0.0001     10     no  species_latin   no 
## sigma^2.4  0.0127  0.1125     30     no      pesticide   no 
## sigma^2.5  0.0881  0.2968     10     no      phylogeny  yes 
## 
## Test for Heterogeneity:
## Q(df = 447) = 3617.6450, p-val < .0001
## 
## Model Results:
## 
## estimate      se     tval   df    pval    ci.lb   ci.ub    
##  -0.0914  0.1883  -0.4857  447  0.6274  -0.4614  0.2785    
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

mod_results(lnVR_intercept_only, mod = "1", data = data, group = "study_id")

##      name    estimate    lowerCL   upperCL   lowerPR  upperPR
## 1 Intrcpt -0.09144646 -0.4614317 0.2785387 -1.311954 1.129061

i2_ml(lnVR_intercept_only)

##         I2_Total      I2_study_id      I2_assay_id I2_species_latin 
##     8.707982e+01     3.128951e-01     6.172057e+01     1.882742e-06 
##     I2_pesticide     I2_phylogeny 
##     3.149301e+00     2.189706e+01

# Given point estimate of lnRR
lnVR_point <- -0.0728

# Calculate the percentage change
lnVR_percentage_change <- (1 - exp(lnVR_point)) * 100
lnVR_percentage_change

## [1] 7.021323

Figure 2

Impacts of pesticide exposure on fish conspecific interactions. The model estimates the average effects of pesticide exposure on conspecific interactions in fish. (A) shows the mean difference between control and treatment groups on a logarithmic scale, where negative values indicate a reduction in conspecific behavioural activity. (B) shows the difference in variances between control and treatment groups, also on a logarithmic scale, where negative values suggest a reduction in the inter-individual variability of conspecific behavioural activity. Shorter whiskers represent 95% confidence intervals, while longer whiskers indicate 95% prediction intervals. ‘k’ represents the number of effect sizes, and the number of studies is in brackets. Each circle corresponds to an effect size, with its size scaled according to precision (inverse sampling error variance).

# Figure 2a)
intercept_only.lnRR_orchard <- orchaRd::orchard_plot(lnRR_intercept_only, group = "study_id",
    xlab = "lnRR", data = data, g = TRUE, k.pos = "right", colour = FALSE, fill = TRUE,
    trunk.size = 3, legend.pos = "none", branch.size = 1.5, twig.size = 1) + scale_fill_manual(values = RColorBrewer::brewer.pal(8,
    "Dark2")[1]) + scale_x_discrete(labels = c("Model estimates"))

# Figure 2b)
intercept_only.lnVR__orchard <- orchaRd::orchard_plot(lnVR_intercept_only, group = "study_id",
    xlab = "lnVR", data = data, g = TRUE, k.pos = "right", colour = FALSE, fill = TRUE,
    trunk.size = 3, legend.pos = "none", branch.size = 1.5, twig.size = 1) + scale_fill_manual(values = RColorBrewer::brewer.pal(8,
    "Dark2")[2]) + scale_x_discrete(labels = c("Model estimates"))

# Combine the two plots
main_text_figure_2 <- intercept_only.lnRR_orchard + intercept_only.lnVR__orchard +
    plot_annotation(tag_levels = "A")

print(main_text_figure_2)

# ggsave(here('figures', 'main_text_figure_2.jpg'), width = 24, height = 10,
# units = 'cm', dpi = 800) ggsave(here('figures', 'main_text_figure_2.pdf'),
# width = 24, height = 10, units = 'cm', dpi = 800)

Single moderator meta-regression

Behaviour characteristics

Moderating effects of behaviour type (lnRR)

# Model
lnRR_mod_behaviour_class <- rma.mv(yi = lnRR, V = lnRRVCV, random = list(~1 | study_id,
    ~1 | assay_id, ~1 | species_latin, ~1 | pesticide), mods = ~behaviour_measured_standardised -
    1, method = "REML", test = "t", data = data, sparse = T)


# Summary results
summary(lnRR_mod_behaviour_class)

## 
## Multivariate Meta-Analysis Model (k = 448; method: REML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -157.6271   315.2542   331.2542   364.0208   331.5853   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor 
## sigma^2.1  0.0491  0.2216     37     no       study_id 
## sigma^2.2  0.0541  0.2326    448     no       assay_id 
## sigma^2.3  0.0622  0.2494     10     no  species_latin 
## sigma^2.4  0.0059  0.0770     30     no      pesticide 
## 
## Test for Residual Heterogeneity:
## QE(df = 444) = 3709.4943, p-val < .0001
## 
## Test of Moderators (coefficients 1:4):
## F(df1 = 4, df2 = 444) = 7.1848, p-val < .0001
## 
## Model Results:
## 
##                                                      estimate      se     tval 
## behaviour_measured_standardisedaggression             -0.1251  0.1160  -1.0779 
## behaviour_measured_standardisedcollective behaviour   -0.1788  0.1218  -1.4675 
## behaviour_measured_standardisedcourtship              -0.4280  0.1173  -3.6501 
## behaviour_measured_standardisedsociality              -0.1530  0.1198  -1.2768 
##                                                       df    pval    ci.lb 
## behaviour_measured_standardisedaggression            444  0.2817  -0.3531 
## behaviour_measured_standardisedcollective behaviour  444  0.1430  -0.4183 
## behaviour_measured_standardisedcourtship             444  0.0003  -0.6585 
## behaviour_measured_standardisedsociality             444  0.2023  -0.3886 
##                                                        ci.ub      
## behaviour_measured_standardisedaggression             0.1030      
## behaviour_measured_standardisedcollective behaviour   0.0607      
## behaviour_measured_standardisedcourtship             -0.1976  *** 
## behaviour_measured_standardisedsociality              0.0825      
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

mod_results(lnRR_mod_behaviour_class, mod = "behaviour_measured_standardised", data = data,
    group = "study_id")

##                   name   estimate    lowerCL     upperCL    lowerPR   upperPR
## 1           Aggression -0.1250780 -0.3531254  0.10296951 -0.9698693 0.7197134
## 2 Collective behaviour -0.1788090 -0.4182769  0.06065887 -1.0267546 0.6691365
## 3            Courtship -0.4280461 -0.6585198 -0.19757233 -1.2734956 0.4174035
## 4            Sociality -0.1530223 -0.3885554  0.08251080 -0.9998650 0.6938205

r2_ml(lnRR_mod_behaviour_class)

##    R2_marginal R2_conditional 
##     0.07060053     0.96783006

# Give point estimate of lnRR
courtship_lnRR_point <- -0.428

# Calculate the percentage change
courtship_lnRR_percentage_change <- (1 - exp(courtship_lnRR_point)) * 100
courtship_lnRR_percentage_change

## [1] 34.81886

Moderating effects of behaviour type (lnVR)

# Model
lnVR_mod_behaviour_class <- rma.mv(yi = lnVR, V = lnVRVCV, random = list(~1 | study_id,
    ~1 | assay_id, ~1 | species_latin, ~1 | pesticide), mods = ~behaviour_measured_standardised -
    1, method = "REML", test = "t", data = data, sparse = T)

# Summary statistics
summary(lnVR_mod_behaviour_class)

## 
## Multivariate Meta-Analysis Model (k = 448; method: REML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -386.9398   773.8797   789.8797   822.6463   790.2107   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor 
## sigma^2.1  0.0287  0.1693     37     no       study_id 
## sigma^2.2  0.2439  0.4938    448     no       assay_id 
## sigma^2.3  0.0217  0.1472     10     no  species_latin 
## sigma^2.4  0.0000  0.0001     30     no      pesticide 
## 
## Test for Residual Heterogeneity:
## QE(df = 444) = 3505.1296, p-val < .0001
## 
## Test of Moderators (coefficients 1:4):
## F(df1 = 4, df2 = 444) = 1.3083, p-val = 0.2660
## 
## Model Results:
## 
##                                                      estimate      se     tval 
## behaviour_measured_standardisedaggression             -0.0470  0.1060  -0.4436 
## behaviour_measured_standardisedcollective behaviour   -0.0481  0.1162  -0.4135 
## behaviour_measured_standardisedcourtship              -0.1674  0.1040  -1.6092 
## behaviour_measured_standardisedsociality               0.0743  0.1144   0.6493 
##                                                       df    pval    ci.lb 
## behaviour_measured_standardisedaggression            444  0.6576  -0.2554 
## behaviour_measured_standardisedcollective behaviour  444  0.6794  -0.2765 
## behaviour_measured_standardisedcourtship             444  0.1083  -0.3718 
## behaviour_measured_standardisedsociality             444  0.5165  -0.1505 
##                                                       ci.ub    
## behaviour_measured_standardisedaggression            0.1613    
## behaviour_measured_standardisedcollective behaviour  0.1804    
## behaviour_measured_standardisedcourtship             0.0370    
## behaviour_measured_standardisedsociality             0.2990    
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

mod_results(lnVR_mod_behaviour_class, mod = "behaviour_measured_standardised", data = data,
    group = "study_id")

##                   name    estimate    lowerCL    upperCL   lowerPR   upperPR
## 1           Aggression -0.04702923 -0.2554049 0.16134647 -1.133221 1.0391626
## 2 Collective behaviour -0.04806303 -0.2764918 0.18036572 -1.138280 1.0421535
## 3            Courtship -0.16737461 -0.3717935 0.03704429 -1.252814 0.9180651
## 4            Sociality  0.07425841 -0.1504989 0.29901568 -1.015195 1.1637115

r2_ml(lnVR_mod_behaviour_class)

##    R2_marginal R2_conditional 
##     0.02163905     0.99999998

Moderate by assay (lnRR)

# Model
lnRR_mod_assay <- rma.mv(yi = lnRR, V = lnRRVCV, random = list(~1 | study_id, ~1 |
    assay_id, ~1 | species_latin, ~1 | pesticide), mods = ~behavioural_assay_standardised2 -
    1, method = "REML", test = "t", data = data, sparse = T)

summary(lnRR_mod_assay)

## 
## Multivariate Meta-Analysis Model (k = 281; method: REML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -112.3984   224.7968   238.7968   264.1901   239.2116   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor 
## sigma^2.1  0.0551  0.2347     28     no       study_id 
## sigma^2.2  0.0597  0.2444    281     no       assay_id 
## sigma^2.3  0.0300  0.1732      8     no  species_latin 
## sigma^2.4  0.0170  0.1303     24     no      pesticide 
## 
## Test for Residual Heterogeneity:
## QE(df = 278) = 2767.0298, p-val < .0001
## 
## Test of Moderators (coefficients 1:3):
## F(df1 = 3, df2 = 278) = 2.4162, p-val = 0.0667
## 
## Model Results:
## 
##                                       estimate      se     tval   df    pval 
## behavioural_assay_standardised2count   -0.2306  0.1073  -2.1496  278  0.0324 
## behavioural_assay_standardised2entry   -0.4129  0.1652  -2.4996  278  0.0130 
## behavioural_assay_standardised2zone    -0.2541  0.1106  -2.2967  278  0.0224 
##                                         ci.lb    ci.ub    
## behavioural_assay_standardised2count  -0.4417  -0.0194  * 
## behavioural_assay_standardised2entry  -0.7381  -0.0877  * 
## behavioural_assay_standardised2zone   -0.4719  -0.0363  * 
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

r2_ml(lnRR_mod_assay)

##    R2_marginal R2_conditional 
##    0.009435225    0.896025643

# Model contrast
lnRR_mod_assay_contrast <- rma.mv(yi = lnRR, V = lnRRVCV, random = list(~1 | study_id,
    ~1 | assay_id, ~1 | species_latin, ~1 | pesticide), mods = ~behavioural_assay_standardised2,
    method = "REML", test = "t", data = data, sparse = T)

summary(lnRR_mod_assay_contrast)

## 
## Multivariate Meta-Analysis Model (k = 281; method: REML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -112.3984   224.7968   238.7968   264.1901   239.2116   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor 
## sigma^2.1  0.0551  0.2347     28     no       study_id 
## sigma^2.2  0.0597  0.2444    281     no       assay_id 
## sigma^2.3  0.0300  0.1732      8     no  species_latin 
## sigma^2.4  0.0170  0.1303     24     no      pesticide 
## 
## Test for Residual Heterogeneity:
## QE(df = 278) = 2767.0298, p-val < .0001
## 
## Test of Moderators (coefficients 2:3):
## F(df1 = 2, df2 = 278) = 0.8597, p-val = 0.4244
## 
## Model Results:
## 
##                                       estimate      se     tval   df    pval 
## intrcpt                                -0.2306  0.1073  -2.1496  278  0.0324 
## behavioural_assay_standardised2entry   -0.1823  0.1397  -1.3056  278  0.1928 
## behavioural_assay_standardised2zone    -0.0235  0.0607  -0.3879  278  0.6984 
##                                         ci.lb    ci.ub    
## intrcpt                               -0.4417  -0.0194  * 
## behavioural_assay_standardised2entry  -0.4573   0.0926    
## behavioural_assay_standardised2zone   -0.1430   0.0959    
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

Moderate by assay (lnVR)

# Model
lnVR_mod_assay <- rma.mv(yi = lnVR, V = lnVRVCV, random = list(~1 | study_id, ~1 |
    assay_id, ~1 | species_latin, ~1 | pesticide), mods = ~behavioural_assay_standardised2 -
    1, method = "REML", test = "t", data = data, sparse = T)

summary(lnVR_mod_assay)

## 
## Multivariate Meta-Analysis Model (k = 281; method: REML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -203.7426   407.4852   421.4852   446.8785   421.9000   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor 
## sigma^2.1  0.0029  0.0536     28     no       study_id 
## sigma^2.2  0.1801  0.4244    281     no       assay_id 
## sigma^2.3  0.0259  0.1610      8     no  species_latin 
## sigma^2.4  0.0173  0.1316     24     no      pesticide 
## 
## Test for Residual Heterogeneity:
## QE(df = 278) = 1922.3628, p-val < .0001
## 
## Test of Moderators (coefficients 1:3):
## F(df1 = 3, df2 = 278) = 3.6855, p-val = 0.0125
## 
## Model Results:
## 
##                                       estimate      se     tval   df    pval 
## behavioural_assay_standardised2count   -0.2039  0.0983  -2.0742  278  0.0390 
## behavioural_assay_standardised2entry   -0.5645  0.1822  -3.0986  278  0.0021 
## behavioural_assay_standardised2zone    -0.1516  0.1046  -1.4496  278  0.1483 
##                                         ci.lb    ci.ub     
## behavioural_assay_standardised2count  -0.3973  -0.0104   * 
## behavioural_assay_standardised2entry  -0.9231  -0.2059  ** 
## behavioural_assay_standardised2zone   -0.3574   0.0543     
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

r2_ml(lnVR_mod_assay)

##    R2_marginal R2_conditional 
##     0.03610299     0.92620514

# Model contrast
lnVR_mod_assay_contrast <- rma.mv(yi = lnVR, V = lnVRVCV, random = list(~1 | study_id,
    ~1 | assay_id, ~1 | species_latin, ~1 | pesticide), mods = ~behavioural_assay_standardised2,
    method = "REML", test = "t", data = data, sparse = T)

summary(lnVR_mod_assay_contrast)

## 
## Multivariate Meta-Analysis Model (k = 281; method: REML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -203.7426   407.4852   421.4852   446.8785   421.9000   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor 
## sigma^2.1  0.0029  0.0536     28     no       study_id 
## sigma^2.2  0.1801  0.4244    281     no       assay_id 
## sigma^2.3  0.0259  0.1610      8     no  species_latin 
## sigma^2.4  0.0173  0.1316     24     no      pesticide 
## 
## Test for Residual Heterogeneity:
## QE(df = 278) = 1922.3628, p-val < .0001
## 
## Test of Moderators (coefficients 2:3):
## F(df1 = 2, df2 = 278) = 3.2048, p-val = 0.0421
## 
## Model Results:
## 
##                                       estimate      se     tval   df    pval 
## intrcpt                                -0.2039  0.0983  -2.0742  278  0.0390 
## behavioural_assay_standardised2entry   -0.3606  0.1717  -2.0999  278  0.0366 
## behavioural_assay_standardised2zone     0.0523  0.0826   0.6328  278  0.5274 
##                                         ci.lb    ci.ub    
## intrcpt                               -0.3973  -0.0104  * 
## behavioural_assay_standardised2entry  -0.6987  -0.0226  * 
## behavioural_assay_standardised2zone   -0.1104   0.2149    
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

Figure 3

# Figure 3a)
behav_mod_orchard.lnRR <- orchaRd::orchard_plot(lnRR_mod_behaviour_class, group = "study_id",
    xlab = "lnRR", data = data, mod = "behaviour_measured_standardised", g = TRUE,
    k.pos = "right", colour = FALSE, fill = TRUE, legend.pos = "none", trunk.size = 3,
    branch.size = 1.5, twig.size = 1, angle = 45) + scale_fill_manual(values = RColorBrewer::brewer.pal(8,
    "Dark2")) + plot_annotation(tag_levels = "A")

# Figure 3b)
behav_mod_orchard.lnVR <- orchaRd::orchard_plot(lnVR_mod_behaviour_class, group = "study_id",
    xlab = "lnVR", mod = "behaviour_measured_standardised", data = data, g = TRUE,
    k.pos = "right", colour = FALSE, fill = TRUE, legend.pos = "none", trunk.size = 3,
    branch.size = 1.5, twig.size = 1, angle = 45) + scale_fill_manual(values = RColorBrewer::brewer.pal(8,
    "Dark2")) + theme(axis.text.y = element_blank()) + plot_annotation(tag_levels = "B")

# Figure 3c)
assay_mod_orchard.lnRR <- orchaRd::orchard_plot(lnRR_mod_assay_contrast, group = "study_id",
    xlab = "lnRR", data = data, mod = "behavioural_assay_standardised2", g = TRUE,
    k.pos = "right", colour = FALSE, fill = TRUE, legend.pos = "none", trunk.size = 3,
    branch.size = 1.5, twig.size = 1, angle = 45) + scale_fill_manual(values = RColorBrewer::brewer.pal(8,
    "Dark2")) + plot_annotation(tag_levels = "C")

# Figure 3d)
assay_mod_orchard.lnVR <- orchaRd::orchard_plot(lnVR_mod_assay_contrast, group = "study_id",
    xlab = "lnVR", data = data, mod = "behavioural_assay_standardised2", g = TRUE,
    k.pos = "right", colour = FALSE, fill = TRUE, legend.pos = "none", trunk.size = 3,
    branch.size = 1.5, twig.size = 1, angle = 45) + scale_fill_manual(values = RColorBrewer::brewer.pal(8,
    "Dark2")) + theme(axis.text.y = element_blank()) + plot_annotation(tag_levels = "D")


main_text_figure_3 <- (behav_mod_orchard.lnRR + behav_mod_orchard.lnVR)/(assay_mod_orchard.lnRR +
    assay_mod_orchard.lnVR) + plot_annotation(tag_levels = "A")

print(main_text_figure_3)

# ggsave(here('figures', 'main_text_figure_3.jpg'), plot = main_text_figure_3,
# width = 28, height = 24, units = 'cm', dpi = 800) ggsave(here('figures',
# 'main_text_figure_3.pdf'),plot = main_text_figure_3, width = 28, height = 24,
# units = 'cm', dpi = 800)

Pesticide characteristics

Moderate by pesticide chemical class (lnRR)

# Model
lnRR_mod_pesticide <- rma.mv(yi = lnRR, V = lnRRVCV, random = list(~1 | study_id,
    ~1 | assay_id, ~1 | species_latin, ~1 | pesticide), mods = ~pesticide_chemical_class -
    1, method = "REML", test = "t", data = data, sparse = T)

# Summary results
summary(lnRR_mod_pesticide)

## 
## Multivariate Meta-Analysis Model (k = 448; method: REML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -154.4215   308.8431   342.8431   412.1239   344.3107   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor 
## sigma^2.1  0.0740  0.2720     37     no       study_id 
## sigma^2.2  0.0569  0.2385    448     no       assay_id 
## sigma^2.3  0.1006  0.3172     10     no  species_latin 
## sigma^2.4  0.0000  0.0000     30     no      pesticide 
## 
## Test for Residual Heterogeneity:
## QE(df = 435) = 4102.5996, p-val < .0001
## 
## Test of Moderators (coefficients 1:13):
## F(df1 = 13, df2 = 435) = 1.2519, p-val = 0.2396
## 
## Model Results:
## 
##                                                             estimate      se 
## pesticide_chemical_classB-methoxyacrylates                   -0.3506  0.3156 
## pesticide_chemical_classcarbamate                            -0.5231  0.3150 
## pesticide_chemical_classdioxolanes                           -0.4687  0.3237 
## pesticide_chemical_classneonicotinoid                        -0.3278  0.2279 
## pesticide_chemical_classorganochlorine                       -0.4560  0.2020 
## pesticide_chemical_classorganophosphate                      -0.2562  0.1657 
## pesticide_chemical_classorganophosphate and organochlorine   -0.3905  0.3074 
## pesticide_chemical_classphenoxy                              -0.2870  0.3277 
## pesticide_chemical_classpyrethroid                           -0.3401  0.1850 
## pesticide_chemical_classrotenones                             0.0826  0.2823 
## pesticide_chemical_classtriazine                             -0.3017  0.1759 
## pesticide_chemical_classtriazole                             -0.5014  0.2123 
## pesticide_chemical_classurea                                  0.0209  0.1939 
##                                                                tval   df 
## pesticide_chemical_classB-methoxyacrylates                  -1.1110  435 
## pesticide_chemical_classcarbamate                           -1.6605  435 
## pesticide_chemical_classdioxolanes                          -1.4481  435 
## pesticide_chemical_classneonicotinoid                       -1.4381  435 
## pesticide_chemical_classorganochlorine                      -2.2570  435 
## pesticide_chemical_classorganophosphate                     -1.5459  435 
## pesticide_chemical_classorganophosphate and organochlorine  -1.2705  435 
## pesticide_chemical_classphenoxy                             -0.8759  435 
## pesticide_chemical_classpyrethroid                          -1.8387  435 
## pesticide_chemical_classrotenones                            0.2925  435 
## pesticide_chemical_classtriazine                            -1.7149  435 
## pesticide_chemical_classtriazole                            -2.3614  435 
## pesticide_chemical_classurea                                 0.1078  435 
##                                                               pval    ci.lb 
## pesticide_chemical_classB-methoxyacrylates                  0.2672  -0.9709 
## pesticide_chemical_classcarbamate                           0.0975  -1.1422 
## pesticide_chemical_classdioxolanes                          0.1483  -1.1049 
## pesticide_chemical_classneonicotinoid                       0.1511  -0.7758 
## pesticide_chemical_classorganochlorine                      0.0245  -0.8530 
## pesticide_chemical_classorganophosphate                     0.1229  -0.5819 
## pesticide_chemical_classorganophosphate and organochlorine  0.2046  -0.9946 
## pesticide_chemical_classphenoxy                             0.3816  -0.9310 
## pesticide_chemical_classpyrethroid                          0.0666  -0.7036 
## pesticide_chemical_classrotenones                           0.7700  -0.4723 
## pesticide_chemical_classtriazine                            0.0871  -0.6475 
## pesticide_chemical_classtriazole                            0.0186  -0.9188 
## pesticide_chemical_classurea                                0.9142  -0.3601 
##                                                               ci.ub    
## pesticide_chemical_classB-methoxyacrylates                   0.2696    
## pesticide_chemical_classcarbamate                            0.0961  . 
## pesticide_chemical_classdioxolanes                           0.1675    
## pesticide_chemical_classneonicotinoid                        0.1202    
## pesticide_chemical_classorganochlorine                      -0.0589  * 
## pesticide_chemical_classorganophosphate                      0.0695    
## pesticide_chemical_classorganophosphate and organochlorine   0.2136    
## pesticide_chemical_classphenoxy                              0.3570    
## pesticide_chemical_classpyrethroid                           0.0234  . 
## pesticide_chemical_classrotenones                            0.6374    
## pesticide_chemical_classtriazine                             0.0441  . 
## pesticide_chemical_classtriazole                            -0.0841  * 
## pesticide_chemical_classurea                                 0.4019    
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

lnRR_pesticide_mod_results <- mod_results(lnRR_mod_pesticide, mod = "pesticide_chemical_class",
    data = data, group = "study_id")

r2_ml(lnRR_mod_pesticide)

##    R2_marginal R2_conditional 
##      0.1028894      1.0000000

Moderate by pesticide chemical class (lnVR)

# Model
lnVR_mod_pesticide <- rma.mv(yi = lnVR, V = lnVRVCV, random = list(~1 | study_id,
    ~1 | assay_id, ~1 | species_latin, ~1 | pesticide), mods = ~pesticide_chemical_class -
    1, method = "REML", test = "t", data = data, sparse = T)

# Summary results
summary(lnVR_mod_pesticide)

## 
## Multivariate Meta-Analysis Model (k = 448; method: REML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -374.3551   748.7102   782.7102   851.9911   784.1778   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor 
## sigma^2.1  0.0000  0.0001     37     no       study_id 
## sigma^2.2  0.2512  0.5012    448     no       assay_id 
## sigma^2.3  0.0187  0.1366     10     no  species_latin 
## sigma^2.4  0.0000  0.0000     30     no      pesticide 
## 
## Test for Residual Heterogeneity:
## QE(df = 435) = 3523.7293, p-val < .0001
## 
## Test of Moderators (coefficients 1:13):
## F(df1 = 13, df2 = 435) = 1.6681, p-val = 0.0649
## 
## Model Results:
## 
##                                                             estimate      se 
## pesticide_chemical_classB-methoxyacrylates                   -0.0979  0.1613 
## pesticide_chemical_classcarbamate                            -0.0717  0.2871 
## pesticide_chemical_classdioxolanes                            0.3694  0.2579 
## pesticide_chemical_classneonicotinoid                         0.0567  0.1425 
## pesticide_chemical_classorganochlorine                        0.0633  0.1799 
## pesticide_chemical_classorganophosphate                      -0.2923  0.1052 
## pesticide_chemical_classorganophosphate and organochlorine   -0.0181  0.3221 
## pesticide_chemical_classphenoxy                               0.0844  0.2109 
## pesticide_chemical_classpyrethroid                            0.0379  0.1048 
## pesticide_chemical_classrotenones                             0.1417  0.2121 
## pesticide_chemical_classtriazine                             -0.0180  0.1133 
## pesticide_chemical_classtriazole                             -0.2512  0.1157 
## pesticide_chemical_classurea                                  0.0229  0.1239 
##                                                                tval   df 
## pesticide_chemical_classB-methoxyacrylates                  -0.6066  435 
## pesticide_chemical_classcarbamate                           -0.2496  435 
## pesticide_chemical_classdioxolanes                           1.4321  435 
## pesticide_chemical_classneonicotinoid                        0.3977  435 
## pesticide_chemical_classorganochlorine                       0.3517  435 
## pesticide_chemical_classorganophosphate                     -2.7775  435 
## pesticide_chemical_classorganophosphate and organochlorine  -0.0563  435 
## pesticide_chemical_classphenoxy                              0.4000  435 
## pesticide_chemical_classpyrethroid                           0.3617  435 
## pesticide_chemical_classrotenones                            0.6680  435 
## pesticide_chemical_classtriazine                            -0.1588  435 
## pesticide_chemical_classtriazole                            -2.1709  435 
## pesticide_chemical_classurea                                 0.1848  435 
##                                                               pval    ci.lb 
## pesticide_chemical_classB-methoxyacrylates                  0.5445  -0.4150 
## pesticide_chemical_classcarbamate                           0.8030  -0.6360 
## pesticide_chemical_classdioxolanes                          0.1528  -0.1376 
## pesticide_chemical_classneonicotinoid                       0.6910  -0.2233 
## pesticide_chemical_classorganochlorine                      0.7252  -0.2903 
## pesticide_chemical_classorganophosphate                     0.0057  -0.4992 
## pesticide_chemical_classorganophosphate and organochlorine  0.9551  -0.6512 
## pesticide_chemical_classphenoxy                             0.6893  -0.3302 
## pesticide_chemical_classpyrethroid                          0.7178  -0.1680 
## pesticide_chemical_classrotenones                           0.5045  -0.2751 
## pesticide_chemical_classtriazine                            0.8739  -0.2407 
## pesticide_chemical_classtriazole                            0.0305  -0.4785 
## pesticide_chemical_classurea                                0.8535  -0.2207 
##                                                               ci.ub     
## pesticide_chemical_classB-methoxyacrylates                   0.2192     
## pesticide_chemical_classcarbamate                            0.4927     
## pesticide_chemical_classdioxolanes                           0.8763     
## pesticide_chemical_classneonicotinoid                        0.3367     
## pesticide_chemical_classorganochlorine                       0.4169     
## pesticide_chemical_classorganophosphate                     -0.0855  ** 
## pesticide_chemical_classorganophosphate and organochlorine   0.6149     
## pesticide_chemical_classphenoxy                              0.4989     
## pesticide_chemical_classpyrethroid                           0.2438     
## pesticide_chemical_classrotenones                            0.5585     
## pesticide_chemical_classtriazine                             0.2047     
## pesticide_chemical_classtriazole                            -0.0238   * 
## pesticide_chemical_classurea                                 0.2665     
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

lnVR_pesticide_mod_results <- mod_results(lnVR_mod_pesticide, mod = "pesticide_chemical_class",
    data = data, group = "study_id")

r2_ml(lnVR_mod_pesticide)

##    R2_marginal R2_conditional 
##     0.08581531     1.00000000

Figure s18

The moderating effects of pesticide chemical class on (A) response magnitude and (B) response variability in conspecific interactions. Shorter whiskers represent 95% confidence intervals, while longer whiskers indicate 95% prediction intervals. ‘k’ represents the number of effect sizes, and the number of studies is in brackets. Each circle corresponds to an effect size, with its size scaled according to precision (inverse sampling error variance).

# Figure s18A
pesticide_all_mod_orchard.lnRR <- orchaRd::orchard_plot(lnRR_mod_pesticide, group = "study_id",
    xlab = "lnRR", data = data, mod = "pesticide_chemical_class", g = TRUE, k.pos = "right",
    colour = FALSE, fill = TRUE, legend.pos = "none", trunk.size = 3, branch.size = 1.5,
    twig.size = 1, angle = 45)

# Figure s18B
pesticide_all_mod_orchard.lnVR <- orchaRd::orchard_plot(lnVR_mod_pesticide, group = "study_id",
    xlab = "lnVR", data = data, mod = "pesticide_chemical_class", g = TRUE, k.pos = "right",
    colour = FALSE, fill = TRUE, legend.pos = "none", trunk.size = 3, branch.size = 1.5,
    twig.size = 1, angle = 45) + theme(axis.text.y = element_blank())


pesticide_all_mod_orchard <- pesticide_all_mod_orchard.lnRR + pesticide_all_mod_orchard.lnVR

print(pesticide_all_mod_orchard)

# ggsave(here('figures', 'pesticide_all_mod_orchard.jpg'), plot =
# pesticide_all_mod_orchard, width = 30, height = 18, units = 'cm', dpi = 800)
# ggsave(here('figures', 'pesticide_all_mod_orchard.pdf'),plot =
# pesticide_all_mod_orchard, width = 30, height = 18, units = 'cm', dpi = 800)

Moderate by concentration of pesticide (lnRR)

# Create dataframe for model with consistent dosage units
data_dosage_model <- data %>%
    filter(dosage != "not reported") %>%
    filter(dosage_unit != "not reported") %>%
    filter(!dosage_unit %in% c("nm", "um", "nM")) %>%
    mutate(dosage = as.numeric(dosage), dosage_unit = as.character(dosage_unit),
        dosage_unit_consistent = case_when(dosage_unit == "mg/L" ~ "ug/L", dosage_unit ==
            "ng/L" ~ "ug/L", dosage_unit == "g/L" ~ "ug/L", dosage_unit == "ppb" ~
            "ug/L", dosage_unit == "ppm" ~ "ug/L", TRUE ~ dosage_unit), dosage_convert_ugL = case_when(dosage_unit ==
            "mg/L" ~ dosage * 1000, dosage_unit == "ng/L" ~ dosage/1000, dosage_unit ==
            "g/L" ~ dosage/1e+06, dosage_unit == "ppm" ~ dosage * 1000, TRUE ~ dosage)) %>%
    filter(!is.na(dosage_convert_ugL)) %>%
    mutate(log_dosage_convert_ugL = log(dosage_convert_ugL))

# Recalculate the VCV matrix based on the new data frame
lnRRVCV_dosage <- metafor::vcalc(vi = lnRRv, cluster = exp_id, obs = assay_id, data = data_dosage_model,
    rho = 0.5)

# Model
lnRR_mod_dosage <- rma.mv(yi = lnRR, V = lnRRVCV_dosage, random = list(~1 | study_id,
    ~1 | assay_id, ~1 | species_latin, ~1 | pesticide), mods = ~log_dosage_convert_ugL -
    1, method = "REML", test = "t", data = data_dosage_model, sparse = T)

# Summary results
summary(lnRR_mod_dosage)

## 
## Multivariate Meta-Analysis Model (k = 424; method: REML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -160.0658   320.1317   330.1317   350.3685   330.2756   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor 
## sigma^2.1  0.0642  0.2535     33     no       study_id 
## sigma^2.2  0.0593  0.2435    424     no       assay_id 
## sigma^2.3  0.0937  0.3062     10     no  species_latin 
## sigma^2.4  0.0068  0.0823     26     no      pesticide 
## 
## Test for Residual Heterogeneity:
## QE(df = 423) = 4780.6970, p-val < .0001
## 
## Model Results:
## 
##                         estimate      se     tval   df    pval    ci.lb   ci.ub 
## log_dosage_convert_ugL   -0.0090  0.0083  -1.0780  423  0.2817  -0.0254  0.0074 
##                           
## log_dosage_convert_ugL    
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

dosage_mod_lnRR_results <- mod_results(lnRR_mod_dosage, mod = "log_dosage_convert_ugL",
    data = data_dosage_model, group = "study_id")

r2_lnRR_dosage <- r2_ml(lnRR_mod_dosage, data_dosage_model)

Moderate by concentration of pesticide (lnVR)

# Recalculate the VCV matrix based on the new data frame
lnVRVCV_dosage <- metafor::vcalc(vi = lnVRv, cluster = exp_id, obs = assay_id, data = data_dosage_model,
    rho = 0.5)

## Model
lnVR_mod_dosage <- rma.mv(yi = lnVR, V = lnVRVCV_dosage, random = list(~1 | study_id,
    ~1 | assay_id, ~1 | species_latin, ~1 | pesticide), mods = ~log_dosage_convert_ugL -
    1, method = "REML", test = "t", data = data_dosage_model, sparse = T)

# Summary results
summary(lnVR_mod_dosage)

## 
## Multivariate Meta-Analysis Model (k = 424; method: REML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -377.7153   755.4307   765.4307   785.6675   765.5745   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor 
## sigma^2.1  0.0146  0.1207     33     no       study_id 
## sigma^2.2  0.2650  0.5148    424     no       assay_id 
## sigma^2.3  0.0000  0.0000     10     no  species_latin 
## sigma^2.4  0.0000  0.0000     26     no      pesticide 
## 
## Test for Residual Heterogeneity:
## QE(df = 423) = 3576.1874, p-val < .0001
## 
## Model Results:
## 
##                         estimate      se     tval   df    pval    ci.lb   ci.ub 
## log_dosage_convert_ugL   -0.0140  0.0093  -1.5142  423  0.1307  -0.0323  0.0042 
##                           
## log_dosage_convert_ugL    
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

dosage_mod_lnVR_results <- mod_results(lnVR_mod_dosage, mod = "log_dosage_convert_ugL",
    data = data_dosage_model, group = "study_id")

r2_lnVR_dosage <- r2_ml(lnVR_mod_dosage, data_dosage_model)

Moderate by duration of pesticide (lnRR)

# Create dataframe for model with consistent duration units
data_duration_model <- data %>%
    filter(!is.na(duration), duration != "not reported") %>%
    mutate(duration = as.numeric(duration), duration_unit = as.character(duration_unit),
        duration_unit_consistent = case_when(duration_unit == "minutes" ~ "hours",
            duration_unit == "days" ~ "hours", duration_unit == "weeks" ~ "hours",
            TRUE ~ duration_unit), duration_convert = case_when(duration_unit ==
            "minutes" ~ duration/60, duration_unit == "days" ~ duration * 24, duration_unit ==
            "weeks" ~ duration * 168, TRUE ~ duration))


# Recalculate the VCV matrix based on the new data frame
lnRRVCV_duration <- metafor::vcalc(vi = lnRRv, cluster = exp_id, obs = assay_id,
    data = data_duration_model, rho = 0.5)

# Model
lnRR_mod_duration <- rma.mv(yi = lnRR, V = lnRRVCV_duration, random = list(~1 | study_id,
    ~1 | assay_id, ~1 | species_latin, ~1 | pesticide), mods = ~duration_convert -
    1, method = "REML", test = "t", data = data_duration_model, sparse = T)


# Summary results
summary(lnRR_mod_duration)

## 
## Multivariate Meta-Analysis Model (k = 447; method: REML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -171.6113   343.2226   353.2226   373.7242   353.3590   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor 
## sigma^2.1  0.0630  0.2510     36     no       study_id 
## sigma^2.2  0.0581  0.2411    447     no       assay_id 
## sigma^2.3  0.0943  0.3070     10     no  species_latin 
## sigma^2.4  0.0064  0.0797     29     no      pesticide 
## 
## Test for Residual Heterogeneity:
## QE(df = 446) = 5152.2750, p-val < .0001
## 
## Model Results:
## 
##                   estimate      se     tval   df    pval    ci.lb   ci.ub    
## duration_convert   -0.0001  0.0001  -0.8544  446  0.3933  -0.0002  0.0001    
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

duration_mod_lnRR_results <- mod_results(lnRR_mod_duration, mod = "duration_convert",
    data = data_duration_model, group = "study_id")

r2_lnRR_duration <- r2_ml(lnRR_mod_duration, data_duration_model)

Moderate by duration of pesticide (lnVR)

# Recalculate the VCV matrix based on the new data frame
lnVRVCV_duration <- metafor::vcalc(vi = lnVRv, cluster = exp_id, obs = assay_id,
    data = data_duration_model, rho = 0.5)

## Model
lnVR_mod_duration <- rma.mv(yi = lnVR, V = lnVRVCV_duration, random = list(~1 | study_id,
    ~1 | assay_id, ~1 | species_latin, ~1 | pesticide), mods = ~log(duration_convert) -
    1, method = "REML", test = "t", data = data_duration_model, sparse = T)

# Summary results
summary(lnVR_mod_duration)

## 
## Multivariate Meta-Analysis Model (k = 447; method: REML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -390.3365   780.6730   790.6730   811.1746   790.8093   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor 
## sigma^2.1  0.0105  0.1024     36     no       study_id 
## sigma^2.2  0.2509  0.5009    447     no       assay_id 
## sigma^2.3  0.0241  0.1553     10     no  species_latin 
## sigma^2.4  0.0024  0.0485     29     no      pesticide 
## 
## Test for Residual Heterogeneity:
## QE(df = 446) = 3618.9593, p-val < .0001
## 
## Model Results:
## 
##                        estimate      se     tval   df    pval    ci.lb   ci.ub 
## log(duration_convert)   -0.0112  0.0129  -0.8625  446  0.3889  -0.0366  0.0143 
##                          
## log(duration_convert)    
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

lnVR_mod_duration_results <- mod_results(lnVR_mod_duration, mod = "duration_convert",
    data = data_duration_model, group = "study_id")

r2_lnVR_duration <- r2_ml(lnVR_mod_duration, data_duration_model)

Moderate by control solvent used (lnRR)

# Model
lnRR_mod_solvent <- rma.mv(yi = lnRR, V = lnRRVCV, random = list(~1 | study_id, ~1 |
    assay_id, ~1 | species_latin, ~1 | pesticide), mods = ~control_solvent - 1, method = "REML",
    test = "t", data = data, sparse = T)
# Summary results
summary(lnRR_mod_solvent)

## 
## Multivariate Meta-Analysis Model (k = 448; method: REML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -158.2294   316.4588   336.4588   377.3719   336.9692   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor 
## sigma^2.1  0.0525  0.2292     37     no       study_id 
## sigma^2.2  0.0560  0.2366    448     no       assay_id 
## sigma^2.3  0.0901  0.3002     10     no  species_latin 
## sigma^2.4  0.0100  0.1001     30     no      pesticide 
## 
## Test for Residual Heterogeneity:
## QE(df = 442) = 4609.1221, p-val < .0001
## 
## Test of Moderators (coefficients 1:6):
## F(df1 = 6, df2 = 442) = 3.2090, p-val = 0.0043
## 
## Model Results:
## 
##                              estimate      se     tval   df    pval    ci.lb 
## control_solventacetone        -0.4324  0.2101  -2.0582  442  0.0402  -0.8453 
## control_solventDMSO           -0.2572  0.1430  -1.7994  442  0.0726  -0.5382 
## control_solventDTNB            0.3652  0.3579   1.0203  442  0.3081  -0.3382 
## control_solventethanol        -0.0796  0.3061  -0.2602  442  0.7949  -0.6813 
## control_solventnone           -0.4687  0.1473  -3.1828  442  0.0016  -0.7581 
## control_solventnot reported   -0.3131  0.1452  -2.1562  442  0.0316  -0.5986 
##                                ci.ub     
## control_solventacetone       -0.0195   * 
## control_solventDMSO           0.0237   . 
## control_solventDTNB           1.0686     
## control_solventethanol        0.5220     
## control_solventnone          -0.1793  ** 
## control_solventnot reported  -0.0277   * 
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

mod_results(lnRR_mod_solvent, mod = "control_solvent", data = data, group = "study_id")  # For prediction intervals

##           name    estimate    lowerCL     upperCL    lowerPR   upperPR
## 1      Acetone -0.43239818 -0.8452817 -0.01951462 -1.4205239 0.5557275
## 2         DMSO -0.25723535 -0.5381937  0.02372303 -1.1979038 0.6834331
## 3         DTNB  0.36517835 -0.3382454  1.06860210 -0.7753148 1.5056715
## 4      Ethanol -0.07964196 -0.6813076  0.52202365 -1.1603459 1.0010620
## 5         None -0.46870558 -0.7581296 -0.17928159 -1.4119372 0.4745260
## 6 Not reported -0.31314903 -0.5985793 -0.02771877 -1.2551628 0.6288648

r2_ml(lnRR_mod_solvent)

##    R2_marginal R2_conditional 
##     0.09182819     0.95638011

# Model
lnRR_mod_solvent2 <- rma.mv(yi = lnRR, V = lnRRVCV, random = list(~1 | study_id,
    ~1 | assay_id, ~1 | species_latin, ~1 | pesticide), mods = ~solvent2 - 1, method = "REML",
    test = "t", data = data, sparse = T)
# Summary results
summary(lnRR_mod_solvent2)

## 
## Multivariate Meta-Analysis Model (k = 322; method: REML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -104.4008   208.8016   220.8016   243.4115   221.0700   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor 
## sigma^2.1  0.0233  0.1526     26     no       study_id 
## sigma^2.2  0.0561  0.2368    322     no       assay_id 
## sigma^2.3  0.0343  0.1851      7     no  species_latin 
## sigma^2.4  0.0366  0.1913     23     no      pesticide 
## 
## Test for Residual Heterogeneity:
## QE(df = 320) = 3517.4706, p-val < .0001
## 
## Test of Moderators (coefficients 1:2):
## F(df1 = 2, df2 = 320) = 7.4927, p-val = 0.0007
## 
## Model Results:
## 
##                       estimate      se     tval   df    pval    ci.lb    ci.ub 
## solvent2none           -0.4323  0.1243  -3.4767  320  0.0006  -0.6769  -0.1877 
## solvent2solvent_used   -0.2364  0.1140  -2.0741  320  0.0389  -0.4607  -0.0122 
##                           
## solvent2none          *** 
## solvent2solvent_used    * 
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

mod_results(lnRR_mod_solvent2, mod = "solvent2", data = data, group = "study_id")  # For prediction intervals

##           name   estimate    lowerCL     upperCL   lowerPR   upperPR
## 1         None -0.4322903 -0.6769184 -0.18766232 -1.233181 0.3686002
## 2 Solvent_used -0.2364478 -0.4607294 -0.01216618 -1.031360 0.5584642

r2_ml(lnRR_mod_solvent2)

##    R2_marginal R2_conditional 
##     0.05832539     0.77057361

# Contrast Model
lnRR_mod_solvent2_contrast <- rma.mv(yi = lnRR, V = lnRRVCV, random = list(~1 | study_id,
    ~1 | assay_id, ~1 | species_latin, ~1 | pesticide), mods = ~solvent2, method = "REML",
    test = "t", data = data, sparse = T)
# Summary results
summary(lnRR_mod_solvent2_contrast)

## 
## Multivariate Meta-Analysis Model (k = 322; method: REML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -104.4008   208.8016   220.8016   243.4115   221.0700   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor 
## sigma^2.1  0.0233  0.1526     26     no       study_id 
## sigma^2.2  0.0561  0.2368    322     no       assay_id 
## sigma^2.3  0.0343  0.1851      7     no  species_latin 
## sigma^2.4  0.0366  0.1913     23     no      pesticide 
## 
## Test for Residual Heterogeneity:
## QE(df = 320) = 3517.4706, p-val < .0001
## 
## Test of Moderators (coefficient 2):
## F(df1 = 1, df2 = 320) = 8.9451, p-val = 0.0030
## 
## Model Results:
## 
##                       estimate      se     tval   df    pval    ci.lb    ci.ub 
## intrcpt                -0.4323  0.1243  -3.4767  320  0.0006  -0.6769  -0.1877 
## solvent2solvent_used    0.1958  0.0655   2.9908  320  0.0030   0.0670   0.3247 
##                           
## intrcpt               *** 
## solvent2solvent_used   ** 
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

mod_results(lnRR_mod_solvent2_contrast, mod = "solvent2", data = data, group = "study_id")

##           name   estimate    lowerCL     upperCL   lowerPR   upperPR
## 1         None -0.4322903 -0.6769184 -0.18766232 -1.233181 0.3686002
## 2 Solvent_used -0.2364478 -0.4607294 -0.01216618 -1.031360 0.5584642

Moderate by control solvent used (lnVR)

# Model
lnVR_mod_solvent <- rma.mv(yi = lnVR, V = lnVRVCV, random = list(~1 | study_id, ~1 |
    assay_id, ~1 | species_latin, ~1 | pesticide), mods = ~control_solvent - 1, method = "REML",
    test = "t", data = data, sparse = T)

# Summary results
summary(lnVR_mod_solvent)

## 
## Multivariate Meta-Analysis Model (k = 448; method: REML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -383.0086   766.0171   786.0171   826.9302   786.5276   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor 
## sigma^2.1  0.0056  0.0750     37     no       study_id 
## sigma^2.2  0.2463  0.4963    448     no       assay_id 
## sigma^2.3  0.0664  0.2578     10     no  species_latin 
## sigma^2.4  0.0088  0.0937     30     no      pesticide 
## 
## Test for Residual Heterogeneity:
## QE(df = 442) = 3591.5475, p-val < .0001
## 
## Test of Moderators (coefficients 1:6):
## F(df1 = 6, df2 = 442) = 1.1873, p-val = 0.3118
## 
## Model Results:
## 
##                              estimate      se     tval   df    pval    ci.lb 
## control_solventacetone         0.0357  0.2062   0.1732  442  0.8626  -0.3695 
## control_solventDMSO           -0.1065  0.1259  -0.8456  442  0.3982  -0.3540 
## control_solventDTNB           -0.1484  0.4262  -0.3483  442  0.7278  -0.9860 
## control_solventethanol         0.6455  0.3544   1.8210  442  0.0693  -0.0512 
## control_solventnone           -0.1624  0.1355  -1.1984  442  0.2314  -0.4286 
## control_solventnot reported   -0.1506  0.1282  -1.1752  442  0.2406  -0.4025 
##                               ci.ub    
## control_solventacetone       0.4409    
## control_solventDMSO          0.1410    
## control_solventDTNB          0.6892    
## control_solventethanol       1.3421  . 
## control_solventnone          0.1039    
## control_solventnot reported  0.1013    
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

mod_results(lnVR_mod_solvent, mod = "control_solvent", data = data, group = "study_id")

##           name    estimate     lowerCL   upperCL    lowerPR  upperPR
## 1      Acetone  0.03570967 -0.36945573 0.4408751 -1.1592330 1.230652
## 2         DMSO -0.10649681 -0.35401172 0.1410181 -1.2575801 1.044586
## 3         DTNB -0.14843971 -0.98603407 0.6891546 -1.5503289 1.253449
## 4      Ethanol  0.64545014 -0.05116164 1.3420619 -0.6770464 1.967947
## 5         None -0.16236262 -0.42863825 0.1039130 -1.3176252 0.992900
## 6 Not reported -0.15061013 -0.40248779 0.1012675 -1.3026394 1.001419

r2_ml(lnVR_mod_solvent)

##    R2_marginal R2_conditional 
##     0.06827873     0.97500236

# Model
lnVR_mod_solvent2 <- rma.mv(yi = lnVR, V = lnVRVCV, random = list(~1 | study_id,
    ~1 | assay_id, ~1 | species_latin, ~1 | pesticide), mods = ~solvent2 - 1, method = "REML",
    test = "t", data = data, sparse = T)
# Summary results
summary(lnVR_mod_solvent2)

## 
## Multivariate Meta-Analysis Model (k = 322; method: REML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -300.4493   600.8985   612.8985   635.5085   613.1669   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor 
## sigma^2.1  0.0000  0.0000     26     no       study_id 
## sigma^2.2  0.2755  0.5249    322     no       assay_id 
## sigma^2.3  0.3615  0.6013      7     no  species_latin 
## sigma^2.4  0.0210  0.1450     23     no      pesticide 
## 
## Test for Residual Heterogeneity:
## QE(df = 320) = 2479.8766, p-val < .0001
## 
## Test of Moderators (coefficients 1:2):
## F(df1 = 2, df2 = 320) = 0.4568, p-val = 0.6337
## 
## Model Results:
## 
##                       estimate      se     tval   df    pval    ci.lb   ci.ub 
## solvent2none           -0.0140  0.2687  -0.0523  320  0.9584  -0.5427  0.5146 
## solvent2solvent_used    0.0752  0.2552   0.2949  320  0.7683  -0.4268  0.5772 
##                         
## solvent2none            
## solvent2solvent_used    
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

mod_results(lnVR_mod_solvent2, mod = "solvent2", data = data, group = "study_id")

##           name    estimate    lowerCL   upperCL   lowerPR  upperPR
## 1         None -0.01404355 -0.5427048 0.5146177 -1.695284 1.667197
## 2 Solvent_used  0.07524158 -0.4267601 0.5772433 -1.597807 1.748290

r2_ml(lnVR_mod_solvent2)

##    R2_marginal R2_conditional 
##    0.002930854    0.968125747

# Model
lnVR_mod_solvent2_contrast <- rma.mv(yi = lnVR, V = lnVRVCV, random = list(~1 | study_id,
    ~1 | assay_id, ~1 | species_latin, ~1 | pesticide), mods = ~solvent2, method = "REML",
    test = "t", data = data, sparse = T)

# Summary results
summary(lnVR_mod_solvent2_contrast)

## 
## Multivariate Meta-Analysis Model (k = 322; method: REML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -300.4493   600.8985   612.8985   635.5085   613.1669   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor 
## sigma^2.1  0.0000  0.0000     26     no       study_id 
## sigma^2.2  0.2755  0.5249    322     no       assay_id 
## sigma^2.3  0.3615  0.6013      7     no  species_latin 
## sigma^2.4  0.0210  0.1450     23     no      pesticide 
## 
## Test for Residual Heterogeneity:
## QE(df = 320) = 2479.8766, p-val < .0001
## 
## Test of Moderators (coefficient 2):
## F(df1 = 1, df2 = 320) = 0.8497, p-val = 0.3573
## 
## Model Results:
## 
##                       estimate      se     tval   df    pval    ci.lb   ci.ub 
## intrcpt                -0.0140  0.2687  -0.0523  320  0.9584  -0.5427  0.5146 
## solvent2solvent_used    0.0893  0.0969   0.9218  320  0.3573  -0.1013  0.2798 
##                         
## intrcpt                 
## solvent2solvent_used    
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

mod_results(lnVR_mod_solvent2_contrast, mod = "solvent2", data = data, group = "study_id")

##           name    estimate    lowerCL   upperCL   lowerPR  upperPR
## 1         None -0.01404355 -0.5427048 0.5146177 -1.695284 1.667197
## 2 Solvent_used  0.07524158 -0.4267601 0.5772433 -1.597807 1.748290

r2_ml(lnVR_mod_solvent2_contrast)

##    R2_marginal R2_conditional 
##    0.002930854    0.968125747

Main text Figure 4

# Filter the mod_table for specific pesticide chemical classes
lnRR_pesticide_mod_results_filter <- dplyr::filter(lnRR_pesticide_mod_results$mod_table,
    name == "Triazole" | name == "Triazine" | name == "Pyrethroid" | name == "Organophosphate" |
        name == "Organochlorine")

# Filter the data for the same pesticide chemical classes
lnRR_pesticide_data_filter <- dplyr::filter(lnRR_pesticide_mod_results$data, moderator ==
    "Triazole" | moderator == "Triazine" | moderator == "Pyrethroid" | moderator ==
    "Organophosphate" | moderator == "Organochlorine")

# Create the lnRR_pesticide_orchard object
lnRR_pesticide_orchard2 <- list(mod_table = lnRR_pesticide_mod_results_filter, data = lnRR_pesticide_data_filter)

# Assign the appropriate classes to the object
class(lnRR_pesticide_orchard2) <- c("orchard", "data.frame")

# Filter the mod_table for lnVR_pesticide_mod_results
lnVR_pesticide_mod_results_filter <- dplyr::filter(lnVR_pesticide_mod_results$mod_table,
    name == "Triazole" | name == "Triazine" | name == "Pyrethroid" | name == "Organophosphate" |
        name == "Organochlorine")

# Filter the data for lnVR_pesticide_mod_results
lnVR_pesticide_data_filter <- dplyr::filter(lnVR_pesticide_mod_results$data, moderator ==
    "Triazole" | moderator == "Triazine" | moderator == "Pyrethroid" | moderator ==
    "Organophosphate" | moderator == "Organochlorine")

# Create the lnVR_pesticide_orchard object
lnVR_pesticide_orchard2 <- list(mod_table = lnVR_pesticide_mod_results_filter, data = lnVR_pesticide_data_filter)
class(lnVR_pesticide_orchard2) <- c("orchard", "data.frame")

# Figure 4a)
pesticide.mod.lnRR <- orchaRd::orchard_plot(lnRR_pesticide_orchard2, group = "study_id",
    xlab = "lnRR", data = data, mod = "pesticide_chemical_class", k.pos = "right",
    colour = FALSE, fill = TRUE, legend.pos = "none", trunk.size = 3, branch.size = 1.5,
    twig.size = 1, angle = 45) + scale_fill_manual(values = c(RColorBrewer::brewer.pal(8,
    "Dark2")))

# Figure 4b)
pesticide.mod.lnVR <- orchaRd::orchard_plot(lnVR_pesticide_orchard2, group = "study_id",
    xlab = "lnVR", data = data, mod = "pesticide_chemical_class", k.pos = "right",
    colour = FALSE, fill = TRUE, legend.pos = "none", trunk.size = 3, branch.size = 1.5,
    twig.size = 1, angle = 45) + scale_fill_manual(values = c(RColorBrewer::brewer.pal(8,
    "Dark2"))) + theme(axis.text.y = element_blank())

# Figure 4c)
dosage_bubble_plot.lnRR <- bubble_plot(dosage_mod_lnRR_results, mod = "log_dosage_convert_ugL",
    group = "study_id", data = data_dosage_model, x = "dosage_convert_ugL", y = "lnRR",
    est.lwd = 1, legend.pos = "bottom.right", k.pos = "bottom.left", ci.col = "red",
    pi.col = "black", est.col = "black", g = TRUE) + annotate(geom = "text", x = 7,
    y = 5.8, label = paste0("italic(R)^{2} == ", round(r2_lnRR_dosage[1], 4)), color = "black",
    parse = TRUE, size = 4) + ggtitle("") + theme(plot.title = element_text(size = 18),
    legend.position = "none", axis.title.x = element_text(size = 16), axis.title.y = element_text(size = 16),
    axis.text.y = element_text(size = 14), axis.text.x = element_text(size = 14)) +
    xlab("Dosage")

# Figure 4d)
dosage_bubble_plot.lnVR <- bubble_plot(dosage_mod_lnVR_results, mod = "log_dosage_convert_ugL",
    group = "study_id", data = data_dosage_model, x = "dosage_convert_ugL", y = "lnVR",
    est.lwd = 1, legend.pos = "bottom.right", k.pos = "bottom.left", ci.col = "red",
    pi.col = "black", est.col = "black", g = TRUE) + annotate(geom = "text", x = 7,
    y = 5.8, label = paste0("italic(R)^{2} == ", round(r2_lnVR_dosage[1], 4)), color = "black",
    parse = TRUE, size = 4) + ggtitle("") + theme(plot.title = element_text(size = 18),
    legend.position = "none", axis.title.x = element_text(size = 16), axis.title.y = element_text(size = 16),
    axis.text.y = element_text(size = 14), axis.text.x = element_text(size = 14)) +
    xlab("Dosage")

# Figure 4e)
duration_bubble_plot.lnRR <- bubble_plot(duration_mod_lnRR_results, mod = "duration_convert",
    group = "study_id", data = data_duration_model, x = "duration_convert", y = "lnRR",
    est.lwd = 1, legend.pos = "bottom.right", k.pos = "bottom.left", ci.col = "red",
    pi.col = "black", est.col = "black", g = TRUE) + annotate(geom = "text", x = 2800,
    y = 1.3, label = paste0("italic(R)^{2} == ", round(r2_lnRR_duration[1], 4)),
    color = "black", parse = TRUE, size = 4) + ggtitle("") + theme(plot.title = element_text(size = 18),
    legend.position = "none", axis.title.x = element_text(size = 16), axis.title.y = element_text(size = 16),
    axis.text.y = element_text(size = 14), axis.text.x = element_text(size = 14)) +
    xlab("Duration")

# Figure 4f)
duration_bubble_plot.lnVR <- bubble_plot(lnVR_mod_duration_results, mod = "duration_convert",
    group = "study_id", data = data_duration_model, x = "duration_convert", y = "lnVR",
    est.lwd = 1, legend.pos = "bottom.right", k.pos = "bottom.left", ci.col = "red",
    pi.col = "black", est.col = "black", g = TRUE) + annotate(geom = "text", x = 2800,
    y = 2.1, label = paste0("italic(R)^{2} == ", round(r2_lnVR_duration[1], 4)),
    color = "black", parse = TRUE, size = 4) + ggtitle("") + theme(plot.title = element_text(size = 18),
    legend.position = "none", axis.title.x = element_text(size = 16), axis.title.y = element_text(size = 16),
    axis.text.y = element_text(size = 14), axis.text.x = element_text(size = 14)) +
    xlab("Duration")

# Figure 4g)
solvent.mod.lnRR2 <- orchaRd::orchard_plot(lnRR_mod_solvent2, group = "study_id",
    xlab = "lnRR", data = data, mod = "solvent2", k.pos = "right", colour = FALSE,
    fill = TRUE, legend.pos = "none", trunk.size = 3, branch.size = 1.5, twig.size = 1,
    angle = 45) + scale_fill_manual(values = c(RColorBrewer::brewer.pal(8, "Dark2"),
    "#66C2A5", "#FC8D62", "#8DA0CB", "#E78AC3", "#A6D854"))

# Figure 4h)
solvent.mod.lnVR2 <- orchaRd::orchard_plot(lnVR_mod_solvent2, group = "study_id",
    xlab = "lnVR", data = data, mod = "solvent2", k.pos = "right", colour = FALSE,
    fill = TRUE, legend.pos = "none", trunk.size = 3, branch.size = 1.5, twig.size = 1,
    angle = 45) + scale_fill_manual(values = c(RColorBrewer::brewer.pal(8, "Dark2"),
    "#66C2A5", "#FC8D62", "#8DA0CB", "#E78AC3", "#A6D854")) + theme(axis.text.y = element_blank())

main_text_figure_4 <- (pesticide.mod.lnRR + pesticide.mod.lnVR)/(dosage_bubble_plot.lnRR +
    dosage_bubble_plot.lnVR)/(duration_bubble_plot.lnRR + duration_bubble_plot.lnVR)/(solvent.mod.lnRR2 +
    solvent.mod.lnVR2) + plot_annotation(tag_levels = "A")

print(main_text_figure_4)

# ggsave(here('figures', 'main_text_figure_4.jpg'),width = 28, height = 40,
# units = 'cm', dpi = 800) ggsave(here('figures',
# 'main_text_figure_4.pdf'),width = 28, height = 40, units = 'cm', dpi = 800)

Species characteristics

Moderate by species (lnRR)

# Model
lnRR_mod_species <- rma.mv(yi = lnRR, V = lnRRVCV, random = list(~1 | study_id, ~1 |
    assay_id, ~1 | species_latin, ~1 | pesticide), mods = ~species_english - 1, method = "REML",
    test = "t", data = data, sparse = T)

# Summary results
summary(lnRR_mod_species)

## 
## Multivariate Meta-Analysis Model (k = 448; method: REML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -155.4986   310.9973   338.9973   396.1484   339.9902   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor 
## sigma^2.1  0.0599  0.2448     37     no       study_id 
## sigma^2.2  0.0577  0.2402    448     no       assay_id 
## sigma^2.3  0.0414  0.2034     10     no  species_latin 
## sigma^2.4  0.0091  0.0954     30     no      pesticide 
## 
## Test for Residual Heterogeneity:
## QE(df = 438) = 4113.4236, p-val < .0001
## 
## Test of Moderators (coefficients 1:10):
## F(df1 = 10, df2 = 438) = 1.7271, p-val = 0.0723
## 
## Model Results:
## 
##                                 estimate      se     tval   df    pval    ci.lb 
## species_englishBleak             -1.0922  0.4247  -2.5720  438  0.0104  -1.9268 
## species_englishbrown trout        0.0678  0.3881   0.1748  438  0.8614  -0.6949 
## species_englishguppy             -0.4675  0.3002  -1.5572  438  0.1202  -1.0576 
## species_englishIberian barbel     0.1383  0.4125   0.3352  438  0.7376  -0.6724 
## species_englishJapanese medaka   -0.3932  0.2678  -1.4685  438  0.1427  -0.9194 
## species_englishkillifish         -0.2456  0.2923  -0.8403  438  0.4012  -0.8200 
## species_englishmarine medaka     -0.1522  0.3378  -0.4506  438  0.6525  -0.8162 
## species_englishNile tilapia      -0.6422  0.3964  -1.6201  438  0.1059  -1.4214 
## species_englishsailfin mollie    -0.2627  0.3345  -0.7852  438  0.4328  -0.9201 
## species_englishzebrafish         -0.0314  0.2124  -0.1478  438  0.8826  -0.4489 
##                                   ci.ub    
## species_englishBleak            -0.2576  * 
## species_englishbrown trout       0.8306    
## species_englishguppy             0.1226    
## species_englishIberian barbel    0.9490    
## species_englishJapanese medaka   0.1330    
## species_englishkillifish         0.3288    
## species_englishmarine medaka     0.5117    
## species_englishNile tilapia      0.1369    
## species_englishsailfin mollie    0.3948    
## species_englishzebrafish         0.3861    
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

r2_ml(lnRR_mod_species)

##    R2_marginal R2_conditional 
##      0.1119298      0.9518961

lnRR_species_mod_results <- mod_results(lnRR_mod_species, mod = "species_english",
    data = data, group = "study_id")

Moderate by species (lnVR)

## ModeL
lnVR_mod_species <- rma.mv(yi = lnVR, V = lnVRVCV, random = list(~1 | study_id, ~1 |
    assay_id, ~1 | species_latin, ~1 | pesticide), mods = ~species_english - 1, method = "REML",
    test = "t", data = data, sparse = T)


# Summary results
summary(lnVR_mod_species)

## 
## Multivariate Meta-Analysis Model (k = 448; method: REML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -377.8838   755.7676   783.7676   840.9187   784.7605   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor 
## sigma^2.1  0.0016  0.0398     37     no       study_id 
## sigma^2.2  0.2483  0.4983    448     no       assay_id 
## sigma^2.3  0.0493  0.2220     10     no  species_latin 
## sigma^2.4  0.0133  0.1155     30     no      pesticide 
## 
## Test for Residual Heterogeneity:
## QE(df = 438) = 3559.4309, p-val < .0001
## 
## Test of Moderators (coefficients 1:10):
## F(df1 = 10, df2 = 438) = 0.9211, p-val = 0.5134
## 
## Model Results:
## 
##                                 estimate      se     tval   df    pval    ci.lb 
## species_englishBleak              0.2207  0.4836   0.4564  438  0.6483  -0.7297 
## species_englishbrown trout        0.2881  0.3927   0.7337  438  0.4635  -0.4836 
## species_englishguppy              0.1616  0.3262   0.4955  438  0.6205  -0.4795 
## species_englishIberian barbel     0.0239  0.4836   0.0493  438  0.9607  -0.9265 
## species_englishJapanese medaka   -0.4085  0.2860  -1.4285  438  0.1539  -0.9705 
## species_englishkillifish         -0.2176  0.2721  -0.7998  438  0.4243  -0.7523 
## species_englishmarine medaka     -0.2494  0.2861  -0.8716  438  0.3839  -0.8117 
## species_englishNile tilapia      -0.8106  0.4098  -1.9782  438  0.0485  -1.6159 
## species_englishsailfin mollie     0.2603  0.2757   0.9443  438  0.3455  -0.2815 
## species_englishzebrafish         -0.0431  0.2276  -0.1893  438  0.8499  -0.4905 
##                                   ci.ub    
## species_englishBleak             1.1711    
## species_englishbrown trout       1.0598    
## species_englishguppy             0.8028    
## species_englishIberian barbel    0.9742    
## species_englishJapanese medaka   0.1535    
## species_englishkillifish         0.3171    
## species_englishmarine medaka     0.3130    
## species_englishNile tilapia     -0.0053  * 
## species_englishsailfin mollie    0.8022    
## species_englishzebrafish         0.4043    
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

lnVR_species_mod_results <- mod_results(lnVR_mod_species, mod = "species_english",
    data = data, group = "study_id")

r2_ml(lnVR_mod_species)

##    R2_marginal R2_conditional 
##     0.07062817     0.96033072

Figure s19

The moderating effects of species chemical class on (A) response magnitude and (B) response variability in conspecific interactions. Shorter whiskers represent 95% confidence intervals, while longer whiskers indicate 95% prediction intervals. ‘k’ represents the number of effect sizes, and the number of studies is in brackets. Each circle corresponds to an effect size, with its size scaled according to precision (inverse sampling error variance).

# Figure s19A)
species_all_mod_orchard.lnRR <- orchaRd::orchard_plot(lnRR_mod_species, group = "study_id",
    xlab = "lnRR", data = data, mod = "species_english", g = TRUE, k.pos = "right",
    colour = FALSE, fill = TRUE, legend.pos = "none", trunk.size = 3, branch.size = 1.5,
    twig.size = 1, angle = 45)

# Figure s19B)
species_all_mod_orchard.lnVR <- orchaRd::orchard_plot(lnVR_mod_species, group = "study_id",
    xlab = "lnVR", data = data, mod = "species_english", g = TRUE, k.pos = "right",
    colour = FALSE, fill = TRUE, legend.pos = "none", trunk.size = 3, branch.size = 1.5,
    twig.size = 1, angle = 45) + theme(axis.text.y = element_blank())


species_all_mod_orchard <- species_all_mod_orchard.lnRR + species_all_mod_orchard.lnVR

print(species_all_mod_orchard)

# ggsave(here('figures', 'species_all_mod_orchard.jpg'), plot =
# species_all_mod_orchard, width = 30, height = 18, units = 'cm', dpi = 800)
# ggsave(here('figures', 'species_all_mod_orchard.pdf'),plot =
# species_all_mod_orchard, width = 30, height = 18, units = 'cm', dpi = 800)

Moderate by sex (lnRR)

# Model
lnRR_mod_sex <- rma.mv(yi = lnRR, V = lnRRVCV, random = list(~1 | study_id, ~1 |
    assay_id, ~1 | species_latin, ~1 | pesticide), mods = ~sex - 1, method = "REML",
    test = "t", data = data, sparse = T)

# Summary results
summary(lnRR_mod_sex)

## 
## Multivariate Meta-Analysis Model (k = 448; method: REML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -166.8356   333.6713   349.6713   382.4379   350.0023   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor 
## sigma^2.1  0.0599  0.2447     37     no       study_id 
## sigma^2.2  0.0575  0.2397    448     no       assay_id 
## sigma^2.3  0.0816  0.2857     10     no  species_latin 
## sigma^2.4  0.0078  0.0885     30     no      pesticide 
## 
## Test for Residual Heterogeneity:
## QE(df = 444) = 4958.0180, p-val < .0001
## 
## Test of Moderators (coefficients 1:4):
## F(df1 = 4, df2 = 444) = 1.7540, p-val = 0.1371
## 
## Model Results:
## 
##                  estimate      se     tval   df    pval    ci.lb    ci.ub     
## sexfemale         -0.2844  0.1397  -2.0361  444  0.0423  -0.5590  -0.0099   * 
## sexmale           -0.2671  0.1318  -2.0270  444  0.0433  -0.5260  -0.0081   * 
## sexmixed          -0.3562  0.1368  -2.6041  444  0.0095  -0.6250  -0.0874  ** 
## sexnot reported   -0.1736  0.1647  -1.0544  444  0.2923  -0.4973   0.1500     
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

mod_results(lnRR_mod_sex, mod = "sex", data = data, group = "study_id")  # For prediction intervals

##           name   estimate    lowerCL      upperCL   lowerPR   upperPR
## 1       Female -0.2844447 -0.5590006 -0.009888818 -1.219430 0.6505404
## 2         Male -0.2670605 -0.5260000 -0.008121092 -1.197580 0.6634586
## 3        Mixed -0.3561937 -0.6250184 -0.087369012 -1.289512 0.5771245
## 4 Not reported -0.1736282 -0.4972699  0.150013425 -1.124186 0.7769296

r2_ml(lnRR_mod_sex)

##    R2_marginal R2_conditional 
##      0.0203154      0.9628741

data_sex <- data %>%
    filter(sex == c("male", "female"))

lnRRVCV_sex <- metafor::vcalc(vi = lnRRv, cluster = exp_id, obs = assay_id, data = data_sex,
    rho = 0.5)

lnRR_mod_sex_contrast <- rma.mv(yi = lnRR, V = lnRRVCV_sex, random = list(~1 | study_id,
    ~1 | assay_id, ~1 | species_latin, ~1 | pesticide), mods = ~sex, method = "REML",
    test = "t", data = data_sex, sparse = T)


summary(lnRR_mod_sex_contrast)

## 
## Multivariate Meta-Analysis Model (k = 72; method: REML)
## 
##   logLik  Deviance       AIC       BIC      AICc   
## -16.7421   33.4841   45.4841   58.9751   46.8175   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor 
## sigma^2.1  0.0000  0.0000     13     no       study_id 
## sigma^2.2  0.0438  0.2094     72     no       assay_id 
## sigma^2.3  0.0227  0.1506      7     no  species_latin 
## sigma^2.4  0.0292  0.1709     14     no      pesticide 
## 
## Test for Residual Heterogeneity:
## QE(df = 70) = 882.3697, p-val < .0001
## 
## Test of Moderators (coefficient 2):
## F(df1 = 1, df2 = 70) = 0.9921, p-val = 0.3227
## 
## Model Results:
## 
##          estimate      se     tval  df    pval    ci.lb   ci.ub    
## intrcpt   -0.2357  0.1195  -1.9725  70  0.0525  -0.4740  0.0026  . 
## sexmale   -0.0809  0.0812  -0.9960  70  0.3227  -0.2429  0.0811    
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

Moderate by sex (lnVR)

# Model
lnVR_mod_sex <- rma.mv(yi = lnVR, V = lnVRVCV, random = list(~1 | study_id, ~1 |
    assay_id, ~1 | species_latin, ~1 | pesticide), mods = ~sex - 1, method = "REML",
    test = "t", data = data, sparse = T)


# Summary results
summary(lnVR_mod_sex)

## 
## Multivariate Meta-Analysis Model (k = 448; method: REML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -387.6801   775.3602   791.3602   824.1268   791.6913   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor 
## sigma^2.1  0.0105  0.1022     37     no       study_id 
## sigma^2.2  0.2502  0.5002    448     no       assay_id 
## sigma^2.3  0.0299  0.1730     10     no  species_latin 
## sigma^2.4  0.0040  0.0634     30     no      pesticide 
## 
## Test for Residual Heterogeneity:
## QE(df = 444) = 3613.1164, p-val < .0001
## 
## Test of Moderators (coefficients 1:4):
## F(df1 = 4, df2 = 444) = 0.5853, p-val = 0.6734
## 
## Model Results:
## 
##                  estimate      se     tval   df    pval    ci.lb   ci.ub    
## sexfemale         -0.0686  0.1288  -0.5331  444  0.5943  -0.3217  0.1844    
## sexmale           -0.0961  0.1046  -0.9186  444  0.3588  -0.3016  0.1095    
## sexmixed          -0.1303  0.1045  -1.2462  444  0.2133  -0.3357  0.0752    
## sexnot reported    0.0381  0.1508   0.2526  444  0.8007  -0.2582  0.3344    
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

mod_results(lnVR_mod_sex, mod = "sex", data = data, group = "study_id")  # For prediction intervals

##           name    estimate    lowerCL    upperCL   lowerPR   upperPR
## 1       Female -0.06863887 -0.3216977 0.18441998 -1.164870 1.0275918
## 2         Male -0.09607752 -0.3016354 0.10948039 -1.182327 0.9901715
## 3        Mixed -0.13027676 -0.3357290 0.07517548 -1.216506 0.9559523
## 4 Not reported  0.03807715 -0.2582014 0.33435569 -1.068930 1.1450838

r2_ml(lnVR_mod_sex)

##    R2_marginal R2_conditional 
##     0.01129353     0.98651090

lnVRVCV_sex <- metafor::vcalc(vi = lnVRv, cluster = exp_id, obs = assay_id, data = data_sex,
    rho = 0.5)

# Model
lnVR_mod_sex_contrast <- rma.mv(yi = lnVR, V = lnVRVCV_sex, random = list(~1 | study_id,
    ~1 | assay_id, ~1 | species_latin, ~1 | pesticide), mods = ~sex, method = "REML",
    test = "t", data = data_sex, sparse = T)

summary(lnVR_mod_sex_contrast)

## 
## Multivariate Meta-Analysis Model (k = 72; method: REML)
## 
##   logLik  Deviance       AIC       BIC      AICc   
## -73.3252  146.6503  158.6503  172.1413  159.9837   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor 
## sigma^2.1  0.0000  0.0000     13     no       study_id 
## sigma^2.2  0.3612  0.6010     72     no       assay_id 
## sigma^2.3  0.0000  0.0000      7     no  species_latin 
## sigma^2.4  0.0030  0.0550     14     no      pesticide 
## 
## Test for Residual Heterogeneity:
## QE(df = 70) = 514.7340, p-val < .0001
## 
## Test of Moderators (coefficient 2):
## F(df1 = 1, df2 = 70) = 0.5050, p-val = 0.4797
## 
## Model Results:
## 
##          estimate      se     tval  df    pval    ci.lb   ci.ub    
## intrcpt   -0.1526  0.1395  -1.0946  70  0.2775  -0.4308  0.1255    
## sexmale    0.1204  0.1694   0.7107  70  0.4797  -0.2174  0.4582    
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

Moderate by source of fish (lnRR)

data_source <- data %>%
    filter(source %in% c("wild collected", "commercial supplier"))

lnRRVCV_source <- metafor::vcalc(vi = lnRRv, cluster = exp_id, obs = assay_id, data = data_source,
    rho = 0.5)

lnVRVCV_source <- metafor::vcalc(vi = lnVRv, cluster = exp_id, obs = assay_id, data = data_source,
    rho = 0.5)

## ModeL
lnRR_mod_source <- rma.mv(yi = lnRR, V = lnRRVCV, random = list(~1 | study_id, ~1 |
    assay_id, ~1 | species_latin, ~1 | pesticide), mods = ~source - 1, method = "REML",
    test = "t", data = data, sparse = T)

# Summary results
summary(lnRR_mod_source)

## 
## Multivariate Meta-Analysis Model (k = 448; method: REML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -162.4387   324.8775   344.8775   385.7906   345.3879   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor 
## sigma^2.1  0.0542  0.2327     37     no       study_id 
## sigma^2.2  0.0579  0.2406    448     no       assay_id 
## sigma^2.3  0.0836  0.2892     10     no  species_latin 
## sigma^2.4  0.0089  0.0945     30     no      pesticide 
## 
## Test for Residual Heterogeneity:
## QE(df = 442) = 4015.5954, p-val < .0001
## 
## Test of Moderators (coefficients 1:6):
## F(df1 = 6, df2 = 442) = 1.6894, p-val = 0.1218
## 
## Model Results:
## 
##                                                   estimate      se     tval 
## sourcecommercial supplier                          -0.1124  0.1747  -0.6430 
## sourcelaboratory stock from not specified source   -0.1486  0.1548  -0.9600 
## sourcelabratory stock from commercial supplier     -0.0772  0.3051  -0.2529 
## sourcelabratory stock from wild population         -0.0717  0.1904  -0.3764 
## sourcenot reported                                 -0.3323  0.1729  -1.9221 
## sourcewild collected                               -0.5485  0.2000  -2.7429 
##                                                    df    pval    ci.lb    ci.ub 
## sourcecommercial supplier                         442  0.5205  -0.4558   0.2311 
## sourcelaboratory stock from not specified source  442  0.3376  -0.4528   0.1556 
## sourcelabratory stock from commercial supplier    442  0.8005  -0.6768   0.5225 
## sourcelabratory stock from wild population        442  0.7068  -0.4459   0.3025 
## sourcenot reported                                442  0.0552  -0.6721   0.0075 
## sourcewild collected                              442  0.0063  -0.9416  -0.1555 
##                                                      
## sourcecommercial supplier                            
## sourcelaboratory stock from not specified source     
## sourcelabratory stock from commercial supplier       
## sourcelabratory stock from wild population           
## sourcenot reported                                 . 
## sourcewild collected                              ** 
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

mod_results(lnRR_mod_source, mod = "source", data = data, group = "study_id")  # For prediction intervals

##                                         name    estimate    lowerCL
## 1                        Commercial supplier -0.11236635 -0.4558037
## 2 Laboratory stock from not specified source -0.14860217 -0.4528214
## 3   Labratory stock from commercial supplier -0.07715564 -0.6768393
## 4       Labratory stock from wild population -0.07167204 -0.4458538
## 5                               Not reported -0.33232415 -0.6721170
## 6                             Wild collected -0.54854971 -0.9415933
##        upperCL   lowerPR   upperPR
## 1  0.231070991 -1.065382 0.8406489
## 2  0.155617080 -1.088197 0.7909925
## 3  0.522527973 -1.149494 0.9951826
## 4  0.302509711 -1.036193 0.8928490
## 5  0.007468741 -1.284032 0.6193838
## 6 -0.155506140 -1.520544 0.4234441

r2_ml(lnRR_mod_source)

##    R2_marginal R2_conditional 
##     0.05111649     0.95855927

## ModeL
lnRR_mod_source_contrast <- rma.mv(yi = lnRR, V = lnRRVCV_source, random = list(~1 |
    study_id, ~1 | assay_id, ~1 | species_latin, ~1 | pesticide), mods = ~source,
    method = "REML", test = "t", data = data_source, sparse = T)

summary(lnRR_mod_source_contrast)

## 
## Multivariate Meta-Analysis Model (k = 214; method: REML)
## 
##   logLik  Deviance       AIC       BIC      AICc   
## -71.0982  142.1964  154.1964  174.3359  154.6062   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor 
## sigma^2.1  0.0899  0.2999     13     no       study_id 
## sigma^2.2  0.0544  0.2332    214     no       assay_id 
## sigma^2.3  0.2066  0.4545      6     no  species_latin 
## sigma^2.4  0.0000  0.0000     11     no      pesticide 
## 
## Test for Residual Heterogeneity:
## QE(df = 212) = 2110.3373, p-val < .0001
## 
## Test of Moderators (coefficient 2):
## F(df1 = 1, df2 = 212) = 0.7505, p-val = 0.3873
## 
## Model Results:
## 
##                       estimate      se     tval   df    pval    ci.lb   ci.ub 
## intrcpt                 0.0189  0.4671   0.0405  212  0.9677  -0.9019  0.9397 
## sourcewild collected   -0.4703  0.5429  -0.8663  212  0.3873  -1.5404  0.5998 
##                         
## intrcpt                 
## sourcewild collected    
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

Moderate by source of fish (lnVR)

## Model
lnVR_mod_source <- rma.mv(yi = lnVR, V = lnVRVCV, random = list(~1 | study_id, ~1 |
    assay_id, ~1 | species_latin, ~1 | pesticide), mods = ~source - 1, method = "REML",
    test = "t", data = data, sparse = T)

# Summary results
summary(lnVR_mod_source)

## 
## Multivariate Meta-Analysis Model (k = 448; method: REML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -383.7800   767.5601   787.5601   828.4732   788.0705   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor 
## sigma^2.1  0.0017  0.0417     37     no       study_id 
## sigma^2.2  0.2485  0.4985    448     no       assay_id 
## sigma^2.3  0.0055  0.0742     10     no  species_latin 
## sigma^2.4  0.0178  0.1334     30     no      pesticide 
## 
## Test for Residual Heterogeneity:
## QE(df = 442) = 3580.3382, p-val < .0001
## 
## Test of Moderators (coefficients 1:6):
## F(df1 = 6, df2 = 442) = 1.5336, p-val = 0.1654
## 
## Model Results:
## 
##                                                   estimate      se     tval 
## sourcecommercial supplier                          -0.1429  0.0956  -1.4955 
## sourcelaboratory stock from not specified source   -0.1487  0.0946  -1.5727 
## sourcelabratory stock from commercial supplier      0.1769  0.2894   0.6112 
## sourcelabratory stock from wild population          0.1877  0.1245   1.5075 
## sourcenot reported                                 -0.1048  0.1130  -0.9278 
## sourcewild collected                               -0.1306  0.1788  -0.7304 
##                                                    df    pval    ci.lb   ci.ub 
## sourcecommercial supplier                         442  0.1355  -0.3307  0.0449 
## sourcelaboratory stock from not specified source  442  0.1165  -0.3346  0.0371 
## sourcelabratory stock from commercial supplier    442  0.5414  -0.3919  0.7458 
## sourcelabratory stock from wild population        442  0.1324  -0.0570  0.4323 
## sourcenot reported                                442  0.3540  -0.3268  0.1172 
## sourcewild collected                              442  0.4656  -0.4820  0.2208 
##                                                     
## sourcecommercial supplier                           
## sourcelaboratory stock from not specified source    
## sourcelabratory stock from commercial supplier      
## sourcelabratory stock from wild population          
## sourcenot reported                                  
## sourcewild collected                                
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

mod_results(lnVR_mod_source, mod = "source", data = data, group = "study_id")  # For prediction intervals

##                                         name   estimate     lowerCL    upperCL
## 1                        Commercial supplier -0.1429156 -0.33072809 0.04489699
## 2 Laboratory stock from not specified source -0.1487342 -0.33460711 0.03713867
## 3   Labratory stock from commercial supplier  0.1769108 -0.39193868 0.74576038
## 4       Labratory stock from wild population  0.1876691 -0.05699927 0.43233749
## 5                               Not reported -0.1048088 -0.32683132 0.11721381
## 6                             Wild collected -0.1305961 -0.48201504 0.22082292
##      lowerPR   upperPR
## 1 -1.1878016 0.9019705
## 2 -1.1932734 0.8958049
## 3 -0.9978671 1.3516888
## 4 -0.8689178 1.2442560
## 5 -1.1563825 0.9467650
## 6 -1.2168781 0.9556860

r2_ml(lnVR_mod_source)

##    R2_marginal R2_conditional 
##     0.04001628     0.93756601

lnVR_mod_source_contrast <- rma.mv(yi = lnVR, V = lnVRVCV_source, random = list(~1 |
    study_id, ~1 | assay_id, ~1 | species_latin, ~1 | pesticide), mods = ~source,
    method = "REML", test = "t", data = data_source, sparse = TRUE)

summary(lnVR_mod_source_contrast)

## 
## Multivariate Meta-Analysis Model (k = 214; method: REML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -185.5394   371.0788   383.0788   403.2183   383.4886   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor 
## sigma^2.1  0.0055  0.0744     13     no       study_id 
## sigma^2.2  0.2727  0.5222    214     no       assay_id 
## sigma^2.3  0.0000  0.0000      6     no  species_latin 
## sigma^2.4  0.0090  0.0948     11     no      pesticide 
## 
## Test for Residual Heterogeneity:
## QE(df = 212) = 2050.7825, p-val < .0001
## 
## Test of Moderators (coefficient 2):
## F(df1 = 1, df2 = 212) = 0.0655, p-val = 0.7982
## 
## Model Results:
## 
##                       estimate      se     tval   df    pval    ci.lb   ci.ub 
## intrcpt                -0.0966  0.0712  -1.3566  212  0.1763  -0.2369  0.0437 
## sourcewild collected   -0.0490  0.1915  -0.2560  212  0.7982  -0.4265  0.3285 
##                         
## intrcpt                 
## sourcewild collected    
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

Figure 5

# Filter the mod_table for specific pesticide chemical classes
lnRR_species_mod_results_filter <- dplyr::filter(lnRR_species_mod_results$mod_table,
    name == "Zebrafish" | name == "Sailfin mollie" | name == "Marine Medaka" | name ==
        "Killifish" | name == "Japanese medaka")

# Filter the data for the same pesticide chemical classes
lnRR_species_data_filter <- dplyr::filter(lnRR_species_mod_results$data, moderator ==
    "Zebrafish" | moderator == "Sailfin mollie" | moderator == "Marine Medaka" |
    moderator == "Killifish" | moderator == "Japanese medaka")

# Create the lnRR_pesticide_orchard object
lnRR_species_orchard <- list(mod_table = lnRR_species_mod_results_filter, data = lnRR_species_data_filter)

# Assign the appropriate classes to the object
class(lnRR_species_orchard) <- c("orchard", "data.frame")

# First plot (lnRR_mod_species)
species.mod_orchard.lnRR2 <- orchaRd::orchard_plot(lnRR_mod_species, group = "study_id",
    xlab = "lnRR", data = data, mod = "species_english", k.pos = "right", colour = FALSE,
    fill = TRUE, trunk.size = 3, branch.size = 1.5, twig.size = 1, angle = 45) +
    scale_fill_manual(values = c(RColorBrewer::brewer.pal(8, "Dark2"), "#66C2A5",
        "#FC8D62", "#8DA0CB", "#E78AC3", "#A6D854"))

# Filter the mod_table for specific pesticide chemical classes
lnVR_species_mod_results_filter <- dplyr::filter(lnVR_species_mod_results$mod_table,
    name == "Zebrafish" | name == "Sailfin mollie" | name == "Marine Medaka" | name ==
        "Killifish" | name == "Japanese medaka")

# Filter the data for the same pesticide chemical classes
lnVR_species_data_filter <- dplyr::filter(lnVR_species_mod_results$data, moderator ==
    "Zebrafish" | moderator == "Sailfin mollie" | moderator == "Marine Medaka" |
    moderator == "Killifish" | moderator == "Japanese medaka")

# Create the lnVR_pesticide_orchard object
lnVR_species_orchard <- list(mod_table = lnVR_species_mod_results_filter, data = lnVR_species_data_filter)

# Assign the appropriate classes to the object
class(lnVR_species_orchard) <- c("orchard", "data.frame")

# Second plot (lnVR_mod_species)
species.mod_orchard.lnVR2 <- orchaRd::orchard_plot(lnVR_mod_species, group = "study_id",
    xlab = "lnVR", data = data, mod = "species_english", k.pos = "right", colour = FALSE,
    fill = TRUE, trunk.size = 3, branch.size = 1.5, twig.size = 1, angle = 45) +
    scale_fill_manual(values = c(RColorBrewer::brewer.pal(8, "Dark2"), "#66C2A5",
        "#FC8D62", "#8DA0CB", "#E78AC3", "#A6D854")) + theme(axis.text.y = element_blank())

# Figure 5a)
species.mod_orchard.lnRR <- orchaRd::orchard_plot(lnRR_species_orchard,
             group = "study_id", 
             xlab = "lnRR",
             data = data,
             mod = "species_english",
             k.pos = "right",
             colour = FALSE,
             fill = TRUE,  # Set fill to TRUE to match the style
             trunk.size = 3, 
             legend.pos = "none",
             branch.size = 1.5,
             twig.size = 1,
             angle = 45) +
  scale_fill_manual(values = c(RColorBrewer::brewer.pal(8, "Dark2"), 
                               "#66C2A5", "#FC8D62", "#8DA0CB", "#E78AC3", "#A6D854")) 

# Figure 5b)
species.mod_orchard.lnVR <- orchaRd::orchard_plot(lnVR_species_orchard,
             group = "study_id", 
             xlab = "lnVR",
             data = data,
             mod = "species_english",
             k.pos = "right",
             colour = FALSE,
             fill = TRUE,  # Set fill to TRUE to match the style
             trunk.size = 3, 
             legend.pos = "none",
             branch.size = 1.5,
             twig.size = 1,
             angle = 45) +
  scale_fill_manual(values = c(RColorBrewer::brewer.pal(8, "Dark2"), 
                               "#66C2A5", "#FC8D62", "#8DA0CB", "#E78AC3", "#A6D854")) +
  theme(axis.text.y = element_blank())

# Figure 5c)
sex_mod_orchard.lnRR <- orchaRd::orchard_plot(lnRR_mod_sex,
             group = "study_id", 
             xlab = "lnRR",
             data = data,
             mod = "sex",
             k.pos = "right",
             colour = FALSE,
             fill = TRUE,  
             trunk.size = 3, 
             legend.pos = "none",
             branch.size = 1.5,
             twig.size = 1,
             angle = 45) +
  scale_fill_manual(values = c(RColorBrewer::brewer.pal(8, "Dark2"), 
                               "#66C2A5", "#FC8D62", "#8DA0CB", "#E78AC3", "#A6D854")) 

# Figure 5d)
sex_mod_orchard.lnVR <- orchaRd::orchard_plot(lnVR_mod_sex,
             group = "study_id", 
             xlab = "lnVR",
             data = data,
             mod = "sex",
             k.pos = "right",
             colour = FALSE,
             fill = TRUE,  
             trunk.size = 3, 
             legend.pos = "none",
             branch.size = 1.5,
             twig.size = 1,
             angle = 45) +
  scale_fill_manual(values = c(RColorBrewer::brewer.pal(8, "Dark2"), 
                               "#66C2A5", "#FC8D62", "#8DA0CB", "#E78AC3", "#A6D854")) +
  theme(axis.text.y = element_blank())

# Figure 5e)
source_mod_orchard.lnRR <- orchaRd::orchard_plot(lnRR_mod_source_contrast,
             group = "study_id", 
             xlab = "lnRR",
             data = data_source,
             mod = "source",
             k.pos = "right",
             colour = FALSE,
             fill = TRUE,  
             trunk.size = 3, 
             legend.pos = "none",
             branch.size = 1.5,
             twig.size = 1,
             angle = 45) +
  scale_fill_manual(values = c(RColorBrewer::brewer.pal(8, "Dark2"), 
                               "#66C2A5", "#FC8D62", "#8DA0CB", "#E78AC3", "#A6D854")) 

# Figure 5f)
source_mod_orchard.lnVR <- orchaRd::orchard_plot(lnVR_mod_source_contrast,
             group = "study_id", 
             xlab = "lnVR",
             data = data_source,
             mod = "source",
             k.pos = "right",
             colour = FALSE,
             fill = TRUE,  
             legend.pos = "none",
             trunk.size = 3, 
             branch.size = 1.5,
             twig.size = 1,
             angle = 45) +
  scale_fill_manual(values = c(RColorBrewer::brewer.pal(8, "Dark2"), 
                               "#66C2A5", "#FC8D62", "#8DA0CB", "#E78AC3", "#A6D854")) +
  theme(axis.text.y = element_blank())



# Combine the plots
main_text_figure_5 <- (species.mod_orchard.lnRR + species.mod_orchard.lnVR)/ (sex_mod_orchard.lnRR + sex_mod_orchard.lnVR)/ (source_mod_orchard.lnRR + source_mod_orchard.lnVR) + plot_annotation(tag_levels = "A")

print(main_text_figure_5)

# ggsave(here("figures", "main_text_figure_5.jpg"), plot = main_text_figure_5,width = 28, height = 30, units = "cm", dpi = 800)
# ggsave(here("figures", "main_text_figure_5.pdf"), plot = main_text_figure_5, width = 28, height = 30, units = "cm", dpi = 800)

Model selection and multi-model inference

lnRR model selection and multi-model inference

# save to save time - running this model is time-consuming

# saveRDS(mlmr.dredge.lnRR, file = 'mlmr.dredge.lnRR.Rds')
mlmr.dredge.lnRR <- readRDS(here("R.data", file = "mlmr.dredge.lnRR.Rds"))

# save(mlmr.dredge.lnRR, file = 'mlmr.dredge.lnRR.Rdata')
load(here("R.data", "mlmr.dredge.lnRR.Rdata"))

### LOAD DATA RATHER THAN RUN MODEL ###
mlmr.full.lnRR <- rma.mv(yi = lnRR, V = lnRRVCV, random = list(~1 | study_id, ~1 |
    assay_id, ~1 | species_latin, ~1 | pesticide), mods = ~behaviour_measured_standardised +
    behavioural_assay_standardised2 + pesticide_chemical_class + control_solvent +
    species_latin + sex + source, method = "ML", test = "t", data = data, sparse = T)

###

r2_ml(mlmr.full.lnRR, data = data)

##    R2_marginal R2_conditional 
##      0.7137822      1.0000000

eval(metafor:::.MuMIn)  # use eval() function to extract helper functions from MuMIn and make them usable in metafor.

mlmr.dredge.lnRR <- dredge(mlmr.full.lnRR, beta = "none", evaluate = TRUE, rank = "AICc",
    trace = 2)

## 
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# multimodel inference
summary(mlmr.full.lnRR)

## 
## Multivariate Meta-Analysis Model (k = 281; method: ML)
## 
##   logLik  Deviance       AIC       BIC      AICc   
## -74.4430  684.7398  220.8860  351.8668  231.8040   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor 
## sigma^2.1  0.0000  0.0000     28     no       study_id 
## sigma^2.2  0.0487  0.2207    281     no       assay_id 
## sigma^2.3  0.0000  0.0000      8     no  species_latin 
## sigma^2.4  0.0000  0.0000     24     no      pesticide 
## 
## Test for Residual Heterogeneity:
## QE(df = 249) = 1428.3135, p-val < .0001
## 
## Test of Moderators (coefficients 2:32):
## F(df1 = 31, df2 = 249) = 6.6242, p-val < .0001
## 
## Model Results:
## 
##                                                      estimate      se     tval 
## intrcpt                                               -0.8067  0.3634  -2.2200 
## behaviour_measured_standardisedcollective behaviour    2.3242  0.7374   3.1520 
## behaviour_measured_standardisedcourtship              -0.0672  0.1025  -0.6553 
## behaviour_measured_standardisedsociality              -0.0794  0.0578  -1.3745 
## behavioural_assay_standardised2entry                  -0.1847  0.1426  -1.2948 
## behavioural_assay_standardised2zone                   -0.0563  0.0628  -0.8970 
## pesticide_chemical_classcarbamate                     -1.0406  0.3319  -3.1353 
## pesticide_chemical_classneonicotinoid                  0.2983  0.2057   1.4505 
## pesticide_chemical_classorganochlorine                -0.1451  0.2497  -0.5813 
## pesticide_chemical_classorganophosphate               -0.4643  0.1958  -2.3708 
## pesticide_chemical_classphenoxy                       -0.3825  0.3003  -1.2739 
## pesticide_chemical_classpyrethroid                    -0.0307  0.2119  -0.1448 
## pesticide_chemical_classrotenones                      0.8495  0.3279   2.5910 
## pesticide_chemical_classtriazine                       0.0417  0.2913   0.1431 
## pesticide_chemical_classtriazole                      -0.4696  0.2073  -2.2655 
## pesticide_chemical_classurea                           0.4112  0.3158   1.3020 
## control_solventDMSO                                    1.3869  0.6323   2.1934 
## control_solventDTNB                                    0.5286  0.2749   1.9232 
## control_solventnone                                    1.1764  0.6257   1.8801 
## control_solventnot reported                            1.5010  0.6373   2.3552 
## species_latinDanio rerio                              -0.2626  0.5797  -0.4530 
## species_latinJenynsia multidentata                    -0.5058  0.6044  -0.8368 
## species_latinOryzias latipes                          -0.8890  0.6325  -1.4054 
## species_latinOryzias melastigma                       -0.9083  0.6104  -1.4879 
## species_latinPoecilia latipinna                       -0.9875  0.6259  -1.5777 
## species_latinPoecilia reticulata                      -0.7434  0.5916  -1.2566 
## sexmale                                               -0.1280  0.0912  -1.4042 
## sexmixed                                               0.0600  0.1214   0.4943 
## sexnot reported                                       -0.5319  0.2268  -2.3449 
## sourcelaboratory stock from not specified source      -0.0903  0.1426  -0.6329 
## sourcelabratory stock from wild population             0.1398  0.3458   0.4043 
## sourcenot reported                                     0.2109  0.2681   0.7867 
##                                                       df    pval    ci.lb 
## intrcpt                                              249  0.0273  -1.5223 
## behaviour_measured_standardisedcollective behaviour  249  0.0018   0.8719 
## behaviour_measured_standardisedcourtship             249  0.5129  -0.2691 
## behaviour_measured_standardisedsociality             249  0.1705  -0.1932 
## behavioural_assay_standardised2entry                 249  0.1966  -0.4655 
## behavioural_assay_standardised2zone                  249  0.3706  -0.1799 
## pesticide_chemical_classcarbamate                    249  0.0019  -1.6942 
## pesticide_chemical_classneonicotinoid                249  0.1482  -0.1068 
## pesticide_chemical_classorganochlorine               249  0.5616  -0.6369 
## pesticide_chemical_classorganophosphate              249  0.0185  -0.8500 
## pesticide_chemical_classphenoxy                      249  0.2039  -0.9740 
## pesticide_chemical_classpyrethroid                   249  0.8850  -0.4480 
## pesticide_chemical_classrotenones                    249  0.0101   0.2038 
## pesticide_chemical_classtriazine                     249  0.8863  -0.5320 
## pesticide_chemical_classtriazole                     249  0.0243  -0.8778 
## pesticide_chemical_classurea                         249  0.1941  -0.2108 
## control_solventDMSO                                  249  0.0292   0.1416 
## control_solventDTNB                                  249  0.0556  -0.0127 
## control_solventnone                                  249  0.0613  -0.0560 
## control_solventnot reported                          249  0.0193   0.2458 
## species_latinDanio rerio                             249  0.6510  -1.4044 
## species_latinJenynsia multidentata                   249  0.4035  -1.6963 
## species_latinOryzias latipes                         249  0.1612  -2.1348 
## species_latinOryzias melastigma                      249  0.1380  -2.1105 
## species_latinPoecilia latipinna                      249  0.1159  -2.2202 
## species_latinPoecilia reticulata                     249  0.2101  -1.9087 
## sexmale                                              249  0.1615  -0.3075 
## sexmixed                                             249  0.6216  -0.1791 
## sexnot reported                                      249  0.0198  -0.9787 
## sourcelaboratory stock from not specified source     249  0.5274  -0.3712 
## sourcelabratory stock from wild population           249  0.6863  -0.5413 
## sourcenot reported                                   249  0.4322  -0.3171 
##                                                        ci.ub     
## intrcpt                                              -0.0910   * 
## behaviour_measured_standardisedcollective behaviour   3.7765  ** 
## behaviour_measured_standardisedcourtship              0.1347     
## behaviour_measured_standardisedsociality              0.0344     
## behavioural_assay_standardised2entry                  0.0962     
## behavioural_assay_standardised2zone                   0.0673     
## pesticide_chemical_classcarbamate                    -0.3869  ** 
## pesticide_chemical_classneonicotinoid                 0.7034     
## pesticide_chemical_classorganochlorine                0.3466     
## pesticide_chemical_classorganophosphate              -0.0786   * 
## pesticide_chemical_classphenoxy                       0.2089     
## pesticide_chemical_classpyrethroid                    0.3866     
## pesticide_chemical_classrotenones                     1.4953   * 
## pesticide_chemical_classtriazine                      0.6153     
## pesticide_chemical_classtriazole                     -0.0613   * 
## pesticide_chemical_classurea                          1.0331     
## control_solventDMSO                                   2.6323   * 
## control_solventDTNB                                   1.0700   . 
## control_solventnone                                   2.4089   . 
## control_solventnot reported                           2.7562   * 
## species_latinDanio rerio                              0.8792     
## species_latinJenynsia multidentata                    0.6847     
## species_latinOryzias latipes                          0.3569     
## species_latinOryzias melastigma                       0.2940     
## species_latinPoecilia latipinna                       0.2452     
## species_latinPoecilia reticulata                      0.4218     
## sexmale                                               0.0515     
## sexmixed                                              0.2991     
## sexnot reported                                      -0.0851   * 
## sourcelaboratory stock from not specified source      0.1906     
## sourcelabratory stock from wild population            0.8210     
## sourcenot reported                                    0.7389     
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

# Select 'best' models based on delta <= 2
best_model <- subset(mlmr.dredge.lnRR, delta <= 2, recalc.weights = FALSE)

# Display the results in a scrollable kable table
best_model %>%
    kable("html") %>%
    kable_styling("bordered", position = "left") %>%
    scroll_box(width = "100%", height = "800px")

	(Intercept)	behaviour_measured_standardised	behavioural_assay_standardised2	control_solvent	pesticide_chemical_class	sex	source	species_latin	df	logLik	AICc	delta	weight
95		NA					NA		31	-76.55126	223.0704	0	0.5697049

# Relative importance values for the predictors
weights_lnRR <- sw(mlmr.dredge.lnRR)

# Convert the named vector into a data frame
weights_lnRR_df <- data.frame(predictor = names(weights_lnRR), weight = as.numeric(weights_lnRR),
    R2_marginal = c(0.07, 0.103, 0.009, 0.092, 0.112, 0.02, 0.051))

# Save to save time - running this model is time-consuming

# saveRDS(mlmr.dredge.lnVR, file = "mlmr.dredge.lnVR.Rds")
mlmr.dredge.lnVR <- readRDS(here("R.data",file = "mlmr.dredge.lnVR.Rds"))

# save(mlmr.dredge.lnVR, file = "mlmr.dredge.lnVR.Rdata") 
load(here("R.data", "mlmr.dredge.lnVR.Rdata"))

### LOAD DATA RATHER THAN RUN MODEL ###
mlmr.full.lnVR <- rma.mv(yi = lnVR, 
                    V = lnVRVCV, 
                    random = list(~1 | study_id,
                                             ~1 | assay_id,
                                             ~1 | species_latin,
                                             ~1 | pesticide),
 mods = ~ behaviour_measured_standardised + behavioural_assay_standardised2 + pesticide_chemical_class + control_solvent +
                      species_latin + sex +  source, 
                     method = "ML", 
                    test = "t", 
                    data = data, 
                    sparse = TRUE)

###

r2_ml(mlmr.full.lnVR, data = data)

##    R2_marginal R2_conditional 
##      0.3057053      1.0000000

eval(metafor:::.MuMIn)  # use eval() to extract helper functions from MuMIn and make them usable in metafor.

mlmr.dredge.lnVR <- dredge(mlmr.full.lnVR, beta = "none", evaluate = TRUE, rank = "AICc", trace = 2)

## 
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# Multimodel inference
summary(mlmr.full.lnVR)

## 
## Multivariate Meta-Analysis Model (k = 281; method: ML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -178.5601   744.7362   429.1203   560.1010   440.0383   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor 
## sigma^2.1  0.0000  0.0000     28     no       study_id 
## sigma^2.2  0.1513  0.3889    281     no       assay_id 
## sigma^2.3  0.0000  0.0000      8     no  species_latin 
## sigma^2.4  0.0000  0.0000     24     no      pesticide 
## 
## Test for Residual Heterogeneity:
## QE(df = 249) = 1653.7460, p-val < .0001
## 
## Test of Moderators (coefficients 2:32):
## F(df1 = 31, df2 = 249) = 2.3438, p-val = 0.0002
## 
## Model Results:
## 
##                                                      estimate      se     tval 
## intrcpt                                               -0.5212  0.5528  -0.9429 
## behaviour_measured_standardisedcollective behaviour    1.7008  0.9384   1.8125 
## behaviour_measured_standardisedcourtship              -0.1397  0.1662  -0.8406 
## behaviour_measured_standardisedsociality               0.2057  0.0938   2.1937 
## behavioural_assay_standardised2entry                  -0.7415  0.2474  -2.9974 
## behavioural_assay_standardised2zone                   -0.1314  0.1036  -1.2674 
## pesticide_chemical_classcarbamate                     -1.4219  0.5286  -2.6900 
## pesticide_chemical_classneonicotinoid                 -0.9036  0.3839  -2.3536 
## pesticide_chemical_classorganochlorine                -0.7255  0.4355  -1.6660 
## pesticide_chemical_classorganophosphate               -0.8423  0.3542  -2.3780 
## pesticide_chemical_classphenoxy                       -0.8139  0.4923  -1.6530 
## pesticide_chemical_classpyrethroid                    -0.8233  0.3506  -2.3486 
## pesticide_chemical_classrotenones                     -0.3742  0.5849  -0.6397 
## pesticide_chemical_classtriazine                      -1.1221  0.4746  -2.3643 
## pesticide_chemical_classtriazole                      -1.1803  0.3715  -3.1776 
## pesticide_chemical_classurea                          -0.6448  0.4746  -1.3586 
## control_solventDMSO                                    1.3370  0.6118   2.1852 
## control_solventDTNB                                   -0.6131  0.5973  -1.0264 
## control_solventnone                                    1.3193  0.5919   2.2289 
## control_solventnot reported                            1.5943  0.6264   2.5454 
## species_latinDanio rerio                              -0.2083  0.5482  -0.3801 
## species_latinJenynsia multidentata                    -0.6283  0.6021  -1.0435 
## species_latinOryzias latipes                          -0.6320  0.6557  -0.9638 
## species_latinOryzias melastigma                       -0.5757  0.6028  -0.9550 
## species_latinPoecilia latipinna                       -1.1071  0.6729  -1.6453 
## species_latinPoecilia reticulata                      -0.6527  0.5966  -1.0940 
## sexmale                                                0.2694  0.1668   1.6146 
## sexmixed                                               0.1489  0.2146   0.6937 
## sexnot reported                                       -0.0899  0.4190  -0.2145 
## sourcelaboratory stock from not specified source       0.1181  0.1687   0.7000 
## sourcelabratory stock from wild population             1.2487  0.5115   2.4413 
## sourcenot reported                                     0.1269  0.4073   0.3116 
##                                                       df    pval    ci.lb 
## intrcpt                                              249  0.3466  -1.6099 
## behaviour_measured_standardisedcollective behaviour  249  0.0711  -0.1474 
## behaviour_measured_standardisedcourtship             249  0.4014  -0.4671 
## behaviour_measured_standardisedsociality             249  0.0292   0.0210 
## behavioural_assay_standardised2entry                 249  0.0030  -1.2288 
## behavioural_assay_standardised2zone                  249  0.2062  -0.3355 
## pesticide_chemical_classcarbamate                    249  0.0076  -2.4630 
## pesticide_chemical_classneonicotinoid                249  0.0194  -1.6597 
## pesticide_chemical_classorganochlorine               249  0.0970  -1.5832 
## pesticide_chemical_classorganophosphate              249  0.0182  -1.5399 
## pesticide_chemical_classphenoxy                      249  0.0996  -1.7835 
## pesticide_chemical_classpyrethroid                   249  0.0196  -1.5138 
## pesticide_chemical_classrotenones                    249  0.5230  -1.5262 
## pesticide_chemical_classtriazine                     249  0.0188  -2.0569 
## pesticide_chemical_classtriazole                     249  0.0017  -1.9119 
## pesticide_chemical_classurea                         249  0.1755  -1.5796 
## control_solventDMSO                                  249  0.0298   0.1320 
## control_solventDTNB                                  249  0.3057  -1.7895 
## control_solventnone                                  249  0.0267   0.1535 
## control_solventnot reported                          249  0.0115   0.3607 
## species_latinDanio rerio                             249  0.7042  -1.2880 
## species_latinJenynsia multidentata                   249  0.2977  -1.8140 
## species_latinOryzias latipes                         249  0.3361  -1.9234 
## species_latinOryzias melastigma                      249  0.3405  -1.7628 
## species_latinPoecilia latipinna                      249  0.1012  -2.4324 
## species_latinPoecilia reticulata                     249  0.2750  -1.8277 
## sexmale                                              249  0.1077  -0.0592 
## sexmixed                                             249  0.4885  -0.2738 
## sexnot reported                                      249  0.8304  -0.9151 
## sourcelaboratory stock from not specified source     249  0.4846  -0.2141 
## sourcelabratory stock from wild population           249  0.0153   0.2413 
## sourcenot reported                                   249  0.7556  -0.6752 
##                                                        ci.ub     
## intrcpt                                               0.5675     
## behaviour_measured_standardisedcollective behaviour   3.5489   . 
## behaviour_measured_standardisedcourtship              0.1876     
## behaviour_measured_standardisedsociality              0.3905   * 
## behavioural_assay_standardised2entry                 -0.2543  ** 
## behavioural_assay_standardised2zone                   0.0728     
## pesticide_chemical_classcarbamate                    -0.3808  ** 
## pesticide_chemical_classneonicotinoid                -0.1474   * 
## pesticide_chemical_classorganochlorine                0.1322   . 
## pesticide_chemical_classorganophosphate              -0.1447   * 
## pesticide_chemical_classphenoxy                       0.1558   . 
## pesticide_chemical_classpyrethroid                   -0.1329   * 
## pesticide_chemical_classrotenones                     0.7779     
## pesticide_chemical_classtriazine                     -0.1873   * 
## pesticide_chemical_classtriazole                     -0.4487  ** 
## pesticide_chemical_classurea                          0.2900     
## control_solventDMSO                                   2.5420   * 
## control_solventDTNB                                   0.5634     
## control_solventnone                                   2.4851   * 
## control_solventnot reported                           2.8280   * 
## species_latinDanio rerio                              0.8713     
## species_latinJenynsia multidentata                    0.5575     
## species_latinOryzias latipes                          0.6595     
## species_latinOryzias melastigma                       0.6115     
## species_latinPoecilia latipinna                       0.2182     
## species_latinPoecilia reticulata                      0.5224     
## sexmale                                               0.5980     
## sexmixed                                              0.5716     
## sexnot reported                                       0.7354     
## sourcelaboratory stock from not specified source      0.4503     
## sourcelabratory stock from wild population            2.2561   * 
## sourcenot reported                                    0.9290     
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

# Select "best" models based on delta <= 2
best_model_vr <- subset(mlmr.dredge.lnVR, delta <= 2, recalc.weights = FALSE)

# Display the results in a scrollable kable table
best_model_vr %>%
  kable("html") %>%
  kable_styling("bordered", position = "left") %>%
  scroll_box(width = "100%", height = "800px")

	(Intercept)	behaviour_measured_standardised	behavioural_assay_standardised2	control_solvent	pesticide_chemical_class	sex	source	species_latin	df	logLik	AICc	delta	weight
75		NA		NA		NA	NA		24	-186.3893	425.4661	0.0000000	0.2151998
3		NA		NA	NA	NA	NA	NA	7	-205.8819	426.1741	0.7080489	0.1510397
67		NA		NA	NA	NA	NA		14	-198.7007	426.9804	1.5142974	0.1009291

# Relative importance values for the predictors
weights_lnVR <- sw(mlmr.dredge.lnVR)

# Convert the named vector into a data frame
weights_lnVR_df <- data.frame(
  predictor = names(weights_lnVR),  
  weight = as.numeric(weights_lnVR),
  R2_marginal = c(0.02, 0.086, 0.036, 0.068, 0.71, 0.011, 0.040)

)

Main text Figure 6

# lnRR model selection plot
weights_lnRR_plot <- weights_lnRR_df %>%
    ggplot(aes(x = reorder(predictor, weight), y = weight)) + geom_col(width = 0.8,
    alpha = 0.7) + coord_flip() + scale_y_continuous(limits = c(0, 1.2), breaks = seq(0,
    1, by = 0.2), expand = c(0, 0)) + geom_text(aes(label = scales::percent(weight,
    accuracy = 1)), size = 6, position = position_stack(vjust = 0.5), color = "white",
    fontface = "bold") + geom_text(aes(y = 1.1, label = paste0("R2 = ", round(R2_marginal,
    2))), size = 4, fontface = "italic", color = "red") + theme_bw() + guides(size = "none") +
    theme(legend.position = "none", axis.text = element_text(color = "black"), axis.title = element_text(face = "bold",
        color = "black"), plot.caption = element_text(size = 10, color = "gray10",
        face = "italic")) + labs(y = "Akaike Weights", x = "Moderators", tag = "A") +
    scale_x_discrete(labels = c("Source of fish", "Behaviour measured", "Control Solvent",
        "Species", "Sex of fish", "Pesticide chemical class", "Behavioural assay"))


# lnVR model selection plot
weights_lnVR_plot <- weights_lnVR_df %>%
    ggplot(aes(x = reorder(predictor, weight), y = weight)) + geom_col(width = 0.8,
    alpha = 0.7) + coord_flip() + scale_y_continuous(limits = c(0, 1.2), breaks = seq(0,
    1, by = 0.2), expand = c(0, 0)) + geom_text(aes(label = scales::percent(weight,
    accuracy = 1)), size = 6, position = position_stack(vjust = 0.5), color = "white",
    fontface = "bold") + geom_text(aes(y = 1.1, label = paste0("R2 = ", round(R2_marginal,
    2))), size = 4, fontface = "italic", color = "red") + theme_bw() + guides(size = "none") +
    theme(legend.position = "none", axis.text = element_text(color = "black"), axis.title = element_text(face = "bold",
        color = "black"), plot.caption = element_text(size = 10, color = "gray10",
        face = "italic")) + labs(caption = "The value in each bar is the relative importance of each moderator based on Akaike weights",
    y = "Akaike Weights", x = "Moderators", tag = "B") + scale_x_discrete(labels = c("Source of fish",
    "Behaviour measured", "Control Solvent", "Species", "Sex of fish", "Pesticide chemical class",
    "Behavioural assay"))


main_text_figure_6 <- weights_lnRR_plot/weights_lnVR_plot

print(main_text_figure_6)

# ggsave(here('figures', 'main_text_figure_6.pdf'), width = 10, height = 10,
# units = 'cm', scale = 2, dpi = 800) ggsave(here('figures',
# 'main_text_figure_6.jpg'), width = 10, height = 10, units = 'cm', scale = 2,
# dpi = 800)

Publication bias

Figure s20

A funnel plot illustrating the distribution of study effect sizes in the meta-analysis. The symmetry of the plot suggests the absence of publication bias.

# Set up a PNG device with desired dimensions and resolution png(filename =
# 'funnel_plot.png', width = 800, height = 600, res = 150)

# Create the funnel plot with gray points
funnel_fig <- funnel(lnRR_intercept_only, yaxis = "seinv", level = c(90, 95), shade = c("white",
    "gray30"), back = "#EBEBEB", legend = FALSE, ylab = "Precision (1/SE)", cex.lab = 1.5,
    digits = 1, xlim = c(-5, 5), pch = 21, col = "gray", bg = "black")

# fig_funnel <- recordPlot() invisible(dev.off())

print(funnel_fig)

##                 x          y slab
## 1   -0.2895670872  9.6318195    1
## 2   -0.2982524951  8.4820306    2
## 3    0.0562281004  2.9750627    3
## 4   -0.7011101941  3.2240522    4
## 5   -1.1269340923  3.2240092    5
## 6   -0.2934188492 12.7655293    6
## 7   -0.2691540083 11.4942347    7
## 8   -0.2674431286 10.4464598    8
## 9   -0.3530576766 16.1669964    9
## 10  -0.3474865777 10.3119167   10
## 11  -0.2555482359 17.4371314   11
## 12  -0.3525005143  8.3317595   12
## 13  -0.4641497549  7.2844548   13
## 14  -0.5849408752  9.2268317   14
## 15  -0.4637459053  8.3552581   15
## 16  -0.5215752377  9.1834900   16
## 17  -0.4687954081  9.5734233   17
## 18  -0.3563336906 13.9182098   18
## 19   0.0463883218  8.0730795   19
## 20  -0.9717259010  6.7392324   20
## 21  -0.0187754690 10.9226609   21
## 22  -0.0256912682 14.8101635   22
## 23   0.1103552116 13.1878378   23
## 24  -0.1776638218 13.1976626   24
## 25  -0.0592543268 30.6181415   25
## 26  -0.3005645925 49.7575758   26
## 27  -0.8383824621  5.0757474   27
## 28  -0.9482091248  5.2398136   28
## 29  -1.1931477158  5.8813239   29
## 30   0.2092602591  6.6982342   30
## 31   0.2984424139  6.6032715   31
## 32   0.2933587925  6.4321509   32
## 33   0.3223981661  9.0445807   33
## 34   0.4164707219 10.4539360   34
## 35   0.1714618190  9.3024101   35
## 36   0.3343691865  9.9150970   36
## 37  -0.0779276601 10.0358393   37
## 38  -0.1701155192 10.8981059   38
## 39  -0.3686652462 11.5103947   39
## 40  -0.0413346208 17.9034716   40
## 41  -0.1675382098 15.2446040   41
## 42  -0.3008911583 22.0469146   42
## 43  -0.0197408876 18.8753805   43
## 44  -0.1445877199 20.5457638   44
## 45  -0.1946178989 20.9415940   45
## 46  -0.1550986605 10.9822328   46
## 47  -0.2512861653 15.5480599   47
## 48  -0.5049285681 15.2704063   48
## 49  -0.1341783716 14.2614925   49
## 50  -0.2023761200 14.9070156   50
## 51  -0.3688435512 13.1714676   51
## 52  -0.0682145526 27.0736230   52
## 53  -0.2278727286 24.2112039   53
## 54  -0.2656199631 21.1405121   54
## 55   0.0381976460 70.3251262   55
## 56   0.0544352835 51.1460497   56
## 57   0.1098502469 63.1920917   57
## 58   0.1209702027 12.3699265   58
## 59   0.3008151525 10.6658531   59
## 60   0.3999407438 11.3110622   60
## 61   0.0213611592 17.2293931   61
## 62   0.1124097972 21.0329566   62
## 63   0.2361047215 21.2437332   63
## 64   0.0068716710 31.8676678   64
## 65   0.1234872678 15.0722922   65
## 66   0.2326668138 24.0167523   66
## 67  -0.1346721442  4.2295531   67
## 68   0.0359729376  5.0850701   68
## 69  -0.2172118306  3.9579177   69
## 70   0.1327446542  4.0011075   70
## 71   0.3033897360  4.7016103   71
## 72   0.0502049678  3.7688484   72
## 73  -0.0185967954  7.6563057   73
## 74  -0.0888729564  7.9605030   74
## 75   0.0551433960 10.7417176   75
## 76  -0.0185967954  7.6563057   76
## 77  -0.0888729564  7.9605030   77
## 78   0.0551433960 10.7417176   78
## 79  -0.2978489520 11.1766779   79
## 80  -0.1452538322 14.0767541   80
## 81   0.7328936043  1.5583392   81
## 82   1.1267006400  1.6263523   82
## 83   1.4584231030  1.6210783   83
## 84  -0.0953513343 12.3254058   84
## 85   0.0375621321 10.7612753   85
## 86   0.2060139223 12.3488694   86
## 87   0.4351920164  3.4979563   87
## 88   0.4860246075  3.4393957   88
## 89  -0.5759321314  1.3811012   89
## 90   0.3610518717  3.1584688   90
## 91  -1.6955087915  0.5527361   91
## 92  -0.8497645275  1.5584285   92
## 93  -0.3451585019  3.8847662   93
## 94  -0.2758603335  3.9605941   94
## 95  -0.6286086594  2.6707731   95
## 96  -0.4567584025  2.8132764   96
## 97  -0.8604759528  3.8426888   97
## 98  -0.9345839249  3.8938391   98
## 99  -0.2682639866  5.2943519   99
## 100 -0.4353180713  4.5428452  100
## 101 -0.1536680787  3.6536282  101
## 102 -0.2917949178  1.7202998  102
## 103 -0.0722948812  0.4818747  103
## 104 -0.3868849144  0.5040212  104
## 105 -0.3839536901  1.2076215  105
## 106 -0.4871494858  1.3808203  106
## 107 -0.4289718130  2.6641231  107
## 108 -0.4032100222  3.7188700  108
## 109 -1.5581338913  0.4119226  109
## 110 -0.2452726932  1.3918470  110
## 111 -0.0203218410  4.6107501  111
## 112  0.0348171424  3.7701820  112
## 113 -0.0890473331  4.8379991  113
## 114 -0.1268371886  4.7157394  114
## 115 -0.0654956783  3.4154151  115
## 116  0.0005743625  2.8632558  116
## 117  0.2657464918  3.6849466  117
## 118  0.0845569485  3.0331357  118
## 119 -0.3128963754  3.7649996  119
## 120  0.1277206418  3.2595961  120
## 121  0.0347385903  3.5834066  121
## 122  0.5330905973  6.0687039  122
## 123 -0.1289210486  7.5482338  123
## 124 -0.7367429870  2.2884179  124
## 125  0.0013467997  6.0380300  125
## 126 -0.4242685962  4.7591048  126
## 127  0.1846703334  3.4354473  127
## 128 -0.3012544747  2.9061033  128
## 129 -0.1496461348  4.5903861  129
## 130 -0.0052014822  5.3505172  130
## 131 -0.2877020856  2.4183951  131
## 132 -0.3248150782  3.5728607  132
## 133  0.2595857437  6.3015213  133
## 134 -0.2918579551  2.3618178  134
## 135 -0.1102722212  4.3510824  135
## 136  0.2211687747  4.2186050  136
## 137  0.2181546997  2.7589687  137
## 138  0.5294237591  4.0436741  138
## 139  0.3619245988  5.5651987  139
## 140  0.8096190319  5.3045574  140
## 141  0.9346890570  1.4355392  141
## 142  0.9158639843  3.3527816  142
## 143 -0.9371002551  1.3633173  143
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## 446  0.3487365649 11.2871863  446
## 447  0.1529422944 11.8141290  447
## 448  0.0620705145 11.4598327  448

Egger’s regression

# Model
eggers_regression <- rma.mv(yi = lnRR, V = lnRRVCV, random = list(~1 | study_id,
    ~1 | assay_id, ~1 | species_latin, ~1 | pesticide), mods = ~sqrt(lnRRv), method = "REML",
    test = "t", data = data, sparse = T)


# Summary
summary(eggers_regression)

## 
## Multivariate Meta-Analysis Model (k = 448; method: REML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -168.4319   336.8637   348.8637   373.4657   349.0551   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor 
## sigma^2.1  0.0535  0.2313     37     no       study_id 
## sigma^2.2  0.0582  0.2412    448     no       assay_id 
## sigma^2.3  0.0613  0.2476     10     no  species_latin 
## sigma^2.4  0.0091  0.0956     30     no      pesticide 
## 
## Test for Residual Heterogeneity:
## QE(df = 446) = 4961.4465, p-val < .0001
## 
## Test of Moderators (coefficient 2):
## F(df1 = 1, df2 = 446) = 0.1718, p-val = 0.6787
## 
## Model Results:
## 
##              estimate      se     tval   df    pval    ci.lb    ci.ub    
## intrcpt       -0.2531  0.1183  -2.1407  446  0.0328  -0.4856  -0.0207  * 
## sqrt(lnRRv)   -0.0809  0.1950  -0.4145  446  0.6787  -0.4642   0.3025    
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

Figure s21

A plot showing the moderating effect of standard error on lnRR. The thick black lines show the prediction from the uni-moderator models with their associated 95% confidence interval (darker shaded area) and 95% prediction interval (lighter shaded area).

# Prepare data for Egger's regression plot
egger_pred <- predict.rma(eggers_regression)
data <- data %>%
    mutate(fit = egger_pred$pred, ci.lb = egger_pred$ci.lb, ci.ub = egger_pred$ci.ub,
        pr.lb = egger_pred$cr.lb, pr.ub = egger_pred$cr.ub)

# Create Egger's regression plot
egger_fig <- ggplot(data, aes(x = sqrt(lnRRv), y = lnRR)) + geom_ribbon(aes(ymin = pr.lb,
    ymax = pr.ub), alpha = 0.1, fill = "gray") + geom_ribbon(aes(ymin = ci.lb, ymax = ci.ub),
    alpha = 0.3, fill = "gray") + geom_point(size = 2, shape = 21, alpha = 0.7, fill = RColorBrewer::brewer.pal(n = 8,
    name = "Dark2")[1], col = "gray25", stroke = 1) + geom_line(aes(y = fit), size = 1.2) +
    labs(x = "Standard Error", y = "lnRR") + theme_bw() + geom_hline(yintercept = 0,
    linetype = 2, colour = "black", alpha = 0.5) + theme(text = element_text(size = 18,
    colour = "black", hjust = 0.5), legend.text = element_text(size = 14), legend.position = c(0,
    0), legend.justification = c(0, 0), legend.background = element_blank(), legend.direction = "horizontal",
    legend.title = element_text(size = 15), panel.border = element_rect(colour = "black",
        fill = NA, size = 1.2))

print(egger_fig)

# ggsave(here('figures', 'egger_figure.pdf'), width = 10, height = 5, units =
# 'cm', scale = 2, dpi = 800) ggsave(here('figures', 'egger_figure.jpg'), width
# = 10, height = 5, units = 'cm', scale = 2, dpi = 800)

Time lag bias

data$pub_year <- str_extract(data$study_id, "\\d{4}")


data$pub_year <- as.numeric(data$pub_year)

# Model
time_lag_bias_model <- rma.mv(yi = lnRR, V = lnRRVCV, random = list(~1 | study_id,
    ~1 | assay_id, ~1 | species_latin, ~1 | pesticide), mods = ~scale(pub_year),
    method = "REML", test = "t", data = data, sparse = T)

# Summary stats
summary(time_lag_bias_model)

## 
## Multivariate Meta-Analysis Model (k = 448; method: REML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -167.6978   335.3957   347.3957   371.9976   347.5870   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor 
## sigma^2.1  0.0521  0.2283     37     no       study_id 
## sigma^2.2  0.0582  0.2412    448     no       assay_id 
## sigma^2.3  0.0531  0.2305     10     no  species_latin 
## sigma^2.4  0.0084  0.0916     30     no      pesticide 
## 
## Test for Residual Heterogeneity:
## QE(df = 446) = 4308.0407, p-val < .0001
## 
## Test of Moderators (coefficient 2):
## F(df1 = 1, df2 = 446) = 1.6718, p-val = 0.1967
## 
## Model Results:
## 
##                  estimate      se     tval   df    pval    ci.lb    ci.ub    
## intrcpt           -0.2215  0.1123  -1.9715  446  0.0493  -0.4422  -0.0007  * 
## scale(pub_year)    0.0582  0.0450   1.2930  446  0.1967  -0.0303   0.1467    
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

lnRR_mod_time_lag_results <- mod_results(time_lag_bias_model, mod = "pub_year", data = data,
    group = "study_id")


r2_lnRR_time_lag <- r2_ml(time_lag_bias_model, data)


# Calculate R^2 value
r2_lnRR_time_lag <- r2_ml(time_lag_bias_model, data)

# Set minimum year for x-axis limit
min_year <- min(data$pub_year, na.rm = TRUE)

Figure s22

A bubble plot showing the moderating effect of publication year on lnRR. The thick black lines show the prediction from the uni-moderator models with their associated 95% confidence interval (red dotted line) and 95% prediction interval (black dotted line).

# Create bubble plot and save as ggplot object
time_lag_bias <- bubble_plot(lnRR_mod_time_lag_results, mod = "pub_year", group = "study_id",
    data = data, x = "pub_year", y = "lnRR", est.lwd = 1, legend.pos = "bottom.right",
    k.pos = "bottom.left", ci.col = "red", pi.col = "black", est.col = "black", g = TRUE) +
    annotate(geom = "text", x = min_year + 2, y = max(data$lnRR, na.rm = TRUE) +
        0.2, label = paste0("italic(R)^{2} ==", round(r2_lnRR_time_lag[1], 5)), color = "black",
        parse = TRUE, size = 4) + geom_point(size = 2, color = "gray25", fill = "blue",
    shape = 21, alpha = 0.7, stroke = 1) + geom_line(color = "blue", size = 1.2) +
    ggtitle("") + theme(plot.title = element_text(size = 18), legend.position = "none",
    axis.title.x = element_text(size = 16), axis.title.y = element_text(size = 16),
    axis.text.y = element_text(size = 14), axis.text.x = element_text(size = 14)) +
    xlab("Publication Year") + scale_x_continuous(limits = c(min_year, max(data$pub_year,
    na.rm = TRUE)))

print(time_lag_bias)

# ggsave(here('figures', 'time_lag_figure.pdf'), width = 10, height = 5, units
# = 'cm', scale = 2, dpi = 800) ggsave(here('figures', 'time_lag_figure.jpg'),
# width = 10, height = 5, units = 'cm', scale = 2, dpi = 800)

Sensitivity Analysis

Leave-one-out analysis

Leave one study out

Intercept only model (lnRR)

data$leave_study <- as.factor(data$study_id)

### create a list to contain model estimates
leave_study_out_model_lnRR <- list()
VCV_leave_study_out_lnRR <- list()

# Save as .Rds file
# saveRDS(leave_study_out_model_lnRR, file = here("R.data", "leave_study_out_model_lnRR.Rds"))

# Load from .Rds file
leave_study_out_model_lnRR <- readRDS(here("R.data", "leave_study_out_model_lnRR.Rds"))

# Save as .Rdata file
# save(leave_study_out_model_lnVR, file = here("R.data", "leave_study_out_model_lnVR.Rdata"))

# Load from .Rdata file
load(here("R.data", "leave_study_out_model_lnVR.Rdata"))


### repeatedly run the multilevel model, leaving out one study at a time
for(i in 1:length(levels(data$leave_study))){
  ### create the data with one study removed at a time
  data_study_leave <- data %>% filter(leave_study != levels(data$leave_study)[i])
  
  ### create a list of VCV matrices for following model fitting
  VCV_leave_study_out_lnRR[[i]] <- impute_covariance_matrix(vi = data_study_leave$lnRRv, cluster = data_study_leave$study_id, r = 0.5)
  
  ### model fitting
  leave_study_out_model_lnRR[[i]] <- rma.mv(yi = lnRR, V = VCV_leave_study_out_lnRR[[i]], 
                                            random = list(~1 | study_id,
                                                          ~1 | assay_id,
                                                          ~1 | species_latin,
                                                          ~1 | pesticide),
                                            method = "REML", 
                                            test = "t",
                                            data = data_study_leave,
                                            sparse = TRUE)
}

results.leave_study_out_model_lnRR <- as.data.frame(cbind(
  sapply(leave_study_out_model_lnRR, function(x) summary(x)$beta), 
  sapply(leave_study_out_model_lnRR, function(x) summary(x)$se),   
  sapply(leave_study_out_model_lnRR, function(x) summary(x)$zval), 
  sapply(leave_study_out_model_lnRR, function(x) summary(x)$pval), 
  sapply(leave_study_out_model_lnRR, function(x) summary(x)$ci.lb),
  sapply(leave_study_out_model_lnRR, function(x) summary(x)$ci.ub) 
))

colnames(results.leave_study_out_model_lnRR) <- c("Estimate", "SE", "zval", "pval", "ci.lb", "ci.ub")
results.leave_study_out_model_lnRR$study_id <- unique(data$study_id)

# Display the results table
kable(results.leave_study_out_model_lnRR) %>%
  kable_styling("striped", position = "left") %>%
  scroll_box(width = "100%", height = "500px")

Estimate	SE	zval	pval	ci.lb	ci.ub	study_id
-0.2707502	0.1234745	-2.192762	0.0288415	-0.5134157	-0.0280847	bellot_2024
-0.2222167	0.1243949	-1.786382	0.0747197	-0.4666926	0.0222591	boscolo_2018
-0.2809559	0.1226510	-2.290694	0.0224586	-0.5220181	-0.0398937	bridi_2017
-0.2708383	0.1246354	-2.173045	0.0303123	-0.5157962	-0.0258805	chen_2022
-0.2732013	0.1265705	-2.158491	0.0314286	-0.5219577	-0.0244449	chung_2023
-0.2800641	0.1204502	-2.325144	0.0205152	-0.5167889	-0.0433392	faria_2021
-0.2709573	0.1229306	-2.204150	0.0280595	-0.5125981	-0.0293165	guo_2023
-0.2720410	0.1228927	-2.213648	0.0273711	-0.5135782	-0.0305038	gusso_2020
-0.2603531	0.1219030	-2.135739	0.0332496	-0.4999347	-0.0207715	hawkey_2020
-0.2727462	0.1231186	-2.215313	0.0272523	-0.5147229	-0.0307696	hawkey_2021
-0.2549523	0.1269547	-2.008215	0.0452325	-0.5044668	-0.0054378	hued_2011
-0.2721784	0.1231900	-2.209419	0.0276731	-0.5143095	-0.0300473	hussian_2020
-0.2691936	0.1225617	-2.196393	0.0286020	-0.5100945	-0.0282927	ilie_2021
-0.2706325	0.1212735	-2.231588	0.0261474	-0.5089827	-0.0322822	ilie_2022
-0.2779020	0.1274424	-2.180609	0.0297366	-0.5283672	-0.0274367	jaensson_2007
-0.2939646	0.1258517	-2.335802	0.0199531	-0.5413144	-0.0466148	khalil_2013
-0.2714868	0.1284528	-2.113514	0.0351309	-0.5239586	-0.0190149	khalil_2017
-0.2706756	0.1235775	-2.190332	0.0290267	-0.5135541	-0.0277971	lei_2022
-0.2044138	0.0834950	-2.448217	0.0147434	-0.3685092	-0.0403184	leite_2023
-0.2722593	0.1233538	-2.207141	0.0278185	-0.5146937	-0.0298249	lin_2024
-0.2692625	0.1234724	-2.180750	0.0297261	-0.5119255	-0.0265995	liu_2023
-0.2748595	0.1231887	-2.231207	0.0261660	-0.5169649	-0.0327541	liu_2023a
-0.2677348	0.1377674	-1.943383	0.0526360	-0.5385325	0.0030628	maclaren_2023
-0.2651540	0.1224645	-2.165151	0.0309093	-0.5058375	-0.0244705	oliveira_2024
-0.2891602	0.1230881	-2.349213	0.0192485	-0.5310649	-0.0472554	olsen_2020
-0.2733496	0.1224296	-2.232709	0.0260637	-0.5139602	-0.0327391	paredes_2019
-0.3064524	0.1281710	-2.390964	0.0172344	-0.5583737	-0.0545310	sanchez_2021
-0.2675961	0.1230901	-2.173985	0.0302423	-0.5095183	-0.0256738	schmidel_2014
-0.3078426	0.1360552	-2.262630	0.0241420	-0.5752365	-0.0404488	shenoy_2012
-0.2381278	0.1218354	-1.954503	0.0512675	-0.4775721	0.0013165	silva_2005
-0.2754738	0.1240649	-2.220401	0.0269701	-0.5193994	-0.0315483	stungaru_2019
-0.2691895	0.1232759	-2.183634	0.0295131	-0.5114679	-0.0269112	tamagno_2023
-0.2395056	0.1216880	-1.968195	0.0496717	-0.4786660	-0.0003452	teather_2001
-0.2615337	0.1209303	-2.162681	0.0311418	-0.4992527	-0.0238146	yan_2023
-0.2728711	0.1212028	-2.251360	0.0248753	-0.5111058	-0.0346363	yang_2023
-0.2364084	0.1157051	-2.043198	0.0416609	-0.4638463	-0.0089705	zaluski_2022
-0.2827246	0.1361799	-2.076111	0.0384815	-0.5503911	-0.0150582	zhou_2021

leave_one_study_out_lnRR_forest_plot <- ggplot(results.leave_study_out_model_lnRR, 
                      aes(x = fct_reorder(as.factor(study_id), Estimate), 
                          y = Estimate, 
                          ymin = ci.lb, 
                          ymax = ci.ub)) +
  geom_pointrange() +
  geom_hline(yintercept = 0, linetype = "dashed", color = "red") +
  theme_bw() +
  theme(legend.position = "none",
        axis.text = element_text(color = "black"),
        axis.title = element_text(face = "bold", color = "black"),
        plot.caption = element_text(size = 10, color = "gray10", face = "italic"),
        axis.text.y = element_text(size = 8)) +
  labs(caption = "The value in each point is the point estimate excluding one study at a time",
       x = "Study ID",
       y = "lnRR") +
       ylim(-0.6, 0.2) +
  coord_flip()

print(leave_one_study_out_lnRR_forest_plot)

# ggsave(here("figures", "leave_one_study_out_lnRR_forest_plot.pdf"), width = 10, height = 10, units = "cm", scale = 2, dpi = 800)
# ggsave(here("figures", "leave_one_study_out_lnRR_forest_plot.jpg"), width = 10, height = 10, units = "cm", scale = 2, dpi = 800)


results.leave_study_out_model_lnRR %>% 
  summarise(estimate = mean(Estimate), # calculate the mean coefficients across the models generated
            se = mean(SE), 
            zval = mean(zval), 
            pval = mean(pval), 
            ci.lb = mean(ci.lb), 
            ci.ub = mean(ci.ub)) %>% 
  kable() %>% kable_styling("striped", position = "left")

estimate	se	zval	pval	ci.lb	ci.ub
-0.2683521	0.1233455	-2.178559	0.0313033	-0.5107802	-0.025924

Intercept only model (lnVR)

data$leave_study <- as.factor(data$study_id)

### create a list to contain model estimates
leave_study_out_model_lnVR <- list()
VCV_leave_study_out_lnVR <- list()

# save to save time - running this model is time-consuming

# Save as .Rds file saveRDS(leave_study_out_model_lnVR, file = here('R.data',
# 'leave_study_out_model_lnVR.Rds'))

# Load from .Rds file
leave_study_out_model_lnVR <- readRDS(here("R.data", "leave_study_out_model_lnVR.Rds"))


# Save as .Rdata file save(leave_study_out_model_lnVR, file = here('R.data',
# 'leave_study_out_model_lnVR.Rdata'))

# Load from .Rdata file
load(here("R.data", "leave_study_out_model_lnVR.Rdata"))


### repeatedly run the multilevel model, leaving out one study at a time
for (i in 1:length(levels(data$leave_study))) {
    data_study_leave <- data %>%
        filter(leave_study != levels(data$leave_study)[i])

    VCV_leave_study_out_lnVR[[i]] <- impute_covariance_matrix(vi = data_study_leave$lnVRv,
        cluster = data_study_leave$study_id, r = 0.5)

    leave_study_out_model_lnVR[[i]] <- rma.mv(yi = lnVR, V = VCV_leave_study_out_lnVR[[i]],
        random = list(~1 | study_id, ~1 | assay_id, ~1 | species_latin, ~1 | pesticide),
        method = "REML", test = "t", data = data_study_leave, sparse = TRUE)
}

results.leave_study_out_model_lnVR <- as.data.frame(cbind(sapply(leave_study_out_model_lnVR,
    function(x) summary(x)$beta), sapply(leave_study_out_model_lnVR, function(x) summary(x)$se),
    sapply(leave_study_out_model_lnVR, function(x) summary(x)$zval), sapply(leave_study_out_model_lnVR,
        function(x) summary(x)$pval), sapply(leave_study_out_model_lnVR, function(x) summary(x)$ci.lb),
    sapply(leave_study_out_model_lnVR, function(x) summary(x)$ci.ub)))

colnames(results.leave_study_out_model_lnVR) <- c("Estimate", "SE", "zval", "pval",
    "ci.lb", "ci.ub")
results.leave_study_out_model_lnVR$study_id <- unique(data$study_id)

# Display the results table
kable(results.leave_study_out_model_lnVR) %>%
    kable_styling("striped", position = "left") %>%
    scroll_box(width = "100%", height = "500px")

Estimate	SE	zval	pval	ci.lb	ci.ub	study_id
-0.0671787	0.0788471	-0.8520129	0.3946652	-0.2221376	0.0877801	bellot_2024
-0.0411794	0.0445311	-0.9247341	0.3556065	-0.1286973	0.0463385	boscolo_2018
-0.0619267	0.0818085	-0.7569719	0.4494765	-0.2227158	0.0988623	bridi_2017
-0.0720351	0.0767686	-0.9383406	0.3485865	-0.2229158	0.0788456	chen_2022
-0.0726168	0.0764294	-0.9501163	0.3425736	-0.2228280	0.0775943	chung_2023
-0.0662749	0.0792111	-0.8366870	0.4032196	-0.2219511	0.0894013	faria_2021
-0.0708509	0.0832146	-0.8514232	0.3950230	-0.2344232	0.0927215	guo_2023
-0.0701593	0.0765486	-0.9165331	0.3598952	-0.2206104	0.0802918	gusso_2020
-0.0699782	0.0772368	-0.9060218	0.3654179	-0.2217752	0.0818188	hawkey_2020
-0.0704540	0.0767763	-0.9176535	0.3593053	-0.2213497	0.0804417	hawkey_2021
-0.0621315	0.0760990	-0.8164555	0.4146825	-0.2116952	0.0874322	hued_2011
-0.0661285	0.0799800	-0.8268127	0.4088028	-0.2233299	0.0910729	hussian_2020
-0.0722795	0.0767748	-0.9414482	0.3470088	-0.2231840	0.0786251	ilie_2021
-0.0698979	0.0785579	-0.8897631	0.3740816	-0.2242951	0.0844993	ilie_2022
-0.0518869	0.1010469	-0.5134927	0.6078622	-0.2504765	0.1467028	jaensson_2007
-0.0441695	0.0436557	-1.0117681	0.3122088	-0.1299708	0.0416318	khalil_2013
-0.0746409	0.0870785	-0.8571675	0.3918287	-0.2457923	0.0965105	khalil_2017
-0.0681779	0.0780268	-0.8737754	0.3827194	-0.2215314	0.0851756	lei_2022
-0.0807308	0.0880518	-0.9168563	0.3597168	-0.2537819	0.0923203	leite_2023
-0.0695566	0.0775106	-0.8973824	0.3700045	-0.2218926	0.0827794	lin_2024
-0.0691347	0.0777895	-0.8887409	0.3746236	-0.2220161	0.0837467	liu_2023
-0.0686691	0.0780861	-0.8794029	0.3796586	-0.2221334	0.0847951	liu_2023a
-0.1037526	0.0730224	-1.4208321	0.1561058	-0.2472866	0.0397814	maclaren_2023
-0.0648373	0.0801198	-0.8092544	0.4188033	-0.2222993	0.0926248	oliveira_2024
-0.0950481	0.0763584	-1.2447618	0.2138730	-0.2451151	0.0550190	olsen_2020
-0.0685988	0.0781455	-0.8778343	0.3805063	-0.2221779	0.0849803	paredes_2019
-0.0510415	0.0749541	-0.6809698	0.4962580	-0.1983644	0.0962815	sanchez_2021
-0.0708787	0.0784105	-0.9039447	0.3665227	-0.2249872	0.0832298	schmidel_2014
-0.0948764	0.0834956	-1.1363036	0.2564438	-0.2589731	0.0692204	shenoy_2012
-0.0577383	0.0908882	-0.6352675	0.5255805	-0.2363617	0.1208851	silva_2005
-0.0735040	0.0700020	-1.0500266	0.2943611	-0.2111359	0.0641279	stungaru_2019
-0.0698323	0.0773919	-0.9023203	0.3673771	-0.2219331	0.0822686	tamagno_2023
-0.0379155	0.0440822	-0.8601083	0.3901967	-0.1245527	0.0487218	teather_2001
-0.0656020	0.0809741	-0.8101601	0.4183170	-0.2247770	0.0935730	yan_2023
-0.0684593	0.0765250	-0.8946008	0.3715093	-0.2188758	0.0819572	yang_2023
-0.0605799	0.0533660	-1.1351769	0.2569533	-0.1654799	0.0443201	zaluski_2022
-0.0669336	0.0974270	-0.6870133	0.4924473	-0.2584297	0.1245625	zhou_2021

leave_one_study_out_lnVR_forest_plot <- ggplot(results.leave_study_out_model_lnVR,
    aes(x = fct_reorder(as.factor(study_id), Estimate), y = Estimate, ymin = ci.lb,
        ymax = ci.ub)) + geom_pointrange() + geom_hline(yintercept = 0, linetype = "dashed",
    color = "red") + theme_bw() + theme(legend.position = "none", axis.text = element_text(color = "black"),
    axis.title = element_text(face = "bold", color = "black"), plot.caption = element_text(size = 10,
        color = "gray10", face = "italic"), axis.text.y = element_text(size = 8)) +
    labs(caption = "The value in each point is the point estimate excluding one study at a time",
        x = "Study ID", y = "lnVR") + coord_flip()

print(leave_one_study_out_lnVR_forest_plot)

# ggsave(here('figures', 'leave_one_study_out_lnVR_forest_plot.pdf'), width =
# 10, height = 10, units = 'cm', scale = 2, dpi = 800) ggsave(here('figures',
# 'leave_one_study_out_lnVR_forest_plot.jpg'), width = 10, height = 10, units =
# 'cm', scale = 2, dpi = 800)

results.leave_study_out_model_lnVR %>%
    summarise(estimate = mean(Estimate), se = mean(SE), zval = mean(zval), pval = mean(pval),
        ci.lb = mean(ci.lb), ci.ub = mean(ci.ub)) %>%
    kable() %>%
    kable_styling("striped", position = "left")

estimate	se	zval	pval	ci.lb	ci.ub
-0.0678285	0.0764647	-0.8976253	0.3757357	-0.2181149	0.0824579

Leave one species out

Intercept only model (lnRR)

# Convert species_latin to a factor and create a new column for the
# leave-one-out procedure
data$leave_species <- as.factor(data$species_latin)

# Initialize lists to contain the model estimates and VCV matrices
leave_species_out_model_lnRR <- list()
VCV_leave_species_out_lnRR <- list()

# save to save time - running this model is time-consuming

# Save as .Rds file saveRDS(leave_species_out_model_lnRR, file = here('R.data',
# 'leave_species_out_model_lnRR.Rds'))

# Load from .Rds file
leave_species_out_model_lnRR <- readRDS(here("R.data", "leave_species_out_model_lnRR.Rds"))


# Save as .Rdata file save(leave_study_out_model_lnVR, file = here('R.data',
# 'leave_species_out_model_lnRR.Rdata'))

# Load from .Rdata file
load(here("R.data", "leave_species_out_model_lnRR.Rdata"))

# Iteratively run the multilevel model, leaving out one species at a time
for (i in 1:length(levels(data$leave_species))) {
    # Create the data with one species removed at a time
    data_species_leave <- data %>%
        filter(leave_species != levels(data$leave_species)[i])

    # Create a VCV matrix for the subset data
    VCV_leave_species_out_lnRR[[i]] <- impute_covariance_matrix(vi = data_species_leave$lnRRv,
        cluster = data_species_leave$study_id, r = 0.5)

    # Model fitting
    leave_species_out_model_lnRR[[i]] <- rma.mv(yi = data_species_leave$lnRR, V = VCV_leave_species_out_lnRR[[i]],
        random = list(~1 | study_id, ~1 | assay_id, ~1 | species_latin, ~1 | pesticide),
        method = "REML", test = "t", data = data_species_leave, sparse = TRUE)
}


results.leave_species_out_model_lnRR <- as.data.frame(cbind(sapply(leave_species_out_model_lnRR,
    function(x) summary(x)$beta), sapply(leave_species_out_model_lnRR, function(x) summary(x)$se),
    sapply(leave_species_out_model_lnRR, function(x) summary(x)$zval), sapply(leave_species_out_model_lnRR,
        function(x) summary(x)$pval), sapply(leave_species_out_model_lnRR, function(x) summary(x)$ci.lb),
    sapply(leave_species_out_model_lnRR, function(x) summary(x)$ci.ub)))

colnames(results.leave_species_out_model_lnRR) <- c("Estimate", "SE", "zval", "pval",
    "ci.lb", "ci.ub")
results.leave_species_out_model_lnRR$species_latin <- unique(data$species_latin)

# Display the results table
kable(results.leave_species_out_model_lnRR) %>%
    kable_styling("striped", position = "left") %>%
    scroll_box(width = "100%", height = "500px")

Estimate	SE	zval	pval	ci.lb	ci.ub	species_latin
-0.1823464	0.0783664	-2.326844	0.0204216	-0.3363605	-0.0283322	Danio rerio
-0.2931214	0.1383311	-2.118984	0.0361534	-0.5670074	-0.0192354	Oreochromis niloticus
-0.2948379	0.1402541	-2.102169	0.0361319	-0.5705235	-0.0191523	Jenynsia multidentata
-0.2715611	0.0946959	-2.867716	0.0043309	-0.4576679	-0.0854543	Salmo trutta
-0.2222167	0.1243949	-1.786382	0.0747197	-0.4666926	0.0222591	Oryzias latipes
-0.2690256	0.1417029	-1.898519	0.0583212	-0.5475706	0.0095193	Luciobarbus bocagei
-0.2827246	0.1361799	-2.076111	0.0384815	-0.5503911	-0.0150582	Alburnus alburnus
-0.2677348	0.1377674	-1.943383	0.0526360	-0.5385325	0.0030628	Poecilia latipinna
-0.2516205	0.1337990	-1.880586	0.0606871	-0.5145834	0.0113424	Poecilia reticulata
-0.3080645	0.1311092	-2.349680	0.0192277	-0.5657377	-0.0503913	Oryzias melastigma

leave_one_species_out_lnRR_forest_plot <- ggplot(results.leave_species_out_model_lnRR,
    aes(x = fct_reorder(as.factor(species_latin), Estimate), y = Estimate, ymin = ci.lb,
        ymax = ci.ub)) + geom_pointrange() + geom_hline(yintercept = 0, linetype = "dashed",
    color = "red") + theme_bw() + theme(legend.position = "none", axis.text = element_text(color = "black"),
    axis.title = element_text(face = "bold", color = "black"), plot.caption = element_text(size = 10,
        color = "gray10", face = "italic"), axis.text.y = element_text(size = 8)) +
    labs(caption = "The value in each point is the estimate excluding one species at a time",
        x = "Species Latin", y = "lnRR") + ylim(-0.6, 0.2) + coord_flip()

print(leave_one_species_out_lnRR_forest_plot)

# ggsave(here('figures', 'leave_one_species_out_lnRR_forest_plot.pdf'), width =
# 10, height = 5, units = 'cm', scale = 2, dpi = 800) ggsave(here('figures',
# 'leave_one_species_out_lnRR_forest_plot.jpg'), width = 10, height = 5, units
# = 'cm', scale = 2, dpi = 800)

results.leave_species_out_model_lnRR %>%
    summarise(estimate = mean(Estimate), se = mean(SE), zval = mean(zval), pval = mean(pval),
        ci.lb = mean(ci.lb), ci.ub = mean(ci.ub)) %>%
    kable() %>%
    kable_styling("striped", position = "left")

estimate	se	zval	pval	ci.lb	ci.ub
-0.2643254	0.1256601	-2.135037	0.0401111	-0.5115067	-0.017144

Intercept only model (lnVR)

# Convert species_latin to a factor and create a new column for the
# leave-one-out procedure
data$leave_species <- as.factor(data$species_latin)

# Initialize lists to contain the model estimates and VCV matrices
leave_species_out_model_lnVR <- list()
VCV_leave_species_out_lnVR <- list()

# Save as .Rds file saveRDS(leave_species_out_model_lnRR, file = here('R.data',
# 'leave_species_out_model_lnVR.Rds'))

# Load from .Rds file
leave_species_out_model_lnVR <- readRDS(here("R.data", "leave_species_out_model_lnVR.Rds"))


# Save as .Rdata file save(leave_study_out_model_lnVR, file = here('R.data',
# 'leave_species_out_model_lnVR.Rdata'))

# Load from .Rdata file
load(here("R.data", "leave_species_out_model_lnVR.Rdata"))

# Iteratively run the multilevel model, leaving out one species at a time
for (i in 1:length(levels(data$leave_species))) {
    # Create the data with one species removed at a time
    data_species_leave <- data %>%
        filter(leave_species != levels(data$leave_species)[i])

    # Create a VCV matrix for the subset data
    VCV_leave_species_out_lnVR[[i]] <- impute_covariance_matrix(vi = data_species_leave$lnVRv,
        cluster = data_species_leave$study_id, r = 0.5)

    # Model fitting
    leave_species_out_model_lnVR[[i]] <- rma.mv(yi = data_species_leave$lnVR, V = VCV_leave_species_out_lnVR[[i]],
        random = list(~1 | study_id, ~1 | assay_id, ~1 | species_latin, ~1 | pesticide),
        method = "REML", test = "t", data = data_species_leave, sparse = TRUE)
}

results.leave_species_out_model_lnVR <- as.data.frame(cbind(sapply(leave_species_out_model_lnVR,
    function(x) summary(x)$beta), sapply(leave_species_out_model_lnVR, function(x) summary(x)$se),
    sapply(leave_species_out_model_lnVR, function(x) summary(x)$zval), sapply(leave_species_out_model_lnVR,
        function(x) summary(x)$pval), sapply(leave_species_out_model_lnVR, function(x) summary(x)$ci.lb),
    sapply(leave_species_out_model_lnVR, function(x) summary(x)$ci.ub)))

colnames(results.leave_species_out_model_lnVR) <- c("Estimate", "SE", "zval", "pval",
    "ci.lb", "ci.ub")
results.leave_species_out_model_lnVR$species_latin <- unique(data$species_latin)

# Display the results table
kable(results.leave_species_out_model_lnVR) %>%
    kable_styling("striped", position = "left") %>%
    scroll_box(width = "100%", height = "500px")

Estimate	SE	zval	pval	ci.lb	ci.ub	species_latin
-0.0762239	0.0823193	-0.9259548	0.3549713	-0.2380067	0.0855589	Danio rerio
-0.1512107	0.1171878	-1.2903283	0.1994175	-0.3832344	0.0808129	Oreochromis niloticus
-0.0388610	0.0845842	-0.4594357	0.6461585	-0.2051210	0.1273990	Jenynsia multidentata
-0.0704455	0.0832357	-0.8463376	0.3978193	-0.2340294	0.0931384	Salmo trutta
-0.0411794	0.0445311	-0.9247341	0.3556065	-0.1286973	0.0463385	Oryzias latipes
-0.0317717	0.0443399	-0.7165478	0.4740562	-0.1189306	0.0553872	Luciobarbus bocagei
-0.0669336	0.0974270	-0.6870133	0.4924473	-0.2584297	0.1245625	Alburnus alburnus
-0.1037526	0.0730224	-1.4208321	0.1561058	-0.2472866	0.0397814	Poecilia latipinna
-0.0873669	0.0886485	-0.9855422	0.3248982	-0.2615929	0.0868592	Poecilia reticulata
-0.0911190	0.0803211	-1.1344338	0.2572261	-0.2489769	0.0667388	Oryzias melastigma

leave_one_species_out_lnVR_forest_plot <- ggplot(results.leave_species_out_model_lnVR,
    aes(x = fct_reorder(as.factor(species_latin), Estimate), y = Estimate, ymin = ci.lb,
        ymax = ci.ub)) + geom_pointrange() + geom_hline(yintercept = 0, linetype = "dashed",
    color = "red") + theme_bw() + theme(legend.position = "none", axis.text = element_text(color = "black"),
    axis.title = element_text(face = "bold", color = "black"), plot.caption = element_text(size = 10,
        color = "gray10", face = "italic"), axis.text.y = element_text(size = 8)) +
    labs(caption = "The value in each point is the estimate excluding one species at a time",
        x = "Species Latin", y = "lnVR") + coord_flip()

print(leave_one_species_out_lnVR_forest_plot)

# ggsave(here('figures', 'leave_one_species_out_lnVR_forest_plot.pdf'), width =
# 10, height = 5, units = 'cm', scale = 2, dpi = 800) ggsave(here('figures',
# 'leave_one_species_out_lnVR_forest_plot.jpg'), width = 10, height = 5, units
# = 'cm', scale = 2, dpi = 800)

results.leave_species_out_model_lnVR %>%
    summarise(estimate = mean(Estimate), se = mean(SE), zval = mean(zval), pval = mean(pval),
        ci.lb = mean(ci.lb), ci.ub = mean(ci.ub)) %>%
    kable() %>%
    kable_styling("striped", position = "left")

estimate	se	zval	pval	ci.lb	ci.ub
-0.0758864	0.0795617	-0.939116	0.3658707	-0.2324305	0.0806577

Leave one pesticide out

Intercept only model (lnRR)

# Convert pesticide_chemical_class to a factor and create a new column for the
# leave-one-out procedure
data$leave_pesticide <- as.factor(data$pesticide_chemical_class)

# Initialize lists to contain the model estimates and VCV matrices
leave_pesticide_out_model_lnRR <- list()
VCV_leave_pesticide_out_lnRR <- list()

# Save as .Rds file saveRDS(leave_species_out_model_lnRR, file = here('R.data',
# 'leave_pesticide_out_model_lnRR.Rds'))

# Load from .Rds file
leave_pesticide_out_model_lnRR <- readRDS(here("R.data", "leave_pesticide_out_model_lnRR.Rds"))


# Save as .Rdata file save(leave_pesticide_out_model_lnRR, file =
# here('R.data', 'leave_pesticide_out_model_lnRR.Rdata'))

# Load from .Rdata file
load(here("R.data", "leave_pesticide_out_model_lnRR.Rdata"))

# Iteratively run the multilevel model, leaving out one pesticide chemical
# class at a time
for (i in 1:length(levels(data$leave_pesticide))) {
    data_pesticide_leave <- data %>%
        filter(leave_pesticide != levels(data$leave_pesticide)[i])

    VCV_leave_pesticide_out_lnRR[[i]] <- impute_covariance_matrix(vi = data_pesticide_leave$lnRRv,
        cluster = data_pesticide_leave$study_id, r = 0.5)

    leave_pesticide_out_model_lnRR[[i]] <- rma.mv(yi = data_pesticide_leave$lnRR,
        V = VCV_leave_pesticide_out_lnRR[[i]], random = list(~1 | study_id, ~1 |
            assay_id, ~1 | species_latin, ~1 | pesticide), method = "REML", test = "t",
        data = data_pesticide_leave, sparse = TRUE)
}

results.leave_pesticide_out_model_lnRR <- as.data.frame(cbind(sapply(leave_pesticide_out_model_lnRR,
    function(x) summary(x)$beta), sapply(leave_pesticide_out_model_lnRR, function(x) summary(x)$se),
    sapply(leave_pesticide_out_model_lnRR, function(x) summary(x)$zval), sapply(leave_pesticide_out_model_lnRR,
        function(x) summary(x)$pval), sapply(leave_pesticide_out_model_lnRR, function(x) summary(x)$ci.lb),
    sapply(leave_pesticide_out_model_lnRR, function(x) summary(x)$ci.ub)))

colnames(results.leave_pesticide_out_model_lnRR) <- c("Estimate", "SE", "zval", "pval",
    "ci.lb", "ci.ub")
results.leave_pesticide_out_model_lnRR$pesticide_chemical_class <- unique(data$pesticide_chemical_class)

# Display the results table
kable(results.leave_pesticide_out_model_lnRR) %>%
    kable_styling("striped", position = "left") %>%
    scroll_box(width = "100%", height = "500px")

Estimate	SE	zval	pval	ci.lb	ci.ub	pesticide_chemical_class
-0.2709573	0.1229306	-2.204150	0.0280595	-0.5125981	-0.0293165	organophosphate
-0.2831370	0.1229412	-2.303027	0.0217408	-0.5247590	-0.0415150	urea
-0.2708383	0.1246354	-2.173045	0.0303123	-0.5157962	-0.0258805	dioxolanes
-0.2784144	0.1262790	-2.204756	0.0280205	-0.5266424	-0.0301864	neonicotinoid
-0.2764455	0.1267305	-2.181365	0.0296936	-0.5255289	-0.0273621	B-methoxyacrylates
-0.3388205	0.1528384	-2.216855	0.0272420	-0.6393639	-0.0382771	phenoxy
-0.2695460	0.1222705	-2.204505	0.0280010	-0.5098469	-0.0292452	organochlorine
-0.2720410	0.1228927	-2.213648	0.0273711	-0.5135782	-0.0305038	organophosphate and organochlorine
-0.2149606	0.0925602	-2.322387	0.0207630	-0.3969804	-0.0329407	triazole
-0.2741606	0.1211721	-2.262573	0.0241758	-0.5123448	-0.0359764	rotenones
-0.2697352	0.1491096	-1.808973	0.0712212	-0.5628898	0.0234194	pyrethroid
-0.2568284	0.1202154	-2.136401	0.0332703	-0.4931817	-0.0204751	triazine
-0.2401524	0.1352142	-1.776088	0.0764618	-0.5059539	0.0256492	carbamate

leave_one_pesticide_out_lnRR_forest_plot <- ggplot(results.leave_pesticide_out_model_lnRR,
    aes(x = fct_reorder(as.factor(pesticide_chemical_class), Estimate), y = Estimate,
        ymin = ci.lb, ymax = ci.ub)) + geom_pointrange() + geom_hline(yintercept = 0,
    linetype = "dashed", color = "red") + theme_bw() + theme(legend.position = "none",
    axis.text = element_text(color = "black"), axis.title = element_text(face = "bold",
        color = "black"), plot.caption = element_text(size = 10, color = "gray10",
        face = "italic"), axis.text.y = element_text(size = 8)) + labs(caption = "The value in each point is the estimate excluding one pesticide at a time",
    x = "Pesticide Chemical Class", y = "lnRR") + ylim(-0.7, 0.2) + coord_flip()

print(leave_one_pesticide_out_lnRR_forest_plot)

# ggsave(here('figures', 'leave_one_pesticide_out_lnRR_forest_plot.pdf'), width
# = 10, height = 5, units = 'cm', scale = 2, dpi = 800) ggsave(here('figures',
# 'leave_one_pesticide_out_lnRR_forest_plot.jpg'), width = 10, height = 5,
# units = 'cm', scale = 2, dpi = 800)

results.leave_pesticide_out_model_lnRR %>%
    summarise(estimate = mean(Estimate), se = mean(SE), zval = mean(zval), pval = mean(pval),
        ci.lb = mean(ci.lb), ci.ub = mean(ci.ub)) %>%
    kable() %>%
    kable_styling("striped", position = "left")

estimate	se	zval	pval	ci.lb	ci.ub
-0.2704644	0.1261377	-2.154444	0.0343333	-0.5184203	-0.0225085

Intercept only model (lnVR)

# Convert pesticide_chemical_class to a factor and create a new column for the leave-one-out procedure
data$leave_pesticide <- as.factor(data$pesticide_chemical_class)

# Initialize lists to contain the model estimates and VCV matrices
leave_pesticide_out_model_lnVR <- list()
VCV_leave_pesticide_out_lnVR <- list()

# Iteratively run the multilevel model, leaving out one pesticide chemical class at a time
for(i in 1:length(levels(data$leave_pesticide))){
  # Create the data with one pesticide removed at a time
  data_pesticide_leave <- data %>% filter(leave_pesticide != levels(data$leave_pesticide)[i])
  
  # Create a VCV matrix for the subset data
  VCV_leave_pesticide_out_lnVR[[i]] <- impute_covariance_matrix(vi = data_pesticide_leave$lnVRv, cluster = data_pesticide_leave$study_id, r = 0.5)
  
  # Model fitting
  leave_pesticide_out_model_lnVR[[i]] <- rma.mv(yi = data_pesticide_leave$lnVR,
                                                V = VCV_leave_pesticide_out_lnVR[[i]],
                                                random = list(~1 | study_id,
                                                              ~1 | assay_id,
                                                              ~1 | species_latin,
                                                              ~1 | pesticide),
                                                method = "REML", 
                                                test = "t",
                                                data = data_pesticide_leave,
                                                sparse = TRUE)
} 

results.leave_pesticide_out_model_lnVR <- as.data.frame(cbind(
  sapply(leave_pesticide_out_model_lnVR, function(x) summary(x)$beta), # extract the beta coefficient from all models
  sapply(leave_pesticide_out_model_lnVR, function(x) summary(x)$se),   # extract the standard error from all models
  sapply(leave_pesticide_out_model_lnVR, function(x) summary(x)$zval), # extract the z value from all models
  sapply(leave_pesticide_out_model_lnVR, function(x) summary(x)$pval), # extract the p value from all models
  sapply(leave_pesticide_out_model_lnVR, function(x) summary(x)$ci.lb),# extract the lower confidence interval for all models
  sapply(leave_pesticide_out_model_lnVR, function(x) summary(x)$ci.ub) # extract the upper confidence interval for all models
))

colnames(results.leave_pesticide_out_model_lnVR) <- c("Estimate", "SE", "zval", "pval", "ci.lb", "ci.ub") # change column names
results.leave_pesticide_out_model_lnVR$pesticide_chemical_class <- unique(data$pesticide_chemical_class)

# Display the results table
kable(results.leave_pesticide_out_model_lnVR) %>%
  kable_styling("striped", position = "left") %>%
  scroll_box(width = "100%", height = "500px")

Estimate	SE	zval	pval	ci.lb	ci.ub	pesticide_chemical_class
-0.0708509	0.0832146	-0.8514232	0.3950230	-0.2344232	0.0927215	organophosphate
-0.0923824	0.0788418	-1.1717441	0.2419311	-0.2473338	0.0625690	urea
-0.0720351	0.0767686	-0.9383406	0.3485865	-0.2229158	0.0788456	dioxolanes
-0.0725936	0.0742223	-0.9780566	0.3286175	-0.2184932	0.0733060	neonicotinoid
-0.0737633	0.0811302	-0.9091967	0.3637521	-0.2332212	0.0856946	B-methoxyacrylates
0.0024225	0.0935039	0.0259081	0.9793447	-0.1814449	0.1862899	phenoxy
-0.0687994	0.0779251	-0.8828923	0.3777722	-0.2219472	0.0843483	organochlorine
-0.0701593	0.0765486	-0.9165331	0.3598952	-0.2206104	0.0802918	organophosphate and organochlorine
-0.0707677	0.1088089	-0.6503850	0.5158539	-0.2847407	0.1432053	triazole
-0.0734635	0.0774377	-0.9486786	0.3433335	-0.2256803	0.0787534	rotenones
-0.1356974	0.0827064	-1.6407124	0.1016592	-0.2983009	0.0269062	pyrethroid
-0.0244357	0.0458342	-0.5331321	0.5942466	-0.1145495	0.0656781	triazine
-0.0364973	0.0911058	-0.4006035	0.6889212	-0.2155914	0.1425968	carbamate

leave_one_pesticide_out_lnVR_forest_plot <- ggplot(results.leave_pesticide_out_model_lnVR, 
                      aes(x = fct_reorder(as.factor(pesticide_chemical_class), Estimate), 
                          y = Estimate, 
                          ymin = ci.lb, 
                          ymax = ci.ub)) +
  geom_pointrange() +
  geom_hline(yintercept = 0, linetype = "dashed", color = "red") +
  theme_bw() +
  theme(legend.position = "none",
        axis.text = element_text(color = "black"),
        axis.title = element_text(face = "bold", color = "black"),
        plot.caption = element_text(size = 10, color = "gray10", face = "italic"),
        axis.text.y = element_text(size = 8)) +
  labs(caption = "The value in each point is the estimate excluding one pesticide at a time",
       x = "Pesticide Chemical Class",
       y = "lnVR") +
  coord_flip()

print(leave_one_pesticide_out_lnVR_forest_plot)

# ggsave(here("figures", "leave_one_pesticide_out_lnVR_forest_plot.pdf"), width = 10, height = 5, units = "cm", scale = 2, dpi = 800)
# ggsave(here("figures", "leave_one_pesticide_out_lnVR_forest_plot.jpg"), width = 10, height = 5, units = "cm", scale = 2, dpi = 800)
 
 results.leave_pesticide_out_model_lnVR %>% 
  summarise(estimate = mean(Estimate), 
            se = mean(SE), 
            zval = mean(zval), 
            pval = mean(pval), 
            ci.lb = mean(ci.lb), 
            ci.ub = mean(ci.ub)) %>% 
  kable() %>% kable_styling("striped", position = "left")

estimate	se	zval	pval	ci.lb	ci.ub
-0.0660787	0.0806191	-0.8304454	0.4337644	-0.2245579	0.0924005

Alternative variance-covariance matrices

Intercept only model (lnRR)

# Model
lnRR_intercept_only2 <- rma.mv(yi = lnRR, V = lnRRVCV2, random = list(~1 | study_id,
    ~1 | assay_id, ~1 | species_latin, ~1 | pesticide), method = "REML", test = "t",
    data = data, sparse = T)

# Summary statistics
summary(lnRR_intercept_only2)

## 
## Multivariate Meta-Analysis Model (k = 448; method: REML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -169.9073   339.8145   349.8145   370.3273   349.9506   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor 
## sigma^2.1  0.0547  0.2338     37     no       study_id 
## sigma^2.2  0.0564  0.2375    448     no       assay_id 
## sigma^2.3  0.0604  0.2457     10     no  species_latin 
## sigma^2.4  0.0076  0.0873     30     no      pesticide 
## 
## Test for Heterogeneity:
## Q(df = 447) = 4339.0531, p-val < .0001
## 
## Model Results:
## 
## estimate      se     tval   df    pval    ci.lb    ci.ub    
##  -0.2655  0.1111  -2.3886  447  0.0173  -0.4839  -0.0470  * 
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

mod_results(lnRR_intercept_only2, mod = "1", data = data, group = "study_id")

##      name   estimate    lowerCL     upperCL  lowerPR   upperPR
## 1 Intrcpt -0.2654576 -0.4838694 -0.04704575 -1.12539 0.5944748

i2_ml(lnRR_intercept_only2)

##         I2_Total      I2_study_id      I2_assay_id I2_species_latin 
##        97.397072        29.730523        30.685913        32.837521 
##     I2_pesticide 
##         4.143115

Intercept only model (lnVR)

# Model
lnVR_intercept_only2 <- rma.mv(yi = lnVR, V = lnVRVCV2, random = list(~1 | study_id,
    ~1 | assay_id, ~1 | species_latin, ~1 | pesticide), method = "REML", test = "t",
    data = data, sparse = TRUE)


# Summary results
summary(lnVR_intercept_only2)

## 
## Multivariate Meta-Analysis Model (k = 448; method: REML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -392.0815   784.1630   794.1630   814.6758   794.2990   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor 
## sigma^2.1  0.0089  0.0945     37     no       study_id 
## sigma^2.2  0.2454  0.4953    448     no       assay_id 
## sigma^2.3  0.0353  0.1880     10     no  species_latin 
## sigma^2.4  0.0024  0.0492     30     no      pesticide 
## 
## Model Results:
## 
## estimate      se     tval   df    pval    ci.lb   ci.ub    
##  -0.0799  0.0894  -0.8933  447  0.3722  -0.2557  0.0959    
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

mod_results(lnVR_intercept_only2, mod = "1", data = data, group = "study_id")  # For prediction intervals

##      name    estimate    lowerCL    upperCL   lowerPR   upperPR
## 1 Intrcpt -0.07990536 -0.2556903 0.09587962 -1.156438 0.9966271

i2_ml(lnVR_intercept_only2)

##         I2_Total      I2_study_id      I2_assay_id I2_species_latin 
##       84.8946375        2.5975924       71.3237081       10.2699094 
##     I2_pesticide 
##        0.7034276

Figure s19

Impacts of pesticide exposure on fish conspecific interactions using alternative more conservative variance covariance matrix

lnRR_intercept_only2_orchard <- orchaRd::orchard_plot(lnRR_intercept_only2, group = "study_id",
    xlab = "lnRR", data = data, g = TRUE, k.pos = "right", colour = FALSE, fill = TRUE,
    trunk.size = 3, legend.pos = "none", branch.size = 1.5, twig.size = 1) + scale_fill_manual(values = RColorBrewer::brewer.pal(8,
    "Dark2")[3]) + scale_x_discrete(labels = c("Model estimates"))

lnVR_intercept_only2_orchard <- orchaRd::orchard_plot(lnVR_intercept_only2, group = "study_id",
    xlab = "lnVR", data = data, g = TRUE, k.pos = "right", colour = FALSE, fill = TRUE,
    trunk.size = 3, legend.pos = "none", branch.size = 1.5, twig.size = 1) + scale_fill_manual(values = RColorBrewer::brewer.pal(8,
    "Dark2")[4]) + scale_x_discrete(labels = c("Model estimates"))

# Combine the two plots
alternative_VCV_figure <- lnRR_intercept_only2_orchard + lnVR_intercept_only2_orchard +
    plot_annotation(tag_levels = "A")


print(alternative_VCV_figure)

# ggsave(here('figures', 'alternative_VCV_figure.jpg'), width = 24, height =
# 10, units = 'cm', dpi = 800) ggsave(here('figures',
# 'alternative_VCV_figure.pdf'), width = 24, height = 10, units = 'cm', dpi =
# 800)

Leave studies with imputed errors out

Intercept only model (lnRR)

data_no_imputed <- data %>%
    filter(data$control_imputed == "No")

lnRRVCV_no_imputed <- metafor::vcalc(vi = lnRRv, cluster = exp_id, obs = assay_id,
    data = data_no_imputed, rho = 0.5)

# Model
lnRR_intercept_only_no_imputed <- rma.mv(yi = lnRR, V = lnRRVCV_no_imputed, random = list(~1 |
    study_id, ~1 | assay_id, ~1 | species_latin, ~1 | pesticide), method = "REML",
    test = "t", data = data_no_imputed, sparse = T)

# Summary statistics
summary(lnRR_intercept_only_no_imputed)

## 
## Multivariate Meta-Analysis Model (k = 448; method: REML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -169.3896   338.7792   348.7792   369.2920   348.9153   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor 
## sigma^2.1  0.0532  0.2308     37     no       study_id 
## sigma^2.2  0.0582  0.2412    448     no       assay_id 
## sigma^2.3  0.0613  0.2477     10     no  species_latin 
## sigma^2.4  0.0080  0.0897     30     no      pesticide 
## 
## Test for Heterogeneity:
## Q(df = 447) = 5125.7373, p-val < .0001
## 
## Model Results:
## 
## estimate      se     tval   df    pval    ci.lb    ci.ub    
##  -0.2669  0.1119  -2.3862  447  0.0174  -0.4868  -0.0471  * 
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

Intercept only model (lnVR)

# Calculate the variance-covariance matrix for lnVR
lnVRVCV_no_imputed <- metafor::vcalc(vi = lnVRv, cluster = exp_id, obs = assay_id,
    data = data_no_imputed, rho = 0.5)

# Model
lnVR_intercept_only_no_imputed <- rma.mv(yi = lnVR, V = lnVRVCV_no_imputed, random = list(~1 |
    study_id, ~1 | assay_id, ~1 | species_latin, ~1 | pesticide), method = "REML",
    test = "t", data = data_no_imputed, sparse = TRUE)

# Summary statistics
summary(lnVR_intercept_only_no_imputed)

## 
## Multivariate Meta-Analysis Model (k = 448; method: REML)
## 
##    logLik   Deviance        AIC        BIC       AICc   
## -390.6297   781.2594   791.2594   811.7722   791.3954   
## 
## Variance Components:
## 
##             estim    sqrt  nlvls  fixed         factor 
## sigma^2.1  0.0088  0.0936     37     no       study_id 
## sigma^2.2  0.2504  0.5004    448     no       assay_id 
## sigma^2.3  0.0240  0.1549     10     no  species_latin 
## sigma^2.4  0.0031  0.0560     30     no      pesticide 
## 
## Test for Heterogeneity:
## Q(df = 447) = 3617.6450, p-val < .0001
## 
## Model Results:
## 
## estimate      se     tval   df    pval    ci.lb   ci.ub    
##  -0.0848  0.0829  -1.0230  447  0.3069  -0.2477  0.0781    
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

# Plot without imputed data - lnRR
lnRR_intercept_only_no_imputed_orchard <- orchaRd::orchard_plot(lnRR_intercept_only_no_imputed,
    group = "study_id", xlab = "lnRR", data = data_no_imputed, g = TRUE, k.pos = "right",
    colour = FALSE, fill = TRUE, trunk.size = 3, legend.pos = "none", branch.size = 1.5,
    twig.size = 1) + scale_fill_manual(values = RColorBrewer::brewer.pal(8, "Dark2")[5]) +
    scale_x_discrete(labels = c("Model estimates"))

# Plot without imputed data - lnVR
lnVR_intercept_only_no_imputed_orchard <- orchaRd::orchard_plot(lnVR_intercept_only_no_imputed,
    group = "study_id", xlab = "lnVR", data = data_no_imputed, g = TRUE, k.pos = "right",
    colour = FALSE, fill = TRUE, trunk.size = 3, legend.pos = "none", branch.size = 1.5,
    twig.size = 1) + scale_fill_manual(values = RColorBrewer::brewer.pal(8, "Dark2")[6]) +
    scale_x_discrete(labels = c("Model estimates"))


# Combine the two plots
no_imputed_figure <- lnRR_intercept_only_no_imputed_orchard + lnVR_intercept_only_no_imputed_orchard +
    plot_annotation(tag_levels = "A")


print(no_imputed_figure)

# Save the plots without imputed data if needed
# ggsave(here('figures','no_imputed_orchard.jpg'), width = 24, height = 10,
# units = 'cm', dpi = 800) ggsave(here('figures','no_imputed_orchard.pdf'),
# width = 24, height = 10, units = 'cm', dpi = 800)

sessionInfo()

## R version 4.2.1 (2022-06-23 ucrt)
## Platform: x86_64-w64-mingw32/x64 (64-bit)
## Running under: Windows 10 x64 (build 22631)
## 
## Matrix products: default
## 
## locale:
## [1] LC_COLLATE=English_Australia.utf8  LC_CTYPE=English_Australia.utf8   
## [3] LC_MONETARY=English_Australia.utf8 LC_NUMERIC=C                      
## [5] LC_TIME=English_Australia.utf8    
## 
## attached base packages:
## [1] stats     graphics  grDevices utils     datasets  methods   base     
## 
## other attached packages:
##  [1] ggsankey_0.0.99999  MuMIn_1.47.5        clubSandwich_0.5.10
##  [4] orchaRd_2.0         rotl_3.1.0          ape_5.6-2          
##  [7] metagear_0.7        metafor_4.0-0       numDeriv_2016.8-1.1
## [10] metadat_1.2-0       Matrix_1.5-1        patchwork_1.2.0    
## [13] magrittr_2.0.3      kableExtra_1.4.0    here_1.0.1         
## [16] lubridate_1.9.2     forcats_1.0.0       stringr_1.5.0      
## [19] dplyr_1.1.0         purrr_1.0.1         readr_2.1.4        
## [22] tidyr_1.3.0         tibble_3.1.8        ggplot2_3.5.1      
## [25] tidyverse_2.0.0    
## 
## loaded via a namespace (and not attached):
##  [1] nlme_3.1-164       RColorBrewer_1.1-3 progress_1.2.2     httr_1.4.7        
##  [5] rprojroot_2.0.3    latex2exp_0.9.6    tools_4.2.1        bslib_0.4.2       
##  [9] utf8_1.2.2         R6_2.5.1           vipor_0.4.5        colorspace_2.0-3  
## [13] withr_3.0.1        tidyselect_1.2.0   prettyunits_1.1.1  emmeans_1.8.5     
## [17] compiler_4.2.1     cli_3.4.1          formatR_1.14       xml2_1.3.3        
## [21] sandwich_3.1-0     labeling_0.4.2     sass_0.4.5         scales_1.3.0      
## [25] mvtnorm_1.1-3      systemfonts_1.0.4  digest_0.6.29      rmarkdown_2.20    
## [29] svglite_2.1.3      rentrez_1.2.3      pkgconfig_2.0.3    htmltools_0.5.4   
## [33] highr_0.10         fastmap_1.1.0      rlang_1.1.0        rstudioapi_0.14   
## [37] farver_2.1.1       jquerylib_0.1.4    generics_0.1.3     zoo_1.8-11        
## [41] jsonlite_1.8.7     Rcpp_1.0.9         ggbeeswarm_0.7.1   munsell_0.5.0     
## [45] fansi_1.0.3        lifecycle_1.0.3    stringi_1.7.8      multcomp_1.4-25   
## [49] yaml_2.3.6         mathjaxr_1.6-0     MASS_7.3-57        grid_4.2.1        
## [53] parallel_4.2.1     crayon_1.5.2       rncl_0.8.6         lattice_0.20-45   
## [57] splines_4.2.1      hms_1.1.2          knitr_1.42         pillar_1.9.0      
## [61] tcltk_4.2.1        estimability_1.4.1 codetools_0.2-18   stats4_4.2.1      
## [65] XML_3.99-0.11      glue_1.6.2         evaluate_0.20      vctrs_0.6.0       
## [69] tzdb_0.3.0         gtable_0.3.2       cachem_1.0.7       xfun_0.37         
## [73] xtable_1.8-4       coda_0.19-4        survival_3.3-1     viridisLite_0.4.2 
## [77] beeswarm_0.4.0     timechange_0.2.0   TH.data_1.1-2      ellipsis_0.3.2